Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming.

abstract：:Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled...

journal_title：Stem cells international

authors： Nicolosi PA,Tombetti E,Maugeri N,Rovere-Querini P,Brunelli S,Manfredi AA

更新日期：2016-01-01 00:00:00

abstract：:Aged tendon-derived stem/progenitor cells (TSPCs) lead to age-related tendon disorders and impair tendon healing. However, the underlying molecular mechanisms of TSPC aging remain largely unknown. Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging. CTGF protein and mRNA levels were ...

journal_title：Stem cells international

authors： Rui YF,Chen MH,Li YJ,Xiao LF,Geng P,Wang P,Xu ZY,Zhang XP,Dai GC

更新日期：2019-11-11 00:00:00

abstract：:Wnt signaling plays crucial role in regulating melanocyte stem cells/melanocyte differentiation in the hair follicle. However, how the Wnt signaling is balanced to be overactivated to control follicular melanocytes behavior remains unknown. Here, by using immunofluorescence staining, we showed that secreted frizzled-r...

journal_title：Stem cells international

authors： Guo H,Lei M,Li Y,Liu Y,Tang Y,Xing Y,Deng F,Yang K

更新日期：2017-01-01 00:00:00

abstract：:The magic angle effect increases the MRI signal of healthy tendon tissue and could be used for more detailed evaluation of tendon structure. Furthermore, it could support the discrimination of hypointense artefacts induced by contrast agents such as superparamagnetic iron oxide used for cell tracking. However, magic a...

journal_title：Stem cells international

authors： Horstmeier C,Ahrberg AB,Berner D,Burk J,Gittel C,Hillmann A,Offhaus J,Brehm W

更新日期：2019-12-17 00:00:00

abstract：:The purpose of this study is to explore why type 2 diabetes mellitus (T2DM) patients are susceptible to pulmonary tuberculosis through detection of serum Toll-like receptor 4 (TLR4), an important immune-related receptor, especially in terms of content and TLR4 gene polymorphism. Patients with T2DM complicated by pulmo...

journal_title：Stem cells international

authors： Li Y,Li D,Zhang J,Liu S,Chen H,Wu K

更新日期：2016-01-01 00:00:00

abstract：:The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of ster...

journal_title：Stem cells international

authors： Aluri HS,Samizadeh M,Edman MC,Hawley DR,Armaos HL,Janga SR,Meng Z,Sendra VG,Hamrah P,Kublin CL,Hamm-Alvarez SF,Zoukhri D

更新日期：2017-01-01 00:00:00

abstract：:In situ detection of MSCs remains difficult and warrants additional methods to aid with their characterization in vivo. Two-photon confocal laser scanning microscopy (TPM) and second harmonic generation (SHG) could fill this gap. Both techniques enable the detection of cells and extracellular structures, based on intr...

journal_title：Stem cells international

authors： Donders R,Sanen K,Paesen R,Slenders E,Gyselaers W,Stinissen P,Ameloot M,Hellings N

更新日期：2016-01-01 00:00:00

abstract：:The use of stem cells as a strategy for tissue repair and regeneration is one of the biomedical research areas that has attracted more interest in the past few years. Despite the classic belief that the central nervous system (CNS) was immutable, now it is well known that cell turnover occurs in the mature CNS. Postna...

journal_title：Stem cells international

authors： Martínez-Herrero S,Larráyoz IM,Ochoa-Callejero L,García-Sanmartín J,Martínez A

更新日期：2012-01-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...

journal_title：Stem cells international

authors： Marketou ME,Parthenakis F,Vardas PE

更新日期：2016-01-01 00:00:00

abstract：:The calcined tooth powder (CTP), a type of allogeneic biomimetic mineralized material, has been confirmed that can promote new bone formation when obtained at high temperature. The aim of this study was to investigate effects of the conditioned medium of calcined tooth powder (CTP-CM) on the osteogenic and odontogenic...

journal_title：Stem cells international

authors： Wu J,Li N,Fan Y,Wang Y,Gu Y,Li Z,Pan Y,Romila G,Zhou Z,Yu J

更新日期：2019-03-19 00:00:00

abstract：:Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring i...

journal_title：Stem cells international

authors： Cimino M,Gonçalves RM,Barrias CC,Martins MCL

更新日期：2017-01-01 00:00:00

abstract：:Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand...

journal_title：Stem cells international

authors： Valerie A,Vassiliki K,Irini M,Nikolaos P,Karampela E,Apostolos P

更新日期：2016-01-01 00:00:00

abstract：:Cardiovascular diseases (CVDs), including atherosclerosis, stroke, and myocardial infarction, is a major cause of death worldwide. In aspects of cell therapy against CVD, it is generally accepted that endothelial progenitor cells (EPCs) are potent neovascular modulators in ischemic tissues. In response to ischemic inj...

journal_title：Stem cells international

authors： Kim H,Kim S,Baek SH,Kwon SM

更新日期：2016-01-01 00:00:00

abstract：:Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a hip disorder, and it threatens patients who require megadose of steroid therapies. Nowadays, no valid therapies can reverse the development of GC-induced ONFH once it occurs. Stem cell therapy to GC-induced ONFH would be a promising choice. Although ...

journal_title：Stem cells international

authors： Zhun W,Donghai L,Zhouyuan Y,Haiyan Z,Pengde K

更新日期：2018-05-22 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) offering valuable anticipations for the treatment of degenerative diseases. They can be found in many tissues including amnion. MSCs from amnion (AM-MSCs) can differentiate into osteoblast similar to that of bone marrow-derived MSCs (BM-MSCs). However, the ability is not much efficient...

journal_title：Stem cells international

authors： Manochantr S,Marupanthorn K,Tantrawatpan C,Kheolamai P,Tantikanlayaporn D,Sanguanjit P

更新日期：2017-01-01 00:00:00

abstract：:As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat degenerative diseases. Muscle differentiation is a multistep process...

journal_title：Stem cells international

authors： Aboalola D,Han VKM

更新日期：2019-02-17 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and...

journal_title：Stem cells international

authors： Agata H,Sumita Y,Hidaka T,Iwatake M,Kagami H,Asahina I

更新日期：2019-11-12 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells that have a strong osteogenic differentiation capacity. However, the molecular mechanism underlying the osteogenic differentiation of MSCs remains largely unknown and thus hinders further development of MSC-based cell therapies for bone repair in the clinic. RSP...

journal_title：Stem cells international

authors： Liang C,Liang G,Zheng X,Huang Y,Huang S,Yin D

更新日期：2020-04-06 00:00:00

abstract：:We previously found that human amniotic mesenchymal stem cells (hAMSCs) in coculture with CF immortalised airway epithelial cells (CFBE41o- line, CFBE) on Transwell® filters acquired an epithelial phenotype and led to the expression of a mature and functional CFTR protein. In order to explore the role of gap junction-...

journal_title：Stem cells international

authors： Carbone A,Zefferino R,Beccia E,Casavola V,Castellani S,Di Gioia S,Giannone V,Seia M,Angiolillo A,Colombo C,Favia M,Conese M

更新日期：2018-01-11 00:00:00

abstract：:Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging population. OSA leads to hypoxia and upper airway muscle injury. However, l...

journal_title：Stem cells international

authors： Zhu LY,Yu LM,Zhang WH,Deng JJ,Liu SF,Huang W,Zhang MH,Lu YQ,Han XX,Liu YH

更新日期：2020-03-04 00:00:00

abstract：:The purpose of this study is to determine if patients with chronic patellar tendinopathy will improve clinically after the inoculation of bone marrow mononuclear cells (BM-MNCs). Eight patients with chronic patellar tendinopathy were included. Patients averaged 24 years old (range 14-35). All patients were refractory ...

journal_title：Stem cells international

authors： Pascual-Garrido C,Rolón A,Makino A

更新日期：2012-01-01 00:00:00

abstract：:Cord blood transplantation (CBT) is an attractive alternative therapy in adult patients with advanced hematological malignancies in whom matched donors are unavailable. However, the risk of complications, especially infections, post-CBT increases the mortality rates in these patients. Although the incidence of acute a...

journal_title：Stem cells international

authors： Narimatsu H

更新日期：2011-01-01 00:00:00

abstract：:Background. Human cardiac-derived progenitor cells (hCPCs) have shown promise in treating heart failure (HF) in adults. The purpose of this study was to describe derivation of hCPCs from pediatric patients with end-stage HF. Methods. At surgery, discarded right atrial tissues (hAA) were obtained from HF patients (n = ...

journal_title：Stem cells international

authors： Steele A,Boucek RJ Jr,Jacobs JP,Steele P,Asante-Korang A,Chamizo W,Steele J,Chai PJ,Quintessenza JA

更新日期：2012-01-01 00:00:00

abstract：:Radiation is the most potent mode of cancer therapy; however, resistance to radiation therapy results in tumor relapse and subsequent fatality. The cancer stem cell (CSC), which has better DNA repair capability, has been shown to contribute to tumor resistance and is an important target for treatment. Signaling molecu...

journal_title：Stem cells international

authors： Pranatharthi A,Ross C,Srivastava S

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...

journal_title：Stem cells international

authors： Park M,Kim YH,Ryu JH,Woo SY,Ryu KH

更新日期：2015-01-01 00:00:00

abstract：:Previously, we demonstrated a high quality of minerals formed by serum-free cultured jaw periosteal cells (JPCs) by Raman spectroscopy but the mineralization extent was not satisfactory. In the present study, we analyzed the proliferation and mineralization potential of human platelet lysate- (hPL-) cultured JPCs in c...

journal_title：Stem cells international

authors： Wanner Y,Umrath F,Waidmann M,Reinert S,Alexander D

更新日期：2017-01-01 00:00:00

abstract：:The Wnt signalling pathway plays a crucial role in the development of the nervous system. This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors. In the present study, we analysed the presence of frizzled-4 in the enteric nervous system of human inf...

journal_title：Stem cells international

authors： Nothelfer K,Obermayr F,Belz N,Reinartz E,Bareiss PM,Bühring HJ,Beschorner R,Just L

更新日期：2016-01-01 00:00:00

abstract：:Periodontal ligament stem cells (PDLSCs) possess self-renewal, multilineage differentiation, and immunomodulatory properties. They play a crucial role in maintaining periodontal homeostasis and also participated in orthodontic tooth movement (OTM). Various studies have applied controlled mechanical stimulation to PDLS...

journal_title：Stem cells international

authors： Huang H,Yang R,Zhou YH

更新日期：2018-09-17 00:00:00

abstract：:Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell ma...

journal_title：Stem cells international

authors： Suresh B,Lee J,Kim KS,Ramakrishna S

更新日期：2016-01-01 00:00:00

abstract：:The cornea is a clear structure, void of blood, and lymphatic vessels, functioning as our window to the world. Limbal epithelial stem cells, occupying the area between avascular cornea and vascularized conjunctiva, have been implicated in tissue border maintenance, preventing conjunctivalisation and propagation of blo...

journal_title：Stem cells international

authors： Notara M,Lentzsch A,Coroneo M,Cursiefen C

更新日期：2018-05-08 00:00:00