Abstract:
:The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells (NK1.1(+)CD3(-)) in the murine liver whose function was currently unknown. In naïve animals, CD11c(+) liver NK cells displayed an activated phenotype and possessed enhanced effector functions when compared with CD11c(-) liver NK cells. During the innate response to adenovirus infection, CD11c(+) NK cells were the more common IFN-gamma-producing NK cells in the liver, demonstrated enhanced lytic capability, and gained a modest degree of APC function. The mechanism of IFN-gamma production in vivo depended on TLR9 ligation as well as IL-12 and -18. Taken together, our findings demonstrate that CD11c(+) NK cells are a unique subset of NK cells in the murine liver that contribute to the defense against adenoviral hepatitis.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Burt BM,Plitas G,Stableford JA,Nguyen HM,Bamboat ZM,Pillarisetty VG,DeMatteo RPdoi
10.1189/jlb.0408256subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1039-46issue
4eissn
0741-5400issn
1938-3673pii
jlb.0408256journal_volume
84pub_type
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