Abstract:
:The use of stem cells as a strategy for tissue repair and regeneration is one of the biomedical research areas that has attracted more interest in the past few years. Despite the classic belief that the central nervous system (CNS) was immutable, now it is well known that cell turnover occurs in the mature CNS. Postnatal neurogenesis is subjected to tight regulation by many growth factors, cell signals, and transcription factors. An emerging molecule involved in this process is adrenomedullin (AM). AM, a 52-amino acid peptide which exerts a plethora of physiological functions, acts as a growth and cell fate regulatory factor for adult neural stem and progenitor cells. AM regulates the proliferation rate and the differentiation into neurons, astrocytes, and oligodendrocytes of stem/progenitor cells, probably through the PI3K/Akt pathway. The active peptides derived from the AM gene are able to regulate the cytoskeleton dynamics, which is extremely important for mature neural cell morphogenesis. In addition, a defective cytoskeleton may impair cell cycle and migration, so AM may contribute to neural stem cell growth regulation by allowing cells to pass through mitosis. Regulation of AM levels may contribute to program stem cells for their use in medical therapies.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Martínez-Herrero S,Larráyoz IM,Ochoa-Callejero L,García-Sanmartín J,Martínez Adoi
10.1155/2012/804717subject
Has Abstractpub_date
2012-01-01 00:00:00pages
804717eissn
1687-966Xissn
1687-9678journal_volume
2012pub_type
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journal_title:Stem cells international
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journal_title:Stem cells international
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abstract::Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are characterized by their unique capacity to stepwise differentiate towards any particular cell type in an adult organism. Pluripotent stem cells provide a beneficial platform to model hereditary diseases and even cancer development. While the inc...
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pub_type: 杂志文章,评审
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journal_title:Stem cells international
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journal_title:Stem cells international
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2017/2601746
更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2012/816049
更新日期:2012-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8483035
更新日期:2020-02-03 00:00:00
abstract::The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, an...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1690896
更新日期:2016-01-01 00:00:00
abstract::Exosomes derived from cancer cells can affect various functions of mesenchymal stem cells (MSCs) via conveying microRNAs (miRs). miR-21 and miR-146a have been demonstrated to regulate MSC proliferation and transformation. Interleukin-6 (IL-6) secreted from transformed MSCs in turn favors the survival of multiple myelo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/9012152
更新日期:2017-01-01 00:00:00
abstract::There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the di...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/9896142
更新日期:2018-12-25 00:00:00
abstract::Mesenchymal stem cells (MSCs) derived from bone marrow can secrete cytokines and growth factors and can transdifferentiate into liver cells. We transplanted polymeric membrane bioencapsulated MSCs into the spleens of 90% partial hepatectomized rats. This resulted in 91.6% recovery rates. This is compared to a recovery...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/697094
更新日期:2012-01-01 00:00:00
abstract::Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/3206807
更新日期:2016-01-01 00:00:00
abstract::During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or r...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2011/619583
更新日期:2011-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/7670316
更新日期:2019-07-11 00:00:00
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pub_type: 杂志文章,评审
doi:10.1155/2017/8354640
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doi:10.1155/2016/1035374
更新日期:2016-01-01 00:00:00
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journal_title:Stem cells international
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更新日期:2016-01-01 00:00:00
abstract:Background:While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. In human studies, the ability to track transplanted cells has been limited to labeling with radioisotopes and tracking using nuclear...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2754927
更新日期:2019-11-14 00:00:00
abstract::Stem cells isolated from adipose tissue show great therapeutic potential in veterinary medicine, but some points such as the use of fresh or cultured cells and route of administration need better knowledge. This study aimed to evaluate the effect of autologous stromal vascular fraction (SVF, n = 4) or allogeneic cultu...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/391274
更新日期:2014-01-01 00:00:00
abstract::A growing body of evidence supports the argument that bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into cardiomyocyte-like cells in an appropriate cellular environment, but the differentiation rate is low. A cocktail method was designed: we investigated the role of 5-azacytidine (5-aza), salvian...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/162024
更新日期:2014-01-01 00:00:00
abstract::Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...
journal_title:Stem cells international
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doi:10.1155/2018/5034679
更新日期:2018-03-11 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. As most GSCs that are located in the perivascular and perinecrotic niches should be remo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/5387041
更新日期:2018-08-23 00:00:00
abstract::Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends o...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/6129596
更新日期:2017-01-01 00:00:00