Abstract:
:Osteoarthritis (OA) can be a debilitating degenerative disease and is the most common form of arthritic disease. There is a general consensus that current nonsurgical therapies are insufficient for younger OA sufferers who are not candidates for knee arthroplasties. Adipose-derived mesenchymal stem cells (MSCs) therapy for the treatment of OA can slow disease progression and lead to neocartilage formation. The mechanism of action is secretion driven. Current clinical preparations from adipose tissue for the treatment of OA include autologous stromal vascular fraction (SVF), SVF plus mature adipocytes, and culture-purified MSCs. Herein we have combined these human adipose-derived preparations with Hyaluronan (Hylan G-F 20: Synvisc) in vitro and measured alterations in cytokine profile. SVF plus mature adipocytes showed the greatest decreased in the proinflammatory cytokines IL-1β, IFN-γ, and VEGF. MCP-1 and MIP-1α decreased substantially in the SVF preparations but not the purified MSCs. The purified MSC preparation was the only one to show increase in MIF. Overall the SVF plus mature adipocytes preparation may be most suited of all the preparations for combination with HA for the treatment of OA, based on the alterations of heavily implicated cytokines in OA disease progression. This will require further validation using in vivo models.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Succar P,Breen EJ,Kuah D,Herbert BRdoi
10.1155/2015/421253subject
Has Abstractpub_date
2015-01-01 00:00:00pages
421253eissn
1687-966Xissn
1687-9678journal_volume
2015pub_type
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
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journal_title:Stem cells international
pub_type: 杂志文章
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journal_title:Stem cells international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5797521
更新日期:2016-01-01 00:00:00
abstract::Human eyelid adipose-derived stem cells (HEASCs) are a new source of autologous mesenchymal stem cells, which are derived from neuroectoderm and potentially applied in the tissue regeneration and cell therapies. Based on the prevalence of blepharoplasty in Asia and the availability of HEASCs, we investigated the effec...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/5654917
更新日期:2018-03-19 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/7564159
更新日期:2018-02-14 00:00:00
abstract::Following the discovery of pluripotent stem (PS) cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells, there has been a great hope that injured tissues can be repaired by transplantation of ES/iPS-derived various specific types of cells such as neural stem cells (NSCs). Although PS cells can be i...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2015/630693
更新日期:2015-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/9501747
更新日期:2018-07-18 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5785786
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/4078215
更新日期:2016-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions. However, aging-induced systemic homeostasis disorders in vivo and cell culture passaging in vitro induce a functional decline of MSCs, switching MSCs to a senescent status with...
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doi:10.1155/2020/8836258
更新日期:2020-09-10 00:00:00
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journal_title:Stem cells international
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更新日期:2019-09-05 00:00:00
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journal_title:Stem cells international
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doi:10.1155/2020/4242130
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/4247168
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/946090
更新日期:2012-01-01 00:00:00
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journal_title:Stem cells international
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更新日期:2018-02-28 00:00:00
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journal_title:Stem cells international
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更新日期:2018-04-03 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/3978595.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2017/9438310
更新日期:2017-01-01 00:00:00