Intermittent Administration of Parathyroid Hormone Enhances Odonto/Osteogenic Differentiation of Stem Cells from the Apical Papilla via JNK and P38 MAPK Pathways.

abstract：:Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m(2) of cyclophosphamide (CFA) and 10 μg/kg/day of granulocyte colony stimulating factor (G-C...

journal_title：Stem cells international

authors： Meraz JE,Arellano-Galindo J,Avalos AM,Mendoza-García E,Jiménez-Hernández E

更新日期：2016-01-01 00:00:00

abstract：:We aim to investigate the effects of adipose-derived stem cells (ASCs) transplantation on irradiation-induced skeletal muscle fibrosis. Sixty-four rabbits were randomly divided into ASCs group and PBS group followed by irradiation at unilateral hip with a single dose of 80 Gy. Nonirradiated side with normal skeletal m...

journal_title：Stem cells international

authors： Sun W,Ni X,Sun S,Cai L,Yu J,Wang J,Nie B,Sun Z,Ni X,Cao X

更新日期：2016-01-01 00:00:00

abstract：:The quality of life of patients with chronic wounds can be extremely poor and, therefore, over the past decades, great efforts have been made to develop efficient strategies to improve the healing process and the social impact associated with these conditions. Cell based therapy, as a modern tissue engineering strateg...

journal_title：Stem cells international

authors： Galateanu B,Bunea MC,Stanescu P,Vasile E,Casarica A,Iovu H,Hermenean A,Zaharia C,Costache M

更新日期：2015-01-01 00:00:00

abstract：:Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide t...

journal_title：Stem cells international

authors： Burke J,Kolhe R,Hunter M,Isales C,Hamrick M,Fulzele S

更新日期：2016-01-01 00:00:00

abstract：:Spinal cord injury (SCI) represents one of the most complicated and heterogeneous pathological processes of central nervous system (CNS) impairments, which is still beyond functional regeneration. Transplantation of mesenchymal stem cells (MSCs) has been shown to promote the repair of the injured spinal cord tissues i...

journal_title：Stem cells international

authors： Qu J,Zhang H

更新日期：2017-01-01 00:00:00

abstract：:Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood. In this study, we investigated the role of EphB4 in regulating the expression of periostin (POSTN) within bone marrow-derived mese...

journal_title：Stem cells international

authors： Zhang F,Zhang Z,Sun D,Dong S,Xu J,Dai F

更新日期：2016-01-01 00:00:00

abstract：:Designing and providing a scaffold are very important for the cells in tissue engineering. Polybutylene succinate (PBS) has high potential as a scaffold for bone regeneration due to its capacity in cell proliferation and differentiation. Also, stem cells from 3rd molar tooth germs were favoured in this study due to th...

journal_title：Stem cells international

authors： Abay N,Gurel Pekozer G,Ramazanoglu M,Kose GT

更新日期：2016-01-01 00:00:00

abstract：:Here, we aimed to answer important and fundamental questions in germ cell biology with special focus on the age of the male donor cells and the possibility to generate embryonic stem cell- (ESC-) like cells. While it is believed that spermatogonial stem cells (SSCs) and truly pluripotent ESC-like cells can be isolated...

journal_title：Stem cells international

authors： Azizi H,Conrad S,Hinz U,Asgari B,Nanus D,Peterziel H,Hajizadeh Moghaddam A,Baharvand H,Skutella T

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess a capacity to enhance cutaneous wound healing that is well characterized. However, the therapeutic effect of MSCs appears to be limited. Modifying MSC target genes to increase necessary biological effects is a promising strategy for wound therapy. Interleukin-10 (IL-10) is an anti...

journal_title：Stem cells international

authors： Xiao S,Huang G,Wei Z,Nie K,Liu Z,Deng C,Wang D

更新日期：2019-06-11 00:00:00

abstract：:This study is aimed at investigating whether human umbilical cord mesenchymal stem cell- (hucMSC-) derived exosomes (hucMSC-exosomes) have a protective effect on acute myocardial infarction (AMI). Exosomes were characterized under transmission electron microscopy and the particles of exosomes were further examined thr...

journal_title：Stem cells international

authors： Zhao Y,Sun X,Cao W,Ma J,Sun L,Qian H,Zhu W,Xu W

更新日期：2015-01-01 00:00:00

abstract：:The use of Mesenchymal Stromal Cells (MSCs) aiming to treat cancer has shown very contradictory results. In an attempt to clarify the contradictory results reported in the literature and the possible role of human fallopian tube Mesenchymal Stromal Cells (htMSCs) against breast cancer, the aim of this study was to eva...

journal_title：Stem cells international

authors： Jazedje T,Ribeiro AL,Pellati M,de Siqueira Bueno HM,Nagata G,Trierveiler M,Rodrigues EG,Zatz M

更新日期：2015-01-01 00:00:00

abstract：:Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...

journal_title：Stem cells international

authors： Juhl M,Follin B,Gad M,Larsen J,Kastrup J,Ekblond A

更新日期：2020-10-26 00:00:00

abstract：Materials and Methods:Ischemic brain injury was induced by dMCAO in Sprague-Dawley rats. The transplantation group received MSC infusion 1 h after dMCAO. Expression of IGF-1 in GFAP+ astrocytes, Iba-1+ microglia/macrophages, CD3+ lymphocytes, Ly6C+ monocytes/macrophages, and neutrophil elastase (NE)+ neutrophils was ex...

journal_title：Stem cells international

authors： Li X,Yu W,Guan Y,Zou H,Liang Z,Huang M,Zhao R,Zhao C,Ren Z,Chen Z

更新日期：2020-09-01 00:00:00

abstract：:Homoeostasis of bone marrow microenvironment depends on a precise balance between cell proliferation and death, which is supported by the cellular-extracellular matrix crosstalk. Multipotent mesenchymal stromal cells (MSC) are the key elements to provide the specialized bone marrow microenvironment by supporting, main...

journal_title：Stem cells international

authors： Cominal JG,da Costa Cacemiro M,Pinto-Simões B,Kolb HJ,Malmegrim KCR,de Castro FA

更新日期：2019-06-02 00:00:00

abstract：:Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has significant potential as a novel treatment for many degenerative bone and joint diseases. Previous studies have established that age negatively affects the proliferation status and the osteogenic and chondrogenic differentiation potenti...

journal_title：Stem cells international

authors： Marędziak M,Marycz K,Tomaszewski KA,Kornicka K,Henry BM

更新日期：2016-01-01 00:00:00

abstract：:Tendinopathy is a tendon disorder characterized by activity-related pain, local edema, focal tenderness to palpation, and decreased strength in the affected area. Tendinopathy is prevalent in both athletes and the general population, highlighting the need to elucidate the pathogenesis of this disorder. Current treatme...

journal_title：Stem cells international

authors： Zhang X,Lin YC,Rui YF,Xu HL,Chen H,Wang C,Teng GJ

更新日期：2016-01-01 00:00:00

abstract：:An intermediate filament protein, Nestin, is known as a neural stem/progenitor cell marker. It was shown to be required for the survival and self-renewal of neural stem cells according to the phenotypes of Nestin knockout mice. Nestin expression has also been reported in vascular endothelial cells, and we recently rep...

journal_title：Stem cells international

authors： Namiki J,Suzuki S,Masuda T,Ishihama Y,Okano H

更新日期：2012-01-01 00:00:00

abstract：:Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in...

journal_title：Stem cells international

authors： Schmal H,Kowal JM,Kassem M,Seidenstuecker M,Bernstein A,Böttiger K,Xiong T,Südkamp NP,Kubosch EJ

更新日期：2018-04-19 00:00:00

abstract：:The magic angle effect increases the MRI signal of healthy tendon tissue and could be used for more detailed evaluation of tendon structure. Furthermore, it could support the discrimination of hypointense artefacts induced by contrast agents such as superparamagnetic iron oxide used for cell tracking. However, magic a...

journal_title：Stem cells international

authors： Horstmeier C,Ahrberg AB,Berner D,Burk J,Gittel C,Hillmann A,Offhaus J,Brehm W

更新日期：2019-12-17 00:00:00

abstract：:Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring i...

journal_title：Stem cells international

authors： Cimino M,Gonçalves RM,Barrias CC,Martins MCL

更新日期：2017-01-01 00:00:00

abstract：:In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted centr...

journal_title：Stem cells international

authors： Catacchio I,Berardi S,Reale A,De Luisi A,Racanelli V,Vacca A,Ria R

更新日期：2013-01-01 00:00:00

abstract：Background:Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of liver failure with a high mortality. This study aimed at investigating the safety and efficacy of the combination treatment of plasma exchange (PE) and umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantatio...

journal_title：Stem cells international

authors： Xu WX,He HL,Pan SW,Chen YL,Zhang ML,Zhu S,Gao ZL,Peng L,Li JG

更新日期：2019-02-04 00:00:00

abstract：:Infections of emerging and reemerging viruses (SARS-CoVs, influenza H1N1, etc.) largely and globally affect human health. Animal models often fail to reflect a physiological status because of species tropism of virus infection. Conventional cell lines are usually genetically and phenotypically different from primary c...

journal_title：Stem cells international

authors： Xia S,Liu J,Yang Y,Wu M,Ye L,Chen S,Zhang T,Zeng Z,Zhang K,Cai K,Long X,Gao W,Fang S,Li H

更新日期：2020-07-09 00:00:00

abstract：Background:Aging is a major risk factor for cardiovascular disease. Cysteine protease cathepsin K (CatK) has been implicated in the process of angiogenesis, but the exact roles of individual CatK in vessel formation during aging are poorly understood. Methods and Results:To study the putative role of CatK in ischemia-...

journal_title：Stem cells international

authors： Yue X,Jiang H,Xu Y,Xia M,Cheng XW

更新日期：2020-06-30 00:00:00

abstract：:Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and str...

journal_title：Stem cells international

authors： Cui D,Li H,Xu X,Ye L,Zhou X,Zheng L,Zhou Y

更新日期：2017-01-01 00:00:00

abstract：:Sepsis, newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the most common cause of death in ICUs and one of the principal causes of death worldwide. Although substantial progress has been made in the understanding of fundamental mechanisms of sepsis, translat...

journal_title：Stem cells international

authors： Horák J,Nalos L,Martínková V,Beneš J,Štengl M,Matějovič M

更新日期：2017-01-01 00:00:00

abstract：:As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat degenerative diseases. Muscle differentiation is a multistep process...

journal_title：Stem cells international

authors： Aboalola D,Han VKM

更新日期：2019-02-17 00:00:00

abstract：Background:Human dermal fibroblasts (HDFs) are the primary cells in skin and are associated with UVB-induced skin photoaging. Adipose-derived stem cells (ASCs) have been proposed as a treatment for skin aging. The goal of this study was to investigate paracrine mechanisms by which ASCs repair HDFs damage from UVB expos...

journal_title：Stem cells international

authors： Qin F,Huang J,Zhang W,Zhang M,Li Z,Si L,Long X,Wang X

更新日期：2020-12-17 00:00:00

abstract：:Human eyelid adipose-derived stem cells (HEASCs) are a new source of autologous mesenchymal stem cells, which are derived from neuroectoderm and potentially applied in the tissue regeneration and cell therapies. Based on the prevalence of blepharoplasty in Asia and the availability of HEASCs, we investigated the effec...

journal_title：Stem cells international

authors： Zhang M,Wang Z,Zhao Y,Zhang L,Xu L,Cao L,He W

更新日期：2018-03-19 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2020/7073805.]. ...

journal_title：Stem cells international

authors： Liang C,Liang G,Zheng X,Huang Y,Huang S,Yin D

更新日期：2020-08-21 00:00:00