GCN5 is essential for IRF-4 gene expression followed by transcriptional activation of Blimp-1 in immature B cells.

abstract：:Immunosuppression following infection with HIV-1 predisposes patients to a myriad of opportunistic pathogens, one of the most important of which is Mtb. Granulysin, expressed by NK cells and CTL, exhibits potent antimicrobial activity against Mtb and several other opportunistic pathogens associated with HIV-1 infectio...

journal_title：Journal of leukocyte biology

authors： Hogg AE,Bowick GC,Herzog NK,Cloyd MW,Endsley JJ

更新日期：2009-11-01 00:00:00

abstract：:Thioglycollate (TG)-elicited peritoneal macrophages (m phi s) were highly proliferative and formed m phi colonies in vitro in the presence of m phi colony-stimulating factor (M-CSF), while resident peritoneal m phi s did not. To determine whether such proliferative m phi s are immigrant or locally activated resident m...

journal_title：Journal of leukocyte biology

authors： Oghiso Y,Yamada Y,Shibata Y

更新日期：1992-10-01 00:00:00

abstract：:To test whether reduced immune responsiveness in early life may be related to the immaturity of neonatal antigen-presenting cells, we comparatively assessed the phenotypic and functional characteristics of dendritic epidermal leukocytes (DEL) and epidermal Langerhans cells (LC) in newborn (NB) and adult mice, respecti...

journal_title：Journal of leukocyte biology

authors： Chang-Rodriguez S,Ecker R,Stingl G,Elbe-Bürger A

更新日期：2004-09-01 00:00:00

abstract：:Emerging evidence suggests that the innate immune system, comprised of Toll-like receptors (TLRs) and their associated molecules, plays a pivotal role in the regulation of intestinal inflammation and in the response to invading pathogens. Although TLRs are thought to have predominantly beneficial effects in pathogen r...

journal_title：Journal of leukocyte biology

authors： Gribar SC,Anand RJ,Sodhi CP,Hackam DJ

更新日期：2008-03-01 00:00:00

abstract：:A protein with interleukin 1 (IL-1) activity was obtained from the human acute monocytic leukemia cell line (THP-1) and purified by ultrafiltration, Ultrogel AcA54 chromatography, isoelectric focusing, and discontinuous polyacrylamide gel electrophoresis. Like the pI 6.8 species of IL-1 from human peripheral blood mon...

journal_title：Journal of leukocyte biology

authors： Krakauer T

更新日期：1985-05-01 00:00:00

abstract：:We have identified three distinct cell phenotypes with respect to the conditions under which cells became susceptible to TNF-mediated lysis. These conditions include: 1) treatment with the protein synthesis inhibitor, cycloheximide; 2) contact with activated macrophages, and 3) infection with vaccinia virus. Whereas v...

journal_title：Journal of leukocyte biology

authors： Woods KM,Chapes SK

更新日期：1993-01-01 00:00:00

abstract：:The mechanisms by which concanavalin A (Con A), a lectin, activates T cells are poorly studied. A low dose of Con A is stimulatory for T cells, whereas a high dose of Con A results in suppression of proliferation and enhanced T cell death. The expression and functional roles of costimulatory receptors, CD28 and cytoto...

journal_title：Journal of leukocyte biology

authors： Mukherjee S,Ahmed A,Nandi D

更新日期：2005-07-01 00:00:00

abstract：:Aged and protein-malnourished hosts have diminished febrile responses and increased morbidity and mortality from infection that could be due to deficiencies in the production of certain monokines. In this study, the ability of peritoneal macrophages from aged and protein-malnourished rats to produce IL-1 and TNF was e...

journal_title：Journal of leukocyte biology

authors： Bradley SF,Vibhagool A,Kunkel SL,Kauffman CA

更新日期：1989-06-01 00:00:00

abstract：:A large body of literature supports the role of interleukin-8 (IL-8) in inflammatory lung disease. Numerous factors induce the local synthesis and secretion of this potent chemokine leading to the recruitment and activation of polymorphonuclear leukocytes. However, little is currently known about the fate of IL-8 secr...

journal_title：Journal of leukocyte biology

authors： Leavell KJ,Peterson MW,Gross TJ

更新日期：1997-03-01 00:00:00

abstract：:Several alterations in the expression of immune-related transcripts were identified recently in the degenerating retina of the retinoschisin knockout (Rs1h(-/Y)) mouse, including the strong expression of the adaptor protein Dap12. As Dap12 is found in leukocytes, we hypothesized that its disease-related expression may...

journal_title：Journal of leukocyte biology

authors： Weigelt K,Ernst W,Walczak Y,Ebert S,Loenhardt T,Klug M,Rehli M,Weber BH,Langmann T

更新日期：2007-12-01 00:00:00

abstract：:This is largely a history of attempts from approximately 1960 until about 1980-81 to understand the mechanisms by which neutrophils are activated by chemotactic factors to induce chemotaxis and granule secretion. As such, it deals with the growth of our knowledge of neutrophil chemotactic factors and their receptors; ...

journal_title：Journal of leukocyte biology

authors： Becker EL

更新日期：1990-04-01 00:00:00

abstract：:During the neoplastic progression, macrophages as well as dendritic and NK cells are attracted into the tumor site and initiate the immune response against transformed cells. They activate and present tumor antigens to T cells, which are then activated to kill tumor cells. However, tumor cells are often capable of esc...

journal_title：Journal of leukocyte biology

authors： Lamagna C,Aurrand-Lions M,Imhof BA

更新日期：2006-10-01 00:00:00

abstract：:A role for the dietary trace mineral element selenium in the reduction of cancer incidence has been documented in numerous epidemiological and experimental studies. The precise mechanism of this antitumor effect is not well understood, but published data suggest that both inhibition of tumor cell growth and enhancemen...

journal_title：Journal of leukocyte biology

authors： Petrie HT,Klassen LW,Kay HD

更新日期：1989-03-01 00:00:00

abstract：:Human chorionic gonadotrophin (hCG) is a hormone produced during pregnancy and present at the implantation site and in the maternal blood. Pregnancy has been proposed to represent a controlled state of inflammation at an early stage at the implantation site and later, systemically extended to the maternal circulation....

journal_title：Journal of leukocyte biology

authors： Wan H,Coppens JM,van Helden-Meeuwsen CG,Leenen PJ,van Rooijen N,Khan NA,Kiekens RC,Benner R,Versnel MA

更新日期：2009-08-01 00:00:00

abstract：:Previous studies about basophils and mast cells identified the ability of IgE to up-regulate FcepsilonRI expression by a process that depends on stabilization of the surface receptor by IgE. However, the mechanism of loss from the cell surface, when unoccupied, is not known. The current studies have examined whether u...

journal_title：Journal of leukocyte biology

authors： MacGlashan DW Jr

更新日期：2007-10-01 00:00:00

abstract：:Several members of the cytokine network play an important role in controlling the replication of the human immunodeficiency virus (HIV) in several experimental systems. Their effects can be categorized in the following three functional groups: (1) HIV-inductive cytokines; (2) HIV-suppressive cytokines; (3) cytokines w...

journal_title：Journal of leukocyte biology

authors： Vicenzi E,Biswas P,Mengozzi M,Poli G

更新日期：1997-07-01 00:00:00

abstract：:Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammat...

journal_title：Journal of leukocyte biology

authors： Cannon AR,Kuprys PV,Cobb AN,Ding X,Kothari AN,Kuo PC,Eberhardt JM,Hammer AM,Morris NL,Li X,Choudhry MA

更新日期：2018-09-01 00:00:00

abstract：:Poxviruses encode a variety of immunomodulatory proteins that subvert the cytokine networks of infected hosts. Myxoma virus, a poxvirus pathogen of rabbits, expresses two distinct 35- to 40-kDa secreted glycoproteins that bind a broad spectrum of chemokines. The first of these, designated M-T7, is encoded by the T7 ge...

journal_title：Journal of leukocyte biology

authors： Lalani AS,McFadden G

更新日期：1997-11-01 00:00:00

abstract：:There is currently no real treatment for blinding disorders that stem from the degeneration of cells in the retina and affect at least 50 million individuals worldwide. The excitement that accompanied the first studies showing the potential of retinal cell transplantation to alleviate the progress of blindness in such...

journal_title：Journal of leukocyte biology

authors： Lund RD,Ono SJ,Keegan DJ,Lawrence JM

更新日期：2003-08-01 00:00:00

abstract：:Although tumor growth enhances macrophage (m phi) cytotoxic activity by increasing their tumor necrosis factor-alpha (TNF-alpha) production, increased prostaglandin E2 (PGE2) synthesis reduces most immune responses during tumor growth. Macrophages that do not express major histocompatibility complex class II molecules...

journal_title：Journal of leukocyte biology

authors： Alleva DG,Burger CJ,Elgert KD

更新日期：1993-05-01 00:00:00

abstract：:Patients with head and neck squamous cell carcinoma (HNSCC) have increased levels of immune-suppressive peripheral blood CD34+ cells. This study showed that the peripheral blood CD34+ cells of HNSCC patients are capable of differentiating into dendritic cells. Because CD34+ cells can differentiate through several path...

journal_title：Journal of leukocyte biology

authors： Lathers DM,Lubbers E,Wright MA,Young MR

更新日期：1999-05-01 00:00:00

abstract：:CD11c, a member of the leukointegrin family, is expressed prominently on tissue macrophages and dendritic cells and binds to complement fragment (iC3b), provisional matrix molecules (fibrinogen), and the Ig superfamily cell adhesion molecule, ICAM-1. CD11c has been proposed to function in phagocytosis, cell migration,...

journal_title：Journal of leukocyte biology

authors： Sadhu C,Ting HJ,Lipsky B,Hensley K,Garcia-Martinez LF,Simon SI,Staunton DE

更新日期：2007-06-01 00:00:00

abstract：:We have shown that losartan, a selective inhibitor of AT1 receptors for angiotensin II (AII), inhibits the binding of [3H]fMLP to neutrophil receptors (FPR). Here, we analyze, in Wistar rats, the effect of losartan on neutrophil recruitment in the lung triggered by fMLP. We found that i.v. infusion of losartan (0.4-20...

journal_title：Journal of leukocyte biology

authors： Raiden S,Pereyra Y,Nahmod V,Alvarez C,Castello L,Giordano M,Geffner J

更新日期：2000-11-01 00:00:00

abstract：:CEACAM6 (CD66c) and CEACAM8 (CD66b) are cell-adhesion proteins on neutrophils that belong to the human carcinoembryonic antigen (CEA) family. CEACAM6 reveals homophilic adhesion and heterophilic adhesion to other CEACAM family antigens including CEACAM8, CEACAM1, and CEA, whereas CEACAM8 exhibits only heterophilic adh...

journal_title：Journal of leukocyte biology

authors： Kuroki M,Abe H,Imakiirei T,Liao S,Uchida H,Yamauchi Y,Oikawa S,Kuroki M

更新日期：2001-10-01 00:00:00

abstract：:The effect of coupling C3bi to immunoglobulin G (IgG) immune complexes (IC) on their ability to produce protein tyrosine phosphorylation and activation of the mitogen-activated protein kinase (MAPK) and the Akt/protein kinase B (PKB) routes was assessed in human monocytes. Cross-linking Fc receptors for IgG activated ...

journal_title：Journal of leukocyte biology

authors： Trinidad AG,de la Puerta ML,Fernández N,Bayón Y,Crespo MS,Alonso A

更新日期：2006-05-01 00:00:00

abstract：:Treatment of mice with a monoclonal antibody (mAb) designated NIMP-R10, directed against the CD11b polypeptide of the CD18/CD11b heterodimeric type 3 complement receptor (CR3), exacerbates listeriosis by preventing myelomonocytic cells from focusing at sites of infected hepatocytes in the liver. Under these conditions...

journal_title：Journal of leukocyte biology

authors： Conlan JW,North RJ

更新日期：1992-07-01 00:00:00

abstract：:The triggering receptor expressed on myeloid cell locus encodes a family of receptors that is emerging as an important class of molecules involved in modulating the innate immune response and inflammation. Of the 4 conserved members, including triggering receptor expressed on myeloid cells 1 and 2 and triggering recep...

journal_title：Journal of leukocyte biology

authors： Thomas KA,King RG,Sestero CM,Justement LB

更新日期：2016-07-01 00:00:00

abstract：:The peritoneal cavity of the mouse is a major source of connective tissue-type mast cells (CTMCs). Flow cytometric analysis using biotinylated recombinant murine mast cell growth factor (rMuMGF) showed that 1 to 3% of the cells in the peritoneal cavity exhibited MGF receptor (MGFR) (or c-kit). CTMCs were the only cell...

journal_title：Journal of leukocyte biology

authors： Chen B,Scheding S,Nakeff A,Ruan Q

更新日期：1994-05-01 00:00:00

abstract：:Eosinophils are generally linked to innate host defense against helminths, as well as the pathologies associated with allergic diseases, such as asthma. Nonetheless, the activities of eosinophils remain poorly understood, which in turn, has prevented detailed definitions of their role(s) in health and disease. Homolog...

journal_title：Journal of leukocyte biology

authors： Doyle AD,Jacobsen EA,Ochkur SI,Willetts L,Shim K,Neely J,Kloeber J,Lesuer WE,Pero RS,Lacy P,Moqbel R,Lee NA,Lee JJ

更新日期：2013-07-01 00:00:00

abstract：:Although HDPs were originally hypothesized to act as antimicrobial agents, they also have been shown to broadly modulate the immune response through the activation of different cell types. We recently developed a series of novel, synthetic peptides, termed IDRs, which are conceptually based on a natural HDP, bovine ba...

journal_title：Journal of leukocyte biology

authors： Niyonsaba F,Madera L,Afacan N,Okumura K,Ogawa H,Hancock RE

更新日期：2013-07-01 00:00:00