Periostin: A Downstream Mediator of EphB4-Induced Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.

abstract：:Dental pulp tissue contains dental pulp stem cells (DPSCs). Dental pulp cells (also known as dental pulp-derived mesenchymal stem cells) are capable of differentiating into multilineage cells including neuron-like cells. The aim of this study was to examine the capability of DPSCs to differentiate into neuron-like cel...

journal_title：Stem cells international

authors： Zainal Ariffin SH,Kermani S,Zainol Abidin IZ,Megat Abdul Wahab R,Yamamoto Z,Senafi S,Zainal Ariffin Z,Abdul Razak M

更新日期：2013-01-01 00:00:00

abstract：:Current tissue engineering techniques are limited by inadequate vascularisation and perfusion of cell-scaffold constructs. Microstructural patterning through biomimetic vascular channels within a polymer scaffold might induce neovascularization, allowing fabrication of large engineered constructs. The network of vascu...

journal_title：Stem cells international

authors： Muller D,Chim H,Bader A,Whiteman M,Schantz JT

更新日期：2010-12-01 00:00:00

abstract：:In recent years several genes have linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) as a spectrum disease; however little is known about what triggers their onset. With the ability to generate patient specific stem cell lines from somatic cells, it is possible to model disease without the n...

journal_title：Stem cells international

authors： Hedges EC,Mehler VJ,Nishimura AL

更新日期：2016-01-01 00:00:00

abstract：Background:While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. In human studies, the ability to track transplanted cells has been limited to labeling with radioisotopes and tracking using nuclear...

journal_title：Stem cells international

authors： Mathiasen AB,Qayyum AA,Jørgensen E,Helqvist S,Ekblond A,Ng M,Bhakoo K,Kastrup J

更新日期：2019-11-14 00:00:00

abstract：:Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell...

journal_title：Stem cells international

authors： Nikolic A,Volarevic V,Armstrong L,Lako M,Stojkovic M

更新日期：2016-01-01 00:00:00

abstract：:Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenati...

journal_title：Stem cells international

authors： Kaur G,Cai C

更新日期：2018-03-29 00:00:00

abstract：:Traditionally, human embryonic stem cells (hESCs) are cultured on inactivated live feeder cells. For clinical application using hESCs, there is a requirement to minimize the risk of contamination with animal components. Extracellular matrix (ECM) derived from feeder cells is the most natural way to provide xeno-free s...

journal_title：Stem cells international

authors： Zhu H,Yang J,Wei Y,Chen HH

更新日期：2015-01-01 00:00:00

abstract：:Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a critical pathophysiological role and can be modula...

journal_title：Stem cells international

authors： Souza BSF,da Silva KN,Silva DN,Rocha VPC,Paredes BD,Azevedo CM,Nonaka CK,Carvalho GB,Vasconcelos JF,Dos Santos RR,Soares MBP

更新日期：2017-01-01 00:00:00

abstract：:Background. Human cardiac-derived progenitor cells (hCPCs) have shown promise in treating heart failure (HF) in adults. The purpose of this study was to describe derivation of hCPCs from pediatric patients with end-stage HF. Methods. At surgery, discarded right atrial tissues (hAA) were obtained from HF patients (n = ...

journal_title：Stem cells international

authors： Steele A,Boucek RJ Jr,Jacobs JP,Steele P,Asante-Korang A,Chamizo W,Steele J,Chai PJ,Quintessenza JA

更新日期：2012-01-01 00:00:00

abstract：:Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent treatment option in this regard. Preclinical studies demonstrate that untreated stem cells, unlike stem cells activated to differentiate into neuronal lineage, do...

journal_title：Stem cells international

authors： Madhu V,Dighe AS,Cui Q,Deal DN

更新日期：2016-01-01 00:00:00

abstract：:This study is aimed at investigating whether human umbilical cord mesenchymal stem cell- (hucMSC-) derived exosomes (hucMSC-exosomes) have a protective effect on acute myocardial infarction (AMI). Exosomes were characterized under transmission electron microscopy and the particles of exosomes were further examined thr...

journal_title：Stem cells international

authors： Zhao Y,Sun X,Cao W,Ma J,Sun L,Qian H,Zhu W,Xu W

更新日期：2015-01-01 00:00:00

abstract：Objective:To investigate the effects of mesenchymal stem cells (MSCs) coated by the extracellular matrix (ECM) on wound healing in diabetic rats. Methods:Mesenchymal stem cells were cocultured with ECM. Cell viabilities were evaluated using MTT assay. The diabetes model was established using both STZ and high-glucose/...

journal_title：Stem cells international

authors： Wang L,Wang F,Zhao L,Yang W,Wan X,Yue C,Mo Z

更新日期：2019-01-28 00:00:00

abstract：:Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring i...

journal_title：Stem cells international

authors： Cimino M,Gonçalves RM,Barrias CC,Martins MCL

更新日期：2017-01-01 00:00:00

abstract：:Tumor hypoxia is associated with malignant biological phenotype including enhanced angiogenesis and metastasis. Hypoxia increases the expression of vascular endothelial cell growth factor (VEGF), which directly participates in angiogenesis by recruiting endothelial cells into hypoxic area and stimulating their prolife...

journal_title：Stem cells international

authors： Chen HF,Wu KJ

更新日期：2016-01-01 00:00:00

abstract：:Oral mesenchymal stem/progenitor cells (MSCs) are renowned in the field of tissue engineering/regeneration for their multilineage differentiation potential and easy acquisition. These cells encompass the periodontal ligament stem/progenitor cells (PDLSCs), the dental pulp stem/progenitor cells (DPSCs), the stem/progen...

journal_title：Stem cells international

authors： Zhou LL,Liu W,Wu YM,Sun WL,Dörfer CE,Fawzy El-Sayed KM

更新日期：2020-02-25 00:00:00

abstract：:The clinical application of human bone marrow mesenchymal stem cells (hBM-MSCs) has generated a great deal of interest because of their potential use in regenerative medicine and tissue engineering. However, safety concerns over hBM-MSCs limit their clinical application. In this study, we observed that hBM-MSC-conditi...

journal_title：Stem cells international

authors： Chen B,Yu J,Wang Q,Zhao Y,Sun L,Xu C,Zhao X,Shen B,Wang M,Xu W,Zhu W

更新日期：2018-07-18 00:00:00

abstract：:Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in...

journal_title：Stem cells international

authors： Schmal H,Kowal JM,Kassem M,Seidenstuecker M,Bernstein A,Böttiger K,Xiong T,Südkamp NP,Kubosch EJ

更新日期：2018-04-19 00:00:00

abstract：:Wnt signalling has been implicated in the regulation of stem cell self-renewal and differentiation; however, the majority of in vitro studies are carried out using monolayer 2D culture techniques. Here, we used mesenchymal stromal cell (MSC) EGFP reporter lines responsive to Wnt pathway activation in a 3D spheroid cul...

journal_title：Stem cells international

authors： Saleh F,Carstairs A,Etheridge SL,Genever P

更新日期：2016-01-01 00:00:00

abstract：:The implantation of stem cells in vivo is the ideal approach for the restoration of normal life functions, such as replenishing the decreasing levels of affected dopaminergic (DA) neurons during neurodegenerative disease conditions. However, combining stem cells with biomaterial scaffolds provides a promising strategy...

journal_title：Stem cells international

authors： Tasnim N,Thakur V,Chattopadhyay M,Joddar B

更新日期：2018-06-03 00:00:00

abstract：:The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blo...

journal_title：Stem cells international

authors： Notara M,Lentzsch A,Coroneo M,Cursiefen C

更新日期：2018-05-08 00:00:00

abstract：:The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC) population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age-related muscle atrophy (sarcopenia) and several dystrophies, regeneration cannot compensate for the loss of muscle tissue. These diso...

journal_title：Stem cells international

authors： Pavlidou T,Marinkovic M,Rosina M,Fuoco C,Vumbaca S,Gargioli C,Castagnoli L,Cesareni G

更新日期：2019-04-24 00:00:00

abstract：:Podocyte death and regeneration are major topics in kidney research but remain controversial. Data obtained in humans demonstrate the existence of cells sited along Bowman's capsule that behave as podocyte progenitors in vitro and in in vivo mouse models of podocyte injury xenotrasplanted with this human-derived popul...

journal_title：Stem cells international

authors： Lombardi D,Lasagni L

更新日期：2015-01-01 00:00:00

abstract：:Obesity, defined as a body mass index of 30 kg/m2 or above, has increased considerably in incidence and frequency within the United States and globally. Associated comorbidities including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease have led to a focus on t...

journal_title：Stem cells international

authors： Bender R,McCarthy M,Brown T,Bukowska J,Smith S,Abbott RD,Kaplan DL,Williams C,Wade JW,Alarcon A,Wu X,Lau F,Gimble JM,Frazier T

更新日期：2020-06-10 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicability, both experimentally and in the clinic. These cells can be isolated from various human tissues that may differ anatomically or developmentally with relative ease. Heterogenei...

journal_title：Stem cells international

authors： Christodoulou I,Kolisis FN,Papaevangeliou D,Zoumpourlis V

更新日期：2013-01-01 00:00:00

abstract：:We aim to investigate the effects of adipose-derived stem cells (ASCs) transplantation on irradiation-induced skeletal muscle fibrosis. Sixty-four rabbits were randomly divided into ASCs group and PBS group followed by irradiation at unilateral hip with a single dose of 80 Gy. Nonirradiated side with normal skeletal m...

journal_title：Stem cells international

authors： Sun W,Ni X,Sun S,Cai L,Yu J,Wang J,Nie B,Sun Z,Ni X,Cao X

更新日期：2016-01-01 00:00:00

abstract：:The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, an...

journal_title：Stem cells international

authors： Yang J,Zhang K,Wu J,Shi J,Xue J,Li J,Chen J,Zhu Y,Wei J,He J,Liu X

更新日期：2016-01-01 00:00:00

abstract：:Adipogenesis is the process through which preadipocytes differentiate into adipocytes. During this process, the preadipocytes cease to proliferate, begin to accumulate lipid droplets, and develop morphologic and biochemical characteristics of mature adipocytes. Mesenchymal stem cells (MSCs) are a type of adult stem ce...

journal_title：Stem cells international

authors： Zhang K,Yang X,Zhao Q,Li Z,Fu F,Zhang H,Zheng M,Zhang S

更新日期：2020-08-12 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues. However, DPSC senescence restricts its clinical applications. Metformin (Met), a common prescription drug for type 2 diabetes, is thought to influence the aging process. This study is aimed at determining the effects of metform...

journal_title：Stem cells international

authors： Zhang S,Zhang R,Qiao P,Ma X,Lu R,Wang F,Li C,E L,Liu H

更新日期：2021-01-06 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...

journal_title：Stem cells international

authors： Park M,Kim YH,Ryu JH,Woo SY,Ryu KH

更新日期：2015-01-01 00:00:00

abstract：:Titanium (Ti) is widely used as a biomaterial for endosseous implants due to its relatively inert surface oxide layer that enables implanted devices the ability of assembling tissue reparative components that culminate in osseointegration. Topographic modifications in the form of micro- and nanoscaled structures signi...

journal_title：Stem cells international

authors： Khan MR,Mordan N,Parkar M,Salih V,Donos N,Brett PM

更新日期：2019-07-01 00:00:00