Abstract：
:Hematopoietic stem cell transplantation (HSCT) is one of a range of therapeutic options available to patients suffering from various diseases. HSCT procedure involves important ethical and legal aspects that can occur at every phase of the procedure: the clinical choice of whether to perform the procedure, pretransplantation preparation regimens, donor selection, stem cell harvest procedure, transplantation phase, and short-term and long-term follow-up care. In this discussion paper, we outline the ethical issue-facing physicians involved in HSCT. Currently, HSCT is a widely accepted treatment for many life-threatening diseases. It thus represents a real therapeutic hope for many patients. It does, however, carry a burden of possible morbidity and mortality. Consequently, there are substantial information and communication issues involved in the consent process for HSCT. In the final decision, the judgements of different parties, such as patients, family members, and healthcare professionals, intersect and overlap and this is particularly true when the patient is a minor. Finally, HSCT is a very expensive procedure. The social and economic concerns of HSCT are discussed within the actual contextual framework of the dramatic increase in healthcare costs and inequalities in healthcare in relation to socioeconomic status, educational status, and ethnicity.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Liso A,Neri M,Maglietta F,La Russa R,Turillazzi Edoi
10.1155/2017/1286246subject
Has Abstractpub_date
2017-01-01 00:00:00pages
1286246eissn
1687-966Xissn
1687-9678journal_volume
2017pub_type
杂志文章,评审abstract：:The quality of life of patients with chronic wounds can be extremely poor and, therefore, over the past decades, great efforts have been made to develop efficient strategies to improve the healing process and the social impact associated with these conditions. Cell based therapy, as a modern tissue engineering strateg...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2015/195096
更新日期：2015-01-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/1960965
更新日期：2017-01-01 00:00:00
abstract：:Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in t...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2019/7513404
更新日期：2019-07-24 00:00:00
abstract：:Dental pulp tissue contains dental pulp stem cells (DPSCs). Dental pulp cells (also known as dental pulp-derived mesenchymal stem cells) are capable of differentiating into multilineage cells including neuron-like cells. The aim of this study was to examine the capability of DPSCs to differentiate into neuron-like cel...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2013/250740
更新日期：2013-01-01 00:00:00
abstract：:Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. Matrigel, derived from mouse sarcoma, has often been used as the supporting m...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/8472712
更新日期：2019-06-13 00:00:00
abstract：:Previously, we demonstrated a high quality of minerals formed by serum-free cultured jaw periosteal cells (JPCs) by Raman spectroscopy but the mineralization extent was not satisfactory. In the present study, we analyzed the proliferation and mineralization potential of human platelet lysate- (hPL-) cultured JPCs in c...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/8303959
更新日期：2017-01-01 00:00:00
abstract：Objective:To investigate the effects of mesenchymal stem cells (MSCs) coated by the extracellular matrix (ECM) on wound healing in diabetic rats. Methods:Mesenchymal stem cells were cocultured with ECM. Cell viabilities were evaluated using MTT assay. The diabetes model was established using both STZ and high-glucose/...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/9564869
更新日期：2019-01-28 00:00:00
abstract：Materials and Methods:Ischemic brain injury was induced by dMCAO in Sprague-Dawley rats. The transplantation group received MSC infusion 1 h after dMCAO. Expression of IGF-1 in GFAP+ astrocytes, Iba-1+ microglia/macrophages, CD3+ lymphocytes, Ly6C+ monocytes/macrophages, and neutrophil elastase (NE)+ neutrophils was ex...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/8853444
更新日期：2020-09-01 00:00:00
abstract：:Osteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenically. Icariin (ICA) is...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2019/5747298
更新日期：2019-04-04 00:00:00
abstract：:The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of ster...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/3134543
更新日期：2017-01-01 00:00:00
abstract：:Human bone marrow mesenchymal stem cells (hBM-MSCs) are the best characterized multipotent adult stem cells. Their self-renewal capacity, multilineage differentiation potential, and immunomodulatory properties have indicated that they can be used in many clinical therapies. In a previous work we studied the DNA methyl...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/5656701
更新日期：2016-01-01 00:00:00
abstract：:A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) causing lethal acute respiratory disease emerged in December 2019. The World Health Organization named this disease "COVID-19" and declared it a pandemic on March 11, 2020. Many studies have shown that mesenchymal stem cells (MSCs) and their exosomes (...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2020/8835986
更新日期：2020-09-24 00:00:00
abstract：:Current tissue engineering techniques are limited by inadequate vascularisation and perfusion of cell-scaffold constructs. Microstructural patterning through biomimetic vascular channels within a polymer scaffold might induce neovascularization, allowing fabrication of large engineered constructs. The network of vascu...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.4061/2011/547247
更新日期：2010-12-01 00:00:00
abstract：:Bone tissue regeneration is considered to be the optimal solution for bone loss. However, diabetic patients have a greater risk of poor bone healing or bone grafting failure than nondiabetics. The purpose of this study was to investigate the influence of the complexes of an adipose-derived stem cell sheet (ASC sheet) ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/2506463
更新日期：2019-07-31 00:00:00
abstract：:Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highl...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/2874283
更新日期：2017-01-01 00:00:00
abstract：:Stem cell therapy with neural precursor cells (NPCs) has the potential to improve neuroregeneration after spinal cord injury (SCI). Unfortunately, survival and differentiation of transplanted NPCs in the injured spinal cord remains low. Growth factors have been successfully used to improve NPC transplantation in anima...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/5674921
更新日期：2020-06-17 00:00:00
abstract：:Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m(2) of cyclophosphamide (CFA) and 10 μg/kg/day of granulocyte colony stimulating factor (G-C...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/4078215
更新日期：2016-01-01 00:00:00
abstract：:Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell ma...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/6705927
更新日期：2016-01-01 00:00:00
abstract：:The calcined tooth powder (CTP), a type of allogeneic biomimetic mineralized material, has been confirmed that can promote new bone formation when obtained at high temperature. The aim of this study was to investigate effects of the conditioned medium of calcined tooth powder (CTP-CM) on the osteogenic and odontogenic...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/4793518
更新日期：2019-03-19 00:00:00
abstract：Background:Ly6Chigh monocytes are inflammatory cells that accumulate in an infarcted myocardium, and Ly6Clow monocytes are believed to be reparative and curb myocardial remodeling. NR4A1 is a novel target for modulating the inflammatory phenotype of monocytes during atherogenesis. Objectives:We aimed to investigate wh...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/2460158
更新日期：2020-01-13 00:00:00
abstract：:Schwann cell (SC) transplantation as a cell-based therapy can enhance peripheral and central nerve repair experimentally, but it is limited by the donor site morbidity for clinical application. We investigated weather respiratory mucosa stem cells (REMSCs), a kind of ectomesenchymal stem cells (EMSCs), isolated from r...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2015/328957
更新日期：2015-01-01 00:00:00
abstract：:Intervertebral disc degeneration (IVD) is a frequent pathological condition. Conservative management often fails, and patients with IVD degeneration may require surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably e...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/921053
更新日期：2012-01-01 00:00:00
abstract：:Skeletal muscle has good regenerative capacity, but the extent of muscle injury and the developed fibrosis might prevent complete regeneration. The in vivo application of human mesenchymal stem cells (HMSCs) of the umbilical cord and the conditioned media (CM) where the HMSCs were cultured and expanded, associated wit...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2014/376918
更新日期：2014-01-01 00:00:00
abstract：:The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated. However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. In this study, our data showed that IL-1β induced LFA-1 e...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/7267142
更新日期：2019-12-27 00:00:00
abstract：:The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem ce...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/816049
更新日期：2012-01-01 00:00:00
abstract：:The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, an...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/1690896
更新日期：2016-01-01 00:00:00
abstract：:As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat degenerative diseases. Muscle differentiation is a multistep process...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/9245938
更新日期：2019-02-17 00:00:00
abstract：:Mesenchymal stem cells (MSCs) possess a capacity to enhance cutaneous wound healing that is well characterized. However, the therapeutic effect of MSCs appears to be limited. Modifying MSC target genes to increase necessary biological effects is a promising strategy for wound therapy. Interleukin-10 (IL-10) is an anti...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/9158016
更新日期：2019-06-11 00:00:00
abstract：:Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM,...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/502136
更新日期：2012-01-01 00:00:00
abstract：:Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. Despite several treatment options, AMD therapy remains difficult, especially for exudative AMD. Mul...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/946090
更新日期：2012-01-01 00:00:00
