Abstract：
:The use of Mesenchymal Stromal Cells (MSCs) aiming to treat cancer has shown very contradictory results. In an attempt to clarify the contradictory results reported in the literature and the possible role of human fallopian tube Mesenchymal Stromal Cells (htMSCs) against breast cancer, the aim of this study was to evaluate the clinical effect of htMSCs in murine mammary adenocarcinoma using two different approaches: (1) coinjections of htMSCs and 4T1 murine tumor cell lineage and (2) injections of htMSCs in mice at the initial stage of mammary adenocarcinoma development. Coinjected animals had a more severe course of the disease and a reduced survival, while tumor-bearing animals treated with 2 intraperitoneal injections of 10(6) htMSCs showed significantly reduced tumor growth and increased lifespan as compared with control animals. Coculture of htMSCs and 4T1 tumor cells revealed an increase in IL-8 and MCP-1 and decreased VEGF production. For the first time, we show that MSCs isolated from a single source and donor when injected in the same animal model and tumor can lead to opposite results depending on the experimental protocol. Also, our results demonstrated that htMSCs can have an inhibitory effect on the development of murine mammary adenocarcinoma.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Jazedje T,Ribeiro AL,Pellati M,de Siqueira Bueno HM,Nagata G,Trierveiler M,Rodrigues EG,Zatz Mdoi
10.1155/2015/796215subject
Has Abstractpub_date
2015-01-01 00:00:00pages
796215eissn
1687-966Xissn
1687-9678journal_volume
2015pub_type
杂志文章abstract：:The implantation of stem cells in vivo is the ideal approach for the restoration of normal life functions, such as replenishing the decreasing levels of affected dopaminergic (DA) neurons during neurodegenerative disease conditions. However, combining stem cells with biomaterial scaffolds provides a promising strategy...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/3410168
更新日期：2018-06-03 00:00:00
abstract：:Articular cartilage defects have been addressed by using multiple strategies. In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). Howev...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/9201492
更新日期：2016-01-01 00:00:00
abstract：:Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM,...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/502136
更新日期：2012-01-01 00:00:00
abstract：:Left-right symmetry breaking is a complex developmental process and an important part of embryonic axis development. As of yet, the biophysical mechanism behind LR asymmetry establishment remains elusive for the overall asymmetry of embryos as well as for the organ-specific asymmetry. Here, we demonstrate that inheren...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/1848605
更新日期：2018-12-02 00:00:00
abstract：:The cardiopulmonary system is made up of the heart and the lungs, with the core function of one complementing the other. The unimpeded and optimal cycling of blood between these two systems is pivotal to the overall function of the entire human body. Although the function of the cardiopulmonary system appears uncompli...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2018/3123961
更新日期：2018-04-29 00:00:00
abstract：:This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD. We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey. Totally, 68 doses of bone marrow derived MSCs were infuse...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/1641402
更新日期：2016-01-01 00:00:00
abstract：:As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat degenerative diseases. Muscle differentiation is a multistep process...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/9245938
更新日期：2019-02-17 00:00:00
abstract：:Autologous stem cell transplantation (ASCT) is a standard treatment for multiple myeloma (MM), but the clinical response and renal curative effect in MM patients with renal failure (RF) remain controversial. The myeloma kidney disease has different types, and most are due to the direct toxic effects of light chain. Al...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2019/9401717
更新日期：2019-10-29 00:00:00
abstract：:Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential tissue integration, and undirected cell differentiation after transplantation in a hostile microenvironment are complications that require refin...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/5946527
更新日期：2017-01-01 00:00:00
abstract：:There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC ...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2018/4516454
更新日期：2018-10-10 00:00:00
abstract：:Two of the main problems of stem cell and regenerative medicine are the exit of pluripotency and differentiation to functional cells or tissues. The answer to these two problems holds great value in the clinical translation of stem cell as well as regenerative medicine research. Although piling researches have reveale...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/8483035
更新日期：2020-02-03 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity. However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic. RSP...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/7073805
更新日期：2020-04-06 00:00:00
abstract：:Osteoarthritis (OA) can be a debilitating degenerative disease and is the most common form of arthritic disease. There is a general consensus that current nonsurgical therapies are insufficient for younger OA sufferers who are not candidates for knee arthroplasties. Adipose-derived mesenchymal stem cells (MSCs) therap...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2015/421253
更新日期：2015-01-01 00:00:00
abstract：:Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for tr...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2015/318269
更新日期：2015-01-01 00:00:00
abstract：:Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. As most GSCs that are located in the perivascular and perinecrotic niches should be remo...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/5387041
更新日期：2018-08-23 00:00:00
abstract：:The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blo...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2018/8620172
更新日期：2018-05-08 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age. Chronic inflammation is considered to be the cause of ovarian dysfunction. Increasing evidence in animal studies and in preliminary clinical trials has demonstrated that MSCs possess immunomodulatory effe...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/9782373
更新日期：2019-09-12 00:00:00
abstract：:Mandibular bone defect reconstruction is an urgent challenge due to the requirements for daily eating and facial aesthetics. Three-dimensional- (3D-) printed titanium (Ti) scaffolds could provide patient-specific implants for bone defects. Appropriate load-bearing properties are also required during bone reconstructio...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/2074021
更新日期：2018-09-05 00:00:00
abstract：:The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated. However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. In this study, our data showed that IL-1β induced LFA-1 e...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/7267142
更新日期：2019-12-27 00:00:00
abstract：:Intestinal stem cells are located at the base of the crypts and are surrounded by a complex structure called niche. This environment is composed mainly of epithelial cells and stroma which provides signals that govern cell maintenance, proliferation, and differentiation. Understanding how the niche regulates stem cell...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/8387297
更新日期：2017-01-01 00:00:00
abstract：Purpose:To investigate the efficacy of recombinant human collagen type I (RHC I) and collagen-like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of limbal epithelial stem cells (LESC) under xeno-free culture conditions. Methods:Human LESC were cultivated on seven different collagen-deri...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/7867613
更新日期：2019-04-01 00:00:00
abstract：:Fetal dermal mesenchymal stem cells (FDMSCs), isolated from fetal skin, are serving as a novel MSC candidate with great potential in regenerative medicine. More recently, the paracrine actions, especially MSC-derived exosomes, are being focused on the vital role in MSC-based cellular therapy. This study was to evaluat...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/2402916
更新日期：2019-06-10 00:00:00
abstract：:A previous study reported the structural characterization of biogenic apatite (BAp) thin films realized by a pulsed electron deposition system by ablation of deproteinized bovine bone. Thin films annealed at 400°C exhibited composition and crystallinity degree very close to those of biogenic apatite; this affinity is ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/3579283
更新日期：2017-01-01 00:00:00
abstract：:Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/3175748
更新日期：2017-01-01 00:00:00
abstract：:Human bone marrow mesenchymal stem cells (hBM-MSCs) are the best characterized multipotent adult stem cells. Their self-renewal capacity, multilineage differentiation potential, and immunomodulatory properties have indicated that they can be used in many clinical therapies. In a previous work we studied the DNA methyl...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/5656701
更新日期：2016-01-01 00:00:00
abstract：:The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/8010961
更新日期：2017-01-01 00:00:00
abstract：:Previous studies have demonstrated that myocardin-related transcription factor A (MRTF-A) generates a link between the dynamics of the actin cytoskeleton and gene expression with its coregulator, serum response factor (SRF). MRTF-A has also been suggested as a regulator of stem cell differentiation. However, the role ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/8853541
更新日期：2020-09-22 00:00:00
abstract：:Mesenchymal stem cells (MSCs), or multipotent mesenchymal stromal cells, are present in almost all organs and tissues, including the amnion. Human amnion-derived mesenchymal stem cell (hAMSC) transplantation has been reported to ameliorate liver fibrosis in animal models. However, the mechanism for the prevention of l...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/4898152
更新日期：2018-10-08 00:00:00
abstract：:During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or r...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.4061/2011/619583
更新日期：2011-01-01 00:00:00
abstract：:Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/8868909
更新日期：2020-10-26 00:00:00
