Abstract:
:Exosomes derived from cancer cells can affect various functions of mesenchymal stem cells (MSCs) via conveying microRNAs (miRs). miR-21 and miR-146a have been demonstrated to regulate MSC proliferation and transformation. Interleukin-6 (IL-6) secreted from transformed MSCs in turn favors the survival of multiple myeloma (MM) cells. However, the effects of MM exosomes on MSC functions remain largely unclear. In this study, we investigated the effects of OPM2 (a MM cell line) exosomes (OPM2-exo) on regulating the proliferation, cancer-associated fibroblast (CAF) transformation, and IL-6 secretion of MSCs and determined the role of miR-21 and miR-146a in these effects. We found that OPM2-exo harbored high levels of miR-21 and miR-146a and that OPM2-exo coculture significantly increased MSC proliferation with upregulation of miR-21 and miR-146a. Moreover, OPM2-exo induced CAF transformation of MSCs, which was evidenced by increased fibroblast-activated protein (FAP), α-smooth muscle actin (α-SMA), and stromal-derived factor 1 (SDF-1) expressions and IL-6 secretion. Inhibition of miR-21 or miR-146a reduced these effects of OPM2-exo on MSCs. In conclusion, MM could promote the proliferation, CAF transformation, and IL-6 secretion of MSCs partially through regulating miR21 and miR146a.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Cheng Q,Li X,Liu J,Ye Q,Chen Y,Tan S,Liu Jdoi
10.1155/2017/9012152subject
Has Abstractpub_date
2017-01-01 00:00:00pages
9012152eissn
1687-966Xissn
1687-9678journal_volume
2017pub_type
杂志文章abstract::The purpose of this study is to determine if patients with chronic patellar tendinopathy will improve clinically after the inoculation of bone marrow mononuclear cells (BM-MNCs). Eight patients with chronic patellar tendinopathy were included. Patients averaged 24 years old (range 14-35). All patients were refractory ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/953510
更新日期:2012-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/7257628
更新日期:2017-01-01 00:00:00
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journal_title:Stem cells international
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1035374
更新日期:2016-01-01 00:00:00
abstract::Beer is one of the most consumed alcoholic beverages in the world, rich in chemical compounds of natural origin with high nutritional and biological value. It is made up of water, barley malt, hops, and yeast. The main nutrients are carbohydrates, amino acids, minerals, vitamins, and other compounds such as polyphenol...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8835813
更新日期:2020-10-10 00:00:00
abstract:Purpose:To investigate the efficacy of recombinant human collagen type I (RHC I) and collagen-like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of limbal epithelial stem cells (LESC) under xeno-free culture conditions. Methods:Human LESC were cultivated on seven different collagen-deri...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/7867613
更新日期:2019-04-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5802529
更新日期:2016-01-01 00:00:00
abstract::Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2011/310928
更新日期:2011-01-01 00:00:00
abstract::Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and t...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/184154
更新日期:2012-01-01 00:00:00
abstract::Fifty-six aphaereses were performed in 23 pediatric patients with malignant hematological and solid tumors, following three different protocols for PBPC mobilization and distributed as follows: A: seventeen mobilized with 4 g/m(2) of cyclophosphamide (CFA) and 10 μg/kg/day of granulocyte colony stimulating factor (G-C...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/4078215
更新日期:2016-01-01 00:00:00
abstract::Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenati...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/9308301
更新日期:2018-03-29 00:00:00
abstract::Tendinopathy is a tendon disorder characterized by activity-related pain, local edema, focal tenderness to palpation, and decreased strength in the affected area. Tendinopathy is prevalent in both athletes and the general population, highlighting the need to elucidate the pathogenesis of this disorder. Current treatme...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4076578
更新日期:2016-01-01 00:00:00
abstract::The cardiopulmonary system is made up of the heart and the lungs, with the core function of one complementing the other. The unimpeded and optimal cycling of blood between these two systems is pivotal to the overall function of the entire human body. Although the function of the cardiopulmonary system appears uncompli...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/3123961
更新日期:2018-04-29 00:00:00
abstract:Background:To reduce morbidity to cleft patients, new approaches have been developed and here, we report for the first time the use of deciduous dental pulp stem cells (DDPSC) associated with a hydroxyapatite-collagen sponge (Bio-Oss Collagen® 250 mg, Geistlich) for closing alveolar defects during secondary dental erup...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/6234167
更新日期:2020-03-12 00:00:00
abstract::Bone tissue regeneration is considered to be the optimal solution for bone loss. However, diabetic patients have a greater risk of poor bone healing or bone grafting failure than nondiabetics. The purpose of this study was to investigate the influence of the complexes of an adipose-derived stem cell sheet (ASC sheet) ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2506463
更新日期:2019-07-31 00:00:00
abstract::The lung is a radiosensitive organ, which imposes limits on the therapeutic dose in thoracic radiotherapy. Irradiated alveolar epithelial cells promote radiation-related pneumonitis and fibrosis. However, the role of lung stem cells (LSCs) in the development of radiation-induced lung injury is still unclear. In this s...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/6312053
更新日期:2020-09-29 00:00:00
abstract::Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time poi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/1706982
更新日期:2018-04-05 00:00:00
abstract::Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/5034679
更新日期:2018-03-11 00:00:00
abstract::Human mesenchymal stem cells derived from the umbilical cord (UC) are a favorable source for allogeneic cell therapy. Here, we successfully isolated the stem cells derived from three different compartments of the human UC, including perivascular stem cells derived from umbilical arteries (UCA-PSCs), perivascular stem ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/3175748
更新日期:2017-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2017/8270498
更新日期:2017-01-01 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/507301
更新日期:2013-01-01 00:00:00
abstract::Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, n...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/8468549
更新日期:2016-01-01 00:00:00
abstract::The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Bind...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/7943495
更新日期:2016-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are somatic cells with a dual capacity for self-renewal and differentiation, and diverse therapeutic applicability, both experimentally and in the clinic. These cells can be isolated from various human tissues that may differ anatomically or developmentally with relative ease. Heterogenei...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/246134
更新日期:2013-01-01 00:00:00
abstract::A stably established population of mouse bone marrow stromal cells (BMSCs) with self-renewal and multilineage differentiation potential was expanded in vitro for more than 50 passages. These cells express high levels of mesenchymal stem cell markers and can be differentiated into adipogenic, chondrogenic, and osteogen...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8857057
更新日期:2020-12-24 00:00:00
abstract::Osteoporosis, femoral head necrosis, and congenital bone defects are orthopedic disorders characterized by reduced bone generation and insufficient bone mass. Bone regenerative therapy primarily relies on the bone marrow mesenchymal stem cells (BMSCs) and their ability to differentiate osteogenically. Icariin (ICA) is...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/5747298
更新日期:2019-04-04 00:00:00
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journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/8835986
更新日期:2020-09-24 00:00:00
abstract::Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. As most GSCs that are located in the perivascular and perinecrotic niches should be remo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/5387041
更新日期:2018-08-23 00:00:00
abstract::Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties vi...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/3057624
更新日期:2018-06-14 00:00:00
abstract::Mesenchymal stem cells (MSCs) possess a capacity to enhance cutaneous wound healing that is well characterized. However, the therapeutic effect of MSCs appears to be limited. Modifying MSC target genes to increase necessary biological effects is a promising strategy for wound therapy. Interleukin-10 (IL-10) is an anti...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/9158016
更新日期:2019-06-11 00:00:00