Differential expression of beta 2-integrins and cytokine production between gammadelta and alphabeta T cells in experimental autoimmune encephalomyelitis.

abstract：:TNF is implicated in the suppression of neutrophil apoptosis during sepsis. Multiple signaling pathways are involved in TNF-mediated antiapoptotic signaling; a role for the MAP kinases (MAPK), ERK1/2, and p38 MAPK has been suggested. Antiapoptotic signaling is mediated principally through TNF receptor-1 (TNFR-1), and ...

journal_title：Journal of leukocyte biology

authors： Kilpatrick LE,Sun S,Mackie D,Baik F,Li H,Korchak HM

更新日期：2006-12-01 00:00:00

abstract：:TNFR-associated periodic syndrome is an autoinflammatory disorder caused by autosomal-dominant mutations in TNFRSF1A, the gene encoding for TNFR superfamily 1A. The lack of knowledge in the field of TNFR-associated periodic syndrome biology is clear, particularly in the context of control of immune self-tolerance. We ...

journal_title：Journal of leukocyte biology

authors： Pucino V,Lucherini OM,Perna F,Obici L,Merlini G,Cattalini M,La Torre F,Maggio MC,Lepore MT,Magnotti F,Galgani M,Galeazzi M,Marone G,De Rosa V,Talarico R,Cantarini L,Matarese G

更新日期：2016-05-01 00:00:00

abstract：:This report focuses on the modulatory role of endogenous H(2)O(2) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma)-induced inducible nitric oxide synthase (NOS2) gene expression in rat peritoneal macrophages. Exogenously added H(2)O(2) was initially found to inhibit the synthesis of NOS2, which prompted us to ...

journal_title：Journal of leukocyte biology

authors： Vega A,Chacón P,Monteseirín J,El Bekay R,Alvarez M,Alba G,Conde J,Martín-Nieto J,Bedoya FJ,Pintado E,Sobrino F

更新日期：2004-06-01 00:00:00

abstract：:NLRP3 is the most crucial member of the NLR family, as it detects the existence of pathogen invasion and self-derived molecules associated with cellular damage. Several studies have reported that excessive NLRP3 inflammasome-mediated caspase-1 activation is a key factor in the development of diseases. Recent studies h...

journal_title：Journal of leukocyte biology

authors： Lin YC,Huang DY,Wang JS,Lin YL,Hsieh SL,Huang KC,Lin WW

更新日期：2015-05-01 00:00:00

abstract：:Introduction of alloantigens into the AC induces a form of immune tolerance known as ACAID, which induces antigen-specific CD8+ Tregs, contributing to ocular immune privilege by down-regulating immune responses. Recent evidence suggests IFN-γ is needed for the suppressive function of CD8+ ACAID Tregs. This study teste...

journal_title：Journal of leukocyte biology

authors： Paunicka K,Chen PW,Niederkorn JY

更新日期：2012-03-01 00:00:00

abstract：:2-Arachidonoyl-glycerol (2-AG) and arachidonyl-ethanolamide (AEA) are endocannabinoids that have been implicated in many physiologic disorders, including obesity, metabolic syndromes, hepatic diseases, pain, neurologic disorders, and inflammation. Their immunomodulatory effects are numerous and are not always mediated...

journal_title：Journal of leukocyte biology

authors： Turcotte C,Chouinard F,Lefebvre JS,Flamand N

更新日期：2015-06-01 00:00:00

abstract：:CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activat...

journal_title：Journal of leukocyte biology

authors： Pauly S,Broll K,Wittmann M,Giegerich G,Schwarz H

更新日期：2002-07-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. C...

journal_title：Journal of leukocyte biology

authors： Hill AD,Naama HA,Calvano SE,Daly JM

更新日期：1995-12-01 00:00:00

abstract：:There is accumulating evidence that omega-3 fatty acids may modulate immune responses. When monocytes were differentiated to dendritic cells (DCs) in the presence of docosahexaenoic acid (DHA), the expression of costimulatory and antigen presentation markers was altered in a concentration-dependent way, positively or ...

journal_title：Journal of leukocyte biology

authors： Zapata-Gonzalez F,Rueda F,Petriz J,Domingo P,Villarroya F,Diaz-Delfin J,de Madariaga MA,Domingo JC

更新日期：2008-10-01 00:00:00

abstract：:Histone acetylation has an important role in gene regulation, DNA replication, and repair. Because these processes are central to the development of the immune system, we investigated the role of a previously unstudied histone acetyltransferase named KAT7 (also known as Myst2 or HBO1) in the regulation of thymopoiesis...

journal_title：Journal of leukocyte biology

authors： Newman DM,Voss AK,Thomas T,Allan RS

更新日期：2017-04-01 00:00:00

abstract：:The role of PI-3K in leukocyte function has been studied extensively. However, the specific role of the p110gamma isoform of PI- 3K in CD4 T lymphocyte function has yet to be defined explicitly. In this study, we report that although p110gamma does not regulate antigen-dependent CD4 T cell activation and proliferation...

journal_title：Journal of leukocyte biology

authors： Thomas MS,Mitchell JS,DeNucci CC,Martin AL,Shimizu Y

更新日期：2008-09-01 00:00:00

abstract：:Neutrophil accumulation and plasma leakage induced in rabbit skin by neutrophil-activating peptide-1 (NAP-1, a 72 amino acid peptide produced by monocytes and a variety of tissue cells), E. coli endotoxin, and interleukin-1 (IL-1) were compared. Neutrophil accumulation at sites injected with NAP-1 was intense, rapid, ...

journal_title：Journal of leukocyte biology

authors： Colditz IG,Zwahlen RD,Baggiolini M

更新日期：1990-08-01 00:00:00

abstract：:Constitutive expression of cell-associated, but not secreted, interleukin-1alpha (IL-1alpha) by oncogene-transformed fibrosarcoma cells induced regressing tumors in mice, a phenomenon that was abrogated by the IL-1 inhibitor, the IL-1 receptor antagonist (IL-1Ra). On the contrary, non-IL-1alpha-expressing tumor cells ...

journal_title：Journal of leukocyte biology

authors： Dvorkin T,Song X,Argov S,White RM,Zoller M,Segal S,Dinarello CA,Voronov E,Apte RN

更新日期：2006-07-01 00:00:00

abstract：:Prevalence of food allergies in the United States is on the rise. Eosinophils are recruited to the intestinal mucosa in substantial numbers in food allergen-driven gastrointestinal (GI) inflammation. Soluble epoxide hydrolase (sEH) is known to play a pro-inflammatory role during inflammation by metabolizing anti-infla...

journal_title：Journal of leukocyte biology

authors： Bastan I,Ge XN,Dileepan M,Greenberg YG,Guedes AG,Hwang SH,Hammock BD,Washabau RJ,Rao SP,Sriramarao P

更新日期：2018-07-01 00:00:00

abstract：:HIV infection of mononuclear phagocytes (MP), mostly as tissue macrophages, is a dominant feature in the pathogenesis of HIV disease and its progression to AIDS. Although the general mechanism of infection is not dissimilar to that of CD4+ T lymphocytes occurring via interaction of the viral envelope with CD4 and a ch...

journal_title：Journal of leukocyte biology

authors： Cassol E,Alfano M,Biswas P,Poli G

更新日期：2006-11-01 00:00:00

abstract：:Macrophages in brain, lung, and lymphatics constitute a major HIV reservoir during subclinical infection and disease. During HIV transmission macrophages are seemingly one of the first cells infected, being as efficient as T cells in supporting productive viral replication. Macrophages control a myriad of cell-mediate...

journal_title：Journal of leukocyte biology

authors： Stevenson M,Gendelman HE

更新日期：1994-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by the presence of multiple senile plaques in the brain tissue, which are also associated with considerable inflammatory infiltrates. Although the precise mechanisms of the pathogenesis of AD remain to be determined, the overproduction ...

journal_title：Journal of leukocyte biology

authors： Cui Y,Le Y,Yazawa H,Gong W,Wang JM

更新日期：2002-10-01 00:00:00

abstract：:Neutrophils are indispensable in the innate immune defense against invading microorganisms. Neutrophils contain SVs and several subsets of granules that are essential for their function. Proteins present in neutrophil SVs and granules are synthesized during terminal granulopoiesis in the bone marrow. The heterogeneity...

journal_title：Journal of leukocyte biology

authors： Rørvig S,Østergaard O,Heegaard NH,Borregaard N

更新日期：2013-10-01 00:00:00

abstract：:The basal presence of immunologically potent cells within the intestinal muscularis externa and their functional significance is unclear. Our aim was to investigate the basal distribution of various leukocyte populations within the rat jejunal muscularis. In addition, we sought to immunohistochemically phenotype the m...

journal_title：Journal of leukocyte biology

authors： Kalff JC,Schwarz NT,Walgenbach KJ,Schraut WH,Bauer AJ

更新日期：1998-06-01 00:00:00

abstract：:Extracellular ATP mediates a diverse array of biological responses in many cell types and tissues, including immune cells. We have demonstrated that ATP induces purinergic receptor P2X(7) mediated membrane permeabilization, apoptosis, and cytokine expression in murine mast cells (MCs). Here, we report that MCs deficie...

journal_title：Journal of leukocyte biology

authors： Bulanova E,Budagian V,Orinska Z,Koch-Nolte F,Haag F,Bulfone-Paus S

更新日期：2009-04-01 00:00:00

abstract：:In vivo, dendritic cells (DC) reside in direct proximity to extracellular matrix (ECM) proteins. Because ECM proteins affect morphology and function of a number of cell types, this study investigated potential effects of ECM proteins on functional properties of DC. DC were generated from murine bone marrow cultures, s...

journal_title：Journal of leukocyte biology

authors： Mahnke K,Bhardwaj RS,Luger TA,Schwarz T,Grabbe S

更新日期：1996-10-01 00:00:00

abstract：:THP-1-derived cell lines were stably transfected with constructs encoding glycophosphatidylinositol (GPI)-anchored or transmembrane forms of human CD14. CD14 expression was associated with enhanced phagocytosis of serum (heat-inactivated)-opsonized Escherichia coli (opEc). Both the GPI-anchored and transmembrane forms...

journal_title：Journal of leukocyte biology

authors： Schiff DE,Kline L,Soldau K,Lee JD,Pugin J,Tobias PS,Ulevitch RJ

更新日期：1997-12-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) encodes the MHC class I-like molecule UL18, which binds with high affinity to the leukocyte Ig-like receptor-1 (LIR-1), an inhibitory receptor commonly expressed on myeloid cells and subsets of NK and T cells. The exact role of UL18 is not known, in particular in relation to its proposed r...

journal_title：Journal of leukocyte biology

authors： Wagner CS,Walther-Jallow L,Buentke E,Ljunggren HG,Achour A,Chambers BJ

更新日期：2008-01-01 00:00:00

abstract：:We investigated the kinetics of macrophage subpopulations and the expression of monocyte chemoattractant protein 1 (MCP-1) in a rat model of bleomycin-induced lung injury. Rat macrophage subpopulations were examined by immunohistochemistry using various anti-rat macrophage monoclonal antibodies (mAbs) and their prolif...

journal_title：Journal of leukocyte biology

authors： Sakanashi Y,Takeya M,Yoshimura T,Feng L,Morioka T,Takahashi K

更新日期：1994-12-01 00:00:00

abstract：:Polymorphonuclear leukocytes (PMNs) exert most of their physiological functions while adherent to surfaces rather than in suspension. PMN adhesion is largely dependent on the function of the beta 2 integrins, CD11a,b,c/CD18. We mimicked engagement of beta 2 integrins by antibody cross-linking of CD18 on isolated human...

journal_title：Journal of leukocyte biology

authors： Walzog B,Seifert R,Zakrzewicz A,Gaehtgens P,Ley K

更新日期：1994-11-01 00:00:00

abstract：:LPS has been widely used to induce inflammatory pain, attributing to production of inflammatory cytokines and sensitization of nociceptors. Paeoniflorin (PF) possesses anti-nociceptive property, but its effect on LPS-induced inflammatory pain has not been investigated. In this study, we aimed to investigate the analge...

journal_title：Journal of leukocyte biology

authors： Yin N,Gao Q,Tao W,Chen J,Bi J,Ding F,Wang Z

更新日期：2020-07-01 00:00:00

abstract：:The current results provide direct evidence for a role of tissue macrophages (M phi) in natural immunity and support the use of immunomodulators to enhance antiviral resistance in immunocompromised individuals. In this study, macrophages (M phi) in the spleen and liver were eliminated by intravenous (i.v.) injection o...

journal_title：Journal of leukocyte biology

authors： Pinto AJ,Stewart D,van Rooijen N,Morahan PS

更新日期：1991-06-01 00:00:00

abstract：:Thioglycolate-elicited peritoneal macrophages from normal C57B1/6J mice were examined in vitro for bacterial lipopolysaccharide (LPS)-stimulated interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF) production. Macrophages from mice administered a single oral dose of levamisole (3 mg/kg) 1 to 4 days prior to mac...

journal_title：Journal of leukocyte biology

authors： Kimball ES,Schneider CR,Fisher MC,Clark MC

更新日期：1992-09-01 00:00:00

abstract：:Extravasation of leukocytes is a crucial process in the immunological defense. In response to a local concentration of chemokines, circulating leukocytes adhere to and migrate across the vascular endothelium toward the inflamed tissue. The small guanosinetriphosphatase Rap1 plays an important role in the regulation of...

journal_title：Journal of leukocyte biology

authors： Lorenowicz MJ,van Gils J,de Boer M,Hordijk PL,Fernandez-Borja M

更新日期：2006-12-01 00:00:00

abstract：:We report the systematic use of large-scale cDNA microarrays to study the gene expression profiles of primary human peripheral blood monocytes (MONO) in comparison with in vitro-differentiated, M-CSF-induced MONO-derived macrophages (MAC) and primary human alveolar MAC (AM), obtained by bronchoalveolar lavage from the...

journal_title：Journal of leukocyte biology

authors： Li J,Pritchard DK,Wang X,Park DR,Bumgarner RE,Schwartz SM,Liles WC

更新日期：2007-01-01 00:00:00