Transplantation of Hypoxic-Preconditioned Bone Mesenchymal Stem Cells Retards Intervertebral Disc Degeneration via Enhancing Implanted Cell Survival and Migration in Rats.

abstract：:Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring i...

journal_title：Stem cells international

authors： Cimino M,Gonçalves RM,Barrias CC,Martins MCL

更新日期：2017-01-01 00:00:00

abstract：:The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors. In the present study, we analysed the presence of frizzled-4 in the enteric nervous system of human inf...

journal_title：Stem cells international

authors： Nothelfer K,Obermayr F,Belz N,Reinartz E,Bareiss PM,Bühring HJ,Beschorner R,Just L

更新日期：2016-01-01 00:00:00

abstract：:We attempted transplantation of adult neural stem cells (ANSCs) inside an autologous venous graft following surgical transsection of nervis cruralis with 30 mm long gap in adult pig. The transplanted cell suspension was a primary culture of neurospheres from adult pig subventricular zone (SVZ) which had been labeled i...

journal_title：Stem cells international

authors： Liard O,Segura S,Sagui E,Nau A,Pascual A,Cambon M,Darlix JL,Fusai T,Moyse E

更新日期：2012-01-01 00:00:00

abstract：:Wnt signalling has been implicated in the regulation of stem cell self-renewal and differentiation; however, the majority of in vitro studies are carried out using monolayer 2D culture techniques. Here, we used mesenchymal stromal cell (MSC) EGFP reporter lines responsive to Wnt pathway activation in a 3D spheroid cul...

journal_title：Stem cells international

authors： Saleh F,Carstairs A,Etheridge SL,Genever P

更新日期：2016-01-01 00:00:00

abstract：:Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging population. OSA leads to hypoxia and upper airway muscle injury. However, l...

journal_title：Stem cells international

authors： Zhu LY,Yu LM,Zhang WH,Deng JJ,Liu SF,Huang W,Zhang MH,Lu YQ,Han XX,Liu YH

更新日期：2020-03-04 00:00:00

abstract：:Due to their immunomodulatory and chemotactic properties, hMSC are being explored to treat immune-related diseases. For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was a...

journal_title：Stem cells international

authors： Blázquez-Prunera A,Almeida CR,Barbosa MA

更新日期：2017-01-01 00:00:00

abstract：:Sepsis, newly defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, is the most common cause of death in ICUs and one of the principal causes of death worldwide. Although substantial progress has been made in the understanding of fundamental mechanisms of sepsis, translat...

journal_title：Stem cells international

authors： Horák J,Nalos L,Martínková V,Beneš J,Štengl M,Matějovič M

更新日期：2017-01-01 00:00:00

abstract：:Three-dimensional (3D) cell culture has been reported to increase the therapeutic potentials of mesenchymal stem cells (MSCs). However, the action mechanisms of 3D MSCs vary greatly and are far from being thoroughly investigated. In this study, we aimed to investigate the therapeutic effects of 3D spheroids of human a...

journal_title：Stem cells international

authors： Zhang X,Hu MG,Pan K,Li CH,Liu R

更新日期：2016-01-01 00:00:00

abstract：:The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC) population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age-related muscle atrophy (sarcopenia) and several dystrophies, regeneration cannot compensate for the loss of muscle tissue. These diso...

journal_title：Stem cells international

authors： Pavlidou T,Marinkovic M,Rosina M,Fuoco C,Vumbaca S,Gargioli C,Castagnoli L,Cesareni G

更新日期：2019-04-24 00:00:00

abstract：:Cardiovascular diseases (CVDs), including atherosclerosis, stroke, and myocardial infarction, is a major cause of death worldwide. In aspects of cell therapy against CVD, it is generally accepted that endothelial progenitor cells (EPCs) are potent neovascular modulators in ischemic tissues. In response to ischemic inj...

journal_title：Stem cells international

authors： Kim H,Kim S,Baek SH,Kwon SM

更新日期：2016-01-01 00:00:00

abstract：:Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and str...

journal_title：Stem cells international

authors： Cui D,Li H,Xu X,Ye L,Zhou X,Zheng L,Zhou Y

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) derived from bone marrow can secrete cytokines and growth factors and can transdifferentiate into liver cells. We transplanted polymeric membrane bioencapsulated MSCs into the spleens of 90% partial hepatectomized rats. This resulted in 91.6% recovery rates. This is compared to a recovery...

journal_title：Stem cells international

authors： Liu ZC,Chang TM

更新日期：2012-01-01 00:00:00

abstract：:Efficient ex vivo expansion of hematopoietic stem cells with a concomitant preservation of stemness and self-renewal potential is still an unresolved ambition. Increased numbers of methods approaching this issue using three-dimensional (3D) cultures were reported. Here, we describe a simplified 3D hanging drop model f...

journal_title：Stem cells international

authors： Schmal O,Seifert J,Schäffer TE,Walter CB,Aicher WK,Klein G

更新日期：2016-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) play important roles in cell fate decisions. However, the miRNAs and their targets involved in the regulation of cardiac lineage specification are largely unexplored. Here, we report novel functions of miR-142-3p in the regulation of cardiomyocyte differentiation from mouse embryonic stem cells (mES...

journal_title：Stem cells international

authors： Chen ZY,Chen F,Cao N,Zhou ZW,Yang HT

更新日期：2017-01-01 00:00:00

abstract：:Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...

journal_title：Stem cells international

authors： Choudry FA,Frontini M

更新日期：2016-01-01 00:00:00

abstract：:Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues. However, DPSC senescence restricts its clinical applications. Metformin (Met), a common prescription drug for type 2 diabetes, is thought to influence the aging process. This study is aimed at determining the effects of metform...

journal_title：Stem cells international

authors： Zhang S,Zhang R,Qiao P,Ma X,Lu R,Wang F,Li C,E L,Liu H

更新日期：2021-01-06 00:00:00

abstract：:There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC ...

journal_title：Stem cells international

authors： Gener P,Seras-Franzoso J,Callejo PG,Andrade F,Rafael D,Martínez F,Montero S,Arango D,Sayós J,Abasolo I,Schwartz S Jr

更新日期：2018-10-10 00:00:00

abstract：:Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...

journal_title：Stem cells international

authors： Juhl M,Follin B,Gad M,Larsen J,Kastrup J,Ekblond A

更新日期：2020-10-26 00:00:00

abstract：:Human eyelid adipose-derived stem cells (HEASCs) are a new source of autologous mesenchymal stem cells, which are derived from neuroectoderm and potentially applied in the tissue regeneration and cell therapies. Based on the prevalence of blepharoplasty in Asia and the availability of HEASCs, we investigated the effec...

journal_title：Stem cells international

authors： Zhang M,Wang Z,Zhao Y,Zhang L,Xu L,Cao L,He W

更新日期：2018-03-19 00:00:00

abstract：:The purpose of this study is to determine if patients with chronic patellar tendinopathy will improve clinically after the inoculation of bone marrow mononuclear cells (BM-MNCs). Eight patients with chronic patellar tendinopathy were included. Patients averaged 24 years old (range 14-35). All patients were refractory ...

journal_title：Stem cells international

authors： Pascual-Garrido C,Rolón A,Makino A

更新日期：2012-01-01 00:00:00

abstract：Background:Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of liver failure with a high mortality. This study aimed at investigating the safety and efficacy of the combination treatment of plasma exchange (PE) and umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantatio...

journal_title：Stem cells international

authors： Xu WX,He HL,Pan SW,Chen YL,Zhang ML,Zhu S,Gao ZL,Peng L,Li JG

更新日期：2019-02-04 00:00:00

abstract：:Schwann cell (SC) transplantation as a cell-based therapy can enhance peripheral and central nerve repair experimentally, but it is limited by the donor site morbidity for clinical application. We investigated weather respiratory mucosa stem cells (REMSCs), a kind of ectomesenchymal stem cells (EMSCs), isolated from r...

journal_title：Stem cells international

authors： Zhang J,Gao X,Zou H,Liu J,Zhang Z

更新日期：2015-01-01 00:00:00

abstract：:Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood. In this study, we investigated the role of EphB4 in regulating the expression of periostin (POSTN) within bone marrow-derived mese...

journal_title：Stem cells international

authors： Zhang F,Zhang Z,Sun D,Dong S,Xu J,Dai F

更新日期：2016-01-01 00:00:00

abstract：:Beer is one of the most consumed alcoholic beverages in the world, rich in chemical compounds of natural origin with high nutritional and biological value. It is made up of water, barley malt, hops, and yeast. The main nutrients are carbohydrates, amino acids, minerals, vitamins, and other compounds such as polyphenol...

journal_title：Stem cells international

authors： Di Domenico M,Feola A,Ambrosio P,Pinto F,Galasso G,Zarrelli A,Di Fabio G,Porcelli M,Scacco S,Inchingolo F,Quagliuolo L,Ballini A,Boccellino M

更新日期：2020-10-10 00:00:00

abstract：:Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. Matrigel, derived from mouse sarcoma, has often been used as the supporting m...

journal_title：Stem cells international

authors： Jee JH,Lee DH,Ko J,Hahn S,Jeong SY,Kim HK,Park E,Choi SY,Jeong S,Lee JW,Cho HJ,Kwon MS,Yoo J

更新日期：2019-06-13 00:00:00

abstract：:Intestinal stem cells are located at the base of the crypts and are surrounded by a complex structure called niche. This environment is composed mainly of epithelial cells and stroma which provides signals that govern cell maintenance, proliferation, and differentiation. Understanding how the niche regulates stem cell...

journal_title：Stem cells international

authors： Gjorevski N,Ordóñez-Morán P

更新日期：2017-01-01 00:00:00

abstract：:Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepato...

journal_title：Stem cells international

authors： Pradip A,Steel D,Jacobsson S,Holmgren G,Ingelman-Sundberg M,Sartipy P,Björquist P,Johansson I,Edsbagge J

更新日期：2016-01-01 00:00:00

abstract：:Metabolism is central to embryonic stem cell (ESC) pluripotency and differentiation, with distinct profiles apparent under different nutrient milieu, and conditions that maintain alternate cell states. The significance of altered nutrient availability, particularly oxygen, and metabolic pathway activity has been highl...

journal_title：Stem cells international

authors： Lees JG,Gardner DK,Harvey AJ

更新日期：2017-01-01 00:00:00

abstract：:A growing body of evidence supports the argument that bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into cardiomyocyte-like cells in an appropriate cellular environment, but the differentiation rate is low. A cocktail method was designed: we investigated the role of 5-azacytidine (5-aza), salvian...

journal_title：Stem cells international

authors： Gao Q,Guo M,Jiang X,Hu X,Wang Y,Fan Y

更新日期：2014-01-01 00:00:00

abstract：:The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blo...

journal_title：Stem cells international

authors： Notara M,Lentzsch A,Coroneo M,Cursiefen C

更新日期：2018-05-08 00:00:00