Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis.

abstract：:A stably established population of mouse bone marrow stromal cells (BMSCs) with self-renewal and multilineage differentiation potential was expanded in vitro for more than 50 passages. These cells express high levels of mesenchymal stem cell markers and can be differentiated into adipogenic, chondrogenic, and osteogen...

journal_title：Stem cells international

authors： Yu L,Hong W,Yang H,Xia YY,Feng Z

更新日期：2020-12-24 00:00:00

abstract：Objective:Special hypoxic and hypertonic microenvironment in intervertebral discs (IVDs) decreases the treatment effect of cell transplantation. We investigated the hypothesis that hypoxic preconditioning (HP) could improve the therapeutic effect of bone mesenchymal stem cells (BMSCs) to IVD degeneration. Methods:BMSC...

journal_title：Stem cells international

authors： Wang W,Wang Y,Deng G,Ma J,Huang X,Yu J,Xi Y,Ye X

更新日期：2018-02-14 00:00:00

abstract：:Delayed administration of kallikrein after cerebral infarction can improve neurological function. However, the appropriate kallkrein treatment time after ischemic stroke has not been illuminated. In this study, we compared the long-term outcome among three kallikrein therapeutic regimens starting at different time poi...

journal_title：Stem cells international

authors： Ni Y,Cai K,Hu Y,Wang CH,Zhang Y,Huang H,Su X,Gu JH

更新日期：2018-04-05 00:00:00

abstract：:Oral mesenchymal stem/progenitor cells (MSCs) are renowned in the field of tissue engineering/regeneration for their multilineage differentiation potential and easy acquisition. These cells encompass the periodontal ligament stem/progenitor cells (PDLSCs), the dental pulp stem/progenitor cells (DPSCs), the stem/progen...

journal_title：Stem cells international

authors： Zhou LL,Liu W,Wu YM,Sun WL,Dörfer CE,Fawzy El-Sayed KM

更新日期：2020-02-25 00:00:00

abstract：:Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...

journal_title：Stem cells international

authors： Sassoli C,Pierucci F,Tani A,Frati A,Chellini F,Matteini F,Vestri A,Anderloni G,Nosi D,Zecchi-Orlandini S,Meacci E

更新日期：2018-03-11 00:00:00

abstract：:Articular cartilage defects have been addressed by using multiple strategies. In the last two decades, promising new strategies by using assorted scaffolds and cell sources to induce tissue regeneration have emerged, such as autologous chondrocyte implantation (ACI) and mesenchymal stem cell implantation (MSCI). Howev...

journal_title：Stem cells international

authors： Deng Z,Jin J,Zhao J,Xu H

更新日期：2016-01-01 00:00:00

abstract：:This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD. We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey. Totally, 68 doses of bone marrow derived MSCs were infuse...

journal_title：Stem cells international

authors： Erbey F,Atay D,Akcay A,Ovali E,Ozturk G

更新日期：2016-01-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties vi...

journal_title：Stem cells international

authors： Wang M,Yuan Q,Xie L

更新日期：2018-06-14 00:00:00

abstract：:Recent studies indicate important roles for long noncoding RNAs (lncRNAs) as essential regulators of gene expression. However, the specific roles of lncRNAs in stenotic lesions of arteriovenous fistula (AVF) failure are still largely unknown. We first analyzed the expression profiles of lncRNAs in human stenosed and n...

journal_title：Stem cells international

authors： Lv L,Qi H,Guo X,Ni Q,Yan Z,Zhang L

更新日期：2017-01-01 00:00:00

abstract：:Intervertebral disc degeneration (IVD) is a frequent pathological condition. Conservative management often fails, and patients with IVD degeneration may require surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably e...

journal_title：Stem cells international

authors： Longo UG,Papapietro N,Petrillo S,Franceschetti E,Maffulli N,Denaro V

更新日期：2012-01-01 00:00:00

abstract：:Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regul...

journal_title：Stem cells international

authors： Jiang S,Guo Y

更新日期：2020-07-08 00:00:00

abstract：:The application of human bone marrow mesenchymal stem cells (hBM-MSCs) in cell-based clinical therapies is hindered by the limited number of cells remaining after the initial isolation process and by cellular senescence following in vitro expansion. Understanding the process of in vitro senescence in hBM-MSCs would en...

journal_title：Stem cells international

authors： Xu Z,Wu W,Shen F,Yu Y,Wang Y,Xiang C

更新日期：2019-07-11 00:00:00

abstract：:Endometriosis is an inflammatory disease with predominance of immunosuppressive M2 macrophages in the pelvic cavity that could be involved in the pathology through support and immune escape of ectopic lesions. Mesenchymal stromal cells (MSC) are found in ectopic lesions, and MSC from nonendometriosis sources are known...

journal_title：Stem cells international

authors： Abomaray F,Gidlöf S,Götherström C

更新日期：2017-01-01 00:00:00

abstract：:Intestinal stem cells are located at the base of the crypts and are surrounded by a complex structure called niche. This environment is composed mainly of epithelial cells and stroma which provides signals that govern cell maintenance, proliferation, and differentiation. Understanding how the niche regulates stem cell...

journal_title：Stem cells international

authors： Gjorevski N,Ordóñez-Morán P

更新日期：2017-01-01 00:00:00

abstract：:Hindlimb ischemia is still a clinical problem with high morbidity and mortality. Patients suffer from consequent rest pain, ulcers, cool limbs, and even amputation. Angiogenesis is a promising target for the treatment of ischemic limbs, providing extra blood for the ischemic region. In the present study, we investigat...

journal_title：Stem cells international

authors： Yin C,Liang Y,Zhang J,Ruan G,Li Z,Pang R,Pan X

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2017/3978595.]. ...

journal_title：Stem cells international

authors： Zadroga A,Jezierska-Woźniak K,Czarzasta J,Barczewska M,Wojtkiewicz J,Maksymowicz W

更新日期：2017-01-01 00:00:00

abstract：:The use of Mesenchymal Stromal Cells (MSCs) aiming to treat cancer has shown very contradictory results. In an attempt to clarify the contradictory results reported in the literature and the possible role of human fallopian tube Mesenchymal Stromal Cells (htMSCs) against breast cancer, the aim of this study was to eva...

journal_title：Stem cells international

authors： Jazedje T,Ribeiro AL,Pellati M,de Siqueira Bueno HM,Nagata G,Trierveiler M,Rodrigues EG,Zatz M

更新日期：2015-01-01 00:00:00

abstract：:Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy (CCC), caused by chronic infection with Trypanosoma cruzi, the exacerbated immune response plays a critical pathophysiological role and can be modula...

journal_title：Stem cells international

authors： Souza BSF,da Silva KN,Silva DN,Rocha VPC,Paredes BD,Azevedo CM,Nonaka CK,Carvalho GB,Vasconcelos JF,Dos Santos RR,Soares MBP

更新日期：2017-01-01 00:00:00

abstract：:Increasing the success rate of rotator cuff healing remains tremendous challenge. Among many approaches, the possibility of activating resident stem cells in situ, without the need to isolate them from biopsies, could represent valuable therapeutic strategy. Along this line, it has been recently demonstrated that lipo...

journal_title：Stem cells international

authors： Randelli P,Menon A,Ragone V,Creo P,Bergante S,Randelli F,De Girolamo L,Alfieri Montrasio U,Banfi G,Cabitza P,Tettamanti G,Anastasia L

更新日期：2016-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Bind...

journal_title：Stem cells international

authors： Dietrich C

更新日期：2016-01-01 00:00:00

abstract：Objective:Mesenchymal stem cells (MSCs) are considered a promising therapy for wound healing. Here, we explored the role of c-Jun in diabetic wound healing using human umbilical cord-derived MSCs (hUC-MSCs). Methods:Freshly isolated hUC-MSCs were subjected to extensive in vitro subcultivation. The cell proliferative a...

journal_title：Stem cells international

authors： Yue C,Guo Z,Luo Y,Yuan J,Wan X,Mo Z

更新日期：2020-01-14 00:00:00

abstract：Background:Cancer stem cell (CSC) promotes angiogenesis which plays an important role in tumor occurrence, growth, and metastasis. Accurately, quantifying the tumor vasculature can help understanding CSC characteristics and improve cancer diagnosis, therapy planning, and evaluation. The objective of this study is to pr...

journal_title：Stem cells international

authors： Zhang L,Zheng F,Peng Z,Hu Z,Yang Z

更新日期：2018-04-03 00:00:00

abstract：:Histone deacetylase inhibitors (HDACi) are small molecules that have important and pleiotropic effects on cell homeostasis. Under distinct developmental conditions, they can promote either self-renewal or differentiation of embryonic stem cells. In addition, they can promote directed differentiation of embryonic and t...

journal_title：Stem cells international

authors： Kretsovali A,Hadjimichael C,Charmpilas N

更新日期：2012-01-01 00:00:00

abstract：:Human bone marrow mesenchymal stem cells (hBM-MSCs) are the best characterized multipotent adult stem cells. Their self-renewal capacity, multilineage differentiation potential, and immunomodulatory properties have indicated that they can be used in many clinical therapies. In a previous work we studied the DNA methyl...

journal_title：Stem cells international

authors： Bentivegna A,Roversi G,Riva G,Paoletta L,Redaelli S,Miloso M,Tredici G,Dalprà L

更新日期：2016-01-01 00:00:00

abstract：:In situ detection of MSCs remains difficult and warrants additional methods to aid with their characterization in vivo. Two-photon confocal laser scanning microscopy (TPM) and second harmonic generation (SHG) could fill this gap. Both techniques enable the detection of cells and extracellular structures, based on intr...

journal_title：Stem cells international

authors： Donders R,Sanen K,Paesen R,Slenders E,Gyselaers W,Stinissen P,Ameloot M,Hellings N

更新日期：2016-01-01 00:00:00

abstract：:There are very few model systems which demonstrate hematopoiesis in vitro. Previously, we described unique splenic stromal cell lines which support the in vitro development of hematopoietic cells and particularly myeloid cells. Here, the 5G3 spleen stromal cell line has been investigated for capacity to support the di...

journal_title：Stem cells international

authors： Lim HK,Periasamy P,O'Neill HC

更新日期：2018-12-25 00:00:00

abstract：:Myocardial infarction is a leading cause of death among all cardiovascular diseases. Cell therapies using a cell population enriched with endothelial progenitor cells (EPCs), expanded CD133+ cells, have promise as a therapeutic option for the treatment of ischemic areas after infarction. Recently, secreted membrane ve...

journal_title：Stem cells international

authors： Angulski ABB,Capriglione LGA,Barchiki F,Brofman P,Stimamiglio MA,Senegaglia AC,Correa A

更新日期：2019-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) possess a capacity to enhance cutaneous wound healing that is well characterized. However, the therapeutic effect of MSCs appears to be limited. Modifying MSC target genes to increase necessary biological effects is a promising strategy for wound therapy. Interleukin-10 (IL-10) is an anti...

journal_title：Stem cells international

authors： Xiao S,Huang G,Wei Z,Nie K,Liu Z,Deng C,Wang D

更新日期：2019-06-11 00:00:00

abstract：:Damage to the nervous system can cause devastating diseases or musculoskeletal dysfunctions and transplantation of progenitor stem cells can be an excellent treatment option in this regard. Preclinical studies demonstrate that untreated stem cells, unlike stem cells activated to differentiate into neuronal lineage, do...

journal_title：Stem cells international

authors： Madhu V,Dighe AS,Cui Q,Deal DN

更新日期：2016-01-01 00:00:00

abstract：:Previously, we demonstrated a high quality of minerals formed by serum-free cultured jaw periosteal cells (JPCs) by Raman spectroscopy but the mineralization extent was not satisfactory. In the present study, we analyzed the proliferation and mineralization potential of human platelet lysate- (hPL-) cultured JPCs in c...

journal_title：Stem cells international

authors： Wanner Y,Umrath F,Waidmann M,Reinert S,Alexander D

更新日期：2017-01-01 00:00:00