Pivotal Cytoprotective Mediators and Promising Therapeutic Strategies for Endothelial Progenitor Cell-Based Cardiovascular Regeneration.

abstract：:Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated wit...

journal_title：Stem cells international

authors： Pereira T,Armada-da Silva PA,Amorim I,Rêma A,Caseiro AR,Gärtner A,Rodrigues M,Lopes MA,Bártolo PJ,Santos JD,Luís AL,Maurício AC

更新日期：2014-01-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder. Current targeted therapies designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein have made a significant breakthrough in the treatment of CML patients. However, CML remains a chronic disease that a patient must manage for lif...

journal_title：Stem cells international

authors： Hamad A,Sahli Z,El Sabban M,Mouteirik M,Nasr R

更新日期：2013-01-01 00:00:00

abstract：:Coronary revascularization remains the standard treatment for obstructive coronary artery disease and can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery. Considerable advances have rendered PCI the most common form of revascularization and improved clinical o...

journal_title：Stem cells international

authors： Simard T,Jung RG,Motazedian P,Di Santo P,Ramirez FD,Russo JJ,Labinaz A,Yousef A,Anantharam B,Pourdjabbar A,Hibbert B

更新日期：2017-01-01 00:00:00

abstract：:Bone tissue regeneration is considered to be the optimal solution for bone loss. However, diabetic patients have a greater risk of poor bone healing or bone grafting failure than nondiabetics. The purpose of this study was to investigate the influence of the complexes of an adipose-derived stem cell sheet (ASC sheet) ...

journal_title：Stem cells international

authors： Xu X,Fang K,Wang L,Liu X,Zhou Y,Song Y

更新日期：2019-07-31 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is a standard treatment for multiple myeloma (MM), but the clinical response and renal curative effect in MM patients with renal failure (RF) remain controversial. The myeloma kidney disease has different types, and most are due to the direct toxic effects of light chain. Al...

journal_title：Stem cells international

authors： Zhong H,Xie X,Xu G

更新日期：2019-10-29 00:00:00

abstract：:Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, n...

journal_title：Stem cells international

authors： Bruno S,Grange C,Tapparo M,Pasquino C,Romagnoli R,Dametto E,Amoroso A,Tetta C,Camussi G

更新日期：2016-01-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential tissue integration, and undirected cell differentiation after transplantation in a hostile microenvironment are complications that require refin...

journal_title：Stem cells international

authors： Mellado-López M,Griffeth RJ,Meseguer-Ripolles J,Cugat R,García M,Moreno-Manzano V

更新日期：2017-01-01 00:00:00

abstract：:Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. Matrigel, derived from mouse sarcoma, has often been used as the supporting m...

journal_title：Stem cells international

authors： Jee JH,Lee DH,Ko J,Hahn S,Jeong SY,Kim HK,Park E,Choi SY,Jeong S,Lee JW,Cho HJ,Kwon MS,Yoo J

更新日期：2019-06-13 00:00:00

abstract：Aim:Few haematopoietic stem cells (HSCs) injected systemically for therapeutic purposes actually reach sites of injury as the vast majority become entrapped within pulmonary capillaries. One promising approach to maintain circulating HSC numbers would be to separate subpopulations with smaller size and/or greater defor...

journal_title：Stem cells international

authors： Du M,Kavanagh D,Zhang Z,Kalia N

更新日期：2019-09-05 00:00:00

abstract：:We attempted transplantation of adult neural stem cells (ANSCs) inside an autologous venous graft following surgical transsection of nervis cruralis with 30 mm long gap in adult pig. The transplanted cell suspension was a primary culture of neurospheres from adult pig subventricular zone (SVZ) which had been labeled i...

journal_title：Stem cells international

authors： Liard O,Segura S,Sagui E,Nau A,Pascual A,Cambon M,Darlix JL,Fusai T,Moyse E

更新日期：2012-01-01 00:00:00

abstract：:Increasing the success rate of rotator cuff healing remains tremendous challenge. Among many approaches, the possibility of activating resident stem cells in situ, without the need to isolate them from biopsies, could represent valuable therapeutic strategy. Along this line, it has been recently demonstrated that lipo...

journal_title：Stem cells international

authors： Randelli P,Menon A,Ragone V,Creo P,Bergante S,Randelli F,De Girolamo L,Alfieri Montrasio U,Banfi G,Cabitza P,Tettamanti G,Anastasia L

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into cells from the mesenchymal lineage. The hypoimmunogenic characteristic of MSCs has encouraged studies using allogeneic MSCs for the treatment of autoimmune diseases and inflammatory conditions. Promising preclinical results and the saf...

journal_title：Stem cells international

authors： Oliveira RL,Chagastelles PC,Sesterheim P,Pranke P

更新日期：2017-01-01 00:00:00

abstract：:Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell...

journal_title：Stem cells international

authors： Nikolic A,Volarevic V,Armstrong L,Lako M,Stojkovic M

更新日期：2016-01-01 00:00:00

abstract：:The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC) population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age-related muscle atrophy (sarcopenia) and several dystrophies, regeneration cannot compensate for the loss of muscle tissue. These diso...

journal_title：Stem cells international

authors： Pavlidou T,Marinkovic M,Rosina M,Fuoco C,Vumbaca S,Gargioli C,Castagnoli L,Cesareni G

更新日期：2019-04-24 00:00:00

abstract：:Chicken embryonic stem cells (cESCs) obtained from stage X embryos provide a novel model for the study of avian embryonic development. A new way to maintain cESCs for a long period in vitro still remains unexplored. We found that the cESCs showed stem cell-like properties in vitro for a long term with the support of D...

journal_title：Stem cells international

authors： Zhang L,Wu Y,Li X,Wei S,Xing Y,Lian Z,Han H

更新日期：2018-05-09 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are currently defined as multipotent stromal cells that undergo sustained in vitro growth and can give rise to cells of multiple mesenchymal lineages, such as adipocytes, chondrocytes, and osteoblasts. The regenerative and immunosuppressive properties of MSCs have led to numerous clinical...

journal_title：Stem cells international

authors： Mabuchi Y,Houlihan DD,Akazawa C,Okano H,Matsuzaki Y

更新日期：2013-01-01 00:00:00

abstract：:Due to their immunomodulatory and chemotactic properties, hMSC are being explored to treat immune-related diseases. For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was a...

journal_title：Stem cells international

authors： Blázquez-Prunera A,Almeida CR,Barbosa MA

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity. However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic. RSP...

journal_title：Stem cells international

authors： Liang C,Liang G,Zheng X,Huang Y,Huang S,Yin D

更新日期：2020-04-06 00:00:00

abstract：:Objectives. Acute lung injury (ALI) is a common clinical critical disease. Stem cells transplantation is recognized as an effective way to repair injured lung tissues. The present study was designed to evaluate the effects of mesenchymal stem cells (MSCs) on repair of lung and its mechanism. Methods. MSCs carrying GFP...

journal_title：Stem cells international

authors： Xin X,Yan L,Guangfa Z,Yan H,Keng L,Chunting W

更新日期：2017-01-01 00:00:00

abstract：Objective:To investigate the effects of mesenchymal stem cells (MSCs) coated by the extracellular matrix (ECM) on wound healing in diabetic rats. Methods:Mesenchymal stem cells were cocultured with ECM. Cell viabilities were evaluated using MTT assay. The diabetes model was established using both STZ and high-glucose/...

journal_title：Stem cells international

authors： Wang L,Wang F,Zhao L,Yang W,Wan X,Yue C,Mo Z

更新日期：2019-01-28 00:00:00

abstract：:There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC ...

journal_title：Stem cells international

authors： Gener P,Seras-Franzoso J,Callejo PG,Andrade F,Rafael D,Martínez F,Montero S,Arango D,Sayós J,Abasolo I,Schwartz S Jr

更新日期：2018-10-10 00:00:00

abstract：:The mesenchymal stem cells (MSCs) are known as highly plastic stem cells and can differentiate into specialized tissues such as adipose tissue, osseous tissue, muscle tissue, and nervous tissue. The differentiation of mesenchymal stem cells is very important in regenerative medicine. Their differentiation process is r...

journal_title：Stem cells international

authors： Wang F,Li X,Li Z,Wang S,Fan J

更新日期：2020-08-01 00:00:00

abstract：:The purpose of this study is to determine if patients with chronic patellar tendinopathy will improve clinically after the inoculation of bone marrow mononuclear cells (BM-MNCs). Eight patients with chronic patellar tendinopathy were included. Patients averaged 24 years old (range 14-35). All patients were refractory ...

journal_title：Stem cells international

authors： Pascual-Garrido C,Rolón A,Makino A

更新日期：2012-01-01 00:00:00

abstract：:Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. The buccal fat pad (BFP) is a specialized adipose tissue that is easy to harvest and contains a rich blood supply, and its harvesting causes low complications for patients. This review focuse...

journal_title：Stem cells international

authors： Salehi-Nik N,Rezai Rad M,Kheiri L,Nazeman P,Nadjmi N,Khojasteh A

更新日期：2017-01-01 00:00:00

abstract：:Myocardial infarction is a leading cause of death among all cardiovascular diseases. Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs), expanded CD133+ cells, have promise as a therapeutic option for the treatment of ischemic areas after infarction. Recently, secreted membrane ve...

journal_title：Stem cells international

authors： Angulski ABB,Capriglione LGA,Barchiki F,Brofman P,Stimamiglio MA,Senegaglia AC,Correa A

更新日期：2019-12-01 00:00:00

abstract：:Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood. In this study, we investigated the role of EphB4 in regulating the expression of periostin (POSTN) within bone marrow-derived mese...

journal_title：Stem cells international

authors： Zhang F,Zhang Z,Sun D,Dong S,Xu J,Dai F

更新日期：2016-01-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age. Chronic inflammation is considered to be the cause of ovarian dysfunction. Increasing evidence in animal studies and in preliminary clinical trials has demonstrated that MSCs possess immunomodulatory effe...

journal_title：Stem cells international

authors： Xie Q,Xiong X,Xiao N,He K,Chen M,Peng J,Su X,Mei H,Dai Y,Wei D,Lin G,Cheng L

更新日期：2019-09-12 00:00:00

abstract：Background:Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology. However, there is still considerable debate about the genotype and function of CAC. Methods and Results:Data from publicly available gene expression data sets were used to analyse the transcriptome of in vit...

journal_title：Stem cells international

authors： Everaert BR,Van Laere SJ,Lembrechts R,Hoymans VY,Timmermans JP,Vrints CJ

更新日期：2019-05-02 00:00:00

abstract：:We have determined the protective effects of Thymus serpyllum (TS) extract and nanoparticle-loaded TS on hydrogen peroxide-induced cell death of mesenchymal stromal cells (MSCs) in vitro. Gas chromatography-mass spectroscopy confirmed the spectrum of active components in the extract. Out of the three different extract...

journal_title：Stem cells international

authors： Baig S,Azizan AHS,Raghavendran HRB,Natarajan E,Naveen S,Murali MR,Nam HY,Kamarul T

更新日期：2019-02-26 00:00:00

abstract：:In situ detection of MSCs remains difficult and warrants additional methods to aid with their characterization in vivo. Two-photon confocal laser scanning microscopy (TPM) and second harmonic generation (SHG) could fill this gap. Both techniques enable the detection of cells and extracellular structures, based on intr...

journal_title：Stem cells international

authors： Donders R,Sanen K,Paesen R,Slenders E,Gyselaers W,Stinissen P,Ameloot M,Hellings N

更新日期：2016-01-01 00:00:00