The Effect of Age on the Regenerative Potential of Human Eyelid Adipose-Derived Stem Cells.

abstract：:Cardiovascular diseases (CVDs), including atherosclerosis, stroke, and myocardial infarction, is a major cause of death worldwide. In aspects of cell therapy against CVD, it is generally accepted that endothelial progenitor cells (EPCs) are potent neovascular modulators in ischemic tissues. In response to ischemic inj...

journal_title：Stem cells international

authors： Kim H,Kim S,Baek SH,Kwon SM

更新日期：2016-01-01 00:00:00

abstract：:Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...

journal_title：Stem cells international

authors： Guo H,Lei M,Li Y,Liu Y,Tang Y,Xing Y,Deng F,Yang K

更新日期：2017-01-01 00:00:00

abstract：:We previously found that human amniotic mesenchymal stem cells (hAMSCs) in coculture with CF immortalised airway epithelial cells (CFBE41o- line, CFBE) on Transwell® filters acquired an epithelial phenotype and led to the expression of a mature and functional CFTR protein. In order to explore the role of gap junction-...

journal_title：Stem cells international

authors： Carbone A,Zefferino R,Beccia E,Casavola V,Castellani S,Di Gioia S,Giannone V,Seia M,Angiolillo A,Colombo C,Favia M,Conese M

更新日期：2018-01-11 00:00:00

abstract：:Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenati...

journal_title：Stem cells international

authors： Kaur G,Cai C

更新日期：2018-03-29 00:00:00

abstract：:Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide t...

journal_title：Stem cells international

authors： Burke J,Kolhe R,Hunter M,Isales C,Hamrick M,Fulzele S

更新日期：2016-01-01 00:00:00

abstract：:Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM,...

journal_title：Stem cells international

authors： Okumura K,Shinohara M,Endo F

更新日期：2012-01-01 00:00:00

abstract：:We have determined the protective effects of Thymus serpyllum (TS) extract and nanoparticle-loaded TS on hydrogen peroxide-induced cell death of mesenchymal stromal cells (MSCs) in vitro. Gas chromatography-mass spectroscopy confirmed the spectrum of active components in the extract. Out of the three different extract...

journal_title：Stem cells international

authors： Baig S,Azizan AHS,Raghavendran HRB,Natarajan E,Naveen S,Murali MR,Nam HY,Kamarul T

更新日期：2019-02-26 00:00:00

abstract：:Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...

journal_title：Stem cells international

authors： Juhl M,Follin B,Gad M,Larsen J,Kastrup J,Ekblond A

更新日期：2020-10-26 00:00:00

abstract：:Blastocyst injection and morula aggregation are commonly used to evaluate stem cell pluripotency based on chimeric contribution of the stem cells. To assess the protocols for generating chimeras from stem cells, 8-cell mouse embryos were either injected or cocultured with mouse embryonic stem cells and induced pluripo...

journal_title：Stem cells international

authors： Guo J,Wu B,Li S,Bao S,Zhao L,Hu S,Sun W,Su J,Dai Y,Li X

更新日期：2014-01-01 00:00:00

abstract：:In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted centr...

journal_title：Stem cells international

authors： Catacchio I,Berardi S,Reale A,De Luisi A,Racanelli V,Vacca A,Ria R

更新日期：2013-01-01 00:00:00

abstract：Purpose:To investigate the efficacy of recombinant human collagen type I (RHC I) and collagen-like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of limbal epithelial stem cells (LESC) under xeno-free culture conditions. Methods:Human LESC were cultivated on seven different collagen-deri...

journal_title：Stem cells international

authors： Haagdorens M,Cėpla V,Melsbach E,Koivusalo L,Skottman H,Griffith M,Valiokas R,Zakaria N,Pintelon I,Tassignon MJ

更新日期：2019-04-01 00:00:00

abstract：Background:Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of liver failure with a high mortality. This study aimed at investigating the safety and efficacy of the combination treatment of plasma exchange (PE) and umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantatio...

journal_title：Stem cells international

authors： Xu WX,He HL,Pan SW,Chen YL,Zhang ML,Zhu S,Gao ZL,Peng L,Li JG

更新日期：2019-02-04 00:00:00

abstract：:Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two s...

journal_title：Stem cells international

authors： Zhou J,Chen Q,Zou Y,Zheng S,Chen Y

更新日期：2019-01-08 00:00:00

abstract：:Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled...

journal_title：Stem cells international

authors： Nicolosi PA,Tombetti E,Maugeri N,Rovere-Querini P,Brunelli S,Manfredi AA

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...

journal_title：Stem cells international

authors： Park M,Kim YH,Ryu JH,Woo SY,Ryu KH

更新日期：2015-01-01 00:00:00

abstract：Background:Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology. However, there is still considerable debate about the genotype and function of CAC. Methods and Results:Data from publicly available gene expression data sets were used to analyse the transcriptome of in vit...

journal_title：Stem cells international

authors： Everaert BR,Van Laere SJ,Lembrechts R,Hoymans VY,Timmermans JP,Vrints CJ

更新日期：2019-05-02 00:00:00

abstract：:Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...

journal_title：Stem cells international

authors： Choudry FA,Frontini M

更新日期：2016-01-01 00:00:00

abstract：:Infections of emerging and reemerging viruses (SARS-CoVs, influenza H1N1, etc.) largely and globally affect human health. Animal models often fail to reflect a physiological status because of species tropism of virus infection. Conventional cell lines are usually genetically and phenotypically different from primary c...

journal_title：Stem cells international

authors： Xia S,Liu J,Yang Y,Wu M,Ye L,Chen S,Zhang T,Zeng Z,Zhang K,Cai K,Long X,Gao W,Fang S,Li H

更新日期：2020-07-09 00:00:00

abstract：:Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and photoreceptor cells. We evaluated the potential of adipose-derived mesenchymal stem cells (ASCs) as a therapeutic tool by studying the migration capacity of ASCs in vitro and their protective effect against RPE cell death under oxidativ...

journal_title：Stem cells international

authors： Barzelay A,Weisthal Algor S,Niztan A,Katz S,Benhamou M,Nakdimon I,Azmon N,Gozlan S,Mezad-Koursh D,Neudorfer M,Goldstein M,Meilik B,Loewenstein A,Barak A

更新日期：2018-12-13 00:00:00

abstract：:Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels a...

journal_title：Stem cells international

authors： Keßler M,Just S,Rottbauer W

更新日期：2012-01-01 00:00:00

abstract：:Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. Some areas of skin are continuously exposed to a variety of environmental stressors that can inflict direct and indirect damage to skin cell DNA. Skin homeostasis is...

journal_title：Stem cells international

authors： Panich U,Sittithumcharee G,Rathviboon N,Jirawatnotai S

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. ...

journal_title：Stem cells international

authors： Chijimatsu R,Ikeya M,Yasui Y,Ikeda Y,Ebina K,Moriguchi Y,Shimomura K,Hart DA,Hideki Y,Norimasa N

更新日期：2017-01-01 00:00:00

abstract：:Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and ...

journal_title：Stem cells international

authors： Pogozhykh O,Prokopyuk V,Figueiredo C,Pogozhykh D

更新日期：2018-01-18 00:00:00

abstract：:Adipose tissues hold great promise in bone tissue engineering since they are available in large quantities as a waste material. The buccal fat pad (BFP) is a specialized adipose tissue that is easy to harvest and contains a rich blood supply, and its harvesting causes low complications for patients. This review focuse...

journal_title：Stem cells international

authors： Salehi-Nik N,Rezai Rad M,Kheiri L,Nazeman P,Nadjmi N,Khojasteh A

更新日期：2017-01-01 00:00:00

abstract：:Tumor microenvironment has been implicated in tumor development and progression. As a three-dimensional tumor microenvironment model, air liquid interface (ALI) organoid culture from oncogene transgenic mouse gastrointestinal tissues was recently produced. However, ALI organoid culture system from tissues of colorecta...

journal_title：Stem cells international

authors： Usui T,Sakurai M,Enjoji S,Kawasaki H,Umata K,Ohama T,Fujiwara N,Yabe R,Tsuji S,Yamawaki H,Hazama S,Takenouchi H,Nakajima M,Tsunedomi R,Suzuki N,Nagano H,Sato K

更新日期：2016-01-01 00:00:00

abstract：:Wnt signalling has been implicated in the regulation of stem cell self-renewal and differentiation; however, the majority of in vitro studies are carried out using monolayer 2D culture techniques. Here, we used mesenchymal stromal cell (MSC) EGFP reporter lines responsive to Wnt pathway activation in a 3D spheroid cul...

journal_title：Stem cells international

authors： Saleh F,Carstairs A,Etheridge SL,Genever P

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity. However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic. RSP...

journal_title：Stem cells international

authors： Liang C,Liang G,Zheng X,Huang Y,Huang S,Yin D

更新日期：2020-04-06 00:00:00

abstract：:Here, we aimed to answer important and fundamental questions in germ cell biology with special focus on the age of the male donor cells and the possibility to generate embryonic stem cell- (ESC-) like cells. While it is believed that spermatogonial stem cells (SSCs) and truly pluripotent ESC-like cells can be isolated...

journal_title：Stem cells international

authors： Azizi H,Conrad S,Hinz U,Asgari B,Nanus D,Peterziel H,Hajizadeh Moghaddam A,Baharvand H,Skutella T

更新日期：2016-01-01 00:00:00

abstract：Aim:Few haematopoietic stem cells (HSCs) injected systemically for therapeutic purposes actually reach sites of injury as the vast majority become entrapped within pulmonary capillaries. One promising approach to maintain circulating HSC numbers would be to separate subpopulations with smaller size and/or greater defor...

journal_title：Stem cells international

authors： Du M,Kavanagh D,Zhang Z,Kalia N

更新日期：2019-09-05 00:00:00

abstract：:Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...

journal_title：Stem cells international

authors： Mingliang R,Bo Z,Zhengguo W

更新日期：2011-01-01 00:00:00