Galectin-3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease Cardiomyopathy.

abstract：:Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, n...

journal_title：Stem cells international

authors： Bruno S,Grange C,Tapparo M,Pasquino C,Romagnoli R,Dametto E,Amoroso A,Tetta C,Camussi G

更新日期：2016-01-01 00:00:00

abstract：:Bone tissue regeneration is considered to be the optimal solution for bone loss. However, diabetic patients have a greater risk of poor bone healing or bone grafting failure than nondiabetics. The purpose of this study was to investigate the influence of the complexes of an adipose-derived stem cell sheet (ASC sheet) ...

journal_title：Stem cells international

authors： Xu X,Fang K,Wang L,Liu X,Zhou Y,Song Y

更新日期：2019-07-31 00:00:00

abstract：:Background. Mouse embryonic stem (ES) cells can be differentiated in vitro by aggregation and/or retinoic acid (RA) treatment. The principal differentiation lineage in vitro is extraembryonic primitive endoderm. Dab2, Laminin, GATA4, GATA5, and GATA6 are expressed in embryonic primitive endoderm and play critical role...

journal_title：Stem cells international

authors： Capo-Chichi CD,Smedberg JL,Rula M,Nicolas E,Yeung AT,Adamo RF,Frolov A,Godwin AK,Xu XX

更新日期：2010-05-11 00:00:00

abstract：:Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...

journal_title：Stem cells international

authors： Mingliang R,Bo Z,Zhengguo W

更新日期：2011-01-01 00:00:00

abstract：:The implantation of stem cells in vivo is the ideal approach for the restoration of normal life functions, such as replenishing the decreasing levels of affected dopaminergic (DA) neurons during neurodegenerative disease conditions. However, combining stem cells with biomaterial scaffolds provides a promising strategy...

journal_title：Stem cells international

authors： Tasnim N,Thakur V,Chattopadhyay M,Joddar B

更新日期：2018-06-03 00:00:00

abstract：:Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. The buccal fat pad (BFP) is a specialized adipose tissue that is easy to harvest and contains a rich blood supply, and its harvesting causes low complications for patients. This review focuse...

journal_title：Stem cells international

authors： Salehi-Nik N,Rezai Rad M,Kheiri L,Nazeman P,Nadjmi N,Khojasteh A

更新日期：2017-01-01 00:00:00

abstract：:Neuromuscular diseases are caused by functional defects of skeletal muscles, directly via muscle pathology or indirectly via disruption of the nervous system. Extensive studies have been performed to improve the outcomes of therapies; however, effective treatment strategies have not been fully established for any majo...

journal_title：Stem cells international

authors： Jiwlawat N,Lynch E,Jeffrey J,Van Dyke JM,Suzuki M

更新日期：2018-04-11 00:00:00

abstract：:Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time poi...

journal_title：Stem cells international

authors： Ni Y,Cai K,Hu Y,Wang CH,Zhang Y,Huang H,Su X,Gu JH

更新日期：2018-04-05 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions. However, aging-induced systemic homeostasis disorders in vivo and cell culture passaging in vitro induce a functional decline of MSCs, switching MSCs to a senescent status with...

journal_title：Stem cells international

authors： Wang R,Wang Y,Zhu L,Liu Y,Li W

更新日期：2020-09-10 00:00:00

abstract：:Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in t...

journal_title：Stem cells international

authors： Saud B,Malla R,Shrestha K

更新日期：2019-07-24 00:00:00

abstract：:Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenati...

journal_title：Stem cells international

authors： Kaur G,Cai C

更新日期：2018-03-29 00:00:00

abstract：:Three-dimensional (3D) cell culture has been reported to increase the therapeutic potentials of mesenchymal stem cells (MSCs). However, the action mechanisms of 3D MSCs vary greatly and are far from being thoroughly investigated. In this study, we aimed to investigate the therapeutic effects of 3D spheroids of human a...

journal_title：Stem cells international

authors： Zhang X,Hu MG,Pan K,Li CH,Liu R

更新日期：2016-01-01 00:00:00

abstract：Background:To reduce morbidity to cleft patients, new approaches have been developed and here, we report for the first time the use of deciduous dental pulp stem cells (DDPSC) associated with a hydroxyapatite-collagen sponge (Bio-Oss Collagen® 250 mg, Geistlich) for closing alveolar defects during secondary dental erup...

journal_title：Stem cells international

authors： Tanikawa DYS,Pinheiro CCG,Almeida MCA,Oliveira CRGCM,Coudry RA,Rocha DL,Bueno DF

更新日期：2020-03-12 00:00:00

abstract：:Urine has become the source of choice for noninvasive renal epithelial cells and renal stem cells which can be used for generating induced pluripotent stem cells. The aim of this study was to generate a 3D nephrogenic progenitor cell model composed of three distinct cell types-urine-derived SIX2-positive renal progeni...

journal_title：Stem cells international

authors： Nguyen L,Spitzhorn LS,Adjaye J

更新日期：2019-05-02 00:00:00

abstract：:Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in...

journal_title：Stem cells international

authors： Schmal H,Kowal JM,Kassem M,Seidenstuecker M,Bernstein A,Böttiger K,Xiong T,Südkamp NP,Kubosch EJ

更新日期：2018-04-19 00:00:00

abstract：:The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly...

journal_title：Stem cells international

authors： Solders M,Gorchs L,Gidlöf S,Tiblad E,Lundell AC,Kaipe H

更新日期：2017-01-01 00:00:00

abstract：:The mesenchymal stem cells (MSCs) are known as highly plastic stem cells and can differentiate into specialized tissues such as adipose tissue, osseous tissue, muscle tissue, and nervous tissue. The differentiation of mesenchymal stem cells is very important in regenerative medicine. Their differentiation process is r...

journal_title：Stem cells international

authors： Wang F,Li X,Li Z,Wang S,Fan J

更新日期：2020-08-01 00:00:00

abstract：:In situ detection of MSCs remains difficult and warrants additional methods to aid with their characterization in vivo. Two-photon confocal laser scanning microscopy (TPM) and second harmonic generation (SHG) could fill this gap. Both techniques enable the detection of cells and extracellular structures, based on intr...

journal_title：Stem cells international

authors： Donders R,Sanen K,Paesen R,Slenders E,Gyselaers W,Stinissen P,Ameloot M,Hellings N

更新日期：2016-01-01 00:00:00

abstract：Materials and Methods:Ischemic brain injury was induced by dMCAO in Sprague-Dawley rats. The transplantation group received MSC infusion 1 h after dMCAO. Expression of IGF-1 in GFAP+ astrocytes, Iba-1+ microglia/macrophages, CD3+ lymphocytes, Ly6C+ monocytes/macrophages, and neutrophil elastase (NE)+ neutrophils was ex...

journal_title：Stem cells international

authors： Li X,Yu W,Guan Y,Zou H,Liang Z,Huang M,Zhao R,Zhao C,Ren Z,Chen Z

更新日期：2020-09-01 00:00:00

abstract：:Hindlimb ischemia is still a clinical problem with high morbidity and mortality. Patients suffer from consequent rest pain, ulcers, cool limbs, and even amputation. Angiogenesis is a promising target for the treatment of ischemic limbs, providing extra blood for the ischemic region. In the present study, we investigat...

journal_title：Stem cells international

authors： Yin C,Liang Y,Zhang J,Ruan G,Li Z,Pang R,Pan X

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2015/496512.]. ...

journal_title：Stem cells international

authors： Sasi SP,Park D,Muralidharan S,Wage J,Kiladjian A,Onufrak J,Enderling H,Yan X,Goukassian DA

更新日期：2016-01-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential tissue integration, and undirected cell differentiation after transplantation in a hostile microenvironment are complications that require refin...

journal_title：Stem cells international

authors： Mellado-López M,Griffeth RJ,Meseguer-Ripolles J,Cugat R,García M,Moreno-Manzano V

更新日期：2017-01-01 00:00:00

abstract：Objective:Parathyroid hormone (PTH) is considered to be essential during the tooth development. Stem cells from the apical papilla (SCAPs) are responsible for dentine formation. However, the interaction between PTH and SCAPs remains unclear. This study was aimed at investigating the effects of PTH on odonto/osteogenic ...

journal_title：Stem cells international

authors： Pang X,Zhuang Y,Li Z,Jing S,Cai Q,Zhang F,Xue C,Yu J

更新日期：2020-02-14 00:00:00

abstract：:Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging population. OSA leads to hypoxia and upper airway muscle injury. However, l...

journal_title：Stem cells international

authors： Zhu LY,Yu LM,Zhang WH,Deng JJ,Liu SF,Huang W,Zhang MH,Lu YQ,Han XX,Liu YH

更新日期：2020-03-04 00:00:00

abstract：:The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, an...

journal_title：Stem cells international

authors： Yang J,Zhang K,Wu J,Shi J,Xue J,Li J,Chen J,Zhu Y,Wei J,He J,Liu X

更新日期：2016-01-01 00:00:00

abstract：:Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated wit...

journal_title：Stem cells international

authors： Pereira T,Armada-da Silva PA,Amorim I,Rêma A,Caseiro AR,Gärtner A,Rodrigues M,Lopes MA,Bártolo PJ,Santos JD,Luís AL,Maurício AC

更新日期：2014-01-01 00:00:00

abstract：Background:Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to pr...

journal_title：Stem cells international

authors： Zhang L,Zheng F,Peng Z,Hu Z,Yang Z

更新日期：2018-04-03 00:00:00

abstract：:Asherman's Syndrome (AS) is an uncommon, acquired, and refractory gynecological disorder. Current treatment was still limited, and stem cell-based therapy has been proposed as a novel strategy for management of AS. Here, we conducted a meta-analysis of self-controlled clinical trials to assess the effectiveness and sa...

journal_title：Stem cells international

authors： Zhao Y,Luo Q,Zhang X,Qin Y,Hao J,Kong D,Wang H,Li G,Gu X,Wang H

更新日期：2020-12-19 00:00:00

abstract：:The calcined tooth powder (CTP), a type of allogeneic biomimetic mineralized material, has been confirmed that can promote new bone formation when obtained at high temperature. The aim of this study was to investigate effects of the conditioned medium of calcined tooth powder (CTP-CM) on the osteogenic and odontogenic...

journal_title：Stem cells international

authors： Wu J,Li N,Fan Y,Wang Y,Gu Y,Li Z,Pan Y,Romila G,Zhou Z,Yu J

更新日期：2019-03-19 00:00:00

abstract：:Aged tendon-derived stem/progenitor cells (TSPCs) lead to age-related tendon disorders and impair tendon healing. However, the underlying molecular mechanisms of TSPC aging remain largely unknown. Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging. CTGF protein and mRNA levels were ...

journal_title：Stem cells international

authors： Rui YF,Chen MH,Li YJ,Xiao LF,Geng P,Wang P,Xu ZY,Zhang XP,Dai GC

更新日期：2019-11-11 00:00:00