Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions.

abstract：:As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat degenerative diseases. Muscle differentiation is a multistep process...

journal_title：Stem cells international

authors： Aboalola D,Han VKM

更新日期：2019-02-17 00:00:00

abstract：:Mandibular bone defect reconstruction is an urgent challenge due to the requirements for daily eating and facial aesthetics. Three-dimensional- (3D-) printed titanium (Ti) scaffolds could provide patient-specific implants for bone defects. Appropriate load-bearing properties are also required during bone reconstructio...

journal_title：Stem cells international

authors： Yu L,Wu Y,Liu J,Li B,Ma B,Li Y,Huang Z,He Y,Wang H,Wu Z,Qiu G

更新日期：2018-09-05 00:00:00

abstract：:Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated wit...

journal_title：Stem cells international

authors： Pereira T,Armada-da Silva PA,Amorim I,Rêma A,Caseiro AR,Gärtner A,Rodrigues M,Lopes MA,Bártolo PJ,Santos JD,Luís AL,Maurício AC

更新日期：2014-01-01 00:00:00

abstract：:Coronary revascularization remains the standard treatment for obstructive coronary artery disease and can be accomplished by either percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery. Considerable advances have rendered PCI the most common form of revascularization and improved clinical o...

journal_title：Stem cells international

authors： Simard T,Jung RG,Motazedian P,Di Santo P,Ramirez FD,Russo JJ,Labinaz A,Yousef A,Anantharam B,Pourdjabbar A,Hibbert B

更新日期：2017-01-01 00:00:00

abstract：:Neuromuscular diseases are caused by functional defects of skeletal muscles, directly via muscle pathology or indirectly via disruption of the nervous system. Extensive studies have been performed to improve the outcomes of therapies; however, effective treatment strategies have not been fully established for any majo...

journal_title：Stem cells international

authors： Jiwlawat N,Lynch E,Jeffrey J,Van Dyke JM,Suzuki M

更新日期：2018-04-11 00:00:00

abstract：:Tendon healing is fraught with complications such as reruptures and adhesion formation due to the formation of scar tissue at the injury site as opposed to the regeneration of native tissue. Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. However, several questions rem...

journal_title：Stem cells international

authors： Gulotta LV,Chaudhury S,Wiznia D

更新日期：2012-01-01 00:00:00

abstract：:The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly...

journal_title：Stem cells international

authors： Solders M,Gorchs L,Gidlöf S,Tiblad E,Lundell AC,Kaipe H

更新日期：2017-01-01 00:00:00

abstract：:Fetal dermal mesenchymal stem cells (FDMSCs), isolated from fetal skin, are serving as a novel MSC candidate with great potential in regenerative medicine. More recently, the paracrine actions, especially MSC-derived exosomes, are being focused on the vital role in MSC-based cellular therapy. This study was to evaluat...

journal_title：Stem cells international

authors： Wang X,Jiao Y,Pan Y,Zhang L,Gong H,Qi Y,Wang M,Gong H,Shao M,Wang X,Jiang D

更新日期：2019-06-10 00:00:00

abstract：:Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highl...

journal_title：Stem cells international

authors： Lees JG,Gardner DK,Harvey AJ

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) derived from bone marrow can secrete cytokines and growth factors and can transdifferentiate into liver cells. We transplanted polymeric membrane bioencapsulated MSCs into the spleens of 90% partial hepatectomized rats. This resulted in 91.6% recovery rates. This is compared to a recovery...

journal_title：Stem cells international

authors： Liu ZC,Chang TM

更新日期：2012-01-01 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues. However, DPSC senescence restricts its clinical applications. Metformin (Met), a common prescription drug for type 2 diabetes, is thought to influence the aging process. This study is aimed at determining the effects of metform...

journal_title：Stem cells international

authors： Zhang S,Zhang R,Qiao P,Ma X,Lu R,Wang F,Li C,E L,Liu H

更新日期：2021-01-06 00:00:00

abstract：:Background. Human cardiac-derived progenitor cells (hCPCs) have shown promise in treating heart failure (HF) in adults. The purpose of this study was to describe derivation of hCPCs from pediatric patients with end-stage HF. Methods. At surgery, discarded right atrial tissues (hAA) were obtained from HF patients (n = ...

journal_title：Stem cells international

authors： Steele A,Boucek RJ Jr,Jacobs JP,Steele P,Asante-Korang A,Chamizo W,Steele J,Chai PJ,Quintessenza JA

更新日期：2012-01-01 00:00:00

abstract：:There are promising results in the use of platelet-rich plasma (PRP) for musculoskeletal tissue repair. However, the variability in the methodology for its obtaining may cause different and opposing findings in the literature. Particularly, the choice of the anticoagulant is the first definition to be made. In this wo...

journal_title：Stem cells international

authors： do Amaral RJ,da Silva NP,Haddad NF,Lopes LS,Ferreira FD,Filho RB,Cappelletti PA,de Mello W,Cordeiro-Spinetti E,Balduino A

更新日期：2016-01-01 00:00:00

abstract：:Vitamin D (Vit D) by means of its biological active form, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In thi...

journal_title：Stem cells international

authors： Posa F,Di Benedetto A,Cavalcanti-Adam EA,Colaianni G,Porro C,Trotta T,Brunetti G,Lo Muzio L,Grano M,Mori G

更新日期：2018-02-28 00:00:00

abstract：:Human bone marrow mesenchymal stem cells (hBM-MSCs) are the best characterized multipotent adult stem cells. Their self-renewal capacity, multilineage differentiation potential, and immunomodulatory properties have indicated that they can be used in many clinical therapies. In a previous work we studied the DNA methyl...

journal_title：Stem cells international

authors： Bentivegna A,Roversi G,Riva G,Paoletta L,Redaelli S,Miloso M,Tredici G,Dalprà L

更新日期：2016-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in cell fate decisions. However, the miRNAs and their targets involved in the regulation of cardiac lineage specification are largely unexplored. Here, we report novel functions of miR-142-3p in the regulation of cardiomyocyte differentiation from mouse embryonic stem cells (mES...

journal_title：Stem cells international

authors： Chen ZY,Chen F,Cao N,Zhou ZW,Yang HT

更新日期：2017-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...

journal_title：Stem cells international

authors： Marketou ME,Parthenakis F,Vardas PE

更新日期：2016-01-01 00:00:00

abstract：:Two of the main problems of stem cell and regenerative medicine are the exit of pluripotency and differentiation to functional cells or tissues. The answer to these two problems holds great value in the clinical translation of stem cell as well as regenerative medicine research. Although piling researches have reveale...

journal_title：Stem cells international

authors： Yang B,Kuang J,Wu C,Zhou W,Zhu S,Jiang H,Zhai Z,Wu Y,Peng J,Liu N,Hu H,Ide NM,Chen R,Zhao M,Zhu P

更新日期：2020-02-03 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...

journal_title：Stem cells international

authors： Park M,Kim YH,Ryu JH,Woo SY,Ryu KH

更新日期：2015-01-01 00:00:00

abstract：:The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC) population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age-related muscle atrophy (sarcopenia) and several dystrophies, regeneration cannot compensate for the loss of muscle tissue. These diso...

journal_title：Stem cells international

authors： Pavlidou T,Marinkovic M,Rosina M,Fuoco C,Vumbaca S,Gargioli C,Castagnoli L,Cesareni G

更新日期：2019-04-24 00:00:00

abstract：:Urine has become the source of choice for noninvasive renal epithelial cells and renal stem cells which can be used for generating induced pluripotent stem cells. The aim of this study was to generate a 3D nephrogenic progenitor cell model composed of three distinct cell types-urine-derived SIX2-positive renal progeni...

journal_title：Stem cells international

authors： Nguyen L,Spitzhorn LS,Adjaye J

更新日期：2019-05-02 00:00:00

abstract：:Spinal cord injury (SCI) represents one of the most complicated and heterogeneous pathological processes of central nervous system (CNS) impairments, which is still beyond functional regeneration. Transplantation of mesenchymal stem cells (MSCs) has been shown to promote the repair of the injured spinal cord tissues i...

journal_title：Stem cells international

authors： Qu J,Zhang H

更新日期：2017-01-01 00:00:00

abstract：:Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, n...

journal_title：Stem cells international

authors： Bruno S,Grange C,Tapparo M,Pasquino C,Romagnoli R,Dametto E,Amoroso A,Tetta C,Camussi G

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2015/496512.]. ...

journal_title：Stem cells international

authors： Sasi SP,Park D,Muralidharan S,Wage J,Kiladjian A,Onufrak J,Enderling H,Yan X,Goukassian DA

更新日期：2016-01-01 00:00:00

abstract：:Left-right symmetry breaking is a complex developmental process and an important part of embryonic axis development. As of yet, the biophysical mechanism behind LR asymmetry establishment remains elusive for the overall asymmetry of embryos as well as for the organ-specific asymmetry. Here, we demonstrate that inheren...

journal_title：Stem cells international

authors： Worley KE,Chin AS,Wan LQ

更新日期：2018-12-02 00:00:00

abstract：:Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...

journal_title：Stem cells international

authors： Choudry FA,Frontini M

更新日期：2016-01-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) belongs to multipotent adult somatic stem cells. A single HSC can reconstitute the entire blood system via self-renewal, differentiation into all lineages of blood cells, and replenishment of cells lost due to attrition or disease in a person's lifetime. Although all blood and immune cell...

journal_title：Stem cells international

authors： Zhang J,Crumpacker C

更新日期：2015-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. Despite several treatment options, AMD therapy remains difficult, especially for exudative AMD. Mul...

journal_title：Stem cells international

authors： Nuzzi R,Gunetti M,Rustichelli D,Roagna B,Fronticelli Bardelli F,Fagioli F,Ferrero I

更新日期：2012-01-01 00:00:00

abstract：:Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in t...

journal_title：Stem cells international

authors： Saud B,Malla R,Shrestha K

更新日期：2019-07-24 00:00:00

abstract：:Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent treatment option in this regard. Preclinical studies demonstrate that untreated stem cells, unlike stem cells activated to differentiate into neuronal lineage, do...

journal_title：Stem cells international

authors： Madhu V,Dighe AS,Cui Q,Deal DN

更新日期：2016-01-01 00:00:00