Abstract：
:We aim to investigate the effects of adipose-derived stem cells (ASCs) transplantation on irradiation-induced skeletal muscle fibrosis. Sixty-four rabbits were randomly divided into ASCs group and PBS group followed by irradiation at unilateral hip with a single dose of 80 Gy. Nonirradiated side with normal skeletal muscle served as normal control. Skeletal muscle tissues were collected from eight rabbits in each group at 1 w, 4 w, 8 w, and 26 w after irradiation. Migration of ASCs was observed in the peripheral tissues along the needle passage in the injured muscle. The proportion of the area of collagen fibers to the total area in sections of ASCs group was lower than those of PBS groups at 4 w, 8 w, and 26 w after irradiation. Significant decrease was noted in the integrated optimal density of the transforming growth factor β1 (TGF-β1) in the ASCs group compared with those of PBS group at 4 w, 8 w, and 26 w after irradiation. Moreover, the expression of TGF-β1 was lower in the ASCs group compared to those of the PBS group at each time point determined by Western blot analysis. ASCs transplantation could alleviate irradiation fibrosis by suppressing the level of TGF-β1 in the irradiated skeletal muscle.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Sun W,Ni X,Sun S,Cai L,Yu J,Wang J,Nie B,Sun Z,Ni X,Cao Xdoi
10.1155/2016/5638204subject
Has Abstractpub_date
2016-01-01 00:00:00pages
5638204eissn
1687-966Xissn
1687-9678journal_volume
2016pub_type
杂志文章abstract：:There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the di...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/9896142
更新日期：2018-12-25 00:00:00
abstract：:Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in t...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2019/7513404
更新日期：2019-07-24 00:00:00
abstract：:Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two s...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2019/4247168
更新日期：2019-01-08 00:00:00
abstract：Background:Aging is a major risk factor for cardiovascular disease. Cysteine protease cathepsin K (CatK) has been implicated in the process of angiogenesis, but the exact roles of individual CatK in vessel formation during aging are poorly understood. Methods and Results:To study the putative role of CatK in ischemia-...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/6938620
更新日期：2020-06-30 00:00:00
abstract：:The latest research achievements in the field of stem cells led in 2016 to the publication of "Guidelines for Stem Cell Research and Clinical Translation" by the International Society for Stem Cell Research (ISSCR). Updating the topics covered in previous publications, the new recommendations offer interesting ethical...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/5080259
更新日期：2017-01-01 00:00:00
abstract：:The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, an...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/1690896
更新日期：2016-01-01 00:00:00
abstract：:Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/2857478
更新日期：2017-01-01 00:00:00
abstract：:Designing and providing a scaffold are very important for the cells in tissue engineering. Polybutylene succinate (PBS) has high potential as a scaffold for bone regeneration due to its capacity in cell proliferation and differentiation. Also, stem cells from 3rd molar tooth germs were favoured in this study due to th...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/8792191
更新日期：2016-01-01 00:00:00
abstract：:Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and t...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/184154
更新日期：2012-01-01 00:00:00
abstract：:Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and str...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/5979741
更新日期：2017-01-01 00:00:00
abstract：:Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development from neural precur...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/9260592
更新日期：2016-01-01 00:00:00
abstract：:We have determined the protective effects of Thymus serpyllum (TS) extract and nanoparticle-loaded TS on hydrogen peroxide-induced cell death of mesenchymal stromal cells (MSCs) in vitro. Gas chromatography-mass spectroscopy confirmed the spectrum of active components in the extract. Out of the three different extract...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/5142518
更新日期：2019-02-26 00:00:00
abstract：:Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/3175748
更新日期：2017-01-01 00:00:00
abstract：:Mutations in WD40-repeat protein 62 (WDR62) are commonly associated with primary microcephaly and other developmental cortical malformations. We used human pluripotent stem cells (hPSC) to examine WDR62 function during human neural differentiation and model early stages of human corticogenesis. Neurospheres lacking WD...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/7848932
更新日期：2017-01-01 00:00:00
abstract：:Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highl...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/2874283
更新日期：2017-01-01 00:00:00
abstract：:Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/3975689
更新日期：2019-09-03 00:00:00
abstract：:Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/1741072
更新日期：2016-01-01 00:00:00
abstract：:Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation must be regulated for applications in regenerative medicine. Stem cells are surrounded by extracellular matrix (ECM) in vivo. The ECM is composed of many types of proteins and glycosaminoglycans that assemble into a complex str...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/6397820
更新日期：2016-01-01 00:00:00
abstract：:Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/5797521
更新日期：2016-01-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties vi...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2018/3057624
更新日期：2018-06-14 00:00:00
abstract：:Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential tissue integration, and undirected cell differentiation after transplantation in a hostile microenvironment are complications that require refin...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/5946527
更新日期：2017-01-01 00:00:00
abstract：:[This corrects the article DOI: 10.1155/2015/496512.]. ...
journal_title：Stem cells international
pub_type： 已发布勘误
doi：10.1155/2016/7958361
更新日期：2016-01-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs), or multipotent mesenchymal stromal cells, are present in almost all organs and tissues, including the amnion. Human amnion-derived mesenchymal stem cell (hAMSC) transplantation has been reported to ameliorate liver fibrosis in animal models. However, the mechanism for the prevention of l...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/4898152
更新日期：2018-10-08 00:00:00
abstract：:The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated. However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. In this study, our data showed that IL-1β induced LFA-1 e...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/7267142
更新日期：2019-12-27 00:00:00
abstract：Background:Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to pr...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/7813729
更新日期：2018-04-03 00:00:00
abstract：:Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and ...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2018/4837930
更新日期：2018-01-18 00:00:00
abstract：:Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell ma...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/6705927
更新日期：2016-01-01 00:00:00
abstract：:Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM,...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/502136
更新日期：2012-01-01 00:00:00
abstract：:A stably established population of mouse bone marrow stromal cells (BMSCs) with self-renewal and multilineage differentiation potential was expanded in vitro for more than 50 passages. These cells express high levels of mesenchymal stem cell markers and can be differentiated into adipogenic, chondrogenic, and osteogen...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/8857057
更新日期：2020-12-24 00:00:00
abstract：:Transcription factors are tools repetitively used by the embryo to generate a variety of lineages. Hence, their context of activation is an important determinant of their ability to specifically trigger certain cell fates, but not others. The context is also consequential when considering directing differentiation of ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/6939438
更新日期：2016-01-01 00:00:00
