Abstract:
:Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell maintenance and differentiation. There are two switches: an E3 ubiquitin ligase enzyme that tags ubiquitin molecules to the target proteins for proteolysis and a second enzyme, the deubiquitinating enzyme (DUBs), that performs the opposite action, thereby preventing proteolysis. In order to maintain stemness and to allow for efficient differentiation, both ubiquitination and deubiquitination molecular switches must operate properly in a balanced manner. In this review, we have summarized the importance of the ubiquitination of core stem cell transcription factors, such as Oct3/4, c-Myc, Sox2, Klf4, Nanog, and LIN28, during cellular reprogramming. Furthermore, we emphasize the role of DUBs in regulating core stem cell transcriptional factors and their function in stem cell maintenance and differentiation. We also discuss the possibility of using DUBs, along with core transcription factors, to efficiently generate induced pluripotent stem cells. Our review provides a relatively new understanding regarding the importance of ubiquitination/deubiquitination of stem cell transcription factors for efficient cellular reprogramming.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Suresh B,Lee J,Kim KS,Ramakrishna Sdoi
10.1155/2016/6705927subject
Has Abstractpub_date
2016-01-01 00:00:00pages
6705927eissn
1687-966Xissn
1687-9678journal_volume
2016pub_type
杂志文章,评审abstract::Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/9010279
更新日期:2016-01-01 00:00:00
abstract::Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4636859
更新日期:2016-01-01 00:00:00
abstract::Periodontal ligament stem cells (PDLSCs) possess self-renewal, multilineage differentiation, and immunomodulatory properties. They play a crucial role in maintaining periodontal homeostasis and also participated in orthodontic tooth movement (OTM). Various studies have applied controlled mechanical stimulation to PDLS...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/6531216
更新日期:2018-09-17 00:00:00
abstract::Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of gene expression. However, the specific roles of lncRNAs in stenotic lesions of arteriovenous fistula (AVF) failure are still largely unknown. We first analyzed the expression profiles of lncRNAs in human stenosed and n...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/4252974
更新日期:2017-01-01 00:00:00
abstract::Tumor hypoxia is associated with malignant biological phenotype including enhanced angiogenesis and metastasis. Hypoxia increases the expression of vascular endothelial cell growth factor (VEGF), which directly participates in angiogenesis by recruiting endothelial cells into hypoxic area and stimulating their prolife...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/6439864
更新日期:2016-01-01 00:00:00
abstract::Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has significant potential as a novel treatment for many degenerative bone and joint diseases. Previous studies have established that age negatively affects the proliferation status and the osteogenic and chondrogenic differentiation potenti...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/2152435
更新日期:2016-01-01 00:00:00
abstract::Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging population. OSA leads to hypoxia and upper airway muscle injury. However, l...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8412598
更新日期:2020-03-04 00:00:00
abstract::Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties vi...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/3057624
更新日期:2018-06-14 00:00:00
abstract::Vitamin D (Vit D) by means of its biological active form, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In thi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/6958713
更新日期:2018-02-28 00:00:00
abstract::Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends o...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/6129596
更新日期:2017-01-01 00:00:00
abstract::Articular cartilage defects have been addressed by using multiple strategies. In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). Howev...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9201492
更新日期:2016-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/106540
更新日期:2015-01-01 00:00:00
abstract::The cardiopulmonary system is made up of the heart and the lungs, with the core function of one complementing the other. The unimpeded and optimal cycling of blood between these two systems is pivotal to the overall function of the entire human body. Although the function of the cardiopulmonary system appears uncompli...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/3123961
更新日期:2018-04-29 00:00:00
abstract::There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC ...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/4516454
更新日期:2018-10-10 00:00:00
abstract::Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and ...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/4837930
更新日期:2018-01-18 00:00:00
abstract::Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicability, both experimentally and in the clinic. These cells can be isolated from various human tissues that may differ anatomically or developmentally with relative ease. Heterogenei...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/246134
更新日期:2013-01-01 00:00:00
abstract::Obesity, defined as a body mass index of 30 kg/m2 or above, has increased considerably in incidence and frequency within the United States and globally. Associated comorbidities including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease have led to a focus on t...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/4242130
更新日期:2020-06-10 00:00:00
abstract::Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in t...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/7513404
更新日期:2019-07-24 00:00:00
abstract::This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD. We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey. Totally, 68 doses of bone marrow derived MSCs were infuse...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1641402
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study is to explore why type 2 diabetes mellitus (T2DM) patients are susceptible to pulmonary tuberculosis through detection of serum Toll-like receptor 4 (TLR4), an important immune-related receptor, especially in terms of content and TLR4 gene polymorphism. Patients with T2DM complicated by pulmo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/8160318
更新日期:2016-01-01 00:00:00
abstract:Background:To reduce morbidity to cleft patients, new approaches have been developed and here, we report for the first time the use of deciduous dental pulp stem cells (DDPSC) associated with a hydroxyapatite-collagen sponge (Bio-Oss Collagen® 250 mg, Geistlich) for closing alveolar defects during secondary dental erup...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/6234167
更新日期:2020-03-12 00:00:00
abstract:Background:While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. In human studies, the ability to track transplanted cells has been limited to labeling with radioisotopes and tracking using nuclear...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2754927
更新日期:2019-11-14 00:00:00
abstract::Previous studies have demonstrated that myocardin-related transcription factor A (MRTF-A) generates a link between the dynamics of the actin cytoskeleton and gene expression with its coregulator, serum response factor (SRF). MRTF-A has also been suggested as a regulator of stem cell differentiation. However, the role ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8853541
更新日期:2020-09-22 00:00:00
abstract::Bone tissue regeneration is considered to be the optimal solution for bone loss. However, diabetic patients have a greater risk of poor bone healing or bone grafting failure than nondiabetics. The purpose of this study was to investigate the influence of the complexes of an adipose-derived stem cell sheet (ASC sheet) ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2506463
更新日期:2019-07-31 00:00:00
abstract::Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/2857478
更新日期:2017-01-01 00:00:00
abstract::The application of human bone marrow mesenchymal stem cells (hBM-MSCs) in cell-based clinical therapies is hindered by the limited number of cells remaining after the initial isolation process and by cellular senescence following in vitro expansion. Understanding the process of in vitro senescence in hBM-MSCs would en...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/7670316
更新日期:2019-07-11 00:00:00
abstract::Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity. However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic. RSP...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/7073805
更新日期:2020-04-06 00:00:00
abstract::Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after establishment of DES. Eye drops containing either bromodeoxyuridi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/250230
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/7073805.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2020/4370849
更新日期:2020-08-21 00:00:00
abstract::Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/1741072
更新日期:2016-01-01 00:00:00