Radiation Induces Pulmonary Fibrosis by Promoting the Fibrogenic Differentiation of Alveolar Stem Cells.

abstract：:Hematopoietic stem cell transplantation (HSCT) is one of a range of therapeutic options available to patients suffering from various diseases. HSCT procedure involves important ethical and legal aspects that can occur at every phase of the procedure: the clinical choice of whether to perform the procedure, pretranspla...

journal_title：Stem cells international

authors： Liso A,Neri M,Maglietta F,La Russa R,Turillazzi E

更新日期：2017-01-01 00:00:00

abstract：:There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the di...

journal_title：Stem cells international

authors： Lim HK,Periasamy P,O'Neill HC

更新日期：2018-12-25 00:00:00

abstract：:Articular cartilage defects have been addressed by using multiple strategies. In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). Howev...

journal_title：Stem cells international

authors： Deng Z,Jin J,Zhao J,Xu H

更新日期：2016-01-01 00:00:00

abstract：:Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. Evidence suggests that mesenchymal stem ce...

journal_title：Stem cells international

authors： Cappetta D,De Angelis A,Spaziano G,Tartaglione G,Piegari E,Esposito G,Ciuffreda LP,Liparulo A,Sgambato M,Russo TP,Rossi F,Berrino L,Urbanek K,D'Agostino B

更新日期：2018-03-14 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions. However, aging-induced systemic homeostasis disorders in vivo and cell culture passaging in vitro induce a functional decline of MSCs, switching MSCs to a senescent status with...

journal_title：Stem cells international

authors： Wang R,Wang Y,Zhu L,Liu Y,Li W

更新日期：2020-09-10 00:00:00

abstract：:In recent years several genes have linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) as a spectrum disease; however little is known about what triggers their onset. With the ability to generate patient specific stem cell lines from somatic cells, it is possible to model disease without the n...

journal_title：Stem cells international

authors： Hedges EC,Mehler VJ,Nishimura AL

更新日期：2016-01-01 00:00:00

abstract：:Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time poi...

journal_title：Stem cells international

authors： Ni Y,Cai K,Hu Y,Wang CH,Zhang Y,Huang H,Su X,Gu JH

更新日期：2018-04-05 00:00:00

abstract：:Urine has become the source of choice for noninvasive renal epithelial cells and renal stem cells which can be used for generating induced pluripotent stem cells. The aim of this study was to generate a 3D nephrogenic progenitor cell model composed of three distinct cell types-urine-derived SIX2-positive renal progeni...

journal_title：Stem cells international

authors： Nguyen L,Spitzhorn LS,Adjaye J

更新日期：2019-05-02 00:00:00

abstract：Purpose:To investigate the efficacy of recombinant human collagen type I (RHC I) and collagen-like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of limbal epithelial stem cells (LESC) under xeno-free culture conditions. Methods:Human LESC were cultivated on seven different collagen-deri...

journal_title：Stem cells international

authors： Haagdorens M,Cėpla V,Melsbach E,Koivusalo L,Skottman H,Griffith M,Valiokas R,Zakaria N,Pintelon I,Tassignon MJ

更新日期：2019-04-01 00:00:00

abstract：Purpose:To determine the effect of the isolation technique and location upon the phenotype of human corneal stroma-derived cells (CSCs). Methods:CSCs were isolated from the corneal stroma center and periphery using the explant or enzymatic digestion technique. The native tissue was stained for functional markers, whil...

journal_title：Stem cells international

authors： Nagymihály R,Veréb Z,Facskó A,Moe MC,Petrovski G

更新日期：2017-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties vi...

journal_title：Stem cells international

authors： Wang M,Yuan Q,Xie L

更新日期：2018-06-14 00:00:00

abstract：Background:While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. In human studies, the ability to track transplanted cells has been limited to labeling with radioisotopes and tracking using nuclear...

journal_title：Stem cells international

authors： Mathiasen AB,Qayyum AA,Jørgensen E,Helqvist S,Ekblond A,Ng M,Bhakoo K,Kastrup J

更新日期：2019-11-14 00:00:00

abstract：:Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. Despite several treatment options, AMD therapy remains difficult, especially for exudative AMD. Mul...

journal_title：Stem cells international

authors： Nuzzi R,Gunetti M,Rustichelli D,Roagna B,Fronticelli Bardelli F,Fagioli F,Ferrero I

更新日期：2012-01-01 00:00:00

abstract：:Exosomes derived from cancer cells can affect various functions of mesenchymal stem cells (MSCs) via conveying microRNAs (miRs). miR-21 and miR-146a have been demonstrated to regulate MSC proliferation and transformation. Interleukin-6 (IL-6) secreted from transformed MSCs in turn favors the survival of multiple myelo...

journal_title：Stem cells international

authors： Cheng Q,Li X,Liu J,Ye Q,Chen Y,Tan S,Liu J

更新日期：2017-01-01 00:00:00

abstract：:Vitamin D (Vit D) by means of its biological active form, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), has a protective effect on the skeleton by acting on calcium homeostasis and bone formation. Furthermore, Vit D has a direct effect on mesenchymal stem cells (MSCs) in stimulating their osteogenic differentiation. In thi...

journal_title：Stem cells international

authors： Posa F,Di Benedetto A,Cavalcanti-Adam EA,Colaianni G,Porro C,Trotta T,Brunetti G,Lo Muzio L,Grano M,Mori G

更新日期：2018-02-28 00:00:00

abstract：:Calcium phosphate- (CaP-) based composite scaffolds have been used extensively for the bone regeneration in bone tissue engineering. Previously, we developed a biomimetic composite nanofibrous membrane of gelatin/β-tricalcium phosphate (TCP) and confirmed their biological activity in vitro and bone regeneration in viv...

journal_title：Stem cells international

authors： Zhang X,Meng S,Huang Y,Xu M,He Y,Lin H,Han J,Chai Y,Wei Y,Deng X

更新日期：2015-01-01 00:00:00

abstract：Background:Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of liver failure with a high mortality. This study aimed at investigating the safety and efficacy of the combination treatment of plasma exchange (PE) and umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantatio...

journal_title：Stem cells international

authors： Xu WX,He HL,Pan SW,Chen YL,Zhang ML,Zhu S,Gao ZL,Peng L,Li JG

更新日期：2019-02-04 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a hip disorder, and it threatens patients who require megadose of steroid therapies. Nowadays, no valid therapies can reverse the development of GC-induced ONFH once it occurs. Stem cell therapy to GC-induced ONFH would be a promising choice. Although ...

journal_title：Stem cells international

authors： Zhun W,Donghai L,Zhouyuan Y,Haiyan Z,Pengde K

更新日期：2018-05-22 00:00:00

abstract：:Female infertility impacts the quality of life and well-being of affected individuals and couples. Female reproductive diseases, such as primary ovarian insufficiency, polycystic ovary syndrome, endometriosis, fallopian tube obstruction, and Asherman syndrome, can induce infertility. In recent years, translational med...

journal_title：Stem cells international

authors： Zhao YX,Chen SR,Su PP,Huang FH,Shi YC,Shi QY,Lin S

更新日期：2019-12-06 00:00:00

abstract：:Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand...

journal_title：Stem cells international

authors： Valerie A,Vassiliki K,Irini M,Nikolaos P,Karampela E,Apostolos P

更新日期：2016-01-01 00:00:00

abstract：:During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or r...

journal_title：Stem cells international

authors： Dey D,Evans GR

更新日期：2011-01-01 00:00:00

abstract：:Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of gene expression. However, the specific roles of lncRNAs in stenotic lesions of arteriovenous fistula (AVF) failure are still largely unknown. We first analyzed the expression profiles of lncRNAs in human stenosed and n...

journal_title：Stem cells international

authors： Lv L,Qi H,Guo X,Ni Q,Yan Z,Zhang L

更新日期：2017-01-01 00:00:00

abstract：:The latest research achievements in the field of stem cells led in 2016 to the publication of "Guidelines for Stem Cell Research and Clinical Translation" by the International Society for Stem Cell Research (ISSCR). Updating the topics covered in previous publications, the new recommendations offer interesting ethical...

journal_title：Stem cells international

authors： Frati P,Scopetti M,Santurro A,Gatto V,Fineschi V

更新日期：2017-01-01 00:00:00

abstract：:Infections of emerging and reemerging viruses (SARS-CoVs, influenza H1N1, etc.) largely and globally affect human health. Animal models often fail to reflect a physiological status because of species tropism of virus infection. Conventional cell lines are usually genetically and phenotypically different from primary c...

journal_title：Stem cells international

authors： Xia S,Liu J,Yang Y,Wu M,Ye L,Chen S,Zhang T,Zeng Z,Zhang K,Cai K,Long X,Gao W,Fang S,Li H

更新日期：2020-07-09 00:00:00

abstract：:The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC) population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age-related muscle atrophy (sarcopenia) and several dystrophies, regeneration cannot compensate for the loss of muscle tissue. These diso...

journal_title：Stem cells international

authors： Pavlidou T,Marinkovic M,Rosina M,Fuoco C,Vumbaca S,Gargioli C,Castagnoli L,Cesareni G

更新日期：2019-04-24 00:00:00

abstract：:Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging population. OSA leads to hypoxia and upper airway muscle injury. However, l...

journal_title：Stem cells international

authors： Zhu LY,Yu LM,Zhang WH,Deng JJ,Liu SF,Huang W,Zhang MH,Lu YQ,Han XX,Liu YH

更新日期：2020-03-04 00:00:00

abstract：:Blastocyst injection and morula aggregation are commonly used to evaluate stem cell pluripotency based on chimeric contribution of the stem cells. To assess the protocols for generating chimeras from stem cells, 8-cell mouse embryos were either injected or cocultured with mouse embryonic stem cells and induced pluripo...

journal_title：Stem cells international

authors： Guo J,Wu B,Li S,Bao S,Zhao L,Hu S,Sun W,Su J,Dai Y,Li X

更新日期：2014-01-01 00:00:00

abstract：:Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...

journal_title：Stem cells international

authors： Mingliang R,Bo Z,Zhengguo W

更新日期：2011-01-01 00:00:00

abstract：:Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. Some areas of skin are continuously exposed to a variety of environmental stressors that can inflict direct and indirect damage to skin cell DNA. Skin homeostasis is...

journal_title：Stem cells international

authors： Panich U,Sittithumcharee G,Rathviboon N,Jirawatnotai S

更新日期：2016-01-01 00:00:00

abstract：:The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated. However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. In this study, our data showed that IL-1β induced LFA-1 e...

journal_title：Stem cells international

authors： Wu TY,Liang YH,Wu JC,Wang HS

更新日期：2019-12-27 00:00:00