Immune Reactions following Cord Blood Transplantations in Adults.

abstract：:Hindlimb ischemia is still a clinical problem with high morbidity and mortality. Patients suffer from consequent rest pain, ulcers, cool limbs, and even amputation. Angiogenesis is a promising target for the treatment of ischemic limbs, providing extra blood for the ischemic region. In the present study, we investigat...

journal_title：Stem cells international

authors： Yin C,Liang Y,Zhang J,Ruan G,Li Z,Pang R,Pan X

更新日期：2016-01-01 00:00:00

abstract：:Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...

journal_title：Stem cells international

authors： Guo H,Lei M,Li Y,Liu Y,Tang Y,Xing Y,Deng F,Yang K

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties vi...

journal_title：Stem cells international

authors： Wang M,Yuan Q,Xie L

更新日期：2018-06-14 00:00:00

abstract：:Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of gene expression. However, the specific roles of lncRNAs in stenotic lesions of arteriovenous fistula (AVF) failure are still largely unknown. We first analyzed the expression profiles of lncRNAs in human stenosed and n...

journal_title：Stem cells international

authors： Lv L,Qi H,Guo X,Ni Q,Yan Z,Zhang L

更新日期：2017-01-01 00:00:00

abstract：:Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are characterized by their unique capacity to stepwise differentiate towards any particular cell type in an adult organism. Pluripotent stem cells provide a beneficial platform to model hereditary diseases and even cancer development. While the inc...

journal_title：Stem cells international

authors： Hohwieler M,Müller M,Frappart PO,Heller S

更新日期：2019-02-25 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and...

journal_title：Stem cells international

authors： Agata H,Sumita Y,Hidaka T,Iwatake M,Kagami H,Asahina I

更新日期：2019-11-12 00:00:00

abstract：:Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two s...

journal_title：Stem cells international

authors： Zhou J,Chen Q,Zou Y,Zheng S,Chen Y

更新日期：2019-01-08 00:00:00

abstract：:A previous study reported the structural characterization of biogenic apatite (BAp) thin films realized by a pulsed electron deposition system by ablation of deproteinized bovine bone. Thin films annealed at 400°C exhibited composition and crystallinity degree very close to those of biogenic apatite; this affinity is ...

journal_title：Stem cells international

authors： Bianchi M,Pisciotta A,Bertoni L,Berni M,Gambardella A,Visani A,Russo A,de Pol A,Carnevale G

更新日期：2017-01-01 00:00:00

abstract：:The implantation of stem cells in vivo is the ideal approach for the restoration of normal life functions, such as replenishing the decreasing levels of affected dopaminergic (DA) neurons during neurodegenerative disease conditions. However, combining stem cells with biomaterial scaffolds provides a promising strategy...

journal_title：Stem cells international

authors： Tasnim N,Thakur V,Chattopadhyay M,Joddar B

更新日期：2018-06-03 00:00:00

abstract：Background:Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy ...

journal_title：Stem cells international

authors： Zhu GQ,Jeon SH,Bae WJ,Choi SW,Jeong HC,Kim KS,Kim SJ,Cho HJ,Ha US,Hong SH,Lee JY,Kwon EB,Kim SW

更新日期：2018-08-29 00:00:00

abstract：:Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends o...

journal_title：Stem cells international

authors： Churchman SM,Boxall SA,McGonagle D,Jones EA

更新日期：2017-01-01 00:00:00

abstract：:The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors. In the present study, we analysed the presence of frizzled-4 in the enteric nervous system of human inf...

journal_title：Stem cells international

authors： Nothelfer K,Obermayr F,Belz N,Reinartz E,Bareiss PM,Bühring HJ,Beschorner R,Just L

更新日期：2016-01-01 00:00:00

abstract：:Previously, we demonstrated a high quality of minerals formed by serum-free cultured jaw periosteal cells (JPCs) by Raman spectroscopy but the mineralization extent was not satisfactory. In the present study, we analyzed the proliferation and mineralization potential of human platelet lysate- (hPL-) cultured JPCs in c...

journal_title：Stem cells international

authors： Wanner Y,Umrath F,Waidmann M,Reinert S,Alexander D

更新日期：2017-01-01 00:00:00

abstract：:During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or r...

journal_title：Stem cells international

authors： Dey D,Evans GR

更新日期：2011-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2015/496512.]. ...

journal_title：Stem cells international

authors： Sasi SP,Park D,Muralidharan S,Wage J,Kiladjian A,Onufrak J,Enderling H,Yan X,Goukassian DA

更新日期：2016-01-01 00:00:00

abstract：:Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated wit...

journal_title：Stem cells international

authors： Pereira T,Armada-da Silva PA,Amorim I,Rêma A,Caseiro AR,Gärtner A,Rodrigues M,Lopes MA,Bártolo PJ,Santos JD,Luís AL,Maurício AC

更新日期：2014-01-01 00:00:00

abstract：:Podocyte death and regeneration are major topics in kidney research but remain controversial. Data obtained in humans demonstrate the existence of cells sited along Bowman's capsule that behave as podocyte progenitors in vitro and in in vivo mouse models of podocyte injury xenotrasplanted with this human-derived popul...

journal_title：Stem cells international

authors： Lombardi D,Lasagni L

更新日期：2015-01-01 00:00:00

abstract：:Neuromuscular diseases are caused by functional defects of skeletal muscles, directly via muscle pathology or indirectly via disruption of the nervous system. Extensive studies have been performed to improve the outcomes of therapies; however, effective treatment strategies have not been fully established for any majo...

journal_title：Stem cells international

authors： Jiwlawat N,Lynch E,Jeffrey J,Van Dyke JM,Suzuki M

更新日期：2018-04-11 00:00:00

abstract：:The cardiopulmonary system is made up of the heart and the lungs, with the core function of one complementing the other. The unimpeded and optimal cycling of blood between these two systems is pivotal to the overall function of the entire human body. Although the function of the cardiopulmonary system appears uncompli...

journal_title：Stem cells international

authors： Fakoya AOJ,Otohinoyi DA,Yusuf J

更新日期：2018-04-29 00:00:00

abstract：:Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic ...

journal_title：Stem cells international

authors： Huang Y,Sakai Y,Hara T,Katsuda T,Ochiya T,Adachi T,Hidaka M,Gu WL,Eguchi S

更新日期：2019-09-03 00:00:00

abstract：:The CRISPR/Cas9 system provides a powerful method for the genetic manipulation of the mammalian genome, allowing knockout of individual genes as well as the generation of genome-wide knockout cell libraries for genetic screening. However, the diploid status of most mammalian cells restricts the application of CRISPR/C...

journal_title：Stem cells international

authors： Yin Z,Chen L

更新日期：2017-01-01 00:00:00

abstract：:Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. Matrigel, derived from mouse sarcoma, has often been used as the supporting m...

journal_title：Stem cells international

authors： Jee JH,Lee DH,Ko J,Hahn S,Jeong SY,Kim HK,Park E,Choi SY,Jeong S,Lee JW,Cho HJ,Kwon MS,Yoo J

更新日期：2019-06-13 00:00:00

abstract：:In situ detection of MSCs remains difficult and warrants additional methods to aid with their characterization in vivo. Two-photon confocal laser scanning microscopy (TPM) and second harmonic generation (SHG) could fill this gap. Both techniques enable the detection of cells and extracellular structures, based on intr...

journal_title：Stem cells international

authors： Donders R,Sanen K,Paesen R,Slenders E,Gyselaers W,Stinissen P,Ameloot M,Hellings N

更新日期：2016-01-01 00:00:00

abstract：:Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood. In this study, we investigated the role of EphB4 in regulating the expression of periostin (POSTN) within bone marrow-derived mese...

journal_title：Stem cells international

authors： Zhang F,Zhang Z,Sun D,Dong S,Xu J,Dai F

更新日期：2016-01-01 00:00:00

abstract：:Current tissue engineering techniques are limited by inadequate vascularisation and perfusion of cell-scaffold constructs. Microstructural patterning through biomimetic vascular channels within a polymer scaffold might induce neovascularization, allowing fabrication of large engineered constructs. The network of vascu...

journal_title：Stem cells international

authors： Muller D,Chim H,Bader A,Whiteman M,Schantz JT

更新日期：2010-12-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Bind...

journal_title：Stem cells international

authors： Dietrich C

更新日期：2016-01-01 00:00:00

abstract：:Female infertility impacts the quality of life and well-being of affected individuals and couples. Female reproductive diseases, such as primary ovarian insufficiency, polycystic ovary syndrome, endometriosis, fallopian tube obstruction, and Asherman syndrome, can induce infertility. In recent years, translational med...

journal_title：Stem cells international

authors： Zhao YX,Chen SR,Su PP,Huang FH,Shi YC,Shi QY,Lin S

更新日期：2019-12-06 00:00:00

abstract：:Here, we aimed to answer important and fundamental questions in germ cell biology with special focus on the age of the male donor cells and the possibility to generate embryonic stem cell- (ESC-) like cells. While it is believed that spermatogonial stem cells (SSCs) and truly pluripotent ESC-like cells can be isolated...

journal_title：Stem cells international

authors： Azizi H,Conrad S,Hinz U,Asgari B,Nanus D,Peterziel H,Hajizadeh Moghaddam A,Baharvand H,Skutella T

更新日期：2016-01-01 00:00:00

abstract：:The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly...

journal_title：Stem cells international

authors： Solders M,Gorchs L,Gidlöf S,Tiblad E,Lundell AC,Kaipe H

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity. However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic. RSP...

journal_title：Stem cells international

authors： Liang C,Liang G,Zheng X,Huang Y,Huang S,Yin D

更新日期：2020-04-06 00:00:00