Abstract:
:Schwann cell (SC) transplantation as a cell-based therapy can enhance peripheral and central nerve repair experimentally, but it is limited by the donor site morbidity for clinical application. We investigated weather respiratory mucosa stem cells (REMSCs), a kind of ectomesenchymal stem cells (EMSCs), isolated from rat nasal septum can differentiate into functional Schwann-like cells (SC-like cells). REMSCs proliferated quickly in vitro and expressed the neural crest markers (nestin, vimentin, SOX10, and CD44). Treated with a mixture of glial growth factors for 7 days, REMSCs differentiated into SC-like cells. The differentiated REMSCs (dREMSCs) exhibited a spindle-like morphology similar to SC cells. Immunocytochemical staining and Western blotting indicated that SC-like cells expressed the glial markers (GFAP, S100β, Galc, and P75) and CNPase. When cocultured with dREMSCs for 5 days, PC12 cells differentiated into mature neuron-like cells with long neurites. More importantly, dREMSCs could form myelin structures with the neurites of PC12 cells at 21 days in vitro. Our data indicated that REMSCs, a kind of EMSCs, could differentiate into SC-like cells and have the ability to promote the differentiation of PC12 cells and form myelin in vitro.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Zhang J,Gao X,Zou H,Liu J,Zhang Zdoi
10.1155/2015/328957subject
Has Abstractpub_date
2015-01-01 00:00:00pages
328957eissn
1687-966Xissn
1687-9678journal_volume
2015pub_type
杂志文章abstract::Cardiovascular diseases (CVDs), including atherosclerosis, stroke, and myocardial infarction, is a major cause of death worldwide. In aspects of cell therapy against CVD, it is generally accepted that endothelial progenitor cells (EPCs) are potent neovascular modulators in ischemic tissues. In response to ischemic inj...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/8340257
更新日期:2016-01-01 00:00:00
abstract::Tendon healing is fraught with complications such as reruptures and adhesion formation due to the formation of scar tissue at the injury site as opposed to the regeneration of native tissue. Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. However, several questions rem...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/291431
更新日期:2012-01-01 00:00:00
abstract::In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted centr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/589139
更新日期:2013-01-01 00:00:00
abstract::Radiation is the most potent mode of cancer therapy; however, resistance to radiation therapy results in tumor relapse and subsequent fatality. The cancer stem cell (CSC), which has better DNA repair capability, has been shown to contribute to tumor resistance and is an important target for treatment. Signaling molecu...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5785786
更新日期:2016-01-01 00:00:00
abstract::Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. The buccal fat pad (BFP) is a specialized adipose tissue that is easy to harvest and contains a rich blood supply, and its harvesting causes low complications for patients. This review focuse...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2017/8354640
更新日期:2017-01-01 00:00:00
abstract::Transcription factors are tools repetitively used by the embryo to generate a variety of lineages. Hence, their context of activation is an important determinant of their ability to specifically trigger certain cell fates, but not others. The context is also consequential when considering directing differentiation of ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/6939438
更新日期:2016-01-01 00:00:00
abstract::Podocyte death and regeneration are major topics in kidney research but remain controversial. Data obtained in humans demonstrate the existence of cells sited along Bowman's capsule that behave as podocyte progenitors in vitro and in in vivo mouse models of podocyte injury xenotrasplanted with this human-derived popul...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2015/678347
更新日期:2015-01-01 00:00:00
abstract::The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blo...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/8620172
更新日期:2018-05-08 00:00:00
abstract::Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8868909
更新日期:2020-10-26 00:00:00
abstract::Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/3975689
更新日期:2019-09-03 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/7073805.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2020/4370849
更新日期:2020-08-21 00:00:00
abstract::A previous study reported the structural characterization of biogenic apatite (BAp) thin films realized by a pulsed electron deposition system by ablation of deproteinized bovine bone. Thin films annealed at 400°C exhibited composition and crystallinity degree very close to those of biogenic apatite; this affinity is ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/3579283
更新日期:2017-01-01 00:00:00
abstract::Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepato...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/2475631
更新日期:2016-01-01 00:00:00
abstract::There are promising results in the use of platelet-rich plasma (PRP) for musculoskeletal tissue repair. However, the variability in the methodology for its obtaining may cause different and opposing findings in the literature. Particularly, the choice of the anticoagulant is the first definition to be made. In this wo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/7414036
更新日期:2016-01-01 00:00:00
abstract::Three-dimensional (3D) cell culture has been reported to increase the therapeutic potentials of mesenchymal stem cells (MSCs). However, the action mechanisms of 3D MSCs vary greatly and are far from being thoroughly investigated. In this study, we aimed to investigate the therapeutic effects of 3D spheroids of human a...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/4626073
更新日期:2016-01-01 00:00:00
abstract::Chicken embryonic stem cells (cESCs) obtained from stage X embryos provide a novel model for the study of avian embryonic development. A new way to maintain cESCs for a long period in vitro still remains unexplored. We found that the cESCs showed stem cell-like properties in vitro for a long term with the support of D...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/2157451
更新日期:2018-05-09 00:00:00
abstract::Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated wit...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/376918
更新日期:2014-01-01 00:00:00
abstract::Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/3206807
更新日期:2016-01-01 00:00:00
abstract::We previously found that human amniotic mesenchymal stem cells (hAMSCs) in coculture with CF immortalised airway epithelial cells (CFBE41o- line, CFBE) on Transwell® filters acquired an epithelial phenotype and led to the expression of a mature and functional CFTR protein. In order to explore the role of gap junction-...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/1203717
更新日期:2018-01-11 00:00:00
abstract::We have determined the protective effects of Thymus serpyllum (TS) extract and nanoparticle-loaded TS on hydrogen peroxide-induced cell death of mesenchymal stromal cells (MSCs) in vitro. Gas chromatography-mass spectroscopy confirmed the spectrum of active components in the extract. Out of the three different extract...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/5142518
更新日期:2019-02-26 00:00:00
abstract::Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/4214281
更新日期:2019-11-12 00:00:00
abstract::The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors. In the present study, we analysed the presence of frizzled-4 in the enteric nervous system of human inf...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/9076823
更新日期:2016-01-01 00:00:00
abstract::Fetal dermal mesenchymal stem cells (FDMSCs), isolated from fetal skin, are serving as a novel MSC candidate with great potential in regenerative medicine. More recently, the paracrine actions, especially MSC-derived exosomes, are being focused on the vital role in MSC-based cellular therapy. This study was to evaluat...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2402916
更新日期:2019-06-10 00:00:00
abstract::Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a hip disorder, and it threatens patients who require megadose of steroid therapies. Nowadays, no valid therapies can reverse the development of GC-induced ONFH once it occurs. Stem cell therapy to GC-induced ONFH would be a promising choice. Although ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/1340252
更新日期:2018-05-22 00:00:00
abstract::Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a critical pathophysiological role and can be modula...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/3282656
更新日期:2017-01-01 00:00:00
abstract::Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging population. OSA leads to hypoxia and upper airway muscle injury. However, l...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8412598
更新日期:2020-03-04 00:00:00
abstract::Obesity, defined as a body mass index of 30 kg/m2 or above, has increased considerably in incidence and frequency within the United States and globally. Associated comorbidities including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease have led to a focus on t...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/4242130
更新日期:2020-06-10 00:00:00
abstract::MicroRNAs (miRNAs) play important roles in cell fate decisions. However, the miRNAs and their targets involved in the regulation of cardiac lineage specification are largely unexplored. Here, we report novel functions of miR-142-3p in the regulation of cardiomyocyte differentiation from mouse embryonic stem cells (mES...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/1769298
更新日期:2017-01-01 00:00:00
abstract::Intervertebral disc degeneration (IVD) is a frequent pathological condition. Conservative management often fails, and patients with IVD degeneration may require surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably e...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/921053
更新日期:2012-01-01 00:00:00
abstract::Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring i...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2017/6597815
更新日期:2017-01-01 00:00:00