Effects of adenosine on inositol 1,4,5-trisphosphate formation and intracellular calcium changes in formyl-Met-Leu-Phe-stimulated human neutrophils.

abstract：:Type I IFNs play an important role in innate and adaptive immunity against viral infections. A novel type I IFN, namely IFN-ε, which can protect against vaginal transmission of HSV2 and Chlamydia muridarum bacterial infection, has been described in mice and humans. Nevertheless, the principle cell type and the express...

journal_title：Journal of leukocyte biology

authors： Demers A,Kang G,Ma F,Lu W,Yuan Z,Li Y,Lewis M,Kraiselburd EN,Montaner L,Li Q

更新日期：2014-12-01 00:00:00

abstract：:Alcohol-induced neuroinflammation is mediated by proinflammatory cytokines, including IL-1β. IL-1β production requires caspase-1 activation by inflammasomes-multiprotein complexes that are assembled in response to danger signals. We hypothesized that alcohol-induced inflammasome activation contributes to increased IL-...

journal_title：Journal of leukocyte biology

authors： Lippai D,Bala S,Petrasek J,Csak T,Levin I,Kurt-Jones EA,Szabo G

更新日期：2013-07-01 00:00:00

abstract：:The membrane fusion events observed during neutrophil degranulation are important aspects of the immunoregulatory system. In an attempt to understand the regulation of granule-plasma membrane fusion, we have begun characterizing human neutrophil cytosol for fusion activity, finding that 50% of the fusogenic activity c...

journal_title：Journal of leukocyte biology

authors： Hessler RJ,Blackwood RA,Brock TG,Francis JW,Harsh DM,Smolen JE

更新日期：1998-03-01 00:00:00

abstract：:The T-box transcription factor Eomes is expressed in cytotoxic immune cells and plays an important role in development, maintenance, and function of these cell types. Identification and separation of cells with differential Eomes expression would allow for better understanding of the transcriptional program governing ...

journal_title：Journal of leukocyte biology

authors： Paley MA,Gordon SM,Bikoff EK,Robertson EJ,Wherry EJ,Reiner SL

更新日期：2013-02-01 00:00:00

abstract：:Leukocytes are a central cellular element of innate-immune defense in mammals. In addition to the generation of toxic oxygen radicals and nitric oxide, leukocytes express and secrete a broad array of antimicrobial proteins and peptides. In the study, an antimicrobial polypeptide was isolated and purified from human pe...

journal_title：Journal of leukocyte biology

authors： Feng Y,Huang N,Wu Q,Wang B

更新日期：2005-11-01 00:00:00

abstract：:The biology of cells of the mononuclear phagocyte system has been studied extensively in the mouse. Studies of the pig as an experimental model have commonly been consigned to specialist animal science journals. In this review, we consider some of the many ways in which the innate immune systems of humans differ from ...

journal_title：Journal of leukocyte biology

authors： Fairbairn L,Kapetanovic R,Sester DP,Hume DA

更新日期：2011-06-01 00:00:00

abstract：:In inflammatory diseases, circulating neutrophils are recruited to sites of injury. Attractant signals are provided by many different chemotactic molecules, such that blockade of one may not prevent neutrophil recruitment effectively. The Slit family of secreted proteins and their transmembrane receptor, Robo, repel a...

journal_title：Journal of leukocyte biology

authors： Tole S,Mukovozov IM,Huang YW,Magalhaes MA,Yan M,Crow MR,Liu GY,Sun CX,Durocher Y,Glogauer M,Robinson LA

更新日期：2009-12-01 00:00:00

abstract：:Histone acetylation has an important role in gene regulation, DNA replication, and repair. Because these processes are central to the development of the immune system, we investigated the role of a previously unstudied histone acetyltransferase named KAT7 (also known as Myst2 or HBO1) in the regulation of thymopoiesis...

journal_title：Journal of leukocyte biology

authors： Newman DM,Voss AK,Thomas T,Allan RS

更新日期：2017-04-01 00:00:00

abstract：:Bone destruction in inflammatory osteolytic diseases including periodontitis is related to excessive activity of osteoclasts (OC), which originate from precursor cells of the myeloid lineage, termed osteoclast precursors (OCP). In contrast to ample knowledge that we currently have on mature OC, little is known about O...

journal_title：Journal of leukocyte biology

authors： Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P

更新日期：2020-10-01 00:00:00

abstract：:Membrane rafts are microdomains of the plasma membrane that have multiple biological functions. The involvement of these structures in the biology of T cells, namely in signal transduction by the TCR, has been widely studied. However, the role of membrane rafts in immunoreceptor signaling in NK cells is less well know...

journal_title：Journal of leukocyte biology

authors： Serrano-Pertierra E,Cernuda-Morollón E,Brdička T,Hoøejši V,López-Larrea C

更新日期：2014-09-01 00:00:00

abstract：:ADAM23 is a member of the brain macrophage-derived chemokine family. Structural homology of ADAM proteins suggests their function as integrin receptors. Previous studies have linked ADAM23 as a dominant contributor to brain development and cancer metastasis. The present studies now show that ADAM23 expression on DCs p...

journal_title：Journal of leukocyte biology

authors： Elizondo DM,Andargie TE,Marshall KM,Zariwala AM,Lipscomb MW

更新日期：2016-11-01 00:00:00

abstract：:Developmental delays, which impair antibacterial host defense, are present in the neutrophil system of human preterm neonates. We hypothesized that diminished production of interleukin-8 (IL-8), a neutrophil chemotactic peptide, might in part be responsible for these defects. To test this, monocytes from the blood of ...

journal_title：Journal of leukocyte biology

authors： Schibler KR,Trautman MS,Liechty KW,White WL,Rothstein G,Christensen RD

更新日期：1993-04-01 00:00:00

abstract：:Freeze-fracture analysis has shown that treatment of cells with phorbol myristate acetate (PMA) results in a loss of intramembranous particles (IMP) associated with the external leaflet of their plasma membranes. It has also been demonstrated that phorbol esters markedly enhance the sensitivity of tumor targets to nat...

journal_title：Journal of leukocyte biology

authors： Nabi ZF,Zucker-Franklin D,Baten A

更新日期：1989-03-01 00:00:00

abstract：:Emerging evidence has revealed that noradrenaline (NA), the main neurotransmitter of the sympathetic nervous system (SNS), regulates a variety of immune functions via binding to adrenergic receptors present on immune cells. In this study, we examined the role of NA in the regulation of neutrophil functions. Neutrophil...

journal_title：Journal of leukocyte biology

authors： Nicholls AJ,Wen SW,Hall P,Hickey MJ,Wong CHY

更新日期：2018-02-01 00:00:00

abstract：:The role of monocyte chemoattractant protein-1 (MCP-1) in the recruitment of blood-derived monocytes in a model of zymosan peritoneal inflammation was investigated. After zymosan injection (1 mg) a rapid influx of polymorphonuclear leukocytes (PMN) and monocytes into the peritoneal cavity associated with mouse MCP-1 (...

journal_title：Journal of leukocyte biology

authors： Ajuebor MN,Flower RJ,Hannon R,Christie M,Bowers K,Verity A,Perretti M

更新日期：1998-01-01 00:00:00

abstract：:The ability of an individual to mount defense responses to infection depend in part on the capacity to produce cytokines such as interleukin 1 (IL-1) and tumor necrosis factor (TNF). The specialized equipment, labor intensity, and sterile practice required for the standard in vitro evaluation of cytokine production ca...

journal_title：Journal of leukocyte biology

authors： Nerad JL,Griffiths JK,Van der Meer JW,Endres S,Poutsiaka DD,Keusch GT,Bennish M,Salam MA,Dinarello CA,Cannon JG

更新日期：1992-12-01 00:00:00

abstract：:TNFR-associated periodic syndrome is an autoinflammatory disorder caused by autosomal-dominant mutations in TNFRSF1A, the gene encoding for TNFR superfamily 1A. The lack of knowledge in the field of TNFR-associated periodic syndrome biology is clear, particularly in the context of control of immune self-tolerance. We ...

journal_title：Journal of leukocyte biology

authors： Pucino V,Lucherini OM,Perna F,Obici L,Merlini G,Cattalini M,La Torre F,Maggio MC,Lepore MT,Magnotti F,Galgani M,Galeazzi M,Marone G,De Rosa V,Talarico R,Cantarini L,Matarese G

更新日期：2016-05-01 00:00:00

abstract：:We have characterized the beta-adrenergic receptor binding site and the beta-adrenergic cAMP response of the HL-60 cell. The hydrophilic ligand [3H]-(-)-CGP-12177 was specifically and reversibly bound to one single class of binding sites (Kd 220 pM and Bmax 1,970 sites/cell). The adrenergic agonists inhibited the spec...

journal_title：Journal of leukocyte biology

authors： Sager G,Bang BE,Pedersen M,Aarbakke J

更新日期：1988-07-01 00:00:00

abstract：:Dendritic cells (DCs) loaded extracorporeally with antigen can be used as an adjuvant in vivo. In this work, we analyzed the migration of transferred DC and monitored the phenotype of new migrants in the draining lymph nodes. It is surprising that we found that a majority of resident DCs expressed donor MHC molecules ...

journal_title：Journal of leukocyte biology

authors： de Heusch M,Blocklet D,Egrise D,Hauquier B,Vermeersch M,Goldman S,Moser M

更新日期：2007-10-01 00:00:00

abstract：:Leucocyte-endothelial cell interactions are important in the inflammatory response. In this study, the effect of peripheral blood mononuclear cell (PBMC) products on endothelial cell (EC) shape was examined and quantified. PBMC were obtained from normal donors by Ficoll-Hypaque separation of heparinized whole blood an...

journal_title：Journal of leukocyte biology

authors： FitzGerald OM,Hess EV,Chance A,Highsmith RF

更新日期：1987-05-01 00:00:00

abstract：:We have shown that low-dose UVB radiation converts Langerhans cells (LC) from immunogenic to tolerogenic APC. Therefore, we questioned whether low-dose UVB irradiation of bone marrow-derived dendritic cells (DC) alters their APC function, thereby inducing tolerance in T cells. To address this issue, cocultures of DC; ...

journal_title：Journal of leukocyte biology

authors： Denfeld RW,Hara H,Tesmann JP,Martin S,Simon JC

更新日期：2001-04-01 00:00:00

abstract：:In recent years, it has become appreciated that immune cells have different metabolic profiles depending on their activation status. During sepsis, circulating leukocytes go through a hyperinflammatory state, which can be accompanied or followed by defective antimicrobial defenses (also described as immune tolerance o...

journal_title：Journal of leukocyte biology

authors： Arts RJ,Gresnigt MS,Joosten LA,Netea MG

更新日期：2017-01-01 00:00:00

abstract：:Glucocorticoids, such as dexamethasone (Dex), are used clinically in the treatment of various inflammatory diseases. Dex acts by inhibiting the expression of inflammatory mediators, such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1). It is surprising that Dex enhances bacter...

journal_title：Journal of leukocyte biology

authors： Reddy KV,Bhattacharjee G,Schabbauer G,Hollis A,Kempf K,Tencati M,O'Connell M,Guha M,Mackman N

更新日期：2004-07-01 00:00:00

abstract：:CXCL8 is the principal human neutrophil-attracting chemokine and a major mediator of inflammation. The chemokine exerts its neutrophil-chemotactic and neutrophil-activating activities via interaction with glycosaminoglycans (GAGs) and activation of the G protein-coupled receptors (GPCRs) CXCR1 and CXCR2. Natural CXCL8...

journal_title：Journal of leukocyte biology

authors： Metzemaekers M,Vandendriessche S,Berghmans N,Gouwy M,Proost P

更新日期：2020-06-01 00:00:00

abstract：:Neonatal humans and rodents are susceptible to infection with encapsulated bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines by splenic macrophages (MPhi) from neonates. In this study, we show that when stim...

journal_title：Journal of leukocyte biology

authors： Chelvarajan L,Popa D,Liu Y,Getchell TV,Stromberg AJ,Bondada S

更新日期：2007-08-01 00:00:00

abstract：:The recently cloned ligand binding component of the type I human interferon-alpha/beta receptor (IFN-alpha/beta R) and its soluble analogue (p40) were characterized. p40 is a potent inhibitor of type I IFNs and antibodies directed against p40 completely block the activity of type I IFNs in human cells. These antibodie...

journal_title：Journal of leukocyte biology

authors： Novick D,Cohen B,Tal N,Rubinstein M

更新日期：1995-05-01 00:00:00

abstract：:When mouse peritoneal cells in early phase-inflammatory exudates were cultured in vitro, the number of polymorphonuclear leukocytes (PMNs) rapidly decreased, whereas the number of macrophages gradually increased during culture. Macrophage growth was also induced by addition of effete PMNs or their debris to macrophage...

journal_title：Journal of leukocyte biology

authors： Yui S,Yamazaki M

更新日期：1986-05-01 00:00:00

abstract：:Ly-49 receptors regulate mouse natural killer cell functions. Members of the polymorphic Ly-49 multigene family recognize specific alleles of major histocompatibility complex class I (MHC I) or MHC I-like proteins. Previous studies have provided insight into the nature of Ly-49A and -C interaction with their high-affi...

journal_title：Journal of leukocyte biology

authors： Osman MS,Silver ET,Varghese JC,Chang CS,Gong DE,Audette GF,Hazes B,Kane KP

更新日期：2005-05-01 00:00:00

abstract：:SIRS is associated with lymphopenia, and prolonged lymphopenia of septic patients has been associated with increased mortality risk. We hypothesize that elevated adenosine during SIRS down-regulates Gi-coupled A1R, which signals an effect that sensitizes a cAMP-dependent lymphotoxic response. In this study, we evaluat...

journal_title：Journal of leukocyte biology

authors： Riff R,Cohen Y,Eini-Rider H,Naamani O,Mazar J,Haviv YS,Chaimovitz C,Douvdevani A

更新日期：2017-07-01 00:00:00

abstract：:The existence of an association between the brain and immunity has been documented. Data show that the nervous and immune systems communicate with one another to maintain immune homeostasis. Activated immune cells secrete cytokines that influence central nervous system activity, which in turn, activates output through...

journal_title：Journal of leukocyte biology

authors： Kin NW,Sanders VM

更新日期：2006-06-01 00:00:00