Regulation of adaptive immune responses by innate cells expressing NK markers and antigen-transporting macrophages.

abstract：:The signaling adapters MyD88 and TRIF are engaged by TLRs and/or receptors of the IL-1 family and are considered important for innate immune responses that combat bacterial infections. Here, the consequences of a combined MyD88 and TRIF deficiency for the innate immune response against severe septic peritonitis was ex...

journal_title：Journal of leukocyte biology

authors： Reim D,Rossmann-Bloeck T,Jusek G,Prazeres da Costa O,Holzmann B

更新日期：2011-09-01 00:00:00

abstract：:In this study, we examined the expression of nerve growth factor (NGF) and its receptors in mouse macrophages and the mechanisms involved in the effect of NGF on tumor necrosis factor (TNF)-alpha production. Macrophages expressed NGF and the NGF receptors TrkA and p75. Treatment of J744 cells or peritoneal macrophages...

journal_title：Journal of leukocyte biology

authors： Barouch R,Kazimirsky G,Appel E,Brodie C

更新日期：2001-06-01 00:00:00

abstract：:Immunosuppressive factors, such as vascular endothelial growth factor, transforming growth factor-beta, prostaglandin E2, interleukin (IL)-10, and IL-6, are made frequently by cancer cells. These factors, along with others, can inhibit the development and function of tumor-reactive effector T cells and the clinical re...

journal_title：Journal of leukocyte biology

authors： Spaner DE

更新日期：2004-08-01 00:00:00

abstract：:Asthma is a chronic inflammatory disease of the airways that afflicts over 30 million individuals in the United States and over 300 million individuals worldwide. The inflammatory response in the airways is often characterized by the analysis of sputum, which contains multiple types of cells including neutrophils, mac...

journal_title：Journal of leukocyte biology

authors： Stewart E,Wang X,Chupp GL,Montgomery RR

更新日期：2020-11-01 00:00:00

abstract：:Mast cell activation requires Cl(-) flux, which maintains the driving force for entry of extracellular calcium and initiates release of mediators such as histamine. However, chloride channel expression in mast cells has been poorly understood. For the first time, reverse transcriptase-polymerase chain reaction shows t...

journal_title：Journal of leukocyte biology

authors： Kulka M,Gilchrist M,Duszyk M,Befus AD

更新日期：2002-01-01 00:00:00

abstract：:We have shown previously that homotypic interaction of resting memory CD4 T cells with activated T cells induces the production of cytokines with immunoregulatory potential (IL-10, IL-4) from the former. Here, we analyzed the effector functions of these T cells stimulated by homotypic T cell interaction. T cells induc...

journal_title：Journal of leukocyte biology

authors： Thümmler K,Leipe J,Ramming A,Schulze-Koops H,Skapenko A

更新日期：2010-11-01 00:00:00

abstract：:As the natural resistance-associated macrophage protein 1 Nramp1 (also known as Slc11a1) modulates Kupffer cell (KC) activation, and KC are responsible for the early phase of warm ischemia/reperfusion (I/R) to the liver, we hypothesized that livers of Nramp1(-/-) mice will be protected from early-phase I/R injury comp...

journal_title：Journal of leukocyte biology

authors： Wyllie S,Seu P,Gao FQ,Gros P,Goss JA

更新日期：2002-11-01 00:00:00

abstract：:The interaction between CD40 on dendritic cells (DC) and its ligand CD154 has been recognized to be an important feature in the maturation of DC. Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Western blot analysis of human DC st...

journal_title：Journal of leukocyte biology

authors： Termeer C,Johannsen H,Braun T,Renkl A,Ahrens T,Denfeld RW,Lappin MB,Weiss JM,Simon JC

更新日期：2001-11-01 00:00:00

abstract：:Fluoroquinolones have immunomodulatory properties and interfere with cytokine production. The aim of this study was to characterize the extent of the superinduced mRNA levels in activated human lymphocytes incubated with ciprofloxacin (5 and 80 micro g/ml) using a cytokine gene expression microarray from R and D Syste...

journal_title：Journal of leukocyte biology

authors： Eriksson E,Forsgren A,Riesbeck K

更新日期：2003-09-01 00:00:00

abstract：:Hybridoma cell lines were produced by fusion of SP2/0 murine myeloma cell line with the spleen cells of Wister rats which were immunized with IgG2a-binding protein isolated from the detergent lysate of a murine macrophagelike cell line, P388D1, by affinity chromatography on IgG-Sepharose 4B. A monoclonal clone (design...

journal_title：Journal of leukocyte biology

authors： Kagami M,Funatsu Y,Suzuki T

更新日期：1989-04-01 00:00:00

abstract：:To become competent killer cells, CD8(+) T cells require stimulation through signal transduction pathways associated with the T-cell receptor, costimulatory molecules such as CD28, and cytokine receptors such as the interleukin (IL)-2 receptor. We used wortmannin and LY294002, two inhibitors of phosphatidylinositol 3-...

journal_title：Journal of leukocyte biology

authors： Phu T,Haeryfar SM,Musgrave BL,Hoskin DW

更新日期：2001-05-01 00:00:00

abstract：:The field of innate immunity is witnessing a paradigm shift regarding "memory" and "programming" dynamics. Past studies of innate leukocytes characterized them as first responders to danger signals with no memory. However, recent findings suggest that innate leukocytes, such as monocytes and neutrophils, are capable o...

journal_title：Journal of leukocyte biology

authors： Lee C,Geng S,Zhang Y,Rahtes A,Li L

更新日期：2017-09-01 00:00:00

abstract：:The transmembrane form of tumor necrosis factor (mTNF), expressed on activated monocytes (MO) and macrophages (MPhi), is able to induce apoptosis in human endothelial cells (EC). Apoptosis is mediated by two distinct mechanisms: direct cell contact and a yet-unidentified soluble protein, death factor X. In addition, m...

journal_title：Journal of leukocyte biology

authors： Kirchner S,Boldt S,Kolch W,Haffner S,Kazak S,Janosch P,Holler E,Andreesen R,Eissner G

更新日期：2004-02-01 00:00:00

abstract：:Neutrophils showed a rapid and transient adhesion to immunoglobulin G (IgG)-coated plates compared with their adhesion to bovine serum albumin (BSA)-coated plates: the adhesion reached a peak after 15 min of incubation and then gradually returned to almost the basal state in 60 min. The addition of monomeric IgG or an...

journal_title：Journal of leukocyte biology

authors： Kusunoki T,Tsuruta S,Higashi H,Hosoi S,Hata D,Sugie K,Mayumi M,Mikawa H

更新日期：1994-06-01 00:00:00

abstract：:The in vitro studies have proposed that human Th1 cells favor expression of CXCR3 or CCR5, whereas Th2 cells favor CCR3 and CCR4. In this study, the in vivo relevance of expression of these chemokine receptors on Th cells was investigated in patients with atopic dermatitis (AD) as the Th2-dominated disorder and nonato...

journal_title：Journal of leukocyte biology

authors： Yamamoto J,Adachi Y,Onoue Y,Adachi YS,Okabe Y,Itazawa T,Toyoda M,Seki T,Morohashi M,Matsushima K,Miyawaki T

更新日期：2000-10-01 00:00:00

abstract：:TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM acts to bridge TLR4 with TRIF, orchestrating the inflammatory response to pathogen challenge. We ha...

journal_title：Journal of leukocyte biology

authors： Verstak B,Stack J,Ve T,Mangan M,Hjerrild K,Jeon J,Stahl R,Latz E,Gay N,Kobe B,Bowie AG,Mansell A

更新日期：2014-09-01 00:00:00

abstract：:This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

journal_title：Journal of leukocyte biology

authors： Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

更新日期：2004-06-01 00:00:00

abstract：:MRL/fas(lpr) mice, which undergo a systemic autoimmune disease with similarities to systemic lupus erythematosus (SLE), display reduced pathology and prolonged survival if rendered deficient in ICAM-1. However, it remains unclear whether this is a result of the ability of ICAM-1 to promote the immune response or media...

journal_title：Journal of leukocyte biology

authors： Norman MU,James WG,Hickey MJ

更新日期：2008-07-01 00:00:00

abstract：:Changes in leukocyte subpopulations and function after spaceflight have been observed but the mechanisms underlying these changes are not well defined. This study investigated the effects of short-term spaceflight (8-15 days) on circulating leukocyte subsets, stress hormones, immunoglobulin levels, and neutrophil func...

journal_title：Journal of leukocyte biology

authors： Stowe RP,Sams CF,Mehta SK,Kaur I,Jones ML,Feeback DL,Pierson DL

更新日期：1999-02-01 00:00:00

abstract：:As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor beta (TGF-beta) superfamily designated macrophage inhibitory cytokine 1 (MIC-1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like ...

journal_title：Journal of leukocyte biology

authors： Fairlie WD,Moore AG,Bauskin AR,Russell PK,Zhang HP,Breit SN

更新日期：1999-01-01 00:00:00

abstract：:Extravasation of leukocytes is a crucial process in the immunological defense. In response to a local concentration of chemokines, circulating leukocytes adhere to and migrate across the vascular endothelium toward the inflamed tissue. The small guanosinetriphosphatase Rap1 plays an important role in the regulation of...

journal_title：Journal of leukocyte biology

authors： Lorenowicz MJ,van Gils J,de Boer M,Hordijk PL,Fernandez-Borja M

更新日期：2006-12-01 00:00:00

abstract：:Rat thymocytes respond to exposure to phytomitogens by oxidant generation as detected by chemiluminescence in presence of luminol. Maximal chemiluminescent response to a wide variety of plant lectins was obtained only after the cells had been incubated for 18 hours at 37 degrees C but not at 4 degrees C. This temperat...

journal_title：Journal of leukocyte biology

authors： Mookerjee BK,Wakerle H,Sharon N,Fischer H

更新日期：1984-04-01 00:00:00

abstract：:Mast cells and MDSCs are increased by parasitic infection and tumor growth. We previously demonstrated that enhanced MDSC development in ADAM10 transgenic mice yielded resistance to Nb infection and that coculturing MDSCs and mast cells enhanced cytokine production. In the current work, we show that MDSC-mast cell coc...

journal_title：Journal of leukocyte biology

authors： Morales JK,Saleem SJ,Martin RK,Saunders BL,Barnstein BO,Faber TW,Pullen NA,Kolawole EM,Brooks KB,Norton SK,Sturgill J,Graham L,Bear HD,Urban JF Jr,Lantz CS,Conrad DH,Ryan JJ

更新日期：2014-04-01 00:00:00

abstract：:Blocking monoclonal antibodies (mAbs) specific to mouse interleukin-1 receptor antagonist (IL-1ra) were prepared by immunizing Armenian hamsters with recombinant mouse IL-1ra. A sensitive and specific ELISA against mouse IL-1ra was also established. In Propionibacterium acnes-induced liver injury, P. acnes induced tra...

journal_title：Journal of leukocyte biology

authors： Fujioka N,Mukaida N,Harada A,Akiyama M,Kasahara T,Kuno K,Ooi A,Mai M,Matsushima K

更新日期：1995-07-01 00:00:00

abstract：:Recently, several studies, including those with respiratory syncytial virus, mouse pneumovirus, and simian virus 5, have reported that virus-specific CD8+ effector cells entering the lung as a result of respiratory infection undergo significant loss of function. The impaired function in these cells has been proposed t...

journal_title：Journal of leukocyte biology

authors： Arimilli S,Palmer EM,Alexander-Miller MA

更新日期：2008-03-01 00:00:00

abstract：:A wealth of scientific and clinical evidence during the past few years has lent credence to the idea that key components of the host immune effector mechanisms can be targeted to boost current tuberculosis (TB) treatment and control patient relapse. These host-directed strategies not only accelerate the clearance of p...

journal_title：Journal of leukocyte biology

authors： Cheng CY,Böhme J,Singhal A

更新日期：2018-02-01 00:00:00

abstract：:Leukocyte adhesion is a key factor in the pathogenesis of organ injury following a variety of stimuli. In this study we have addressed the role of leukocyte adhesion in hypertensives as a risk factor for organ injury. In the spontaneously hypertensive rat (SHR), the number of circulating leukocytes and their level of ...

journal_title：Journal of leukocyte biology

authors： Suzuki H,Zweifach BW,Forrest MJ,Schmid-Schönbein GW

更新日期：1995-01-01 00:00:00

abstract：:Primitive macrophages emerged in the sinusoidal lumen of the fetal mouse liver at 10 days of gestation before the initiation of hepatic hematopoiesis and matured into fetal macrophages. In the culture of cell suspensions from the fetal liver with LP3-conditioned medium, monocyte colonies were formed, but monocytopoies...

journal_title：Journal of leukocyte biology

authors： Naito M,Takahashi K,Nishikawa S

更新日期：1990-07-01 00:00:00

abstract：:Macrophages in brain, lung, and lymphatics constitute a major HIV reservoir during subclinical infection and disease. During HIV transmission macrophages are seemingly one of the first cells infected, being as efficient as T cells in supporting productive viral replication. Macrophages control a myriad of cell-mediate...

journal_title：Journal of leukocyte biology

authors： Stevenson M,Gendelman HE

更新日期：1994-09-01 00:00:00

abstract：:CD137 ligand (CD137L) is expressed on APCs and crosslinks CD137, a powerful costimulatory molecule on T cells during cognate interactions, and thereby greatly enhances immune responses. We report that CD137 can be transferred from activated T cells and from tumor cells that express CD137 to other cells via trogocytosi...

journal_title：Journal of leukocyte biology

authors： Shao Z,Harfuddin Z,Pang WL,Nickles E,Koh LK,Schwarz H

更新日期：2015-05-01 00:00:00