Abstract：
:Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled with deficient angiogenesis leads to chronic hypoxia and tissue ischemia, enforcing a positive feed-forward loop sustaining vascular remodelling, further exacerbated by extracellular matrix accumulation due to fibrosis. Despite numerous developments and a growing number of controlled clinical trials no treatment has been shown so far to alter SSc natural history, outlining the need of further investigation in the molecular pathways involved in the pathogenesis of the disease. We review some processes potentially involved in SSc vasculopathy, with attention to the possible effect of sustained vascular inflammation on the plasticity of vascular cells. Specifically we focus on mesenchymal transition, a key phenomenon in the cardiac and vascular development as well as in the remodelling of injured vessels. Recent work supports the role of transforming growth factor-beta, Wnt, and Notch signaling in these processes. Importantly, endothelial-mesenchymal transition may be reversible, possibly offering novel cues for treatment.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Nicolosi PA,Tombetti E,Maugeri N,Rovere-Querini P,Brunelli S,Manfredi AAdoi
10.1155/2016/4636859subject
Has Abstractpub_date
2016-01-01 00:00:00pages
4636859eissn
1687-966Xissn
1687-9678journal_volume
2016pub_type
杂志文章,评审abstract：:The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blo...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2018/8620172
更新日期：2018-05-08 00:00:00
abstract：:Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a critical pathophysiological role and can be modula...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/3282656
更新日期：2017-01-01 00:00:00
abstract：:Hematopoietic stem cell transplantation (HSCT) is one of a range of therapeutic options available to patients suffering from various diseases. HSCT procedure involves important ethical and legal aspects that can occur at every phase of the procedure: the clinical choice of whether to perform the procedure, pretranspla...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/1286246
更新日期：2017-01-01 00:00:00
abstract：:Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated wit...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2014/376918
更新日期：2014-01-01 00:00:00
abstract：:Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/3175748
更新日期：2017-01-01 00:00:00
abstract：Materials and Methods:Ischemic brain injury was induced by dMCAO in Sprague-Dawley rats. The transplantation group received MSC infusion 1 h after dMCAO. Expression of IGF-1 in GFAP+ astrocytes, Iba-1+ microglia/macrophages, CD3+ lymphocytes, Ly6C+ monocytes/macrophages, and neutrophil elastase (NE)+ neutrophils was ex...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/8853444
更新日期：2020-09-01 00:00:00
abstract：:As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat degenerative diseases. Muscle differentiation is a multistep process...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/9245938
更新日期：2019-02-17 00:00:00
abstract：:Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM,...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/502136
更新日期：2012-01-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Bind...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/7943495
更新日期：2016-01-01 00:00:00
abstract：:Obesity, defined as a body mass index of 30 kg/m2 or above, has increased considerably in incidence and frequency within the United States and globally. Associated comorbidities including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease have led to a focus on t...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/4242130
更新日期：2020-06-10 00:00:00
abstract：:There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the di...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/9896142
更新日期：2018-12-25 00:00:00
abstract：:Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/3975689
更新日期：2019-09-03 00:00:00
abstract：:Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide t...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/5802529
更新日期：2016-01-01 00:00:00
abstract：:The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, an...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/1690896
更新日期：2016-01-01 00:00:00
abstract：:Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. Matrigel, derived from mouse sarcoma, has often been used as the supporting m...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/8472712
更新日期：2019-06-13 00:00:00
abstract：:Osteoarthritis (OA) can be a debilitating degenerative disease and is the most common form of arthritic disease. There is a general consensus that current nonsurgical therapies are insufficient for younger OA sufferers who are not candidates for knee arthroplasties. Adipose-derived mesenchymal stem cells (MSCs) therap...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2015/421253
更新日期：2015-01-01 00:00:00
abstract：:Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of the...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/4209891
更新日期：2016-01-01 00:00:00
abstract：:Hindlimb ischemia is still a clinical problem with high morbidity and mortality. Patients suffer from consequent rest pain, ulcers, cool limbs, and even amputation. Angiogenesis is a promising target for the treatment of ischemic limbs, providing extra blood for the ischemic region. In the present study, we investigat...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/9742034
更新日期：2016-01-01 00:00:00
abstract：:Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/5797521
更新日期：2016-01-01 00:00:00
abstract：:Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has significant potential as a novel treatment for many degenerative bone and joint diseases. Previous studies have established that age negatively affects the proliferation status and the osteogenic and chondrogenic differentiation potenti...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/2152435
更新日期：2016-01-01 00:00:00
abstract：:Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/2857478
更新日期：2017-01-01 00:00:00
abstract：Background:Aging is a major risk factor for cardiovascular disease. Cysteine protease cathepsin K (CatK) has been implicated in the process of angiogenesis, but the exact roles of individual CatK in vessel formation during aging are poorly understood. Methods and Results:To study the putative role of CatK in ischemia-...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/6938620
更新日期：2020-06-30 00:00:00
abstract：:We attempted transplantation of adult neural stem cells (ANSCs) inside an autologous venous graft following surgical transsection of nervis cruralis with 30 mm long gap in adult pig. The transplanted cell suspension was a primary culture of neurospheres from adult pig subventricular zone (SVZ) which had been labeled i...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/128732
更新日期：2012-01-01 00:00:00
abstract：:The magic angle effect increases the MRI signal of healthy tendon tissue and could be used for more detailed evaluation of tendon structure. Furthermore, it could support the discrimination of hypointense artefacts induced by contrast agents such as superparamagnetic iron oxide used for cell tracking. However, magic a...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/5670106
更新日期：2019-12-17 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into cells from the mesenchymal lineage. The hypoimmunogenic characteristic of MSCs has encouraged studies using allogeneic MSCs for the treatment of autoimmune diseases and inflammatory conditions. Promising preclinical results and the saf...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/9824698
更新日期：2017-01-01 00:00:00
abstract：:Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/5720758
更新日期：2016-01-01 00:00:00
abstract：:Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m(2) of cyclophosphamide (CFA) and 10 μg/kg/day of granulocyte colony stimulating factor (G-C...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/4078215
更新日期：2016-01-01 00:00:00
abstract：:Female infertility impacts the quality of life and well-being of affected individuals and couples. Female reproductive diseases, such as primary ovarian insufficiency, polycystic ovary syndrome, endometriosis, fallopian tube obstruction, and Asherman syndrome, can induce infertility. In recent years, translational med...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2019/9071720
更新日期：2019-12-06 00:00:00
abstract：:Intervertebral disc degeneration (IVD) is a frequent pathological condition. Conservative management often fails, and patients with IVD degeneration may require surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably e...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/921053
更新日期：2012-01-01 00:00:00
abstract：:There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC ...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2018/4516454
更新日期：2018-10-10 00:00:00
