Human Liver Stem Cells Suppress T-Cell Proliferation, NK Activity, and Dendritic Cell Differentiation.

abstract：:Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicability, both experimentally and in the clinic. These cells can be isolated from various human tissues that may differ anatomically or developmentally with relative ease. Heterogenei...

journal_title：Stem cells international

authors： Christodoulou I,Kolisis FN,Papaevangeliou D,Zoumpourlis V

更新日期：2013-01-01 00:00:00

abstract：:The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC) population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age-related muscle atrophy (sarcopenia) and several dystrophies, regeneration cannot compensate for the loss of muscle tissue. These diso...

journal_title：Stem cells international

authors： Pavlidou T,Marinkovic M,Rosina M,Fuoco C,Vumbaca S,Gargioli C,Castagnoli L,Cesareni G

更新日期：2019-04-24 00:00:00

abstract：:Tumor hypoxia is associated with malignant biological phenotype including enhanced angiogenesis and metastasis. Hypoxia increases the expression of vascular endothelial cell growth factor (VEGF), which directly participates in angiogenesis by recruiting endothelial cells into hypoxic area and stimulating their prolife...

journal_title：Stem cells international

authors： Chen HF,Wu KJ

更新日期：2016-01-01 00:00:00

abstract：:Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic ...

journal_title：Stem cells international

authors： Huang Y,Sakai Y,Hara T,Katsuda T,Ochiya T,Adachi T,Hidaka M,Gu WL,Eguchi S

更新日期：2019-09-03 00:00:00

abstract：Objective:To investigate the effects of mesenchymal stem cells (MSCs) coated by the extracellular matrix (ECM) on wound healing in diabetic rats. Methods:Mesenchymal stem cells were cocultured with ECM. Cell viabilities were evaluated using MTT assay. The diabetes model was established using both STZ and high-glucose/...

journal_title：Stem cells international

authors： Wang L,Wang F,Zhao L,Yang W,Wan X,Yue C,Mo Z

更新日期：2019-01-28 00:00:00

abstract：:Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in...

journal_title：Stem cells international

authors： Schmal H,Kowal JM,Kassem M,Seidenstuecker M,Bernstein A,Böttiger K,Xiong T,Südkamp NP,Kubosch EJ

更新日期：2018-04-19 00:00:00

abstract：:Myocardial infarction is a leading cause of death among all cardiovascular diseases. Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs), expanded CD133+ cells, have promise as a therapeutic option for the treatment of ischemic areas after infarction. Recently, secreted membrane ve...

journal_title：Stem cells international

authors： Angulski ABB,Capriglione LGA,Barchiki F,Brofman P,Stimamiglio MA,Senegaglia AC,Correa A

更新日期：2019-12-01 00:00:00

abstract：:Previous studies have demonstrated that myocardin-related transcription factor A (MRTF-A) generates a link between the dynamics of the actin cytoskeleton and gene expression with its coregulator, serum response factor (SRF). MRTF-A has also been suggested as a regulator of stem cell differentiation. However, the role ...

journal_title：Stem cells international

authors： Hyväri L,Vanhatupa S,Halonen HT,Kääriäinen M,Miettinen S

更新日期：2020-09-22 00:00:00

abstract：:Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after establishment of DES. Eye drops containing either bromodeoxyuridi...

journal_title：Stem cells international

authors： Beyazyıldız E,Pınarlı FA,Beyazyıldız O,Hekimoğlu ER,Acar U,Demir MN,Albayrak A,Kaymaz F,Sobacı G,Delibaşı T

更新日期：2014-01-01 00:00:00

abstract：Background:Human dermal fibroblasts (HDFs) are the primary cells in skin and are associated with UVB-induced skin photoaging. Adipose-derived stem cells (ASCs) have been proposed as a treatment for skin aging. The goal of this study was to investigate paracrine mechanisms by which ASCs repair HDFs damage from UVB expos...

journal_title：Stem cells international

authors： Qin F,Huang J,Zhang W,Zhang M,Li Z,Si L,Long X,Wang X

更新日期：2020-12-17 00:00:00

abstract：:Periodontal ligament stem cells (PDLSCs) possess self-renewal, multilineage differentiation, and immunomodulatory properties. They play a crucial role in maintaining periodontal homeostasis and also participated in orthodontic tooth movement (OTM). Various studies have applied controlled mechanical stimulation to PDLS...

journal_title：Stem cells international

authors： Huang H,Yang R,Zhou YH

更新日期：2018-09-17 00:00:00

abstract：:The latest research achievements in the field of stem cells led in 2016 to the publication of "Guidelines for Stem Cell Research and Clinical Translation" by the International Society for Stem Cell Research (ISSCR). Updating the topics covered in previous publications, the new recommendations offer interesting ethical...

journal_title：Stem cells international

authors： Frati P,Scopetti M,Santurro A,Gatto V,Fineschi V

更新日期：2017-01-01 00:00:00

abstract：:The lung is a radiosensitive organ, which imposes limits on the therapeutic dose in thoracic radiotherapy. Irradiated alveolar epithelial cells promote radiation-related pneumonitis and fibrosis. However, the role of lung stem cells (LSCs) in the development of radiation-induced lung injury is still unclear. In this s...

journal_title：Stem cells international

authors： Wang LK,Wu TJ,Hong JH,Chen FH,Yu J,Wang CC

更新日期：2020-09-29 00:00:00

abstract：Aim:Few haematopoietic stem cells (HSCs) injected systemically for therapeutic purposes actually reach sites of injury as the vast majority become entrapped within pulmonary capillaries. One promising approach to maintain circulating HSC numbers would be to separate subpopulations with smaller size and/or greater defor...

journal_title：Stem cells international

authors： Du M,Kavanagh D,Zhang Z,Kalia N

更新日期：2019-09-05 00:00:00

abstract：:Increasing the success rate of rotator cuff healing remains tremendous challenge. Among many approaches, the possibility of activating resident stem cells in situ, without the need to isolate them from biopsies, could represent valuable therapeutic strategy. Along this line, it has been recently demonstrated that lipo...

journal_title：Stem cells international

authors： Randelli P,Menon A,Ragone V,Creo P,Bergante S,Randelli F,De Girolamo L,Alfieri Montrasio U,Banfi G,Cabitza P,Tettamanti G,Anastasia L

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess immunosuppressive properties and have been described in the tumor microenvironment of glioblastoma multiforme (GBM). This manuscript has two major topics-first, to describe isolated and cultured MSCs derived from GBM (GB-MSCs) and second, to examine their in vitro immunosuppressiv...

journal_title：Stem cells international

authors： Tumangelova-Yuzeir K,Naydenov E,Ivanova-Todorova E,Krasimirova E,Vasilev G,Nachev S,Kyurkchiev D

更新日期：2019-05-02 00:00:00

abstract：:Schwann cell (SC) transplantation as a cell-based therapy can enhance peripheral and central nerve repair experimentally, but it is limited by the donor site morbidity for clinical application. We investigated weather respiratory mucosa stem cells (REMSCs), a kind of ectomesenchymal stem cells (EMSCs), isolated from r...

journal_title：Stem cells international

authors： Zhang J,Gao X,Zou H,Liu J,Zhang Z

更新日期：2015-01-01 00:00:00

abstract：:Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide t...

journal_title：Stem cells international

authors： Burke J,Kolhe R,Hunter M,Isales C,Hamrick M,Fulzele S

更新日期：2016-01-01 00:00:00

abstract：:Beer is one of the most consumed alcoholic beverages in the world, rich in chemical compounds of natural origin with high nutritional and biological value. It is made up of water, barley malt, hops, and yeast. The main nutrients are carbohydrates, amino acids, minerals, vitamins, and other compounds such as polyphenol...

journal_title：Stem cells international

authors： Di Domenico M,Feola A,Ambrosio P,Pinto F,Galasso G,Zarrelli A,Di Fabio G,Porcelli M,Scacco S,Inchingolo F,Quagliuolo L,Ballini A,Boccellino M

更新日期：2020-10-10 00:00:00

abstract：Purpose:To investigate the efficacy of recombinant human collagen type I (RHC I) and collagen-like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of limbal epithelial stem cells (LESC) under xeno-free culture conditions. Methods:Human LESC were cultivated on seven different collagen-deri...

journal_title：Stem cells international

authors： Haagdorens M,Cėpla V,Melsbach E,Koivusalo L,Skottman H,Griffith M,Valiokas R,Zakaria N,Pintelon I,Tassignon MJ

更新日期：2019-04-01 00:00:00

abstract：:The quality of life of patients with chronic wounds can be extremely poor and, therefore, over the past decades, great efforts have been made to develop efficient strategies to improve the healing process and the social impact associated with these conditions. Cell based therapy, as a modern tissue engineering strateg...

journal_title：Stem cells international

authors： Galateanu B,Bunea MC,Stanescu P,Vasile E,Casarica A,Iovu H,Hermenean A,Zaharia C,Costache M

更新日期：2015-01-01 00:00:00

abstract：:Osteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenically. Icariin (ICA) is...

journal_title：Stem cells international

authors： Yang A,Yu C,Lu Q,Li H,Li Z,He C

更新日期：2019-04-04 00:00:00

abstract：:Sepsis, newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the most common cause of death in ICUs and one of the principal causes of death worldwide. Although substantial progress has been made in the understanding of fundamental mechanisms of sepsis, translat...

journal_title：Stem cells international

authors： Horák J,Nalos L,Martínková V,Beneš J,Štengl M,Matějovič M

更新日期：2017-01-01 00:00:00

abstract：:Designing and providing a scaffold are very important for the cells in tissue engineering. Polybutylene succinate (PBS) has high potential as a scaffold for bone regeneration due to its capacity in cell proliferation and differentiation. Also, stem cells from 3rd molar tooth germs were favoured in this study due to th...

journal_title：Stem cells international

authors： Abay N,Gurel Pekozer G,Ramazanoglu M,Kose GT

更新日期：2016-01-01 00:00:00

abstract：:Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...

journal_title：Stem cells international

authors： Choudry FA,Frontini M

更新日期：2016-01-01 00:00:00

abstract：:Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highl...

journal_title：Stem cells international

authors： Lees JG,Gardner DK,Harvey AJ

更新日期：2017-01-01 00:00:00

abstract：:Autologous stem cell transplantation (ASCT) is a standard treatment for multiple myeloma (MM), but the clinical response and renal curative effect in MM patients with renal failure (RF) remain controversial. The myeloma kidney disease has different types, and most are due to the direct toxic effects of light chain. Al...

journal_title：Stem cells international

authors： Zhong H,Xie X,Xu G

更新日期：2019-10-29 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for tr...

journal_title：Stem cells international

authors： Zhu J,Xiao Y,Li Z,Han F,Xiao T,Zhang Z,Geng F

更新日期：2015-01-01 00:00:00

abstract：:The calcined tooth powder (CTP), a type of allogeneic biomimetic mineralized material, has been confirmed that can promote new bone formation when obtained at high temperature. The aim of this study was to investigate effects of the conditioned medium of calcined tooth powder (CTP-CM) on the osteogenic and odontogenic...

journal_title：Stem cells international

authors： Wu J,Li N,Fan Y,Wang Y,Gu Y,Li Z,Pan Y,Romila G,Zhou Z,Yu J

更新日期：2019-03-19 00:00:00

abstract：:Homoeostasis of bone marrow microenvironment depends on a precise balance between cell proliferation and death, which is supported by the cellular-extracellular matrix crosstalk. Multipotent mesenchymal stromal cells (MSC) are the key elements to provide the specialized bone marrow microenvironment by supporting, main...

journal_title：Stem cells international

authors： Cominal JG,da Costa Cacemiro M,Pinto-Simões B,Kolb HJ,Malmegrim KCR,de Castro FA

更新日期：2019-06-02 00:00:00