Abstract:
:Female infertility impacts the quality of life and well-being of affected individuals and couples. Female reproductive diseases, such as primary ovarian insufficiency, polycystic ovary syndrome, endometriosis, fallopian tube obstruction, and Asherman syndrome, can induce infertility. In recent years, translational medicine has developed rapidly, and clinical researchers are focusing on the treatment of female infertility using novel approaches. Owing to the advantages of convenient samples, abundant sources, and avoidable ethical issues, mesenchymal stem cells (MSCs) can be applied widely in the clinic. This paper reviews recent advances in using four types of MSCs, bone marrow stromal cells, adipose-derived stem cells, menstrual blood mesenchymal stem cells, and umbilical cord mesenchymal stem cells. Each of these have been used for the treatment of ovarian and uterine diseases, and provide new approaches for the treatment of female infertility.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Zhao YX,Chen SR,Su PP,Huang FH,Shi YC,Shi QY,Lin Sdoi
10.1155/2019/9071720subject
Has Abstractpub_date
2019-12-06 00:00:00pages
9071720eissn
1687-966Xissn
1687-9678journal_volume
2019pub_type
杂志文章,评审abstract::An intermediate filament protein, Nestin, is known as a neural stem/progenitor cell marker. It was shown to be required for the survival and self-renewal of neural stem cells according to the phenotypes of Nestin knockout mice. Nestin expression has also been reported in vascular endothelial cells, and we recently rep...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/430138
更新日期:2012-01-01 00:00:00
abstract::Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues. However, DPSC senescence restricts its clinical applications. Metformin (Met), a common prescription drug for type 2 diabetes, is thought to influence the aging process. This study is aimed at determining the effects of metform...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2021/6616240
更新日期:2021-01-06 00:00:00
abstract::The use of stem cells as a strategy for tissue repair and regeneration is one of the biomedical research areas that has attracted more interest in the past few years. Despite the classic belief that the central nervous system (CNS) was immutable, now it is well known that cell turnover occurs in the mature CNS. Postna...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/804717
更新日期:2012-01-01 00:00:00
abstract::Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/4142031
更新日期:2018-04-19 00:00:00
abstract:Objective:Mesenchymal stem cells (MSCs) are considered a promising therapy for wound healing. Here, we explored the role of c-Jun in diabetic wound healing using human umbilical cord-derived MSCs (hUC-MSCs). Methods:Freshly isolated hUC-MSCs were subjected to extensive in vitro subcultivation. The cell proliferative a...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/7430968
更新日期:2020-01-14 00:00:00
abstract::A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) causing lethal acute respiratory disease emerged in December 2019. The World Health Organization named this disease "COVID-19" and declared it a pandemic on March 11, 2020. Many studies have shown that mesenchymal stem cells (MSCs) and their exosomes (...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/8835986
更新日期:2020-09-24 00:00:00
abstract::Whether liver epithelial cells contribute to the development of hepatic scarring by undergoing epithelial-to-mesenchymal transition (EMT) is a controversial issue. Herein, we revisit the concept of EMT in cholangiopathies, a group of severe hepatic disorders primarily targeting the bile duct epithelial cell (cholangio...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/2953727
更新日期:2016-01-01 00:00:00
abstract::Here, we aimed to answer important and fundamental questions in germ cell biology with special focus on the age of the male donor cells and the possibility to generate embryonic stem cell- (ESC-) like cells. While it is believed that spermatogonial stem cells (SSCs) and truly pluripotent ESC-like cells can be isolated...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/8216312
更新日期:2016-01-01 00:00:00
abstract::Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of the...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4209891
更新日期:2016-01-01 00:00:00
abstract::Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends o...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/6129596
更新日期:2017-01-01 00:00:00
abstract::Transcription factors are tools repetitively used by the embryo to generate a variety of lineages. Hence, their context of activation is an important determinant of their ability to specifically trigger certain cell fates, but not others. The context is also consequential when considering directing differentiation of ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/6939438
更新日期:2016-01-01 00:00:00
abstract::Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation must be regulated for applications in regenerative medicine. Stem cells are surrounded by extracellular matrix (ECM) in vivo. The ECM is composed of many types of proteins and glycosaminoglycans that assemble into a complex str...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/6397820
更新日期:2016-01-01 00:00:00
abstract::Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two s...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/4247168
更新日期:2019-01-08 00:00:00
abstract::In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted centr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/589139
更新日期:2013-01-01 00:00:00
abstract::As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat degenerative diseases. Muscle differentiation is a multistep process...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/9245938
更新日期:2019-02-17 00:00:00
abstract:Background:Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to pr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/7813729
更新日期:2018-04-03 00:00:00
abstract:Background:Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/1302672
更新日期:2018-08-29 00:00:00
abstract::Two of the main problems of stem cell and regenerative medicine are the exit of pluripotency and differentiation to functional cells or tissues. The answer to these two problems holds great value in the clinical translation of stem cell as well as regenerative medicine research. Although piling researches have reveale...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8483035
更新日期:2020-02-03 00:00:00
abstract::The latest research achievements in the field of stem cells led in 2016 to the publication of "Guidelines for Stem Cell Research and Clinical Translation" by the International Society for Stem Cell Research (ISSCR). Updating the topics covered in previous publications, the new recommendations offer interesting ethical...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2017/5080259
更新日期:2017-01-01 00:00:00
abstract::Retrotransposons comprise a significant fraction of mammalian genome with unclear functions. Increasing evidence shows that they are not just remnants of ancient retroviruses but play important roles in multiple biological processes. Retrotransposons are epigenetically silenced in most somatic tissues and become react...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/6239245
更新日期:2018-07-15 00:00:00
abstract::Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/9010279
更新日期:2016-01-01 00:00:00
abstract::Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development from neural precur...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9260592
更新日期:2016-01-01 00:00:00
abstract:Purpose:To investigate the efficacy of recombinant human collagen type I (RHC I) and collagen-like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of limbal epithelial stem cells (LESC) under xeno-free culture conditions. Methods:Human LESC were cultivated on seven different collagen-deri...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/7867613
更新日期:2019-04-01 00:00:00
abstract::Schwann cell (SC) transplantation as a cell-based therapy can enhance peripheral and central nerve repair experimentally, but it is limited by the donor site morbidity for clinical application. We investigated weather respiratory mucosa stem cells (REMSCs), a kind of ectomesenchymal stem cells (EMSCs), isolated from r...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/328957
更新日期:2015-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) possess immunosuppressive properties and have been described in the tumor microenvironment of glioblastoma multiforme (GBM). This manuscript has two major topics-first, to describe isolated and cultured MSCs derived from GBM (GB-MSCs) and second, to examine their in vitro immunosuppressiv...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/6904638
更新日期:2019-05-02 00:00:00
abstract::Bone tissue regeneration is considered to be the optimal solution for bone loss. However, diabetic patients have a greater risk of poor bone healing or bone grafting failure than nondiabetics. The purpose of this study was to investigate the influence of the complexes of an adipose-derived stem cell sheet (ASC sheet) ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2506463
更新日期:2019-07-31 00:00:00
abstract::Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5797521
更新日期:2016-01-01 00:00:00
abstract::Oral mesenchymal stem/progenitor cells (MSCs) are renowned in the field of tissue engineering/regeneration for their multilineage differentiation potential and easy acquisition. These cells encompass the periodontal ligament stem/progenitor cells (PDLSCs), the dental pulp stem/progenitor cells (DPSCs), the stem/progen...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/1327405
更新日期:2020-02-25 00:00:00
abstract::In recent years several genes have linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) as a spectrum disease; however little is known about what triggers their onset. With the ability to generate patient specific stem cell lines from somatic cells, it is possible to model disease without the n...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9279516
更新日期:2016-01-01 00:00:00
abstract:Background:To reduce morbidity to cleft patients, new approaches have been developed and here, we report for the first time the use of deciduous dental pulp stem cells (DDPSC) associated with a hydroxyapatite-collagen sponge (Bio-Oss Collagen® 250 mg, Geistlich) for closing alveolar defects during secondary dental erup...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/6234167
更新日期:2020-03-12 00:00:00