Abstract:
:Articular cartilage defects have been addressed by using multiple strategies. In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). However, it is still controversial in the clinical strategies when to choose these treatments. Thus, we conducted a systematic review and meta-analyses to compare the efficacy and safety of different cartilage treatments. In our study, 17 studies were selected to compare different treatments for cartilage defects. The results of meta-analyses indicated that cell-based cartilage treatments showed significant better efficacy than cell-free treatments did (OR: 4.27, 95% CI: 2.19-8.34; WMD: 10.11, 95% CI: 2.69-16.53). Another result indicated that MACT had significant better efficacy than traditional ACI did (OR: 0.49, 95% CI: 0.30-0.82). Besides, the incidence of graft hypertrophy of MACT was slightly lower than that of traditional ACI (OR: 2.43, 95% CI: 1.00-5.94). Current data showed that the cell-based treatments and MACT are better options for cartilage treatments, but more well-designed comparative studies are still needed to enhance our understanding of different treatments for cartilage defects.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Deng Z,Jin J,Zhao J,Xu Hdoi
10.1155/2016/9201492subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9201492eissn
1687-966Xissn
1687-9678journal_volume
2016pub_type
杂志文章,评审abstract::Fetal dermal mesenchymal stem cells (FDMSCs), isolated from fetal skin, are serving as a novel MSC candidate with great potential in regenerative medicine. More recently, the paracrine actions, especially MSC-derived exosomes, are being focused on the vital role in MSC-based cellular therapy. This study was to evaluat...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2402916
更新日期:2019-06-10 00:00:00
abstract::Mandibular bone defect reconstruction is an urgent challenge due to the requirements for daily eating and facial aesthetics. Three-dimensional- (3D-) printed titanium (Ti) scaffolds could provide patient-specific implants for bone defects. Appropriate load-bearing properties are also required during bone reconstructio...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/2074021
更新日期:2018-09-05 00:00:00
abstract::Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of gene expression. However, the specific roles of lncRNAs in stenotic lesions of arteriovenous fistula (AVF) failure are still largely unknown. We first analyzed the expression profiles of lncRNAs in human stenosed and n...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/4252974
更新日期:2017-01-01 00:00:00
abstract:Background:Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a common type of liver failure with a high mortality. This study aimed at investigating the safety and efficacy of the combination treatment of plasma exchange (PE) and umbilical cord-derived mesenchymal stem cell (UC-MSCs) transplantatio...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/4130757
更新日期:2019-02-04 00:00:00
abstract::The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Bind...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/7943495
更新日期:2016-01-01 00:00:00
abstract::Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear. The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for tr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/318269
更新日期:2015-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are one of the main stem cells that have been used for advanced therapies and regenerative medicine. To carry out the translational clinical application of MSCs, their manufacturing and administration in human must be controlled; therefore they should be considered as medicine: stem cell-...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/9783408
更新日期:2016-01-01 00:00:00
abstract::Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/8868909
更新日期:2020-10-26 00:00:00
abstract::A growing body of evidence supports the argument that bone marrow-derived mesenchymal stem cells (MSCs) can differentiate into cardiomyocyte-like cells in an appropriate cellular environment, but the differentiation rate is low. A cocktail method was designed: we investigated the role of 5-azacytidine (5-aza), salvian...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/162024
更新日期:2014-01-01 00:00:00
abstract::Blastocyst injection and morula aggregation are commonly used to evaluate stem cell pluripotency based on chimeric contribution of the stem cells. To assess the protocols for generating chimeras from stem cells, 8-cell mouse embryos were either injected or cocultured with mouse embryonic stem cells and induced pluripo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/409021
更新日期:2014-01-01 00:00:00
abstract::Homoeostasis of bone marrow microenvironment depends on a precise balance between cell proliferation and death, which is supported by the cellular-extracellular matrix crosstalk. Multipotent mesenchymal stromal cells (MSC) are the key elements to provide the specialized bone marrow microenvironment by supporting, main...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/6854080
更新日期:2019-06-02 00:00:00
abstract::This study is aimed at investigating whether human umbilical cord mesenchymal stem cell- (hucMSC-) derived exosomes (hucMSC-exosomes) have a protective effect on acute myocardial infarction (AMI). Exosomes were characterized under transmission electron microscopy and the particles of exosomes were further examined thr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/761643
更新日期:2015-01-01 00:00:00
abstract::Stem cell therapy with neural precursor cells (NPCs) has the potential to improve neuroregeneration after spinal cord injury (SCI). Unfortunately, survival and differentiation of transplanted NPCs in the injured spinal cord remains low. Growth factors have been successfully used to improve NPC transplantation in anima...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2020/5674921
更新日期:2020-06-17 00:00:00
abstract::Increasing the success rate of rotator cuff healing remains tremendous challenge. Among many approaches, the possibility of activating resident stem cells in situ, without the need to isolate them from biopsies, could represent valuable therapeutic strategy. Along this line, it has been recently demonstrated that lipo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/4373410
更新日期:2016-01-01 00:00:00
abstract::Here, we aimed to answer important and fundamental questions in germ cell biology with special focus on the age of the male donor cells and the possibility to generate embryonic stem cell- (ESC-) like cells. While it is believed that spermatogonial stem cells (SSCs) and truly pluripotent ESC-like cells can be isolated...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/8216312
更新日期:2016-01-01 00:00:00
abstract::Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and ...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/4837930
更新日期:2018-01-18 00:00:00
abstract::Mesenchymal stem cells (MSCs) possess immunosuppressive properties and have been described in the tumor microenvironment of glioblastoma multiforme (GBM). This manuscript has two major topics-first, to describe isolated and cultured MSCs derived from GBM (GB-MSCs) and second, to examine their in vitro immunosuppressiv...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/6904638
更新日期:2019-05-02 00:00:00
abstract::Myocardial infarction is a leading cause of death among all cardiovascular diseases. Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs), expanded CD133+ cells, have promise as a therapeutic option for the treatment of ischemic areas after infarction. Recently, secreted membrane ve...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/4802578
更新日期:2019-12-01 00:00:00
abstract::A previous study reported the structural characterization of biogenic apatite (BAp) thin films realized by a pulsed electron deposition system by ablation of deproteinized bovine bone. Thin films annealed at 400°C exhibited composition and crystallinity degree very close to those of biogenic apatite; this affinity is ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/3579283
更新日期:2017-01-01 00:00:00
abstract::In situ detection of MSCs remains difficult and warrants additional methods to aid with their characterization in vivo. Two-photon confocal laser scanning microscopy (TPM) and second harmonic generation (SHG) could fill this gap. Both techniques enable the detection of cells and extracellular structures, based on intr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/5457132
更新日期:2016-01-01 00:00:00
abstract::During embryonic development pluripotency is progressively lost irreversibly by cell division, differentiation, migration and organ formation. Terminally differentiated cells do not generate other kinds of cells. Pluripotent stem cells are a great source of varying cell types that are used for tissue regeneration or r...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.4061/2011/619583
更新日期:2011-01-01 00:00:00
abstract::Within the field of regenerative medicine, many have sought to use stem cells as a promising way to heal human tissue; however, in the past few years, exosomes (packaged vesicles released from cells) have shown more exciting promise. Specifically, stem cell-derived exosomes have demonstrated great ability to provide t...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/5802529
更新日期:2016-01-01 00:00:00
abstract::Human embryonic stem cells (hESCs) are being utilized in diverse areas of studies such as development and disease modeling, cell replacement therapy, or drug toxicity testing because of their potential to be differentiated into any cell type in the body. The directed differentiation of hESCs into hepatocytes could pro...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/5968236
更新日期:2019-01-22 00:00:00
abstract::The application of human bone marrow mesenchymal stem cells (hBM-MSCs) in cell-based clinical therapies is hindered by the limited number of cells remaining after the initial isolation process and by cellular senescence following in vitro expansion. Understanding the process of in vitro senescence in hBM-MSCs would en...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/7670316
更新日期:2019-07-11 00:00:00
abstract::Periodontal ligament stem cells (PDLSCs) possess self-renewal, multilineage differentiation, and immunomodulatory properties. They play a crucial role in maintaining periodontal homeostasis and also participated in orthodontic tooth movement (OTM). Various studies have applied controlled mechanical stimulation to PDLS...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/6531216
更新日期:2018-09-17 00:00:00
abstract::Chemically induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. Three-dimensional (3D) structures generated from liver progenitor cells possess wide applications in cell transplantation, disease model, and drug testing. Here, we report on the spontaneous formation of 3D cystic ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/3975689
更新日期:2019-09-03 00:00:00
abstract::We previously found that human amniotic mesenchymal stem cells (hAMSCs) in coculture with CF immortalised airway epithelial cells (CFBE41o- line, CFBE) on Transwell® filters acquired an epithelial phenotype and led to the expression of a mature and functional CFTR protein. In order to explore the role of gap junction-...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/1203717
更新日期:2018-01-11 00:00:00
abstract::Mesenchymal stem cells (MSCs) derived from induced pluripotent stem cells (iPSCs) are a promising cell source for the repair of skeletal disorders. Recently, neural crest cells (NCCs) were reported to be effective for inducing mesenchymal progenitors, which have potential to differentiate into osteochondral lineages. ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2017/1960965
更新日期:2017-01-01 00:00:00
abstract::This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD. We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey. Totally, 68 doses of bone marrow derived MSCs were infuse...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/1641402
更新日期:2016-01-01 00:00:00
abstract::The use of Mesenchymal Stromal Cells (MSCs) aiming to treat cancer has shown very contradictory results. In an attempt to clarify the contradictory results reported in the literature and the possible role of human fallopian tube Mesenchymal Stromal Cells (htMSCs) against breast cancer, the aim of this study was to eva...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/796215
更新日期:2015-01-01 00:00:00