Abstract:
:Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM, however, an extracellular matrix gel with exogenous EGF can be used as a substitute for the mesenchyme during BrM in the developing salivary epithelium. Stem/progenitor cells isolated from salivary glands in humans and rodents can be classified as mesenchymal stem cell-like, bone-marrow-derived, duct cell-like, and embryonic epithelium-like cells. Salivary-gland-derived progenitor (SGP) cells isolated from duct-ligated rats, mice, and swine submandibular glands share similar characteristics, including intracellular laminin and α6β1-integrin expression, similar to the embryonic salivary epithelia during the pseudoglandular stage. Progenitor cells also isolated from human salivary glands (human SGP cells) having the same characteristics differentiate into hepatocyte-like cells when transplanted into the liver. Similar to the dissociated embryonic salivary epithelium, human SGP cells aggregate to self-organize into branching organ-like structures on Matrigel plus exogenous EGF. These results suggest the possibility that tissue stem cells organize rudiment-like structures, and the embryonic cells that organize into whole tissues during development are preserved even in adult tissues.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Okumura K,Shinohara M,Endo Fdoi
10.1155/2012/502136subject
Has Abstractpub_date
2012-01-01 00:00:00pages
502136eissn
1687-966Xissn
1687-9678journal_volume
2012pub_type
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journal_title:Stem cells international
pub_type: 杂志文章
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/496512.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
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abstract::[This corrects the article DOI: 10.1155/2017/3978595.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
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更新日期:2017-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/9245938
更新日期:2019-02-17 00:00:00
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pub_type: 杂志文章
doi:10.1155/2020/8483035
更新日期:2020-02-03 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9260592
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
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doi:10.1155/2017/4252974
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/9275248
更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,评审
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