Stem Cells and Cellular Origins of Mammary Gland: Updates in Rationale, Controversies, and Cancer Relevance.

abstract：:Neuromuscular diseases are caused by functional defects of skeletal muscles, directly via muscle pathology or indirectly via disruption of the nervous system. Extensive studies have been performed to improve the outcomes of therapies; however, effective treatment strategies have not been fully established for any majo...

journal_title：Stem cells international

authors： Jiwlawat N,Lynch E,Jeffrey J,Van Dyke JM,Suzuki M

更新日期：2018-04-11 00:00:00

abstract：:Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand...

journal_title：Stem cells international

authors： Valerie A,Vassiliki K,Irini M,Nikolaos P,Karampela E,Apostolos P

更新日期：2016-01-01 00:00:00

abstract：:Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenati...

journal_title：Stem cells international

authors： Kaur G,Cai C

更新日期：2018-03-29 00:00:00

abstract：:Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic ...

journal_title：Stem cells international

authors： Huang Y,Sakai Y,Hara T,Katsuda T,Ochiya T,Adachi T,Hidaka M,Gu WL,Eguchi S

更新日期：2019-09-03 00:00:00

abstract：:Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in...

journal_title：Stem cells international

authors： Schmal H,Kowal JM,Kassem M,Seidenstuecker M,Bernstein A,Böttiger K,Xiong T,Südkamp NP,Kubosch EJ

更新日期：2018-04-19 00:00:00

abstract：:The purpose of this study is to determine if patients with chronic patellar tendinopathy will improve clinically after the inoculation of bone marrow mononuclear cells (BM-MNCs). Eight patients with chronic patellar tendinopathy were included. Patients averaged 24 years old (range 14-35). All patients were refractory ...

journal_title：Stem cells international

authors： Pascual-Garrido C,Rolón A,Makino A

更新日期：2012-01-01 00:00:00

abstract：:Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation must be regulated for applications in regenerative medicine. Stem cells are surrounded by extracellular matrix (ECM) in vivo. The ECM is composed of many types of proteins and glycosaminoglycans that assemble into a complex str...

journal_title：Stem cells international

authors： Hoshiba T,Chen G,Endo C,Maruyama H,Wakui M,Nemoto E,Kawazoe N,Tanaka M

更新日期：2016-01-01 00:00:00

abstract：:In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted centr...

journal_title：Stem cells international

authors： Catacchio I,Berardi S,Reale A,De Luisi A,Racanelli V,Vacca A,Ria R

更新日期：2013-01-01 00:00:00

abstract：:The calcined tooth powder (CTP), a type of allogeneic biomimetic mineralized material, has been confirmed that can promote new bone formation when obtained at high temperature. The aim of this study was to investigate effects of the conditioned medium of calcined tooth powder (CTP-CM) on the osteogenic and odontogenic...

journal_title：Stem cells international

authors： Wu J,Li N,Fan Y,Wang Y,Gu Y,Li Z,Pan Y,Romila G,Zhou Z,Yu J

更新日期：2019-03-19 00:00:00

abstract：:Osteoarthritis (OA) can be a debilitating degenerative disease and is the most common form of arthritic disease. There is a general consensus that current nonsurgical therapies are insufficient for younger OA sufferers who are not candidates for knee arthroplasties. Adipose-derived mesenchymal stem cells (MSCs) therap...

journal_title：Stem cells international

authors： Succar P,Breen EJ,Kuah D,Herbert BR

更新日期：2015-01-01 00:00:00

abstract：:Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring i...

journal_title：Stem cells international

authors： Cimino M,Gonçalves RM,Barrias CC,Martins MCL

更新日期：2017-01-01 00:00:00

abstract：Background:Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy ...

journal_title：Stem cells international

authors： Zhu GQ,Jeon SH,Bae WJ,Choi SW,Jeong HC,Kim KS,Kim SJ,Cho HJ,Ha US,Hong SH,Lee JY,Kwon EB,Kim SW

更新日期：2018-08-29 00:00:00

abstract：:Mesenchymal stem cells (MSCs) derived from bone marrow can secrete cytokines and growth factors and can transdifferentiate into liver cells. We transplanted polymeric membrane bioencapsulated MSCs into the spleens of 90% partial hepatectomized rats. This resulted in 91.6% recovery rates. This is compared to a recovery...

journal_title：Stem cells international

authors： Liu ZC,Chang TM

更新日期：2012-01-01 00:00:00

abstract：:Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...

journal_title：Stem cells international

authors： Choudry FA,Frontini M

更新日期：2016-01-01 00:00:00

abstract：:Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell...

journal_title：Stem cells international

authors： Nikolic A,Volarevic V,Armstrong L,Lako M,Stojkovic M

更新日期：2016-01-01 00:00:00

abstract：Objective:Mesenchymal stem cells (MSCs) are considered a promising therapy for wound healing. Here, we explored the role of c-Jun in diabetic wound healing using human umbilical cord-derived MSCs (hUC-MSCs). Methods:Freshly isolated hUC-MSCs were subjected to extensive in vitro subcultivation. The cell proliferative a...

journal_title：Stem cells international

authors： Yue C,Guo Z,Luo Y,Yuan J,Wan X,Mo Z

更新日期：2020-01-14 00:00:00

abstract：:The objective of this paper is to describe in detail the method of organotypic longitudinal spinal cord slice culture and the scientific basis for its potential utility. The technique is based on the interface method, which was described previously and thereafter was modified in our laboratory. The most important adva...

journal_title：Stem cells international

authors： Sypecka J,Koniusz S,Kawalec M,Sarnowska A

更新日期：2015-01-01 00:00:00

abstract：:A stably established population of mouse bone marrow stromal cells (BMSCs) with self-renewal and multilineage differentiation potential was expanded in vitro for more than 50 passages. These cells express high levels of mesenchymal stem cell markers and can be differentiated into adipogenic, chondrogenic, and osteogen...

journal_title：Stem cells international

authors： Yu L,Hong W,Yang H,Xia YY,Feng Z

更新日期：2020-12-24 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...

journal_title：Stem cells international

authors： Marketou ME,Parthenakis F,Vardas PE

更新日期：2016-01-01 00:00:00

abstract：:Tendon healing is fraught with complications such as reruptures and adhesion formation due to the formation of scar tissue at the injury site as opposed to the regeneration of native tissue. Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. However, several questions rem...

journal_title：Stem cells international

authors： Gulotta LV,Chaudhury S,Wiznia D

更新日期：2012-01-01 00:00:00

abstract：Background:While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. In human studies, the ability to track transplanted cells has been limited to labeling with radioisotopes and tracking using nuclear...

journal_title：Stem cells international

authors： Mathiasen AB,Qayyum AA,Jørgensen E,Helqvist S,Ekblond A,Ng M,Bhakoo K,Kastrup J

更新日期：2019-11-14 00:00:00

abstract：:The CRISPR/Cas9 system provides a powerful method for the genetic manipulation of the mammalian genome, allowing knockout of individual genes as well as the generation of genome-wide knockout cell libraries for genetic screening. However, the diploid status of most mammalian cells restricts the application of CRISPR/C...

journal_title：Stem cells international

authors： Yin Z,Chen L

更新日期：2017-01-01 00:00:00

abstract：:Fetal dermal mesenchymal stem cells (FDMSCs), isolated from fetal skin, are serving as a novel MSC candidate with great potential in regenerative medicine. More recently, the paracrine actions, especially MSC-derived exosomes, are being focused on the vital role in MSC-based cellular therapy. This study was to evaluat...

journal_title：Stem cells international

authors： Wang X,Jiao Y,Pan Y,Zhang L,Gong H,Qi Y,Wang M,Gong H,Shao M,Wang X,Jiang D

更新日期：2019-06-10 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Bind...

journal_title：Stem cells international

authors： Dietrich C

更新日期：2016-01-01 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is a standard treatment for multiple myeloma (MM), but the clinical response and renal curative effect in MM patients with renal failure (RF) remain controversial. The myeloma kidney disease has different types, and most are due to the direct toxic effects of light chain. Al...

journal_title：Stem cells international

authors： Zhong H,Xie X,Xu G

更新日期：2019-10-29 00:00:00

abstract：:Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, n...

journal_title：Stem cells international

authors： Bruno S,Grange C,Tapparo M,Pasquino C,Romagnoli R,Dametto E,Amoroso A,Tetta C,Camussi G

更新日期：2016-01-01 00:00:00

abstract：:We aim to investigate the effects of adipose-derived stem cells (ASCs) transplantation on irradiation-induced skeletal muscle fibrosis. Sixty-four rabbits were randomly divided into ASCs group and PBS group followed by irradiation at unilateral hip with a single dose of 80 Gy. Nonirradiated side with normal skeletal m...

journal_title：Stem cells international

authors： Sun W,Ni X,Sun S,Cai L,Yu J,Wang J,Nie B,Sun Z,Ni X,Cao X

更新日期：2016-01-01 00:00:00

abstract：:In recent years several genes have linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) as a spectrum disease; however little is known about what triggers their onset. With the ability to generate patient specific stem cell lines from somatic cells, it is possible to model disease without the n...

journal_title：Stem cells international

authors： Hedges EC,Mehler VJ,Nishimura AL

更新日期：2016-01-01 00:00:00

abstract：:Oral mesenchymal stem/progenitor cells (MSCs) are renowned in the field of tissue engineering/regeneration for their multilineage differentiation potential and easy acquisition. These cells encompass the periodontal ligament stem/progenitor cells (PDLSCs), the dental pulp stem/progenitor cells (DPSCs), the stem/progen...

journal_title：Stem cells international

authors： Zhou LL,Liu W,Wu YM,Sun WL,Dörfer CE,Fawzy El-Sayed KM

更新日期：2020-02-25 00:00:00

abstract：:Wnt signalling has been implicated in the regulation of stem cell self-renewal and differentiation; however, the majority of in vitro studies are carried out using monolayer 2D culture techniques. Here, we used mesenchymal stromal cell (MSC) EGFP reporter lines responsive to Wnt pathway activation in a 3D spheroid cul...

journal_title：Stem cells international

authors： Saleh F,Carstairs A,Etheridge SL,Genever P

更新日期：2016-01-01 00:00:00