Concise Review: Are Stimulated Somatic Cells Truly Reprogrammed into an ES/iPS-Like Pluripotent State? Better Understanding by Ischemia-Induced Multipotent Stem Cells in a Mouse Model of Cerebral Infarction.

abstract：:Mutations in WD40-repeat protein 62 (WDR62) are commonly associated with primary microcephaly and other developmental cortical malformations. We used human pluripotent stem cells (hPSC) to examine WDR62 function during human neural differentiation and model early stages of human corticogenesis. Neurospheres lacking WD...

journal_title：Stem cells international

authors： Alshawaf AJ,Antonic A,Skafidas E,Ng DC,Dottori M

更新日期：2017-01-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for tr...

journal_title：Stem cells international

authors： Zhu J,Xiao Y,Li Z,Han F,Xiao T,Zhang Z,Geng F

更新日期：2015-01-01 00:00:00

abstract：:Previously, we demonstrated a high quality of minerals formed by serum-free cultured jaw periosteal cells (JPCs) by Raman spectroscopy but the mineralization extent was not satisfactory. In the present study, we analyzed the proliferation and mineralization potential of human platelet lysate- (hPL-) cultured JPCs in c...

journal_title：Stem cells international

authors： Wanner Y,Umrath F,Waidmann M,Reinert S,Alexander D

更新日期：2017-01-01 00:00:00

abstract：:Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regul...

journal_title：Stem cells international

authors： Jiang S,Guo Y

更新日期：2020-07-08 00:00:00

abstract：:Obesity, defined as a body mass index of 30 kg/m2 or above, has increased considerably in incidence and frequency within the United States and globally. Associated comorbidities including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease have led to a focus on t...

journal_title：Stem cells international

authors： Bender R,McCarthy M,Brown T,Bukowska J,Smith S,Abbott RD,Kaplan DL,Williams C,Wade JW,Alarcon A,Wu X,Lau F,Gimble JM,Frazier T

更新日期：2020-06-10 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) offering valuable anticipations for the treatment of degenerative diseases. They can be found in many tissues including amnion. MSCs from amnion (AM-MSCs) can differentiate into osteoblast similar to that of bone marrow-derived MSCs (BM-MSCs). However, the ability is not much efficient...

journal_title：Stem cells international

authors： Manochantr S,Marupanthorn K,Tantrawatpan C,Kheolamai P,Tantikanlayaporn D,Sanguanjit P

更新日期：2017-01-01 00:00:00

abstract：:The application of human bone marrow mesenchymal stem cells (hBM-MSCs) in cell-based clinical therapies is hindered by the limited number of cells remaining after the initial isolation process and by cellular senescence following in vitro expansion. Understanding the process of in vitro senescence in hBM-MSCs would en...

journal_title：Stem cells international

authors： Xu Z,Wu W,Shen F,Yu Y,Wang Y,Xiang C

更新日期：2019-07-11 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are one of the main stem cells that have been used for advanced therapies and regenerative medicine. To carry out the translational clinical application of MSCs, their manufacturing and administration in human must be controlled; therefore they should be considered as medicine: stem cell-...

journal_title：Stem cells international

authors： Galvez-Martin P,Sabata R,Verges J,Zugaza JL,Ruiz A,Clares B

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2015/496512.]. ...

journal_title：Stem cells international

authors： Sasi SP,Park D,Muralidharan S,Wage J,Kiladjian A,Onufrak J,Enderling H,Yan X,Goukassian DA

更新日期：2016-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...

journal_title：Stem cells international

authors： Marketou ME,Parthenakis F,Vardas PE

更新日期：2016-01-01 00:00:00

abstract：:Calcium phosphate- (CaP-) based composite scaffolds have been used extensively for the bone regeneration in bone tissue engineering. Previously, we developed a biomimetic composite nanofibrous membrane of gelatin/β-tricalcium phosphate (TCP) and confirmed their biological activity in vitro and bone regeneration in viv...

journal_title：Stem cells international

authors： Zhang X,Meng S,Huang Y,Xu M,He Y,Lin H,Han J,Chai Y,Wei Y,Deng X

更新日期：2015-01-01 00:00:00

abstract：:The objective of this paper is to describe in detail the method of organotypic longitudinal spinal cord slice culture and the scientific basis for its potential utility. The technique is based on the interface method, which was described previously and thereafter was modified in our laboratory. The most important adva...

journal_title：Stem cells international

authors： Sypecka J,Koniusz S,Kawalec M,Sarnowska A

更新日期：2015-01-01 00:00:00

abstract：:Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem ...

journal_title：Stem cells international

authors： Xu L,Zhou J,Liu J,Liu Y,Wang L,Jiang R,Diao Z,Yan G,Pèault B,Sun H,Ding L

更新日期：2017-01-01 00:00:00

abstract：:Human embryonic stem cells (hESCs) are being utilized in diverse areas of studies such as development and disease modeling, cell replacement therapy, or drug toxicity testing because of their potential to be differentiated into any cell type in the body. The directed differentiation of hESCs into hepatocytes could pro...

journal_title：Stem cells international

authors： Varghese DS,Alawathugoda TT,Ansari SA

更新日期：2019-01-22 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a hip disorder, and it threatens patients who require megadose of steroid therapies. Nowadays, no valid therapies can reverse the development of GC-induced ONFH once it occurs. Stem cell therapy to GC-induced ONFH would be a promising choice. Although ...

journal_title：Stem cells international

authors： Zhun W,Donghai L,Zhouyuan Y,Haiyan Z,Pengde K

更新日期：2018-05-22 00:00:00

abstract：:Left-right symmetry breaking is a complex developmental process and an important part of embryonic axis development. As of yet, the biophysical mechanism behind LR asymmetry establishment remains elusive for the overall asymmetry of embryos as well as for the organ-specific asymmetry. Here, we demonstrate that inheren...

journal_title：Stem cells international

authors： Worley KE,Chin AS,Wan LQ

更新日期：2018-12-02 00:00:00

abstract：:Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two s...

journal_title：Stem cells international

authors： Zhou J,Chen Q,Zou Y,Zheng S,Chen Y

更新日期：2019-01-08 00:00:00

abstract：Materials and Methods:Ischemic brain injury was induced by dMCAO in Sprague-Dawley rats. The transplantation group received MSC infusion 1 h after dMCAO. Expression of IGF-1 in GFAP+ astrocytes, Iba-1+ microglia/macrophages, CD3+ lymphocytes, Ly6C+ monocytes/macrophages, and neutrophil elastase (NE)+ neutrophils was ex...

journal_title：Stem cells international

authors： Li X,Yu W,Guan Y,Zou H,Liang Z,Huang M,Zhao R,Zhao C,Ren Z,Chen Z

更新日期：2020-09-01 00:00:00

abstract：:In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin. Recently, surprising new findings have contradicted centr...

journal_title：Stem cells international

authors： Catacchio I,Berardi S,Reale A,De Luisi A,Racanelli V,Vacca A,Ria R

更新日期：2013-01-01 00:00:00

abstract：:We attempted transplantation of adult neural stem cells (ANSCs) inside an autologous venous graft following surgical transsection of nervis cruralis with 30 mm long gap in adult pig. The transplanted cell suspension was a primary culture of neurospheres from adult pig subventricular zone (SVZ) which had been labeled i...

journal_title：Stem cells international

authors： Liard O,Segura S,Sagui E,Nau A,Pascual A,Cambon M,Darlix JL,Fusai T,Moyse E

更新日期：2012-01-01 00:00:00

abstract：:Dental pulp tissue contains dental pulp stem cells (DPSCs). Dental pulp cells (also known as dental pulp-derived mesenchymal stem cells) are capable of differentiating into multilineage cells including neuron-like cells. The aim of this study was to examine the capability of DPSCs to differentiate into neuron-like cel...

journal_title：Stem cells international

authors： Zainal Ariffin SH,Kermani S,Zainol Abidin IZ,Megat Abdul Wahab R,Yamamoto Z,Senafi S,Zainal Ariffin Z,Abdul Razak M

更新日期：2013-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicability, both experimentally and in the clinic. These cells can be isolated from various human tissues that may differ anatomically or developmentally with relative ease. Heterogenei...

journal_title：Stem cells international

authors： Christodoulou I,Kolisis FN,Papaevangeliou D,Zoumpourlis V

更新日期：2013-01-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) belongs to multipotent adult somatic stem cells. A single HSC can reconstitute the entire blood system via self-renewal, differentiation into all lineages of blood cells, and replenishment of cells lost due to attrition or disease in a person's lifetime. Although all blood and immune cell...

journal_title：Stem cells international

authors： Zhang J,Crumpacker C

更新日期：2015-01-01 00:00:00

abstract：:Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...

journal_title：Stem cells international

authors： Juhl M,Follin B,Gad M,Larsen J,Kastrup J,Ekblond A

更新日期：2020-10-26 00:00:00

abstract：:Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. Matrigel, derived from mouse sarcoma, has often been used as the supporting m...

journal_title：Stem cells international

authors： Jee JH,Lee DH,Ko J,Hahn S,Jeong SY,Kim HK,Park E,Choi SY,Jeong S,Lee JW,Cho HJ,Kwon MS,Yoo J

更新日期：2019-06-13 00:00:00

abstract：:A previous study reported the structural characterization of biogenic apatite (BAp) thin films realized by a pulsed electron deposition system by ablation of deproteinized bovine bone. Thin films annealed at 400°C exhibited composition and crystallinity degree very close to those of biogenic apatite; this affinity is ...

journal_title：Stem cells international

authors： Bianchi M,Pisciotta A,Bertoni L,Berni M,Gambardella A,Visani A,Russo A,de Pol A,Carnevale G

更新日期：2017-01-01 00:00:00

abstract：:The quality of life of patients with chronic wounds can be extremely poor and, therefore, over the past decades, great efforts have been made to develop efficient strategies to improve the healing process and the social impact associated with these conditions. Cell based therapy, as a modern tissue engineering strateg...

journal_title：Stem cells international

authors： Galateanu B,Bunea MC,Stanescu P,Vasile E,Casarica A,Iovu H,Hermenean A,Zaharia C,Costache M

更新日期：2015-01-01 00:00:00

abstract：:Tumor microenvironment has been implicated in tumor development and progression. As a three-dimensional tumor microenvironment model, air liquid interface (ALI) organoid culture from oncogene transgenic mouse gastrointestinal tissues was recently produced. However, ALI organoid culture system from tissues of colorecta...

journal_title：Stem cells international

authors： Usui T,Sakurai M,Enjoji S,Kawasaki H,Umata K,Ohama T,Fujiwara N,Yabe R,Tsuji S,Yamawaki H,Hazama S,Takenouchi H,Nakajima M,Tsunedomi R,Suzuki N,Nagano H,Sato K

更新日期：2016-01-01 00:00:00

abstract：:Adipose-derived stem cells (ASCs) are a promising therapeutic alternative for tissue repair in various clinical applications. However, restrictive cell survival, differential tissue integration, and undirected cell differentiation after transplantation in a hostile microenvironment are complications that require refin...

journal_title：Stem cells international

authors： Mellado-López M,Griffeth RJ,Meseguer-Ripolles J,Cugat R,García M,Moreno-Manzano V

更新日期：2017-01-01 00:00:00

abstract：:Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels a...

journal_title：Stem cells international

authors： Keßler M,Just S,Rottbauer W

更新日期：2012-01-01 00:00:00