Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury.

abstract：:Vitamin D (Vit D) by means of its biological active form, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In thi...

journal_title：Stem cells international

authors： Posa F,Di Benedetto A,Cavalcanti-Adam EA,Colaianni G,Porro C,Trotta T,Brunetti G,Lo Muzio L,Grano M,Mori G

更新日期：2018-02-28 00:00:00

abstract：Aim:Few haematopoietic stem cells (HSCs) injected systemically for therapeutic purposes actually reach sites of injury as the vast majority become entrapped within pulmonary capillaries. One promising approach to maintain circulating HSC numbers would be to separate subpopulations with smaller size and/or greater defor...

journal_title：Stem cells international

authors： Du M,Kavanagh D,Zhang Z,Kalia N

更新日期：2019-09-05 00:00:00

abstract：:Background. Mouse embryonic stem (ES) cells can be differentiated in vitro by aggregation and/or retinoic acid (RA) treatment. The principal differentiation lineage in vitro is extraembryonic primitive endoderm. Dab2, Laminin, GATA4, GATA5, and GATA6 are expressed in embryonic primitive endoderm and play critical role...

journal_title：Stem cells international

authors： Capo-Chichi CD,Smedberg JL,Rula M,Nicolas E,Yeung AT,Adamo RF,Frolov A,Godwin AK,Xu XX

更新日期：2010-05-11 00:00:00

abstract：:Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenati...

journal_title：Stem cells international

authors： Kaur G,Cai C

更新日期：2018-03-29 00:00:00

abstract：:Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source...

journal_title：Stem cells international

authors： Wankhade UD,Shen M,Kolhe R,Fulzele S

更新日期：2016-01-01 00:00:00

abstract：:Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation must be regulated for applications in regenerative medicine. Stem cells are surrounded by extracellular matrix (ECM) in vivo. The ECM is composed of many types of proteins and glycosaminoglycans that assemble into a complex str...

journal_title：Stem cells international

authors： Hoshiba T,Chen G,Endo C,Maruyama H,Wakui M,Nemoto E,Kawazoe N,Tanaka M

更新日期：2016-01-01 00:00:00

abstract：:Fetal dermal mesenchymal stem cells (FDMSCs), isolated from fetal skin, are serving as a novel MSC candidate with great potential in regenerative medicine. More recently, the paracrine actions, especially MSC-derived exosomes, are being focused on the vital role in MSC-based cellular therapy. This study was to evaluat...

journal_title：Stem cells international

authors： Wang X,Jiao Y,Pan Y,Zhang L,Gong H,Qi Y,Wang M,Gong H,Shao M,Wang X,Jiang D

更新日期：2019-06-10 00:00:00

abstract：:The calcined tooth powder (CTP), a type of allogeneic biomimetic mineralized material, has been confirmed that can promote new bone formation when obtained at high temperature. The aim of this study was to investigate effects of the conditioned medium of calcined tooth powder (CTP-CM) on the osteogenic and odontogenic...

journal_title：Stem cells international

authors： Wu J,Li N,Fan Y,Wang Y,Gu Y,Li Z,Pan Y,Romila G,Zhou Z,Yu J

更新日期：2019-03-19 00:00:00

abstract：:Cardiovascular diseases (CVDs), including atherosclerosis, stroke, and myocardial infarction, is a major cause of death worldwide. In aspects of cell therapy against CVD, it is generally accepted that endothelial progenitor cells (EPCs) are potent neovascular modulators in ischemic tissues. In response to ischemic inj...

journal_title：Stem cells international

authors： Kim H,Kim S,Baek SH,Kwon SM

更新日期：2016-01-01 00:00:00

abstract：:Intestinal stem cells are located at the base of the crypts and are surrounded by a complex structure called niche. This environment is composed mainly of epithelial cells and stroma which provides signals that govern cell maintenance, proliferation, and differentiation. Understanding how the niche regulates stem cell...

journal_title：Stem cells international

authors： Gjorevski N,Ordóñez-Morán P

更新日期：2017-01-01 00:00:00

abstract：:Tumor hypoxia is associated with malignant biological phenotype including enhanced angiogenesis and metastasis. Hypoxia increases the expression of vascular endothelial cell growth factor (VEGF), which directly participates in angiogenesis by recruiting endothelial cells into hypoxic area and stimulating their prolife...

journal_title：Stem cells international

authors： Chen HF,Wu KJ

更新日期：2016-01-01 00:00:00

abstract：:The CRISPR/Cas9 system provides a powerful method for the genetic manipulation of the mammalian genome, allowing knockout of individual genes as well as the generation of genome-wide knockout cell libraries for genetic screening. However, the diploid status of most mammalian cells restricts the application of CRISPR/C...

journal_title：Stem cells international

authors： Yin Z,Chen L

更新日期：2017-01-01 00:00:00

abstract：:Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and photoreceptor cells. We evaluated the potential of adipose-derived mesenchymal stem cells (ASCs) as a therapeutic tool by studying the migration capacity of ASCs in vitro and their protective effect against RPE cell death under oxidativ...

journal_title：Stem cells international

authors： Barzelay A,Weisthal Algor S,Niztan A,Katz S,Benhamou M,Nakdimon I,Azmon N,Gozlan S,Mezad-Koursh D,Neudorfer M,Goldstein M,Meilik B,Loewenstein A,Barak A

更新日期：2018-12-13 00:00:00

abstract：:The implantation of stem cells in vivo is the ideal approach for the restoration of normal life functions, such as replenishing the decreasing levels of affected dopaminergic (DA) neurons during neurodegenerative disease conditions. However, combining stem cells with biomaterial scaffolds provides a promising strategy...

journal_title：Stem cells international

authors： Tasnim N,Thakur V,Chattopadhyay M,Joddar B

更新日期：2018-06-03 00:00:00

abstract：:Previous studies have demonstrated that myocardin-related transcription factor A (MRTF-A) generates a link between the dynamics of the actin cytoskeleton and gene expression with its coregulator, serum response factor (SRF). MRTF-A has also been suggested as a regulator of stem cell differentiation. However, the role ...

journal_title：Stem cells international

authors： Hyväri L,Vanhatupa S,Halonen HT,Kääriäinen M,Miettinen S

更新日期：2020-09-22 00:00:00

abstract：:Cord blood transplantation (CBT) is an attractive alternative therapy in adult patients with advanced hematological malignancies in whom matched donors are unavailable. However, the risk of complications, especially infections, post-CBT increases the mortality rates in these patients. Although the incidence of acute a...

journal_title：Stem cells international

authors： Narimatsu H

更新日期：2011-01-01 00:00:00

abstract：:Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...

journal_title：Stem cells international

authors： Juhl M,Follin B,Gad M,Larsen J,Kastrup J,Ekblond A

更新日期：2020-10-26 00:00:00

abstract：:Previously, we demonstrated a high quality of minerals formed by serum-free cultured jaw periosteal cells (JPCs) by Raman spectroscopy but the mineralization extent was not satisfactory. In the present study, we analyzed the proliferation and mineralization potential of human platelet lysate- (hPL-) cultured JPCs in c...

journal_title：Stem cells international

authors： Wanner Y,Umrath F,Waidmann M,Reinert S,Alexander D

更新日期：2017-01-01 00:00:00

abstract：:An intermediate filament protein, Nestin, is known as a neural stem/progenitor cell marker. It was shown to be required for the survival and self-renewal of neural stem cells according to the phenotypes of Nestin knockout mice. Nestin expression has also been reported in vascular endothelial cells, and we recently rep...

journal_title：Stem cells international

authors： Namiki J,Suzuki S,Masuda T,Ishihama Y,Okano H

更新日期：2012-01-01 00:00:00

abstract：:Calcium phosphate- (CaP-) based composite scaffolds have been used extensively for the bone regeneration in bone tissue engineering. Previously, we developed a biomimetic composite nanofibrous membrane of gelatin/β-tricalcium phosphate (TCP) and confirmed their biological activity in vitro and bone regeneration in viv...

journal_title：Stem cells international

authors： Zhang X,Meng S,Huang Y,Xu M,He Y,Lin H,Han J,Chai Y,Wei Y,Deng X

更新日期：2015-01-01 00:00:00

abstract：:Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and str...

journal_title：Stem cells international

authors： Cui D,Li H,Xu X,Ye L,Zhou X,Zheng L,Zhou Y

更新日期：2017-01-01 00:00:00

abstract：:Transcription factors are tools repetitively used by the embryo to generate a variety of lineages. Hence, their context of activation is an important determinant of their ability to specifically trigger certain cell fates, but not others. The context is also consequential when considering directing differentiation of ...

journal_title：Stem cells international

authors： Nair GG,Odorico JS

更新日期：2016-01-01 00:00:00

abstract：:Mutations in WD40-repeat protein 62 (WDR62) are commonly associated with primary microcephaly and other developmental cortical malformations. We used human pluripotent stem cells (hPSC) to examine WDR62 function during human neural differentiation and model early stages of human corticogenesis. Neurospheres lacking WD...

journal_title：Stem cells international

authors： Alshawaf AJ,Antonic A,Skafidas E,Ng DC,Dottori M

更新日期：2017-01-01 00:00:00

abstract：:Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of the...

journal_title：Stem cells international

authors： Bakopoulou A,About I

更新日期：2016-01-01 00:00:00

abstract：:Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regul...

journal_title：Stem cells international

authors： Jiang S,Guo Y

更新日期：2020-07-08 00:00:00

abstract：:Intervertebral disc degeneration (IVD) is a frequent pathological condition. Conservative management often fails, and patients with IVD degeneration may require surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably e...

journal_title：Stem cells international

authors： Longo UG,Papapietro N,Petrillo S,Franceschetti E,Maffulli N,Denaro V

更新日期：2012-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Bind...

journal_title：Stem cells international

authors： Dietrich C

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are one of the main stem cells that have been used for advanced therapies and regenerative medicine. To carry out the translational clinical application of MSCs, their manufacturing and administration in human must be controlled; therefore they should be considered as medicine: stem cell-...

journal_title：Stem cells international

authors： Galvez-Martin P,Sabata R,Verges J,Zugaza JL,Ruiz A,Clares B

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...

journal_title：Stem cells international

authors： Park M,Kim YH,Ryu JH,Woo SY,Ryu KH

更新日期：2015-01-01 00:00:00

abstract：:Urine has become the source of choice for noninvasive renal epithelial cells and renal stem cells which can be used for generating induced pluripotent stem cells. The aim of this study was to generate a 3D nephrogenic progenitor cell model composed of three distinct cell types-urine-derived SIX2-positive renal progeni...

journal_title：Stem cells international

authors： Nguyen L,Spitzhorn LS,Adjaye J

更新日期：2019-05-02 00:00:00