Abstract:
:Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time points following mouse cerebral ischemia. Furthermore, the protective mechanisms involving neurogenesis, angiogenesis, and AKT-GSK3β-VEGF signaling pathway were analyzed. Human tissue kallikrein was injected through the tail vein daily starting at 8 h, 24 h, or 36 h after right middle cerebral artery occlusion (MCAO) until the 28th day. Three therapeutic regimens all protected against neurological dysfunction, but kallikrein treatment starting at 8 h after MCAO had the best efficacy. Additionally, kallikrein treatment at 8 h after MCAO significantly enhanced cell proliferation including neural stem cell and induced differentiation of neural stem cell into mature neuron. Kallikrein treatment starting at 8 h also promoted more angiogenesis than other two treatment regimens, which was associated with AKT-GSK3β-VEGF signaling pathway. Thus, we confirm that three delayed kallikrein treatments provide protection against cerebral infarction and furthermore suggest that kallikrein treatment starting at 8 h had a better effect than that at 24 h and 36 h. These findings provide the experimental data contributing to better clinical application of exogenous kallikrein.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Ni Y,Cai K,Hu Y,Wang CH,Zhang Y,Huang H,Su X,Gu JHdoi
10.1155/2018/1706982subject
Has Abstractpub_date
2018-04-05 00:00:00pages
1706982eissn
1687-966Xissn
1687-9678journal_volume
2018pub_type
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/5387041
更新日期:2018-08-23 00:00:00
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journal_title:Stem cells international
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journal_title:Stem cells international
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更新日期:2018-04-03 00:00:00
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
pub_type: 杂志文章,评审
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journal_title:Stem cells international
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doi:10.1155/2020/8878370
更新日期:2020-12-17 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5720758
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
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journal_title:Stem cells international
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/6904638
更新日期:2019-05-02 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1641402
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/1340252
更新日期:2018-05-22 00:00:00
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journal_title:Stem cells international
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doi:10.1155/2016/1035374
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/8472712
更新日期:2019-06-13 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/9275248
更新日期:2017-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5802529
更新日期:2016-01-01 00:00:00
abstract::The mesenchymal stem cells (MSCs) are known as highly plastic stem cells and can differentiate into specialized tissues such as adipose tissue, osseous tissue, muscle tissue, and nervous tissue. The differentiation of mesenchymal stem cells is very important in regenerative medicine. Their differentiation process is r...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/3763069
更新日期:2020-08-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
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journal_title:Stem cells international
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journal_title:Stem cells international
pub_type: 杂志文章
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journal_title:Stem cells international
pub_type: 杂志文章
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更新日期:2020-06-30 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
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journal_title:Stem cells international
pub_type: 杂志文章
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/9010279
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4287158
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9783408
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/4802578
更新日期:2019-12-01 00:00:00