Label-Free Imaging of Umbilical Cord Tissue Morphology and Explant-Derived Cells.

abstract：:The clinical application of human bone marrow mesenchymal stem cells (hBM-MSCs) has generated a great deal of interest because of their potential use in regenerative medicine and tissue engineering. However, safety concerns over hBM-MSCs limit their clinical application. In this study, we observed that hBM-MSC-conditi...

journal_title：Stem cells international

authors： Chen B,Yu J,Wang Q,Zhao Y,Sun L,Xu C,Zhao X,Shen B,Wang M,Xu W,Zhu W

更新日期：2018-07-18 00:00:00

abstract：:Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood. In this study, we investigated the role of EphB4 in regulating the expression of periostin (POSTN) within bone marrow-derived mese...

journal_title：Stem cells international

authors： Zhang F,Zhang Z,Sun D,Dong S,Xu J,Dai F

更新日期：2016-01-01 00:00:00

abstract：:Efficient ex vivo expansion of hematopoietic stem cells with a concomitant preservation of stemness and self-renewal potential is still an unresolved ambition. Increased numbers of methods approaching this issue using three-dimensional (3D) cultures were reported. Here, we describe a simplified 3D hanging drop model f...

journal_title：Stem cells international

authors： Schmal O,Seifert J,Schäffer TE,Walter CB,Aicher WK,Klein G

更新日期：2016-01-01 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and t...

journal_title：Stem cells international

authors： Kretsovali A,Hadjimichael C,Charmpilas N

更新日期：2012-01-01 00:00:00

abstract：:Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...

journal_title：Stem cells international

authors： Sassoli C,Pierucci F,Tani A,Frati A,Chellini F,Matteini F,Vestri A,Anderloni G,Nosi D,Zecchi-Orlandini S,Meacci E

更新日期：2018-03-11 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and...

journal_title：Stem cells international

authors： Agata H,Sumita Y,Hidaka T,Iwatake M,Kagami H,Asahina I

更新日期：2019-11-12 00:00:00

abstract：:Hematopoietic stem cell transplantation (HSCT) is one of a range of therapeutic options available to patients suffering from various diseases. HSCT procedure involves important ethical and legal aspects that can occur at every phase of the procedure: the clinical choice of whether to perform the procedure, pretranspla...

journal_title：Stem cells international

authors： Liso A,Neri M,Maglietta F,La Russa R,Turillazzi E

更新日期：2017-01-01 00:00:00

abstract：Background:Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology. However, there is still considerable debate about the genotype and function of CAC. Methods and Results:Data from publicly available gene expression data sets were used to analyse the transcriptome of in vit...

journal_title：Stem cells international

authors： Everaert BR,Van Laere SJ,Lembrechts R,Hoymans VY,Timmermans JP,Vrints CJ

更新日期：2019-05-02 00:00:00

abstract：:Myocarditis is a common inflammatory cardiomyopathy, associated with cardiomyocyte apoptosis, which can lead to chronic left ventricular dysfunction. Under conventional heart failure therapy, inflammatory cardiomyopathy typically has a progressive course, indicating a need for alternative therapeutic strategies to imp...

journal_title：Stem cells international

authors： Miteva K,Van Linthout S,Volk HD,Tschöpe C

更新日期：2013-01-01 00:00:00

abstract：:The latest research achievements in the field of stem cells led in 2016 to the publication of "Guidelines for Stem Cell Research and Clinical Translation" by the International Society for Stem Cell Research (ISSCR). Updating the topics covered in previous publications, the new recommendations offer interesting ethical...

journal_title：Stem cells international

authors： Frati P,Scopetti M,Santurro A,Gatto V,Fineschi V

更新日期：2017-01-01 00:00:00

abstract：:Left-right symmetry breaking is a complex developmental process and an important part of embryonic axis development. As of yet, the biophysical mechanism behind LR asymmetry establishment remains elusive for the overall asymmetry of embryos as well as for the organ-specific asymmetry. Here, we demonstrate that inheren...

journal_title：Stem cells international

authors： Worley KE,Chin AS,Wan LQ

更新日期：2018-12-02 00:00:00

abstract：:The magic angle effect increases the MRI signal of healthy tendon tissue and could be used for more detailed evaluation of tendon structure. Furthermore, it could support the discrimination of hypointense artefacts induced by contrast agents such as superparamagnetic iron oxide used for cell tracking. However, magic a...

journal_title：Stem cells international

authors： Horstmeier C,Ahrberg AB,Berner D,Burk J,Gittel C,Hillmann A,Offhaus J,Brehm W

更新日期：2019-12-17 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are currently defined as multipotent stromal cells that undergo sustained in vitro growth and can give rise to cells of multiple mesenchymal lineages, such as adipocytes, chondrocytes, and osteoblasts. The regenerative and immunosuppressive properties of MSCs have led to numerous clinical...

journal_title：Stem cells international

authors： Mabuchi Y,Houlihan DD,Akazawa C,Okano H,Matsuzaki Y

更新日期：2013-01-01 00:00:00

abstract：:Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well-coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell ma...

journal_title：Stem cells international

authors： Suresh B,Lee J,Kim KS,Ramakrishna S

更新日期：2016-01-01 00:00:00

abstract：:Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends o...

journal_title：Stem cells international

authors： Churchman SM,Boxall SA,McGonagle D,Jones EA

更新日期：2017-01-01 00:00:00

abstract：:Female infertility impacts the quality of life and well-being of affected individuals and couples. Female reproductive diseases, such as primary ovarian insufficiency, polycystic ovary syndrome, endometriosis, fallopian tube obstruction, and Asherman syndrome, can induce infertility. In recent years, translational med...

journal_title：Stem cells international

authors： Zhao YX,Chen SR,Su PP,Huang FH,Shi YC,Shi QY,Lin S

更新日期：2019-12-06 00:00:00

abstract：:The migration of administered mesenchymal stem cells (MSCs) to sites of injury via the bloodstream has been demonstrated. However, the underlying mechanisms of umbilical cord MSC adhesion to endothelial cells during transendothelial migration are still unclear. In this study, our data showed that IL-1β induced LFA-1 e...

journal_title：Stem cells international

authors： Wu TY,Liang YH,Wu JC,Wang HS

更新日期：2019-12-27 00:00:00

abstract：:Podocyte death and regeneration are major topics in kidney research but remain controversial. Data obtained in humans demonstrate the existence of cells sited along Bowman's capsule that behave as podocyte progenitors in vitro and in in vivo mouse models of podocyte injury xenotrasplanted with this human-derived popul...

journal_title：Stem cells international

authors： Lombardi D,Lasagni L

更新日期：2015-01-01 00:00:00

abstract：:Following the discovery of pluripotent stem (PS) cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells, there has been a great hope that injured tissues can be repaired by transplantation of ES/iPS-derived various specific types of cells such as neural stem cells (NSCs). Although PS cells can be i...

journal_title：Stem cells international

authors： Nakagomi T,Nakano-Doi A,Narita A,Matsuyama T

更新日期：2015-01-01 00:00:00

abstract：Background:Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to pr...

journal_title：Stem cells international

authors： Zhang L,Zheng F,Peng Z,Hu Z,Yang Z

更新日期：2018-04-03 00:00:00

abstract：:Schwann cell (SC) transplantation as a cell-based therapy can enhance peripheral and central nerve repair experimentally, but it is limited by the donor site morbidity for clinical application. We investigated weather respiratory mucosa stem cells (REMSCs), a kind of ectomesenchymal stem cells (EMSCs), isolated from r...

journal_title：Stem cells international

authors： Zhang J,Gao X,Zou H,Liu J,Zhang Z

更新日期：2015-01-01 00:00:00

abstract：:Whether liver epithelial cells contribute to the development of hepatic scarring by undergoing epithelial-to-mesenchymal transition (EMT) is a controversial issue. Herein, we revisit the concept of EMT in cholangiopathies, a group of severe hepatic disorders primarily targeting the bile duct epithelial cell (cholangio...

journal_title：Stem cells international

authors： Fabris L,Brivio S,Cadamuro M,Strazzabosco M

更新日期：2016-01-01 00:00:00

abstract：:Blastocyst injection and morula aggregation are commonly used to evaluate stem cell pluripotency based on chimeric contribution of the stem cells. To assess the protocols for generating chimeras from stem cells, 8-cell mouse embryos were either injected or cocultured with mouse embryonic stem cells and induced pluripo...

journal_title：Stem cells international

authors： Guo J,Wu B,Li S,Bao S,Zhao L,Hu S,Sun W,Su J,Dai Y,Li X

更新日期：2014-01-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) belongs to multipotent adult somatic stem cells. A single HSC can reconstitute the entire blood system via self-renewal, differentiation into all lineages of blood cells, and replenishment of cells lost due to attrition or disease in a person's lifetime. Although all blood and immune cell...

journal_title：Stem cells international

authors： Zhang J,Crumpacker C

更新日期：2015-01-01 00:00:00

abstract：:Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...

journal_title：Stem cells international

authors： Mingliang R,Bo Z,Zhengguo W

更新日期：2011-01-01 00:00:00

abstract：:Infections of emerging and reemerging viruses (SARS-CoVs, influenza H1N1, etc.) largely and globally affect human health. Animal models often fail to reflect a physiological status because of species tropism of virus infection. Conventional cell lines are usually genetically and phenotypically different from primary c...

journal_title：Stem cells international

authors： Xia S,Liu J,Yang Y,Wu M,Ye L,Chen S,Zhang T,Zeng Z,Zhang K,Cai K,Long X,Gao W,Fang S,Li H

更新日期：2020-07-09 00:00:00

abstract：:Left ventricular hypertrophy (LVH) is a strong predictor of adverse cardiovascular outcomes. It is the result of complex mechanisms that include not only an increase in protein synthesis and cell size but also proliferating cardiac progenitor cells and the influx of bone marrow-derived cells developing into cardiomyoc...

journal_title：Stem cells international

authors： Marketou ME,Parthenakis F,Vardas PE

更新日期：2016-01-01 00:00:00

abstract：:This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD. We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey. Totally, 68 doses of bone marrow derived MSCs were infuse...

journal_title：Stem cells international

authors： Erbey F,Atay D,Akcay A,Ovali E,Ozturk G

更新日期：2016-01-01 00:00:00

abstract：:The objective of this paper is to describe in detail the method of organotypic longitudinal spinal cord slice culture and the scientific basis for its potential utility. The technique is based on the interface method, which was described previously and thereafter was modified in our laboratory. The most important adva...

journal_title：Stem cells international

authors： Sypecka J,Koniusz S,Kawalec M,Sarnowska A

更新日期：2015-01-01 00:00:00

abstract：:Adipogenesis is the process through which preadipocytes differentiate into adipocytes. During this process, the preadipocytes cease to proliferate, begin to accumulate lipid droplets, and develop morphologic and biochemical characteristics of mature adipocytes. Mesenchymal stem cells (MSCs) are a type of adult stem ce...

journal_title：Stem cells international

authors： Zhang K,Yang X,Zhao Q,Li Z,Fu F,Zhang H,Zheng M,Zhang S

更新日期：2020-08-12 00:00:00