Abstract:
:Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highlighted by extensive studies of their impact on preimplantation embryo development, physiology, and viability. ESC similarly modulate their metabolism in response to altered metabolite levels, with changes in nutrient availability shown to have a lasting impact on derived cell identity through the regulation of the epigenetic landscape. Further, the preferential use of glucose and anaplerotic glutamine metabolism serves to not only support cell growth and proliferation but also minimise reactive oxygen species production. However, the perinuclear localisation of spherical, electron-poor mitochondria in ESC is proposed to sustain ESC nuclear-mitochondrial crosstalk and a mitochondrial-H2O2 presence, to facilitate signalling to support self-renewal through the stabilisation of HIFα, a process that may be favoured under physiological oxygen. The environment in which a cell is grown is therefore a critical regulator and determinant of cell fate, with metabolism, and particularly mitochondria, acting as an interface between the environment and the epigenome.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Lees JG,Gardner DK,Harvey AJdoi
10.1155/2017/2874283subject
Has Abstractpub_date
2017-01-01 00:00:00pages
2874283eissn
1687-966Xissn
1687-9678journal_volume
2017pub_type
杂志文章,评审abstract:Materials and Methods:Ischemic brain injury was induced by dMCAO in Sprague-Dawley rats. The transplantation group received MSC infusion 1 h after dMCAO. Expression of IGF-1 in GFAP+ astrocytes, Iba-1+ microglia/macrophages, CD3+ lymphocytes, Ly6C+ monocytes/macrophages, and neutrophil elastase (NE)+ neutrophils was ex...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8853444
更新日期:2020-09-01 00:00:00
abstract::A growing body of evidence supports the argument that bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into cardiomyocyte-like cells in an appropriate cellular environment, but the differentiation rate is low. A cocktail method was designed: we investigated the role of 5-azacytidine (5-aza), salvian...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/162024
更新日期:2014-01-01 00:00:00
abstract:Background:Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology. However, there is still considerable debate about the genotype and function of CAC. Methods and Results:Data from publicly available gene expression data sets were used to analyse the transcriptome of in vit...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/9545261
更新日期:2019-05-02 00:00:00
abstract::There are promising results in the use of platelet-rich plasma (PRP) for musculoskeletal tissue repair. However, the variability in the methodology for its obtaining may cause different and opposing findings in the literature. Particularly, the choice of the anticoagulant is the first definition to be made. In this wo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/7414036
更新日期:2016-01-01 00:00:00
abstract::Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5720758
更新日期:2016-01-01 00:00:00
abstract:Objective:Special hypoxic and hypertonic microenvironment in intervertebral discs (IVDs) decreases the treatment effect of cell transplantation. We investigated the hypothesis that hypoxic preconditioning (HP) could improve the therapeutic effect of bone mesenchymal stem cells (BMSCs) to IVD degeneration. Methods:BMSC...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/7564159
更新日期:2018-02-14 00:00:00
abstract::A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) causing lethal acute respiratory disease emerged in December 2019. The World Health Organization named this disease "COVID-19" and declared it a pandemic on March 11, 2020. Many studies have shown that mesenchymal stem cells (MSCs) and their exosomes (...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/8835986
更新日期:2020-09-24 00:00:00
abstract::Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5797521
更新日期:2016-01-01 00:00:00
abstract:Background:Human dermal fibroblasts (HDFs) are the primary cells in skin and are associated with UVB-induced skin photoaging. Adipose-derived stem cells (ASCs) have been proposed as a treatment for skin aging. The goal of this study was to investigate paracrine mechanisms by which ASCs repair HDFs damage from UVB expos...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8878370
更新日期:2020-12-17 00:00:00
abstract::Beer is one of the most consumed alcoholic beverages in the world, rich in chemical compounds of natural origin with high nutritional and biological value. It is made up of water, barley malt, hops, and yeast. The main nutrients are carbohydrates, amino acids, minerals, vitamins, and other compounds such as polyphenol...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8835813
更新日期:2020-10-10 00:00:00
abstract::Previously, we demonstrated a high quality of minerals formed by serum-free cultured jaw periosteal cells (JPCs) by Raman spectroscopy but the mineralization extent was not satisfactory. In the present study, we analyzed the proliferation and mineralization potential of human platelet lysate- (hPL-) cultured JPCs in c...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/8303959
更新日期:2017-01-01 00:00:00
abstract::Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood. In this study, we investigated the role of EphB4 in regulating the expression of periostin (POSTN) within bone marrow-derived mese...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/7241829
更新日期:2016-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties vi...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/3057624
更新日期:2018-06-14 00:00:00
abstract::Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in t...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/7513404
更新日期:2019-07-24 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/3978595.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2017/9438310
更新日期:2017-01-01 00:00:00
abstract::Background. Mouse embryonic stem (ES) cells can be differentiated in vitro by aggregation and/or retinoic acid (RA) treatment. The principal differentiation lineage in vitro is extraembryonic primitive endoderm. Dab2, Laminin, GATA4, GATA5, and GATA6 are expressed in embryonic primitive endoderm and play critical role...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2010/602068
更新日期:2010-05-11 00:00:00
abstract::The magic angle effect increases the MRI signal of healthy tendon tissue and could be used for more detailed evaluation of tendon structure. Furthermore, it could support the discrimination of hypointense artefacts induced by contrast agents such as superparamagnetic iron oxide used for cell tracking. However, magic a...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/5670106
更新日期:2019-12-17 00:00:00
abstract::Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into cells from the mesenchymal lineage. The hypoimmunogenic characteristic of MSCs has encouraged studies using allogeneic MSCs for the treatment of autoimmune diseases and inflammatory conditions. Promising preclinical results and the saf...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/9824698
更新日期:2017-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/106540
更新日期:2015-01-01 00:00:00
abstract::The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors. In the present study, we analysed the presence of frizzled-4 in the enteric nervous system of human inf...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/9076823
更新日期:2016-01-01 00:00:00
abstract::Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and photoreceptor cells. We evaluated the potential of adipose-derived mesenchymal stem cells (ASCs) as a therapeutic tool by studying the migration capacity of ASCs in vitro and their protective effect against RPE cell death under oxidativ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/9682856
更新日期:2018-12-13 00:00:00
abstract::The application of human bone marrow mesenchymal stem cells (hBM-MSCs) in cell-based clinical therapies is hindered by the limited number of cells remaining after the initial isolation process and by cellular senescence following in vitro expansion. Understanding the process of in vitro senescence in hBM-MSCs would en...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/7670316
更新日期:2019-07-11 00:00:00
abstract::Oral mesenchymal stem/progenitor cells (MSCs) are renowned in the field of tissue engineering/regeneration for their multilineage differentiation potential and easy acquisition. These cells encompass the periodontal ligament stem/progenitor cells (PDLSCs), the dental pulp stem/progenitor cells (DPSCs), the stem/progen...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/1327405
更新日期:2020-02-25 00:00:00
abstract::Mesenchymal stem cells (MSCs) possess a capacity to enhance cutaneous wound healing that is well characterized. However, the therapeutic effect of MSCs appears to be limited. Modifying MSC target genes to increase necessary biological effects is a promising strategy for wound therapy. Interleukin-10 (IL-10) is an anti...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/9158016
更新日期:2019-06-11 00:00:00
abstract::Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels a...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/462161
更新日期:2012-01-01 00:00:00
abstract::A previous study reported the structural characterization of biogenic apatite (BAp) thin films realized by a pulsed electron deposition system by ablation of deproteinized bovine bone. Thin films annealed at 400°C exhibited composition and crystallinity degree very close to those of biogenic apatite; this affinity is ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/3579283
更新日期:2017-01-01 00:00:00
abstract::Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell ma...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/6705927
更新日期:2016-01-01 00:00:00
abstract::A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved. From the perspectives of clinicians and researchers alike, the promi...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4287158
更新日期:2016-01-01 00:00:00
abstract::This study is aimed at investigating whether human umbilical cord mesenchymal stem cell- (hucMSC-) derived exosomes (hucMSC-exosomes) have a protective effect on acute myocardial infarction (AMI). Exosomes were characterized under transmission electron microscopy and the particles of exosomes were further examined thr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/761643
更新日期:2015-01-01 00:00:00
abstract::Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2011/310928
更新日期:2011-01-01 00:00:00