Epigenetic Clock: DNA Methylation in Aging.

Abstract:

:Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regulators involved in this process. Regular fluctuations in global DNA methylation levels have been shown to accurately estimate biological age and disease prognosis. In this review, we discuss recent findings regarding the relationship between variations in DNA methylation level patterns and aging. In addition, we introduce the known mechanisms by which DNA methylation regulators affect aging and related diseases. As more studies uncover the mechanisms by which DNA methylation regulates aging, antiaging interventions and treatments for related diseases may be developed that enable human life extension.

journal_name

Stem Cells Int

journal_title

Stem cells international

authors

Jiang S,Guo Y

doi

10.1155/2020/1047896

subject

Has Abstract

pub_date

2020-07-08 00:00:00

pages

1047896

eissn

1687-966X

issn

1687-9678

journal_volume

2020

pub_type

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