Abstract:
:This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD. We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey. Totally, 68 doses of bone marrow derived MSCs were infused. The median dose of MSC was 1.18 × 10(6) cells per kg body weight. Overall, complete response (CR) was documented in 18 patients, partial response (PR) was documented in 7 patients, and no response (NR) was documented in 8 patients. The 2-year estimated probability of overall survival (OS) for patients achieving CR and PR/NR was 63.8% and 29.4%, respectively (p = 0.0002). While the cumulative incidence of transplant related mortality (TRM) at day 100 after first MSC infusion was 46.6% in PR/NR patients, there was no any TRM at day 100 after first MSC infusion in CR patients (p = 0.001). Twelve patients developed chronic GVHD (cGVHD); eight of them were alive, with five having extensive disease and three having limited disease. In conclusion, MSCs appear to be safe and effective treatment option for pediatric patients with steroid refractory aGVHD. But the efficacy of MSCs on cGVHD in aGVHD patients treated with MSCs seems to be limited.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Erbey F,Atay D,Akcay A,Ovali E,Ozturk Gdoi
10.1155/2016/1641402subject
Has Abstractpub_date
2016-01-01 00:00:00pages
1641402eissn
1687-966Xissn
1687-9678journal_volume
2016pub_type
杂志文章abstract::Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity. However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic. RSP...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/7073805
更新日期:2020-04-06 00:00:00
abstract::Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development from neural precur...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9260592
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
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journal_title:Stem cells international
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abstract::Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are characterized by their unique capacity to stepwise differentiate towards any particular cell type in an adult organism. Pluripotent stem cells provide a beneficial platform to model hereditary diseases and even cancer development. While the inc...
journal_title:Stem cells international
pub_type: 杂志文章,评审
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journal_title:Stem cells international
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/430138
更新日期:2012-01-01 00:00:00
abstract::Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/5034679
更新日期:2018-03-11 00:00:00
abstract::Articular cartilage defects have been addressed by using multiple strategies. In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). Howev...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9201492
更新日期:2016-01-01 00:00:00
abstract::Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regul...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/1047896
更新日期:2020-07-08 00:00:00
abstract:Background:Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to pr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/7813729
更新日期:2018-04-03 00:00:00
abstract::A major challenge in cartilage repair is the lack of chondrogenic cells migrating from healthy tissue into damaged areas and strategies to promote this should be developed. The aim of this study was to evaluate the effect of peripheral blood derived mononuclear cell (PBMC) stimulation on mesenchymal stromal cells (MSC...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/323454
更新日期:2015-01-01 00:00:00
abstract:Aim:Few haematopoietic stem cells (HSCs) injected systemically for therapeutic purposes actually reach sites of injury as the vast majority become entrapped within pulmonary capillaries. One promising approach to maintain circulating HSC numbers would be to separate subpopulations with smaller size and/or greater defor...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/8540706
更新日期:2019-09-05 00:00:00
abstract::The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem ce...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/816049
更新日期:2012-01-01 00:00:00
abstract::Traditionally, human embryonic stem cells (hESCs) are cultured on inactivated live feeder cells. For clinical application using hESCs, there is a requirement to minimize the risk of contamination with animal components. Extracellular matrix (ECM) derived from feeder cells is the most natural way to provide xeno-free s...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/621057
更新日期:2015-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/3215962
更新日期:2017-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2017/2601746
更新日期:2017-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/7073805.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2020/4370849
更新日期:2020-08-21 00:00:00
abstract::MicroRNAs (miRNAs) play important roles in cell fate decisions. However, the miRNAs and their targets involved in the regulation of cardiac lineage specification are largely unexplored. Here, we report novel functions of miR-142-3p in the regulation of cardiomyocyte differentiation from mouse embryonic stem cells (mES...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/1769298
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abstract::Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues. However, DPSC senescence restricts its clinical applications. Metformin (Met), a common prescription drug for type 2 diabetes, is thought to influence the aging process. This study is aimed at determining the effects of metform...
journal_title:Stem cells international
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journal_title:Stem cells international
pub_type: 杂志文章
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abstract::The lung is a radiosensitive organ, which imposes limits on the therapeutic dose in thoracic radiotherapy. Irradiated alveolar epithelial cells promote radiation-related pneumonitis and fibrosis. However, the role of lung stem cells (LSCs) in the development of radiation-induced lung injury is still unclear. In this s...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/6312053
更新日期:2020-09-29 00:00:00
abstract::Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepato...
journal_title:Stem cells international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract::Tendinopathy is a tendon disorder characterized by activity-related pain, local edema, focal tenderness to palpation, and decreased strength in the affected area. Tendinopathy is prevalent in both athletes and the general population, highlighting the need to elucidate the pathogenesis of this disorder. Current treatme...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4076578
更新日期:2016-01-01 00:00:00
abstract::Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and t...
journal_title:Stem cells international
pub_type: 杂志文章
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abstract::Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriv...
journal_title:Stem cells international
pub_type: 杂志文章,评审
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abstract::Exosomes derived from cancer cells can affect various functions of mesenchymal stem cells (MSCs) via conveying microRNAs (miRs). miR-21 and miR-146a have been demonstrated to regulate MSC proliferation and transformation. Interleukin-6 (IL-6) secreted from transformed MSCs in turn favors the survival of multiple myelo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/9012152
更新日期:2017-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/1960965
更新日期:2017-01-01 00:00:00