Abstract:
:The immune system modulates a number of biological processes to properly defend against pathogens. Here, we review how crosstalk between nuclear hormone receptors and the innate immune system may influence multiple biological functions during an immune response. Although nuclear hormone receptor repression of innate immune responses and inflammation has been well studied, a number of new studies have identified repression of nuclear hormone receptor signaling by various innate immune responses. IFN regulatory factor 3, a key transcription factor involved in the induction of antiviral genes, may play a role in mediating such crosstalk between the innate immune response and nuclear receptor-regulated metabolism. This crosstalk mechanism is now implicated in the pathogenesis of atherosclerosis and Reye's syndrome and could provide an explanation for other pathogen-associated metabolic and developmental disorders.
journal_name
J Leukoc Bioljournal_title
Journal of leukocyte biologyauthors
Chow EK,Razani B,Cheng Gdoi
10.1189/jlb.1206741subject
Has Abstractpub_date
2007-08-01 00:00:00pages
187-95issue
2eissn
0741-5400issn
1938-3673pii
jlb.1206741journal_volume
82pub_type
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