Mesenchymal Stem Cells Derived and Cultured from Glioblastoma Multiforme Increase Tregs, Downregulate Th17, and Induce the Tolerogenic Phenotype of Monocyte-Derived Cells.

abstract：:Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and ...

journal_title：Stem cells international

authors： Pogozhykh O,Prokopyuk V,Figueiredo C,Pogozhykh D

更新日期：2018-01-18 00:00:00

abstract：:Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...

journal_title：Stem cells international

authors： Mingliang R,Bo Z,Zhengguo W

更新日期：2011-01-01 00:00:00

abstract：Purpose:To determine the effect of the isolation technique and location upon the phenotype of human corneal stroma-derived cells (CSCs). Methods:CSCs were isolated from the corneal stroma center and periphery using the explant or enzymatic digestion technique. The native tissue was stained for functional markers, whil...

journal_title：Stem cells international

authors： Nagymihály R,Veréb Z,Facskó A,Moe MC,Petrovski G

更新日期：2017-01-01 00:00:00

abstract：:A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) causing lethal acute respiratory disease emerged in December 2019. The World Health Organization named this disease "COVID-19" and declared it a pandemic on March 11, 2020. Many studies have shown that mesenchymal stem cells (MSCs) and their exosomes (...

journal_title：Stem cells international

authors： Alzahrani FA,Saadeldin IM,Ahmad A,Kumar D,Azhar EI,Siddiqui AJ,Kurdi B,Sajini A,Alrefaei AF,Jahan S

更新日期：2020-09-24 00:00:00

abstract：:Transcription factors are tools repetitively used by the embryo to generate a variety of lineages. Hence, their context of activation is an important determinant of their ability to specifically trigger certain cell fates, but not others. The context is also consequential when considering directing differentiation of ...

journal_title：Stem cells international

authors： Nair GG,Odorico JS

更新日期：2016-01-01 00:00:00

abstract：:The clinical application of human bone marrow mesenchymal stem cells (hBM-MSCs) has generated a great deal of interest because of their potential use in regenerative medicine and tissue engineering. However, safety concerns over hBM-MSCs limit their clinical application. In this study, we observed that hBM-MSC-conditi...

journal_title：Stem cells international

authors： Chen B,Yu J,Wang Q,Zhao Y,Sun L,Xu C,Zhao X,Shen B,Wang M,Xu W,Zhu W

更新日期：2018-07-18 00:00:00

abstract：:The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of ster...

journal_title：Stem cells international

authors： Aluri HS,Samizadeh M,Edman MC,Hawley DR,Armaos HL,Janga SR,Meng Z,Sendra VG,Hamrah P,Kublin CL,Hamm-Alvarez SF,Zoukhri D

更新日期：2017-01-01 00:00:00

abstract：:Objectives. Acute lung injury (ALI) is a common clinical critical disease. Stem cells transplantation is recognized as an effective way to repair injured lung tissues. The present study was designed to evaluate the effects of mesenchymal stem cells (MSCs) on repair of lung and its mechanism. Methods. MSCs carrying GFP...

journal_title：Stem cells international

authors： Xin X,Yan L,Guangfa Z,Yan H,Keng L,Chunting W

更新日期：2017-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/3978595.]. ...

journal_title：Stem cells international

authors： Zadroga A,Jezierska-Woźniak K,Czarzasta J,Barczewska M,Wojtkiewicz J,Maksymowicz W

更新日期：2017-01-01 00:00:00

abstract：Objective:To investigate the effects of mesenchymal stem cells (MSCs) coated by the extracellular matrix (ECM) on wound healing in diabetic rats. Methods:Mesenchymal stem cells were cocultured with ECM. Cell viabilities were evaluated using MTT assay. The diabetes model was established using both STZ and high-glucose/...

journal_title：Stem cells international

authors： Wang L,Wang F,Zhao L,Yang W,Wan X,Yue C,Mo Z

更新日期：2019-01-28 00:00:00

abstract：:Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic ...

journal_title：Stem cells international

authors： Huang Y,Sakai Y,Hara T,Katsuda T,Ochiya T,Adachi T,Hidaka M,Gu WL,Eguchi S

更新日期：2019-09-03 00:00:00

abstract：:Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...

journal_title：Stem cells international

authors： Guo H,Lei M,Li Y,Liu Y,Tang Y,Xing Y,Deng F,Yang K

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) offering valuable anticipations for the treatment of degenerative diseases. They can be found in many tissues including amnion. MSCs from amnion (AM-MSCs) can differentiate into osteoblast similar to that of bone marrow-derived MSCs (BM-MSCs). However, the ability is not much efficient...

journal_title：Stem cells international

authors： Manochantr S,Marupanthorn K,Tantrawatpan C,Kheolamai P,Tantikanlayaporn D,Sanguanjit P

更新日期：2017-01-01 00:00:00

abstract：:Beer is one of the most consumed alcoholic beverages in the world, rich in chemical compounds of natural origin with high nutritional and biological value. It is made up of water, barley malt, hops, and yeast. The main nutrients are carbohydrates, amino acids, minerals, vitamins, and other compounds such as polyphenol...

journal_title：Stem cells international

authors： Di Domenico M,Feola A,Ambrosio P,Pinto F,Galasso G,Zarrelli A,Di Fabio G,Porcelli M,Scacco S,Inchingolo F,Quagliuolo L,Ballini A,Boccellino M

更新日期：2020-10-10 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...

journal_title：Stem cells international

authors： Park M,Kim YH,Ryu JH,Woo SY,Ryu KH

更新日期：2015-01-01 00:00:00

abstract：:Tumor microenvironment has been implicated in tumor development and progression. As a three-dimensional tumor microenvironment model, air liquid interface (ALI) organoid culture from oncogene transgenic mouse gastrointestinal tissues was recently produced. However, ALI organoid culture system from tissues of colorecta...

journal_title：Stem cells international

authors： Usui T,Sakurai M,Enjoji S,Kawasaki H,Umata K,Ohama T,Fujiwara N,Yabe R,Tsuji S,Yamawaki H,Hazama S,Takenouchi H,Nakajima M,Tsunedomi R,Suzuki N,Nagano H,Sato K

更新日期：2016-01-01 00:00:00

abstract：:The application of human bone marrow mesenchymal stem cells (hBM-MSCs) in cell-based clinical therapies is hindered by the limited number of cells remaining after the initial isolation process and by cellular senescence following in vitro expansion. Understanding the process of in vitro senescence in hBM-MSCs would en...

journal_title：Stem cells international

authors： Xu Z,Wu W,Shen F,Yu Y,Wang Y,Xiang C

更新日期：2019-07-11 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential tissue integration, and undirected cell differentiation after transplantation in a hostile microenvironment are complications that require refin...

journal_title：Stem cells international

authors： Mellado-López M,Griffeth RJ,Meseguer-Ripolles J,Cugat R,García M,Moreno-Manzano V

更新日期：2017-01-01 00:00:00

abstract：:The use of Mesenchymal Stromal Cells (MSCs) aiming to treat cancer has shown very contradictory results. In an attempt to clarify the contradictory results reported in the literature and the possible role of human fallopian tube Mesenchymal Stromal Cells (htMSCs) against breast cancer, the aim of this study was to eva...

journal_title：Stem cells international

authors： Jazedje T,Ribeiro AL,Pellati M,de Siqueira Bueno HM,Nagata G,Trierveiler M,Rodrigues EG,Zatz M

更新日期：2015-01-01 00:00:00

abstract：:Two of the main problems of stem cell and regenerative medicine are the exit of pluripotency and differentiation to functional cells or tissues. The answer to these two problems holds great value in the clinical translation of stem cell as well as regenerative medicine research. Although piling researches have reveale...

journal_title：Stem cells international

authors： Yang B,Kuang J,Wu C,Zhou W,Zhu S,Jiang H,Zhai Z,Wu Y,Peng J,Liu N,Hu H,Ide NM,Chen R,Zhao M,Zhu P

更新日期：2020-02-03 00:00:00

abstract：:Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two s...

journal_title：Stem cells international

authors： Zhou J,Chen Q,Zou Y,Zheng S,Chen Y

更新日期：2019-01-08 00:00:00

abstract：:Here, we aimed to answer important and fundamental questions in germ cell biology with special focus on the age of the male donor cells and the possibility to generate embryonic stem cell- (ESC-) like cells. While it is believed that spermatogonial stem cells (SSCs) and truly pluripotent ESC-like cells can be isolated...

journal_title：Stem cells international

authors： Azizi H,Conrad S,Hinz U,Asgari B,Nanus D,Peterziel H,Hajizadeh Moghaddam A,Baharvand H,Skutella T

更新日期：2016-01-01 00:00:00

abstract：:Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated wit...

journal_title：Stem cells international

authors： Pereira T,Armada-da Silva PA,Amorim I,Rêma A,Caseiro AR,Gärtner A,Rodrigues M,Lopes MA,Bártolo PJ,Santos JD,Luís AL,Maurício AC

更新日期：2014-01-01 00:00:00

abstract：:In cholestatic liver diseases, impaired bile excretion disrupts lipid homeostasis. We investigated changes of lipid metabolism, including mitochondrial β-oxidation, in a rat model of bile duct ligation (BDL) in which chorionic plate-derived mesenchymal stem cells (CP-MSCs) were transplanted. Serum cholesterol level, w...

journal_title：Stem cells international

authors： Lee YB,Choi JH,Kim EN,Seok J,Lee HJ,Yoon JH,Kim GJ

更新日期：2017-01-01 00:00:00

abstract：:Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled...

journal_title：Stem cells international

authors： Nicolosi PA,Tombetti E,Maugeri N,Rovere-Querini P,Brunelli S,Manfredi AA

更新日期：2016-01-01 00:00:00

abstract：:The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem ce...

journal_title：Stem cells international

authors： Aprea J,Calegari F

更新日期：2012-01-01 00:00:00

abstract：:Efficient ex vivo expansion of hematopoietic stem cells with a concomitant preservation of stemness and self-renewal potential is still an unresolved ambition. Increased numbers of methods approaching this issue using three-dimensional (3D) cultures were reported. Here, we describe a simplified 3D hanging drop model f...

journal_title：Stem cells international

authors： Schmal O,Seifert J,Schäffer TE,Walter CB,Aicher WK,Klein G

更新日期：2016-01-01 00:00:00

abstract：:Whether liver epithelial cells contribute to the development of hepatic scarring by undergoing epithelial-to-mesenchymal transition (EMT) is a controversial issue. Herein, we revisit the concept of EMT in cholangiopathies, a group of severe hepatic disorders primarily targeting the bile duct epithelial cell (cholangio...

journal_title：Stem cells international

authors： Fabris L,Brivio S,Cadamuro M,Strazzabosco M

更新日期：2016-01-01 00:00:00

abstract：:The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly...

journal_title：Stem cells international

authors： Solders M,Gorchs L,Gidlöf S,Tiblad E,Lundell AC,Kaipe H

更新日期：2017-01-01 00:00:00

abstract：:Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has significant potential as a novel treatment for many degenerative bone and joint diseases. Previous studies have established that age negatively affects the proliferation status and the osteogenic and chondrogenic differentiation potenti...

journal_title：Stem cells international

authors： Marędziak M,Marycz K,Tomaszewski KA,Kornicka K,Henry BM

更新日期：2016-01-01 00:00:00