A cocktail method for promoting cardiomyocyte differentiation from bone marrow-derived mesenchymal stem cells.

abstract：:In cholestatic liver diseases, impaired bile excretion disrupts lipid homeostasis. We investigated changes of lipid metabolism, including mitochondrial β-oxidation, in a rat model of bile duct ligation (BDL) in which chorionic plate-derived mesenchymal stem cells (CP-MSCs) were transplanted. Serum cholesterol level, w...

journal_title：Stem cells international

authors： Lee YB,Choi JH,Kim EN,Seok J,Lee HJ,Yoon JH,Kim GJ

更新日期：2017-01-01 00:00:00

abstract：:Efficient ex vivo expansion of hematopoietic stem cells with a concomitant preservation of stemness and self-renewal potential is still an unresolved ambition. Increased numbers of methods approaching this issue using three-dimensional (3D) cultures were reported. Here, we describe a simplified 3D hanging drop model f...

journal_title：Stem cells international

authors： Schmal O,Seifert J,Schäffer TE,Walter CB,Aicher WK,Klein G

更新日期：2016-01-01 00:00:00

abstract：:Titanium (Ti) is widely used as a biomaterial for endosseous implants due to its relatively inert surface oxide layer that enables implanted devices the ability of assembling tissue reparative components that culminate in osseointegration. Topographic modifications in the form of micro- and nanoscaled structures signi...

journal_title：Stem cells international

authors： Khan MR,Mordan N,Parkar M,Salih V,Donos N,Brett PM

更新日期：2019-07-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicability, both experimentally and in the clinic. These cells can be isolated from various human tissues that may differ anatomically or developmentally with relative ease. Heterogenei...

journal_title：Stem cells international

authors： Christodoulou I,Kolisis FN,Papaevangeliou D,Zoumpourlis V

更新日期：2013-01-01 00:00:00

abstract：Purpose:To determine the effect of the isolation technique and location upon the phenotype of human corneal stroma-derived cells (CSCs). Methods:CSCs were isolated from the corneal stroma center and periphery using the explant or enzymatic digestion technique. The native tissue was stained for functional markers, whil...

journal_title：Stem cells international

authors： Nagymihály R,Veréb Z,Facskó A,Moe MC,Petrovski G

更新日期：2017-01-01 00:00:00

abstract：:Increasing the success rate of rotator cuff healing remains tremendous challenge. Among many approaches, the possibility of activating resident stem cells in situ, without the need to isolate them from biopsies, could represent valuable therapeutic strategy. Along this line, it has been recently demonstrated that lipo...

journal_title：Stem cells international

authors： Randelli P,Menon A,Ragone V,Creo P,Bergante S,Randelli F,De Girolamo L,Alfieri Montrasio U,Banfi G,Cabitza P,Tettamanti G,Anastasia L

更新日期：2016-01-01 00:00:00

abstract：:Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends o...

journal_title：Stem cells international

authors： Churchman SM,Boxall SA,McGonagle D,Jones EA

更新日期：2017-01-01 00:00:00

abstract：:Left-right symmetry breaking is a complex developmental process and an important part of embryonic axis development. As of yet, the biophysical mechanism behind LR asymmetry establishment remains elusive for the overall asymmetry of embryos as well as for the organ-specific asymmetry. Here, we demonstrate that inheren...

journal_title：Stem cells international

authors： Worley KE,Chin AS,Wan LQ

更新日期：2018-12-02 00:00:00

abstract：:Mutations in WD40-repeat protein 62 (WDR62) are commonly associated with primary microcephaly and other developmental cortical malformations. We used human pluripotent stem cells (hPSC) to examine WDR62 function during human neural differentiation and model early stages of human corticogenesis. Neurospheres lacking WD...

journal_title：Stem cells international

authors： Alshawaf AJ,Antonic A,Skafidas E,Ng DC,Dottori M

更新日期：2017-01-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) belongs to multipotent adult somatic stem cells. A single HSC can reconstitute the entire blood system via self-renewal, differentiation into all lineages of blood cells, and replenishment of cells lost due to attrition or disease in a person's lifetime. Although all blood and immune cell...

journal_title：Stem cells international

authors： Zhang J,Crumpacker C

更新日期：2015-01-01 00:00:00

abstract：:The mesenchymal stem cells (MSCs) are known as highly plastic stem cells and can differentiate into specialized tissues such as adipose tissue, osseous tissue, muscle tissue, and nervous tissue. The differentiation of mesenchymal stem cells is very important in regenerative medicine. Their differentiation process is r...

journal_title：Stem cells international

authors： Wang F,Li X,Li Z,Wang S,Fan J

更新日期：2020-08-01 00:00:00

abstract：:The CRISPR/Cas9 system provides a powerful method for the genetic manipulation of the mammalian genome, allowing knockout of individual genes as well as the generation of genome-wide knockout cell libraries for genetic screening. However, the diploid status of most mammalian cells restricts the application of CRISPR/C...

journal_title：Stem cells international

authors： Yin Z,Chen L

更新日期：2017-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. As most GSCs that are located in the perivascular and perinecrotic niches should be remo...

journal_title：Stem cells international

authors： Nishikawa M,Inoue A,Ohnishi T,Kohno S,Ohue S,Matsumoto S,Suehiro S,Yamashita D,Ozaki S,Watanabe H,Yano H,Takahashi H,Kitazawa R,Tanaka J,Kunieda T

更新日期：2018-08-23 00:00:00

abstract：:Obesity, defined as a body mass index of 30 kg/m2 or above, has increased considerably in incidence and frequency within the United States and globally. Associated comorbidities including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease have led to a focus on t...

journal_title：Stem cells international

authors： Bender R,McCarthy M,Brown T,Bukowska J,Smith S,Abbott RD,Kaplan DL,Williams C,Wade JW,Alarcon A,Wu X,Lau F,Gimble JM,Frazier T

更新日期：2020-06-10 00:00:00

abstract：:We aim to investigate the effects of adipose-derived stem cells (ASCs) transplantation on irradiation-induced skeletal muscle fibrosis. Sixty-four rabbits were randomly divided into ASCs group and PBS group followed by irradiation at unilateral hip with a single dose of 80 Gy. Nonirradiated side with normal skeletal m...

journal_title：Stem cells international

authors： Sun W,Ni X,Sun S,Cai L,Yu J,Wang J,Nie B,Sun Z,Ni X,Cao X

更新日期：2016-01-01 00:00:00

abstract：Background:Human dermal fibroblasts (HDFs) are the primary cells in skin and are associated with UVB-induced skin photoaging. Adipose-derived stem cells (ASCs) have been proposed as a treatment for skin aging. The goal of this study was to investigate paracrine mechanisms by which ASCs repair HDFs damage from UVB expos...

journal_title：Stem cells international

authors： Qin F,Huang J,Zhang W,Zhang M,Li Z,Si L,Long X,Wang X

更新日期：2020-12-17 00:00:00

abstract：:Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased inciden...

journal_title：Stem cells international

authors： Owczarczyk-Saczonek A,Krajewska-Włodarczyk M,Kruszewska A,Banasiak Ł,Placek W,Maksymowicz W,Wojtkiewicz J

更新日期：2018-08-05 00:00:00

abstract：:Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood. In this study, we investigated the role of EphB4 in regulating the expression of periostin (POSTN) within bone marrow-derived mese...

journal_title：Stem cells international

authors： Zhang F,Zhang Z,Sun D,Dong S,Xu J,Dai F

更新日期：2016-01-01 00:00:00

abstract：:Exosomes derived from cancer cells can affect various functions of mesenchymal stem cells (MSCs) via conveying microRNAs (miRs). miR-21 and miR-146a have been demonstrated to regulate MSC proliferation and transformation. Interleukin-6 (IL-6) secreted from transformed MSCs in turn favors the survival of multiple myelo...

journal_title：Stem cells international

authors： Cheng Q,Li X,Liu J,Ye Q,Chen Y,Tan S,Liu J

更新日期：2017-01-01 00:00:00

abstract：:Schwann cell (SC) transplantation as a cell-based therapy can enhance peripheral and central nerve repair experimentally, but it is limited by the donor site morbidity for clinical application. We investigated weather respiratory mucosa stem cells (REMSCs), a kind of ectomesenchymal stem cells (EMSCs), isolated from r...

journal_title：Stem cells international

authors： Zhang J,Gao X,Zou H,Liu J,Zhang Z

更新日期：2015-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into cells from the mesenchymal lineage. The hypoimmunogenic characteristic of MSCs has encouraged studies using allogeneic MSCs for the treatment of autoimmune diseases and inflammatory conditions. Promising preclinical results and the saf...

journal_title：Stem cells international

authors： Oliveira RL,Chagastelles PC,Sesterheim P,Pranke P

更新日期：2017-01-01 00:00:00

abstract：:The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors. In the present study, we analysed the presence of frizzled-4 in the enteric nervous system of human inf...

journal_title：Stem cells international

authors： Nothelfer K,Obermayr F,Belz N,Reinartz E,Bareiss PM,Bühring HJ,Beschorner R,Just L

更新日期：2016-01-01 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues. However, DPSC senescence restricts its clinical applications. Metformin (Met), a common prescription drug for type 2 diabetes, is thought to influence the aging process. This study is aimed at determining the effects of metform...

journal_title：Stem cells international

authors： Zhang S,Zhang R,Qiao P,Ma X,Lu R,Wang F,Li C,E L,Liu H

更新日期：2021-01-06 00:00:00

abstract：:Dental pulp tissue contains dental pulp stem cells (DPSCs). Dental pulp cells (also known as dental pulp-derived mesenchymal stem cells) are capable of differentiating into multilineage cells including neuron-like cells. The aim of this study was to examine the capability of DPSCs to differentiate into neuron-like cel...

journal_title：Stem cells international

authors： Zainal Ariffin SH,Kermani S,Zainol Abidin IZ,Megat Abdul Wahab R,Yamamoto Z,Senafi S,Zainal Ariffin Z,Abdul Razak M

更新日期：2013-01-01 00:00:00

abstract：:Tendon healing is fraught with complications such as reruptures and adhesion formation due to the formation of scar tissue at the injury site as opposed to the regeneration of native tissue. Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. However, several questions rem...

journal_title：Stem cells international

authors： Gulotta LV,Chaudhury S,Wiznia D

更新日期：2012-01-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder. Current targeted therapies designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein have made a significant breakthrough in the treatment of CML patients. However, CML remains a chronic disease that a patient must manage for lif...

journal_title：Stem cells international

authors： Hamad A,Sahli Z,El Sabban M,Mouteirik M,Nasr R

更新日期：2013-01-01 00:00:00

abstract：Objective:Mesenchymal stem cells (MSCs) are considered a promising therapy for wound healing. Here, we explored the role of c-Jun in diabetic wound healing using human umbilical cord-derived MSCs (hUC-MSCs). Methods:Freshly isolated hUC-MSCs were subjected to extensive in vitro subcultivation. The cell proliferative a...

journal_title：Stem cells international

authors： Yue C,Guo Z,Luo Y,Yuan J,Wan X,Mo Z

更新日期：2020-01-14 00:00:00

abstract：:Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels a...

journal_title：Stem cells international

authors： Keßler M,Just S,Rottbauer W

更新日期：2012-01-01 00:00:00

abstract：:Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after establishment of DES. Eye drops containing either bromodeoxyuridi...

journal_title：Stem cells international

authors： Beyazyıldız E,Pınarlı FA,Beyazyıldız O,Hekimoğlu ER,Acar U,Demir MN,Albayrak A,Kaymaz F,Sobacı G,Delibaşı T

更新日期：2014-01-01 00:00:00

abstract：:Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. Evidence suggests that mesenchymal stem ce...

journal_title：Stem cells international

authors： Cappetta D,De Angelis A,Spaziano G,Tartaglione G,Piegari E,Esposito G,Ciuffreda LP,Liparulo A,Sgambato M,Russo TP,Rossi F,Berrino L,Urbanek K,D'Agostino B

更新日期：2018-03-14 00:00:00