Abstract:
:Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source of several adipokines and cytokines which have been deemed important for both normal metabolic function and disease formation. The discoveries of metabolically active brown AT in adult humans and adipose tissue derived stem cells (ADSC) have been key findings in the past decade with potential therapeutic implications. ADSCs represent an enticing pool of multipotent adult stem cells because of their noncontroversial nature, relative abundance, ease of isolation, and expandability. A decade and a half since the discovery of ADSCs, the scientific community is still working to uncover their therapeutic potential in a wide range of diseases. In this review, we provide an overview of the recent developments in the field of ADSCs and examine their potential use in transplantation and cell-based therapies for the regeneration of diseased organs and systems. We also hope to provide perspective on how to best utilize this readily available, powerful pool of stem cells in the future.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Wankhade UD,Shen M,Kolhe R,Fulzele Sdoi
10.1155/2016/3206807subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3206807eissn
1687-966Xissn
1687-9678journal_volume
2016pub_type
杂志文章,评审abstract::The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated. However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. In this study, our data showed that IL-1β induced LFA-1 e...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/7267142
更新日期:2019-12-27 00:00:00
abstract::Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regul...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/1047896
更新日期:2020-07-08 00:00:00
abstract::Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/5034679
更新日期:2018-03-11 00:00:00
abstract::Autologous stem cell transplantation (ASCT) is a standard treatment for multiple myeloma (MM), but the clinical response and renal curative effect in MM patients with renal failure (RF) remain controversial. The myeloma kidney disease has different types, and most are due to the direct toxic effects of light chain. Al...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/9401717
更新日期:2019-10-29 00:00:00
abstract::We have determined the protective effects of Thymus serpyllum (TS) extract and nanoparticle-loaded TS on hydrogen peroxide-induced cell death of mesenchymal stromal cells (MSCs) in vitro. Gas chromatography-mass spectroscopy confirmed the spectrum of active components in the extract. Out of the three different extract...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/5142518
更新日期:2019-02-26 00:00:00
abstract::Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and str...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2017/5979741
更新日期:2017-01-01 00:00:00
abstract::Homoeostasis of bone marrow microenvironment depends on a precise balance between cell proliferation and death, which is supported by the cellular-extracellular matrix crosstalk. Multipotent mesenchymal stromal cells (MSC) are the key elements to provide the specialized bone marrow microenvironment by supporting, main...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/6854080
更新日期:2019-06-02 00:00:00
abstract::Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5720758
更新日期:2016-01-01 00:00:00
abstract::Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/4142031
更新日期:2018-04-19 00:00:00
abstract::Mandibular bone defect reconstruction is an urgent challenge due to the requirements for daily eating and facial aesthetics. Three-dimensional- (3D-) printed titanium (Ti) scaffolds could provide patient-specific implants for bone defects. Appropriate load-bearing properties are also required during bone reconstructio...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/2074021
更新日期:2018-09-05 00:00:00
abstract::Endometriosis is an inflammatory disease with predominance of immunosuppressive M2 macrophages in the pelvic cavity that could be involved in the pathology through support and immune escape of ectopic lesions. Mesenchymal stromal cells (MSC) are found in ectopic lesions, and MSC from nonendometriosis sources are known...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/3215962
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study is to determine if patients with chronic patellar tendinopathy will improve clinically after the inoculation of bone marrow mononuclear cells (BM-MNCs). Eight patients with chronic patellar tendinopathy were included. Patients averaged 24 years old (range 14-35). All patients were refractory ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/953510
更新日期:2012-01-01 00:00:00
abstract::In situ detection of MSCs remains difficult and warrants additional methods to aid with their characterization in vivo. Two-photon confocal laser scanning microscopy (TPM) and second harmonic generation (SHG) could fill this gap. Both techniques enable the detection of cells and extracellular structures, based on intr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/5457132
更新日期:2016-01-01 00:00:00
abstract::Traditionally, human embryonic stem cells (hESCs) are cultured on inactivated live feeder cells. For clinical application using hESCs, there is a requirement to minimize the risk of contamination with animal components. Extracellular matrix (ECM) derived from feeder cells is the most natural way to provide xeno-free s...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/621057
更新日期:2015-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/106540
更新日期:2015-01-01 00:00:00
abstract::Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent treatment option in this regard. Preclinical studies demonstrate that untreated stem cells, unlike stem cells activated to differentiate into neuronal lineage, do...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1035374
更新日期:2016-01-01 00:00:00
abstract::An intermediate filament protein, Nestin, is known as a neural stem/progenitor cell marker. It was shown to be required for the survival and self-renewal of neural stem cells according to the phenotypes of Nestin knockout mice. Nestin expression has also been reported in vascular endothelial cells, and we recently rep...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/430138
更新日期:2012-01-01 00:00:00
abstract::The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, an...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1690896
更新日期:2016-01-01 00:00:00
abstract:Objective:Mesenchymal stem cells (MSCs) are considered a promising therapy for wound healing. Here, we explored the role of c-Jun in diabetic wound healing using human umbilical cord-derived MSCs (hUC-MSCs). Methods:Freshly isolated hUC-MSCs were subjected to extensive in vitro subcultivation. The cell proliferative a...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/7430968
更新日期:2020-01-14 00:00:00
abstract::Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4636859
更新日期:2016-01-01 00:00:00
abstract::Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. Matrigel, derived from mouse sarcoma, has often been used as the supporting m...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/8472712
更新日期:2019-06-13 00:00:00
abstract::Chicken embryonic stem cells (cESCs) obtained from stage X embryos provide a novel model for the study of avian embryonic development. A new way to maintain cESCs for a long period in vitro still remains unexplored. We found that the cESCs showed stem cell-like properties in vitro for a long term with the support of D...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/2157451
更新日期:2018-05-09 00:00:00
abstract::Due to their immunomodulatory and chemotactic properties, hMSC are being explored to treat immune-related diseases. For their use in human therapies, it is necessary to culture hMSC in xeno-free conditions. In this study, the impact that a xeno-free medium based on a human plasma derivate has on these properties was a...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/2185351
更新日期:2017-01-01 00:00:00
abstract::Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has significant potential as a novel treatment for many degenerative bone and joint diseases. Previous studies have established that age negatively affects the proliferation status and the osteogenic and chondrogenic differentiation potenti...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/2152435
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/7073805.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2020/4370849
更新日期:2020-08-21 00:00:00
abstract::Tendinopathy is a tendon disorder characterized by activity-related pain, local edema, focal tenderness to palpation, and decreased strength in the affected area. Tendinopathy is prevalent in both athletes and the general population, highlighting the need to elucidate the pathogenesis of this disorder. Current treatme...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4076578
更新日期:2016-01-01 00:00:00
abstract::Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder. Current targeted therapies designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein have made a significant breakthrough in the treatment of CML patients. However, CML remains a chronic disease that a patient must manage for lif...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/724360
更新日期:2013-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. Despite several treatment options, AMD therapy remains difficult, especially for exudative AMD. Mul...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/946090
更新日期:2012-01-01 00:00:00
abstract::Cord blood transplantation (CBT) is an attractive alternative therapy in adult patients with advanced hematological malignancies in whom matched donors are unavailable. However, the risk of complications, especially infections, post-CBT increases the mortality rates in these patients. Although the incidence of acute a...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2011/607569
更新日期:2011-01-01 00:00:00
abstract::Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2011/310928
更新日期:2011-01-01 00:00:00