CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging.

abstract：:The use of Mesenchymal Stromal Cells (MSCs) aiming to treat cancer has shown very contradictory results. In an attempt to clarify the contradictory results reported in the literature and the possible role of human fallopian tube Mesenchymal Stromal Cells (htMSCs) against breast cancer, the aim of this study was to eva...

journal_title：Stem cells international

authors： Jazedje T,Ribeiro AL,Pellati M,de Siqueira Bueno HM,Nagata G,Trierveiler M,Rodrigues EG,Zatz M

更新日期：2015-01-01 00:00:00

abstract：:Chicken embryonic stem cells (cESCs) obtained from stage X embryos provide a novel model for the study of avian embryonic development. A new way to maintain cESCs for a long period in vitro still remains unexplored. We found that the cESCs showed stem cell-like properties in vitro for a long term with the support of D...

journal_title：Stem cells international

authors： Zhang L,Wu Y,Li X,Wei S,Xing Y,Lian Z,Han H

更新日期：2018-05-09 00:00:00

abstract：:There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC ...

journal_title：Stem cells international

authors： Gener P,Seras-Franzoso J,Callejo PG,Andrade F,Rafael D,Martínez F,Montero S,Arango D,Sayós J,Abasolo I,Schwartz S Jr

更新日期：2018-10-10 00:00:00

abstract：:Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...

journal_title：Stem cells international

authors： Sassoli C,Pierucci F,Tani A,Frati A,Chellini F,Matteini F,Vestri A,Anderloni G,Nosi D,Zecchi-Orlandini S,Meacci E

更新日期：2018-03-11 00:00:00

abstract：:Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...

journal_title：Stem cells international

authors： Mingliang R,Bo Z,Zhengguo W

更新日期：2011-01-01 00:00:00

abstract：:Adipogenesis is the process through which preadipocytes differentiate into adipocytes. During this process, the preadipocytes cease to proliferate, begin to accumulate lipid droplets, and develop morphologic and biochemical characteristics of mature adipocytes. Mesenchymal stem cells (MSCs) are a type of adult stem ce...

journal_title：Stem cells international

authors： Zhang K,Yang X,Zhao Q,Li Z,Fu F,Zhang H,Zheng M,Zhang S

更新日期：2020-08-12 00:00:00

abstract：:Hematopoietic stem cell (HSC) belongs to multipotent adult somatic stem cells. A single HSC can reconstitute the entire blood system via self-renewal, differentiation into all lineages of blood cells, and replenishment of cells lost due to attrition or disease in a person's lifetime. Although all blood and immune cell...

journal_title：Stem cells international

authors： Zhang J,Crumpacker C

更新日期：2015-01-01 00:00:00

abstract：Aim:Few haematopoietic stem cells (HSCs) injected systemically for therapeutic purposes actually reach sites of injury as the vast majority become entrapped within pulmonary capillaries. One promising approach to maintain circulating HSC numbers would be to separate subpopulations with smaller size and/or greater defor...

journal_title：Stem cells international

authors： Du M,Kavanagh D,Zhang Z,Kalia N

更新日期：2019-09-05 00:00:00

abstract：:Human embryonic stem cells (hESCs) are being utilized in diverse areas of studies such as development and disease modeling, cell replacement therapy, or drug toxicity testing because of their potential to be differentiated into any cell type in the body. The directed differentiation of hESCs into hepatocytes could pro...

journal_title：Stem cells international

authors： Varghese DS,Alawathugoda TT,Ansari SA

更新日期：2019-01-22 00:00:00

abstract：:Mesenchymal stem cells (MSCs) derived from bone marrow can secrete cytokines and growth factors and can transdifferentiate into liver cells. We transplanted polymeric membrane bioencapsulated MSCs into the spleens of 90% partial hepatectomized rats. This resulted in 91.6% recovery rates. This is compared to a recovery...

journal_title：Stem cells international

authors： Liu ZC,Chang TM

更新日期：2012-01-01 00:00:00

abstract：Background:Ly6Chigh monocytes are inflammatory cells that accumulate in an infarcted myocardium, and Ly6Clow monocytes are believed to be reparative and curb myocardial remodeling. NR4A1 is a novel target for modulating the inflammatory phenotype of monocytes during atherogenesis. Objectives:We aimed to investigate wh...

journal_title：Stem cells international

authors： Lu W,Ma G,Sheng Z,Wang Q,Chen L,Qi J,Shi R,Ji J,Ji Z,Dai Q

更新日期：2020-01-13 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for tr...

journal_title：Stem cells international

authors： Zhu J,Xiao Y,Li Z,Han F,Xiao T,Zhang Z,Geng F

更新日期：2015-01-01 00:00:00

abstract：:Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, n...

journal_title：Stem cells international

authors： Bruno S,Grange C,Tapparo M,Pasquino C,Romagnoli R,Dametto E,Amoroso A,Tetta C,Camussi G

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...

journal_title：Stem cells international

authors： Park M,Kim YH,Ryu JH,Woo SY,Ryu KH

更新日期：2015-01-01 00:00:00

abstract：:Intestinal stem cells are located at the base of the crypts and are surrounded by a complex structure called niche. This environment is composed mainly of epithelial cells and stroma which provides signals that govern cell maintenance, proliferation, and differentiation. Understanding how the niche regulates stem cell...

journal_title：Stem cells international

authors： Gjorevski N,Ordóñez-Morán P

更新日期：2017-01-01 00:00:00

abstract：:Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepato...

journal_title：Stem cells international

authors： Pradip A,Steel D,Jacobsson S,Holmgren G,Ingelman-Sundberg M,Sartipy P,Björquist P,Johansson I,Edsbagge J

更新日期：2016-01-01 00:00:00

abstract：:The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of ster...

journal_title：Stem cells international

authors： Aluri HS,Samizadeh M,Edman MC,Hawley DR,Armaos HL,Janga SR,Meng Z,Sendra VG,Hamrah P,Kublin CL,Hamm-Alvarez SF,Zoukhri D

更新日期：2017-01-01 00:00:00

abstract：:The latest research achievements in the field of stem cells led in 2016 to the publication of "Guidelines for Stem Cell Research and Clinical Translation" by the International Society for Stem Cell Research (ISSCR). Updating the topics covered in previous publications, the new recommendations offer interesting ethical...

journal_title：Stem cells international

authors： Frati P,Scopetti M,Santurro A,Gatto V,Fineschi V

更新日期：2017-01-01 00:00:00

abstract：:Following the discovery of pluripotent stem (PS) cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells, there has been a great hope that injured tissues can be repaired by transplantation of ES/iPS-derived various specific types of cells such as neural stem cells (NSCs). Although PS cells can be i...

journal_title：Stem cells international

authors： Nakagomi T,Nakano-Doi A,Narita A,Matsuyama T

更新日期：2015-01-01 00:00:00

abstract：:Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...

journal_title：Stem cells international

authors： Guo H,Lei M,Li Y,Liu Y,Tang Y,Xing Y,Deng F,Yang K

更新日期：2017-01-01 00:00:00

abstract：:Exosomes derived from cancer cells can affect various functions of mesenchymal stem cells (MSCs) via conveying microRNAs (miRs). miR-21 and miR-146a have been demonstrated to regulate MSC proliferation and transformation. Interleukin-6 (IL-6) secreted from transformed MSCs in turn favors the survival of multiple myelo...

journal_title：Stem cells international

authors： Cheng Q,Li X,Liu J,Ye Q,Chen Y,Tan S,Liu J

更新日期：2017-01-01 00:00:00

abstract：:The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated. However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. In this study, our data showed that IL-1β induced LFA-1 e...

journal_title：Stem cells international

authors： Wu TY,Liang YH,Wu JC,Wang HS

更新日期：2019-12-27 00:00:00

abstract：:Due to their immunomodulatory and chemotactic properties, hMSC are being explored to treat immune-related diseases. For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was a...

journal_title：Stem cells international

authors： Blázquez-Prunera A,Almeida CR,Barbosa MA

更新日期：2017-01-01 00:00:00

abstract：:The mesenchymal stem cells (MSCs) are known as highly plastic stem cells and can differentiate into specialized tissues such as adipose tissue, osseous tissue, muscle tissue, and nervous tissue. The differentiation of mesenchymal stem cells is very important in regenerative medicine. Their differentiation process is r...

journal_title：Stem cells international

authors： Wang F,Li X,Li Z,Wang S,Fan J

更新日期：2020-08-01 00:00:00

abstract：:Beer is one of the most consumed alcoholic beverages in the world, rich in chemical compounds of natural origin with high nutritional and biological value. It is made up of water, barley malt, hops, and yeast. The main nutrients are carbohydrates, amino acids, minerals, vitamins, and other compounds such as polyphenol...

journal_title：Stem cells international

authors： Di Domenico M,Feola A,Ambrosio P,Pinto F,Galasso G,Zarrelli A,Di Fabio G,Porcelli M,Scacco S,Inchingolo F,Quagliuolo L,Ballini A,Boccellino M

更新日期：2020-10-10 00:00:00

abstract：:Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem ...

journal_title：Stem cells international

authors： Xu L,Zhou J,Liu J,Liu Y,Wang L,Jiang R,Diao Z,Yan G,Pèault B,Sun H,Ding L

更新日期：2017-01-01 00:00:00

abstract：:Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled...

journal_title：Stem cells international

authors： Nicolosi PA,Tombetti E,Maugeri N,Rovere-Querini P,Brunelli S,Manfredi AA

更新日期：2016-01-01 00:00:00

abstract：:Two of the main problems of stem cell and regenerative medicine are the exit of pluripotency and differentiation to functional cells or tissues. The answer to these two problems holds great value in the clinical translation of stem cell as well as regenerative medicine research. Although piling researches have reveale...

journal_title：Stem cells international

authors： Yang B,Kuang J,Wu C,Zhou W,Zhu S,Jiang H,Zhai Z,Wu Y,Peng J,Liu N,Hu H,Ide NM,Chen R,Zhao M,Zhu P

更新日期：2020-02-03 00:00:00

abstract：:Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of the...

journal_title：Stem cells international

authors： Bakopoulou A,About I

更新日期：2016-01-01 00:00:00

abstract：:This study is aimed at investigating whether human umbilical cord mesenchymal stem cell- (hucMSC-) derived exosomes (hucMSC-exosomes) have a protective effect on acute myocardial infarction (AMI). Exosomes were characterized under transmission electron microscopy and the particles of exosomes were further examined thr...

journal_title：Stem cells international

authors： Zhao Y,Sun X,Cao W,Ma J,Sun L,Qian H,Zhu W,Xu W

更新日期：2015-01-01 00:00:00