Abstract:
:Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of their intriguing biological properties. Their capacity to reconstitute various dental and nondental tissues and the inherent angiogenic, neurogenic, and immunomodulatory properties of their secretome have been a subject of meticulous and costly research by various groups over the past decade. Key milestone achievements have exemplified their clinical utility in Regenerative Dentistry, as surrogate therapeutic modules for conventional biomaterial-based approaches, offering regeneration of damaged oral tissues instead of simply "filling the gaps." Thus, the essential next step to validate these immense advances is the implementation of well-designed clinical trials paving the way for exploiting these fascinating research achievements for patient well-being: the ultimate aim of this ground breaking technology. This review paper presents a concise overview of the major biological properties of the human dental MSCs, critical for the translational pathway "from bench to clinic."
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Bakopoulou A,About Idoi
10.1155/2016/4209891subject
Has Abstractpub_date
2016-01-01 00:00:00pages
4209891eissn
1687-966Xissn
1687-9678journal_volume
2016pub_type
杂志文章,评审abstract::Mandibular bone defect reconstruction is an urgent challenge due to the requirements for daily eating and facial aesthetics. Three-dimensional- (3D-) printed titanium (Ti) scaffolds could provide patient-specific implants for bone defects. Appropriate load-bearing properties are also required during bone reconstructio...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/2074021
更新日期:2018-09-05 00:00:00
abstract::Vitamin D (Vit D) by means of its biological active form, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In thi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/6958713
更新日期:2018-02-28 00:00:00
abstract::Podocyte death and regeneration are major topics in kidney research but remain controversial. Data obtained in humans demonstrate the existence of cells sited along Bowman's capsule that behave as podocyte progenitors in vitro and in in vivo mouse models of podocyte injury xenotrasplanted with this human-derived popul...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2015/678347
更新日期:2015-01-01 00:00:00
abstract::Due to their immunomodulatory and chemotactic properties, hMSC are being explored to treat immune-related diseases. For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was a...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/2185351
更新日期:2017-01-01 00:00:00
abstract::Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. The buccal fat pad (BFP) is a specialized adipose tissue that is easy to harvest and contains a rich blood supply, and its harvesting causes low complications for patients. This review focuse...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2017/8354640
更新日期:2017-01-01 00:00:00
abstract::Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/3175748
更新日期:2017-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) derived from bone marrow can secrete cytokines and growth factors and can transdifferentiate into liver cells. We transplanted polymeric membrane bioencapsulated MSCs into the spleens of 90% partial hepatectomized rats. This resulted in 91.6% recovery rates. This is compared to a recovery...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/697094
更新日期:2012-01-01 00:00:00
abstract::The calcined tooth powder (CTP), a type of allogeneic biomimetic mineralized material, has been confirmed that can promote new bone formation when obtained at high temperature. The aim of this study was to investigate effects of the conditioned medium of calcined tooth powder (CTP-CM) on the osteogenic and odontogenic...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/4793518
更新日期:2019-03-19 00:00:00
abstract::Osteoarthritis (OA) can be a debilitating degenerative disease and is the most common form of arthritic disease. There is a general consensus that current nonsurgical therapies are insufficient for younger OA sufferers who are not candidates for knee arthroplasties. Adipose-derived mesenchymal stem cells (MSCs) therap...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/421253
更新日期:2015-01-01 00:00:00
abstract::A stably established population of mouse bone marrow stromal cells (BMSCs) with self-renewal and multilineage differentiation potential was expanded in vitro for more than 50 passages. These cells express high levels of mesenchymal stem cell markers and can be differentiated into adipogenic, chondrogenic, and osteogen...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8857057
更新日期:2020-12-24 00:00:00
abstract::Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/3206807
更新日期:2016-01-01 00:00:00
abstract:Background:Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of liver failure with a high mortality. This study aimed at investigating the safety and efficacy of the combination treatment of plasma exchange (PE) and umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantatio...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/4130757
更新日期:2019-02-04 00:00:00
abstract::Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent treatment option in this regard. Preclinical studies demonstrate that untreated stem cells, unlike stem cells activated to differentiate into neuronal lineage, do...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1035374
更新日期:2016-01-01 00:00:00
abstract::Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends o...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/6129596
更新日期:2017-01-01 00:00:00
abstract::Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential tissue integration, and undirected cell differentiation after transplantation in a hostile microenvironment are complications that require refin...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/5946527
更新日期:2017-01-01 00:00:00
abstract::A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved. From the perspectives of clinicians and researchers alike, the promi...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4287158
更新日期:2016-01-01 00:00:00
abstract::Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are characterized by their unique capacity to stepwise differentiate towards any particular cell type in an adult organism. Pluripotent stem cells provide a beneficial platform to model hereditary diseases and even cancer development. While the inc...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/9301382
更新日期:2019-02-25 00:00:00
abstract::Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two s...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/4247168
更新日期:2019-01-08 00:00:00
abstract:Purpose:To determine the effect of the isolation technique and location upon the phenotype of human corneal stroma-derived cells (CSCs). Methods:CSCs were isolated from the corneal stroma center and periphery using the explant or enzymatic digestion technique. The native tissue was stained for functional markers, whil...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/9275248
更新日期:2017-01-01 00:00:00
abstract::Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and ...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/4837930
更新日期:2018-01-18 00:00:00
abstract::This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD. We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey. Totally, 68 doses of bone marrow derived MSCs were infuse...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1641402
更新日期:2016-01-01 00:00:00
abstract::Tendon healing is fraught with complications such as reruptures and adhesion formation due to the formation of scar tissue at the injury site as opposed to the regeneration of native tissue. Stem cells are an attractive option in developing cell-based therapies to improve tendon healing. However, several questions rem...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/291431
更新日期:2012-01-01 00:00:00
abstract::Myocardial infarction is a leading cause of death among all cardiovascular diseases. Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs), expanded CD133+ cells, have promise as a therapeutic option for the treatment of ischemic areas after infarction. Recently, secreted membrane ve...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/4802578
更新日期:2019-12-01 00:00:00
abstract::Schwann cell (SC) transplantation as a cell-based therapy can enhance peripheral and central nerve repair experimentally, but it is limited by the donor site morbidity for clinical application. We investigated weather respiratory mucosa stem cells (REMSCs), a kind of ectomesenchymal stem cells (EMSCs), isolated from r...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/328957
更新日期:2015-01-01 00:00:00
abstract::In cholestatic liver diseases, impaired bile excretion disrupts lipid homeostasis. We investigated changes of lipid metabolism, including mitochondrial β-oxidation, in a rat model of bile duct ligation (BDL) in which chorionic plate-derived mesenchymal stem cells (CP-MSCs) were transplanted. Serum cholesterol level, w...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/5180579
更新日期:2017-01-01 00:00:00
abstract::Stem cells are a promising cell source for regenerative medicine. Stem cell differentiation must be regulated for applications in regenerative medicine. Stem cells are surrounded by extracellular matrix (ECM) in vivo. The ECM is composed of many types of proteins and glycosaminoglycans that assemble into a complex str...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/6397820
更新日期:2016-01-01 00:00:00
abstract:Aim:Few haematopoietic stem cells (HSCs) injected systemically for therapeutic purposes actually reach sites of injury as the vast majority become entrapped within pulmonary capillaries. One promising approach to maintain circulating HSC numbers would be to separate subpopulations with smaller size and/or greater defor...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/8540706
更新日期:2019-09-05 00:00:00
abstract::Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicability, both experimentally and in the clinic. These cells can be isolated from various human tissues that may differ anatomically or developmentally with relative ease. Heterogenei...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/246134
更新日期:2013-01-01 00:00:00
abstract::Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regul...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/1047896
更新日期:2020-07-08 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/7073805.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2020/4370849
更新日期:2020-08-21 00:00:00