Abstract:
:Mesenchymal stem cells (MSCs) derived from bone marrow can secrete cytokines and growth factors and can transdifferentiate into liver cells. We transplanted polymeric membrane bioencapsulated MSCs into the spleens of 90% partial hepatectomized rats. This resulted in 91.6% recovery rates. This is compared to a recovery rate of 21.4% in the 90% hepatectomized rats and 25% in the 90% hepatectomized rats receiving intrasplenic transplantation of free MSCs. After 14 days, the remnant livers in the bioencapsulated MSCs group are not significantly different in weight when compared to the sham control group. From day 1 to day 3 after surgery, in the bioencapsulated MSCs group, the plasma HGF and IL-6 were significantly higher than those in the free MSCs group and control group (P < 0.01); plasma TNF-α was significantly lower (P < 0.001). We concluded that the intrasplenic transplantation of bioencapsulated MSCs significantly increases the recovery rates of 90% hepatectomized rats. It is likely that the initial effect is from proliver regeneration factors followed later by the transdifferentiated hepatocyte-like cells. However, histopathological analysis and hepatocyte proliferation study will be needed to better understand the regenerative mechanisms of this result. This study has implications in improving the survival and recovery of patients with very severe liver failure due to hepatitis, trauma, or extensive surgical resection.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Liu ZC,Chang TMdoi
10.1155/2012/697094subject
Has Abstractpub_date
2012-01-01 00:00:00pages
697094eissn
1687-966Xissn
1687-9678journal_volume
2012pub_type
杂志文章abstract::Vitamin D (Vit D) by means of its biological active form, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In thi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/6958713
更新日期:2018-02-28 00:00:00
abstract::Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after establishment of DES. Eye drops containing either bromodeoxyuridi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/250230
更新日期:2014-01-01 00:00:00
abstract::The quality of life of patients with chronic wounds can be extremely poor and, therefore, over the past decades, great efforts have been made to develop efficient strategies to improve the healing process and the social impact associated with these conditions. Cell based therapy, as a modern tissue engineering strateg...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/195096
更新日期:2015-01-01 00:00:00
abstract::Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2011/310928
更新日期:2011-01-01 00:00:00
abstract::Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling cues present in the microenvironment change with development and disease. This work aims to assess the influence of two distinct signaling moieties on CPCs: cyc...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/8364382
更新日期:2016-01-01 00:00:00
abstract::The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC) population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age-related muscle atrophy (sarcopenia) and several dystrophies, regeneration cannot compensate for the loss of muscle tissue. These diso...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/5980465
更新日期:2019-04-24 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. As most GSCs that are located in the perivascular and perinecrotic niches should be remo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/5387041
更新日期:2018-08-23 00:00:00
abstract::Podocyte death and regeneration are major topics in kidney research but remain controversial. Data obtained in humans demonstrate the existence of cells sited along Bowman's capsule that behave as podocyte progenitors in vitro and in in vivo mouse models of podocyte injury xenotrasplanted with this human-derived popul...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2015/678347
更新日期:2015-01-01 00:00:00
abstract:Objective:Special hypoxic and hypertonic microenvironment in intervertebral discs (IVDs) decreases the treatment effect of cell transplantation. We investigated the hypothesis that hypoxic preconditioning (HP) could improve the therapeutic effect of bone mesenchymal stem cells (BMSCs) to IVD degeneration. Methods:BMSC...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/7564159
更新日期:2018-02-14 00:00:00
abstract::The application of human bone marrow mesenchymal stem cells (hBM-MSCs) in cell-based clinical therapies is hindered by the limited number of cells remaining after the initial isolation process and by cellular senescence following in vitro expansion. Understanding the process of in vitro senescence in hBM-MSCs would en...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/7670316
更新日期:2019-07-11 00:00:00
abstract::Transcription factors are tools repetitively used by the embryo to generate a variety of lineages. Hence, their context of activation is an important determinant of their ability to specifically trigger certain cell fates, but not others. The context is also consequential when considering directing differentiation of ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/6939438
更新日期:2016-01-01 00:00:00
abstract::Hematopoietic stem cell (HSC) belongs to multipotent adult somatic stem cells. A single HSC can reconstitute the entire blood system via self-renewal, differentiation into all lineages of blood cells, and replenishment of cells lost due to attrition or disease in a person's lifetime. Although all blood and immune cell...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2015/148064
更新日期:2015-01-01 00:00:00
abstract:Background:Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to pr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/7813729
更新日期:2018-04-03 00:00:00
abstract::Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time poi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/1706982
更新日期:2018-04-05 00:00:00
abstract:Background:Aging is a major risk factor for cardiovascular disease. Cysteine protease cathepsin K (CatK) has been implicated in the process of angiogenesis, but the exact roles of individual CatK in vessel formation during aging are poorly understood. Methods and Results:To study the putative role of CatK in ischemia-...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/6938620
更新日期:2020-06-30 00:00:00
abstract::During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or r...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2011/619583
更新日期:2011-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into cells from the mesenchymal lineage. The hypoimmunogenic characteristic of MSCs has encouraged studies using allogeneic MSCs for the treatment of autoimmune diseases and inflammatory conditions. Promising preclinical results and the saf...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/9824698
更新日期:2017-01-01 00:00:00
abstract:Background:While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. In human studies, the ability to track transplanted cells has been limited to labeling with radioisotopes and tracking using nuclear...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2754927
更新日期:2019-11-14 00:00:00
abstract::Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5797521
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/7073805.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2020/4370849
更新日期:2020-08-21 00:00:00
abstract::Designing and providing a scaffold are very important for the cells in tissue engineering. Polybutylene succinate (PBS) has high potential as a scaffold for bone regeneration due to its capacity in cell proliferation and differentiation. Also, stem cells from 3rd molar tooth germs were favoured in this study due to th...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/8792191
更新日期:2016-01-01 00:00:00
abstract::Articular cartilage defects have been addressed by using multiple strategies. In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). Howev...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9201492
更新日期:2016-01-01 00:00:00
abstract::Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development from neural precur...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9260592
更新日期:2016-01-01 00:00:00
abstract::A stably established population of mouse bone marrow stromal cells (BMSCs) with self-renewal and multilineage differentiation potential was expanded in vitro for more than 50 passages. These cells express high levels of mesenchymal stem cell markers and can be differentiated into adipogenic, chondrogenic, and osteogen...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8857057
更新日期:2020-12-24 00:00:00
abstract::Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5720758
更新日期:2016-01-01 00:00:00
abstract::In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted centr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/589139
更新日期:2013-01-01 00:00:00
abstract::Dental pulp tissue contains dental pulp stem cells (DPSCs). Dental pulp cells (also known as dental pulp-derived mesenchymal stem cells) are capable of differentiating into multilineage cells including neuron-like cells. The aim of this study was to examine the capability of DPSCs to differentiate into neuron-like cel...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/250740
更新日期:2013-01-01 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age. Chronic inflammation is considered to be the cause of ovarian dysfunction. Increasing evidence in animal studies and in preliminary clinical trials has demonstrated that MSCs possess immunomodulatory effe...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/9782373
更新日期:2019-09-12 00:00:00
abstract::Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, n...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/8468549
更新日期:2016-01-01 00:00:00
abstract::There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the di...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/9896142
更新日期:2018-12-25 00:00:00