Abstract:
:Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development from neural precursor cells in the embryonic, postnatal, and injured CNS. Here we review recent studies on BMP4 signalling in the generation of neurons, astrocytes, and oligodendroglial cells in the CNS. We also discuss putative mechanisms that BMP4 may utilise to influence glial cell development following CNS injury and highlight some questions for further research.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Cole AE,Murray SS,Xiao Jdoi
10.1155/2016/9260592subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9260592eissn
1687-966Xissn
1687-9678journal_volume
2016pub_type
杂志文章,评审abstract::Spinal cord injury (SCI) represents one of the most complicated and heterogeneous pathological processes of central nervous system (CNS) impairments, which is still beyond functional regeneration. Transplantation of mesenchymal stem cells (MSCs) has been shown to promote the repair of the injured spinal cord tissues i...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2017/5251313
更新日期:2017-01-01 00:00:00
abstract::Hepatotoxicity is one of the most cited reasons for withdrawal of approved drugs from the market. The use of nonclinically relevant in vitro and in vivo testing systems contributes to the high attrition rates. Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepato...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/2475631
更新日期:2016-01-01 00:00:00
abstract::Tumor microenvironment has been implicated in tumor development and progression. As a three-dimensional tumor microenvironment model, air liquid interface (ALI) organoid culture from oncogene transgenic mouse gastrointestinal tissues was recently produced. However, ALI organoid culture system from tissues of colorecta...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/7053872
更新日期:2016-01-01 00:00:00
abstract::Neuromuscular diseases are caused by functional defects of skeletal muscles, directly via muscle pathology or indirectly via disruption of the nervous system. Extensive studies have been performed to improve the outcomes of therapies; however, effective treatment strategies have not been fully established for any majo...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/6241681
更新日期:2018-04-11 00:00:00
abstract::Mesenchymal stem cells (MSCs) are currently defined as multipotent stromal cells that undergo sustained in vitro growth and can give rise to cells of multiple mesenchymal lineages, such as adipocytes, chondrocytes, and osteoblasts. The regenerative and immunosuppressive properties of MSCs have led to numerous clinical...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2013/507301
更新日期:2013-01-01 00:00:00
abstract::Increasing the success rate of rotator cuff healing remains tremendous challenge. Among many approaches, the possibility of activating resident stem cells in situ, without the need to isolate them from biopsies, could represent valuable therapeutic strategy. Along this line, it has been recently demonstrated that lipo...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/4373410
更新日期:2016-01-01 00:00:00
abstract::A major challenge in cartilage repair is the lack of chondrogenic cells migrating from healthy tissue into damaged areas and strategies to promote this should be developed. The aim of this study was to evaluate the effect of peripheral blood derived mononuclear cell (PBMC) stimulation on mesenchymal stromal cells (MSC...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/323454
更新日期:2015-01-01 00:00:00
abstract::Human bone marrow mesenchymal stem cells (hBM-MSCs) are the best characterized multipotent adult stem cells. Their self-renewal capacity, multilineage differentiation potential, and immunomodulatory properties have indicated that they can be used in many clinical therapies. In a previous work we studied the DNA methyl...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/5656701
更新日期:2016-01-01 00:00:00
abstract::The quality of life of patients with chronic wounds can be extremely poor and, therefore, over the past decades, great efforts have been made to develop efficient strategies to improve the healing process and the social impact associated with these conditions. Cell based therapy, as a modern tissue engineering strateg...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/195096
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study is to determine if patients with chronic patellar tendinopathy will improve clinically after the inoculation of bone marrow mononuclear cells (BM-MNCs). Eight patients with chronic patellar tendinopathy were included. Patients averaged 24 years old (range 14-35). All patients were refractory ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2012/953510
更新日期:2012-01-01 00:00:00
abstract::Purpose. The current study was set out to address the therapeutic efficacy of topically applied mesenchymal stem cells (MSCs) on dry eye syndrome (DES) induced by benzalkonium chloride (BAC) in rats. Methods. Rats were divided into two groups just after establishment of DES. Eye drops containing either bromodeoxyuridi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2014/250230
更新日期:2014-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) possess immunosuppressive properties and have been described in the tumor microenvironment of glioblastoma multiforme (GBM). This manuscript has two major topics-first, to describe isolated and cultured MSCs derived from GBM (GB-MSCs) and second, to examine their in vitro immunosuppressiv...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/6904638
更新日期:2019-05-02 00:00:00
abstract::Autologous stem cell transplantation (ASCT) is a standard treatment for multiple myeloma (MM), but the clinical response and renal curative effect in MM patients with renal failure (RF) remain controversial. The myeloma kidney disease has different types, and most are due to the direct toxic effects of light chain. Al...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/9401717
更新日期:2019-10-29 00:00:00
abstract::Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time poi...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2018/1706982
更新日期:2018-04-05 00:00:00
abstract::A novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) causing lethal acute respiratory disease emerged in December 2019. The World Health Organization named this disease "COVID-19" and declared it a pandemic on March 11, 2020. Many studies have shown that mesenchymal stem cells (MSCs) and their exosomes (...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/8835986
更新日期:2020-09-24 00:00:00
abstract::The mesenchymal stem cells (MSCs) are known as highly plastic stem cells and can differentiate into specialized tissues such as adipose tissue, osseous tissue, muscle tissue, and nervous tissue. The differentiation of mesenchymal stem cells is very important in regenerative medicine. Their differentiation process is r...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/3763069
更新日期:2020-08-01 00:00:00
abstract:Background:While regenerative stem cell therapy for ischemic heart disease has moved into phase 3 studies, little is still known about retention and migration of cell posttransplantation. In human studies, the ability to track transplanted cells has been limited to labeling with radioisotopes and tracking using nuclear...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/2754927
更新日期:2019-11-14 00:00:00
abstract::Stem cell has immense potential in regenerative cellular therapy. Mesenchymal stem cells (MSCs) can become a potential attractive candidate for therapy due to its remarkable ability of self-renewal and differentiation into three lineages, i.e., ectoderm, mesoderm, and endoderm. Stem cell holds tremendous promises in t...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/7513404
更新日期:2019-07-24 00:00:00
abstract::This study is aimed at investigating whether human umbilical cord mesenchymal stem cell- (hucMSC-) derived exosomes (hucMSC-exosomes) have a protective effect on acute myocardial infarction (AMI). Exosomes were characterized under transmission electron microscopy and the particles of exosomes were further examined thr...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/761643
更新日期:2015-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2015/496512.]. ...
journal_title:Stem cells international
pub_type: 已发布勘误
doi:10.1155/2016/7958361
更新日期:2016-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation an...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2015/106540
更新日期:2015-01-01 00:00:00
abstract::Mesenchymal stem/stromal cells (MSCs) are known to be useful for treating local bone diseases. However, it is not known if MSCs are effective for treating systemic bone diseases, as the risk for mortality following intravenous MSC administration has hindered research progress. In this study, we compared the safety and...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/4214281
更新日期:2019-11-12 00:00:00
abstract::Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has significant potential as a novel treatment for many degenerative bone and joint diseases. Previous studies have established that age negatively affects the proliferation status and the osteogenic and chondrogenic differentiation potenti...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2016/2152435
更新日期:2016-01-01 00:00:00
abstract::Placental structures, capable to persist in a genetically foreign organism, are a natural model of allogeneic engraftment carrying a number of distinctive properties. In this review, the main features of the placenta and its derivatives such as structure, cellular composition, immunological and endocrine aspects, and ...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2018/4837930
更新日期:2018-01-18 00:00:00
abstract::Skin is the largest human organ. Skin continually reconstructs itself to ensure its viability, integrity, and ability to provide protection for the body. Some areas of skin are continuously exposed to a variety of environmental stressors that can inflict direct and indirect damage to skin cell DNA. Skin homeostasis is...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/7370642
更新日期:2016-01-01 00:00:00
abstract::Tendinopathy is a tendon disorder characterized by activity-related pain, local edema, focal tenderness to palpation, and decreased strength in the affected area. Tendinopathy is prevalent in both athletes and the general population, highlighting the need to elucidate the pathogenesis of this disorder. Current treatme...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2016/4076578
更新日期:2016-01-01 00:00:00
abstract::Aged tendon-derived stem/progenitor cells (TSPCs) lead to age-related tendon disorders and impair tendon healing. However, the underlying molecular mechanisms of TSPC aging remain largely unknown. Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging. CTGF protein and mRNA levels were ...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/6257537
更新日期:2019-11-11 00:00:00
abstract::Homoeostasis of bone marrow microenvironment depends on a precise balance between cell proliferation and death, which is supported by the cellular-extracellular matrix crosstalk. Multipotent mesenchymal stromal cells (MSC) are the key elements to provide the specialized bone marrow microenvironment by supporting, main...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2019/6854080
更新日期:2019-06-02 00:00:00
abstract::Organoid is a cell organization grown in a three-dimensional (3D) culture system which represents all characteristics of its origin. However, this organ-like structure requires supporting matrix to maintain its characteristics and functions. Matrigel, derived from mouse sarcoma, has often been used as the supporting m...
journal_title:Stem cells international
pub_type: 杂志文章
doi:10.1155/2019/8472712
更新日期:2019-06-13 00:00:00
abstract::Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regul...
journal_title:Stem cells international
pub_type: 杂志文章,评审
doi:10.1155/2020/1047896
更新日期:2020-07-08 00:00:00