Abstract:
:Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after establishment of DES. Eye drops containing either bromodeoxyuridine labeled MSCs (n = 9) or phosphate buffer solution (n = 7) were topically applied once daily for one week. Schirmer test, break-up time score, ocular surface evaluation tests, and corneal inflammatory index scoring tests were applied to all rats at baseline and after treatment. All rats were sacrificed after one week for histological and electron microscopic analysis. Results. Mean aqueous tear volume and tear film stability were significantly increased in rats treated with MSCs (P < 0.05). Infiltration of bromodeoxyuridine labeled MSCs into the meibomian glands and conjunctival epithelium was observed in MSCs treated rats. Increased number of secretory granules and number of goblet cells were observed in MSCs treated rats. Conclusion. Topical application of MSCs could be a safe and effective method for the treatment of DES and could potentially be used for further clinical research studies.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Beyazyıldız E,Pınarlı FA,Beyazyıldız O,Hekimoğlu ER,Acar U,Demir MN,Albayrak A,Kaymaz F,Sobacı G,Delibaşı Tdoi
10.1155/2014/250230subject
Has Abstractpub_date
2014-01-01 00:00:00pages
250230eissn
1687-966Xissn
1687-9678journal_volume
2014pub_type
杂志文章abstract::Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and...
journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
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