Lung Mesenchymal Stem Cells Ameliorate Elastase-Induced Damage in an Animal Model of Emphysema.

Abstract:

:Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. Evidence suggests that mesenchymal stem cells (MSCs) possess the ability to engraft the injured tissues and induce repair via a paracrine effect. Thus, the aim of this study was to test the effects of the intratracheal administration of lung-derived mouse MSCs in a model of elastase-induced emphysema. Pulmonary function (static lung compliance) showed an increased stiffness induced by elastase, while morphometric findings (mean linear intercept and tissue/alveolar area) confirmed the severity of alveolar disruption. Contrarily, MSC administration partially restored lung elasticity and alveolar architecture. In the absence of evidence that MSCs acquired epithelial phenotype, we detected an increased proliferative activity of aquaporin 5- and surfactant protein C-positive lung cells, suggesting MSC-driven paracrine mechanisms. The data indicate the mediation of hepatocyte growth factor in amplifying MSC-driven tissue response after injury. Our study shed light on supportive properties of lung-derived MSCs, although the full identification of mechanisms orchestrated by MSCs and responsible for epithelial repair after injury is a critical aspect yet to be achieved.

journal_name

Stem Cells Int

journal_title

Stem cells international

authors

Cappetta D,De Angelis A,Spaziano G,Tartaglione G,Piegari E,Esposito G,Ciuffreda LP,Liparulo A,Sgambato M,Russo TP,Rossi F,Berrino L,Urbanek K,D'Agostino B

doi

10.1155/2018/9492038

subject

Has Abstract

pub_date

2018-03-14 00:00:00

pages

9492038

eissn

1687-966X

issn

1687-9678

journal_volume

2018

pub_type

杂志文章
  • Adipose-Derived Mesenchymal Stem Cells Migrate and Rescue RPE in the Setting of Oxidative Stress.

    abstract::Oxidative stress leads to the degeneration of retinal pigment epithelial (RPE) and photoreceptor cells. We evaluated the potential of adipose-derived mesenchymal stem cells (ASCs) as a therapeutic tool by studying the migration capacity of ASCs in vitro and their protective effect against RPE cell death under oxidativ...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2018/9682856

    authors: Barzelay A,Weisthal Algor S,Niztan A,Katz S,Benhamou M,Nakdimon I,Azmon N,Gozlan S,Mezad-Koursh D,Neudorfer M,Goldstein M,Meilik B,Loewenstein A,Barak A

    更新日期:2018-12-13 00:00:00

  • Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome.

    abstract::The purpose of the present study was to test the potential of mouse bone marrow-derived mesenchymal stem cells (BD-MSCs) in improving tear production in a mouse model of Sjögren's syndrome dry eye and to investigate the underlying mechanisms involved. NOD mice (n = 20) were randomized to receive i.p. injection of ster...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2017/3134543

    authors: Aluri HS,Samizadeh M,Edman MC,Hawley DR,Armaos HL,Janga SR,Meng Z,Sendra VG,Hamrah P,Kublin CL,Hamm-Alvarez SF,Zoukhri D

    更新日期:2017-01-01 00:00:00

  • Bioelectric state and cell cycle control of Mammalian neural stem cells.

    abstract::The concerted action of ion channels and pumps establishing a resting membrane potential has been most thoroughly studied in the context of excitable cells, most notably neurons, but emerging evidences indicate that they are also involved in controlling proliferation and differentiation of nonexcitable somatic stem ce...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2012/816049

    authors: Aprea J,Calegari F

    更新日期:2012-01-01 00:00:00

  • Vascular Remodelling and Mesenchymal Transition in Systemic Sclerosis.

    abstract::Fibrosis of the skin and of internal organs, autoimmunity, and vascular inflammation are hallmarks of Systemic Sclerosis (SSc). The injury and activation of endothelial cells, with hyperplasia of the intima and eventual obliteration of the vascular lumen, are early features of SSc. Reduced capillary blood flow coupled...

    journal_title:Stem cells international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/4636859

    authors: Nicolosi PA,Tombetti E,Maugeri N,Rovere-Querini P,Brunelli S,Manfredi AA

    更新日期:2016-01-01 00:00:00

  • Contribution of Mouse Embryonic Stem Cells and Induced Pluripotent Stem Cells to Chimeras through Injection and Coculture of Embryos.

    abstract::Blastocyst injection and morula aggregation are commonly used to evaluate stem cell pluripotency based on chimeric contribution of the stem cells. To assess the protocols for generating chimeras from stem cells, 8-cell mouse embryos were either injected or cocultured with mouse embryonic stem cells and induced pluripo...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2014/409021

    authors: Guo J,Wu B,Li S,Bao S,Zhao L,Hu S,Sun W,Su J,Dai Y,Li X

    更新日期:2014-01-01 00:00:00

  • 3D Spheroid Culture Enhances the Expression of Antifibrotic Factors in Human Adipose-Derived MSCs and Improves Their Therapeutic Effects on Hepatic Fibrosis.

    abstract::Three-dimensional (3D) cell culture has been reported to increase the therapeutic potentials of mesenchymal stem cells (MSCs). However, the action mechanisms of 3D MSCs vary greatly and are far from being thoroughly investigated. In this study, we aimed to investigate the therapeutic effects of 3D spheroids of human a...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2016/4626073

    authors: Zhang X,Hu MG,Pan K,Li CH,Liu R

    更新日期:2016-01-01 00:00:00

  • Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a.

    abstract::Exosomes derived from cancer cells can affect various functions of mesenchymal stem cells (MSCs) via conveying microRNAs (miRs). miR-21 and miR-146a have been demonstrated to regulate MSC proliferation and transformation. Interleukin-6 (IL-6) secreted from transformed MSCs in turn favors the survival of multiple myelo...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2017/9012152

    authors: Cheng Q,Li X,Liu J,Ye Q,Chen Y,Tan S,Liu J

    更新日期:2017-01-01 00:00:00

  • Conditioned Medium from Human Amnion-Derived Mesenchymal Stem Cells Regulates Activation of Primary Hepatic Stellate Cells.

    abstract::Mesenchymal stem cells (MSCs), or multipotent mesenchymal stromal cells, are present in almost all organs and tissues, including the amnion. Human amnion-derived mesenchymal stem cell (hAMSC) transplantation has been reported to ameliorate liver fibrosis in animal models. However, the mechanism for the prevention of l...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2018/4898152

    authors: Fu Q,Ohnishi S,Sakamoto N

    更新日期:2018-10-08 00:00:00

  • Peripheral Circulation and Astrocytes Contribute to the MSC-Mediated Increase in IGF-1 Levels in the Infarct Cortex in a dMCAO Rat Model.

    abstract:Materials and Methods:Ischemic brain injury was induced by dMCAO in Sprague-Dawley rats. The transplantation group received MSC infusion 1 h after dMCAO. Expression of IGF-1 in GFAP+ astrocytes, Iba-1+ microglia/macrophages, CD3+ lymphocytes, Ly6C+ monocytes/macrophages, and neutrophil elastase (NE)+ neutrophils was ex...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2020/8853444

    authors: Li X,Yu W,Guan Y,Zou H,Liang Z,Huang M,Zhao R,Zhao C,Ren Z,Chen Z

    更新日期:2020-09-01 00:00:00

  • Stem Cells and Cellular Origins of Mammary Gland: Updates in Rationale, Controversies, and Cancer Relevance.

    abstract::Evidences have supported the pivotal roles of stem cells in mammary gland development. Many molecular markers have been identified to characterize mammary stem cells. Cellular fate mapping of mammary stem cells by lineage tracing has put unprecedented insights into the mammary stem cell biology, which identified two s...

    journal_title:Stem cells international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/4247168

    authors: Zhou J,Chen Q,Zou Y,Zheng S,Chen Y

    更新日期:2019-01-08 00:00:00

  • Transgenic Strategies to Study Podocyte Loss and Regeneration.

    abstract::Podocyte death and regeneration are major topics in kidney research but remain controversial. Data obtained in humans demonstrate the existence of cells sited along Bowman's capsule that behave as podocyte progenitors in vitro and in in vivo mouse models of podocyte injury xenotrasplanted with this human-derived popul...

    journal_title:Stem cells international

    pub_type: 杂志文章,评审

    doi:10.1155/2015/678347

    authors: Lombardi D,Lasagni L

    更新日期:2015-01-01 00:00:00

  • Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis.

    abstract::The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2017/8010961

    authors: Solders M,Gorchs L,Gidlöf S,Tiblad E,Lundell AC,Kaipe H

    更新日期:2017-01-01 00:00:00

  • Epigenetic Clock: DNA Methylation in Aging.

    abstract::Aging, which is accompanied by decreased organ function and increased disease incidence, limits human lifespan and has attracted investigators for thousands of years. In recent decades, with the rapid development of biology, scientists have shown that epigenetic modifications, especially DNA methylation, are key regul...

    journal_title:Stem cells international

    pub_type: 杂志文章,评审

    doi:10.1155/2020/1047896

    authors: Jiang S,Guo Y

    更新日期:2020-07-08 00:00:00

  • Comparison of Regenerative Tissue Quality following Matrix-Associated Cell Implantation Using Amplified Chondrocytes Compared to Synovium-Derived Stem Cells in a Rabbit Model for Cartilage Lesions.

    abstract::Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2018/4142031

    authors: Schmal H,Kowal JM,Kassem M,Seidenstuecker M,Bernstein A,Böttiger K,Xiong T,Südkamp NP,Kubosch EJ

    更新日期:2018-04-19 00:00:00

  • 3D Culture of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) Could Improve Bone Regeneration in 3D-Printed Porous Ti6Al4V Scaffolds.

    abstract::Mandibular bone defect reconstruction is an urgent challenge due to the requirements for daily eating and facial aesthetics. Three-dimensional- (3D-) printed titanium (Ti) scaffolds could provide patient-specific implants for bone defects. Appropriate load-bearing properties are also required during bone reconstructio...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2018/2074021

    authors: Yu L,Wu Y,Liu J,Li B,Ma B,Li Y,Huang Z,He Y,Wang H,Wu Z,Qiu G

    更新日期:2018-09-05 00:00:00

  • The Paracrine Effect of Adipose-Derived Stem Cells Orchestrates Competition between Different Damaged Dermal Fibroblasts to Repair UVB-Induced Skin Aging.

    abstract:Background:Human dermal fibroblasts (HDFs) are the primary cells in skin and are associated with UVB-induced skin photoaging. Adipose-derived stem cells (ASCs) have been proposed as a treatment for skin aging. The goal of this study was to investigate paracrine mechanisms by which ASCs repair HDFs damage from UVB expos...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2020/8878370

    authors: Qin F,Huang J,Zhang W,Zhang M,Li Z,Si L,Long X,Wang X

    更新日期:2020-12-17 00:00:00

  • Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar.

    abstract::Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2016/9010279

    authors: Valerie A,Vassiliki K,Irini M,Nikolaos P,Karampela E,Apostolos P

    更新日期:2016-01-01 00:00:00

  • Periostin: A Downstream Mediator of EphB4-Induced Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells.

    abstract::Erythropoietin-producing hepatocyte B4 (EphB4) has been reported to be a key molecular switch in the regulation of bone homeostasis, but the underlying mechanism remains poorly understood. In this study, we investigated the role of EphB4 in regulating the expression of periostin (POSTN) within bone marrow-derived mese...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2016/7241829

    authors: Zhang F,Zhang Z,Sun D,Dong S,Xu J,Dai F

    更新日期:2016-01-01 00:00:00

  • Corrigendum to "Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries".

    abstract::[This corrects the article DOI: 10.1155/2017/3978595.]. ...

    journal_title:Stem cells international

    pub_type: 已发布勘误

    doi:10.1155/2017/9438310

    authors: Zadroga A,Jezierska-Woźniak K,Czarzasta J,Barczewska M,Wojtkiewicz J,Maksymowicz W

    更新日期:2017-01-01 00:00:00

  • Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis.

    abstract::Asherman's Syndrome (AS) is an uncommon, acquired, and refractory gynecological disorder. Current treatment was still limited, and stem cell-based therapy has been proposed as a novel strategy for management of AS. Here, we conducted a meta-analysis of self-controlled clinical trials to assess the effectiveness and sa...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2020/8820538

    authors: Zhao Y,Luo Q,Zhang X,Qin Y,Hao J,Kong D,Wang H,Li G,Gu X,Wang H

    更新日期:2020-12-19 00:00:00

  • Roles of Mesenchymal Stem Cells in Spinal Cord Injury.

    abstract::Spinal cord injury (SCI) represents one of the most complicated and heterogeneous pathological processes of central nervous system (CNS) impairments, which is still beyond functional regeneration. Transplantation of mesenchymal stem cells (MSCs) has been shown to promote the repair of the injured spinal cord tissues i...

    journal_title:Stem cells international

    pub_type: 杂志文章,评审

    doi:10.1155/2017/5251313

    authors: Qu J,Zhang H

    更新日期:2017-01-01 00:00:00

  • Identification of Macrophage Genotype and Key Biological Pathways in Circulating Angiogenic Cell Transcriptome.

    abstract:Background:Circulating angiogenic cells (CAC) have been identified as important regulators of vascular biology. However, there is still considerable debate about the genotype and function of CAC. Methods and Results:Data from publicly available gene expression data sets were used to analyse the transcriptome of in vit...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2019/9545261

    authors: Everaert BR,Van Laere SJ,Lembrechts R,Hoymans VY,Timmermans JP,Vrints CJ

    更新日期:2019-05-02 00:00:00

  • Mesenchymal Stromal Cells Are More Immunosuppressive In Vitro If They Are Derived from Endometriotic Lesions than from Eutopic Endometrium.

    abstract::Endometriosis is an inflammatory disease with predominance of immunosuppressive M2 macrophages in the pelvic cavity that could be involved in the pathology through support and immune escape of ectopic lesions. Mesenchymal stromal cells (MSC) are found in ectopic lesions, and MSC from nonendometriosis sources are known...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2017/3215962

    authors: Abomaray F,Gidlöf S,Götherström C

    更新日期:2017-01-01 00:00:00

  • Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells.

    abstract::Allogeneic cell-based therapies using adipose tissue-derived stromal cells (ASCs) offer an off-the-shelf alternative to autologous therapy. An underlying assumption is that ASC can modulate the immune response of the recipient. However, in vitro models are required to explore and identify cell interactions and mechani...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2020/8868909

    authors: Juhl M,Follin B,Gad M,Larsen J,Kastrup J,Ekblond A

    更新日期:2020-10-26 00:00:00

  • In Vitro Studies of Bacterial Cellulose and Magnetic Nanoparticles Smart Nanocomposites for Efficient Chronic Wounds Healing.

    abstract::The quality of life of patients with chronic wounds can be extremely poor and, therefore, over the past decades, great efforts have been made to develop efficient strategies to improve the healing process and the social impact associated with these conditions. Cell based therapy, as a modern tissue engineering strateg...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2015/195096

    authors: Galateanu B,Bunea MC,Stanescu P,Vasile E,Casarica A,Iovu H,Hermenean A,Zaharia C,Costache M

    更新日期:2015-01-01 00:00:00

  • Osteogenic Differentiation of hDPSCs on Biogenic Bone Apatite Thin Films.

    abstract::A previous study reported the structural characterization of biogenic apatite (BAp) thin films realized by a pulsed electron deposition system by ablation of deproteinized bovine bone. Thin films annealed at 400°C exhibited composition and crystallinity degree very close to those of biogenic apatite; this affinity is ...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2017/3579283

    authors: Bianchi M,Pisciotta A,Bertoni L,Berni M,Gambardella A,Visani A,Russo A,de Pol A,Carnevale G

    更新日期:2017-01-01 00:00:00

  • Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells.

    abstract::Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. Despite several treatment options, AMD therapy remains difficult, especially for exudative AMD. Mul...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2012/946090

    authors: Nuzzi R,Gunetti M,Rustichelli D,Roagna B,Fronticelli Bardelli F,Fagioli F,Ferrero I

    更新日期:2012-01-01 00:00:00

  • Mesenchymal stem cell for prevention and management of intervertebral disc degeneration.

    abstract::Intervertebral disc degeneration (IVD) is a frequent pathological condition. Conservative management often fails, and patients with IVD degeneration may require surgical intervention. Several treatment strategies have been proposed, although only surgical discectomy and arthrodesis have been proved to be predictably e...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2012/921053

    authors: Longo UG,Papapietro N,Petrillo S,Franceschetti E,Maffulli N,Denaro V

    更新日期:2012-01-01 00:00:00

  • Human Liver Stem Cells Suppress T-Cell Proliferation, NK Activity, and Dendritic Cell Differentiation.

    abstract::Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver. Preclinical studies indicate that HLSCs could be a good candidate for cell therapy. The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, n...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2016/8468549

    authors: Bruno S,Grange C,Tapparo M,Pasquino C,Romagnoli R,Dametto E,Amoroso A,Tetta C,Camussi G

    更新日期:2016-01-01 00:00:00

  • Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma.

    abstract::Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumor and a subpopulation of glioma stem-like cells (GSCs) is likely responsible for the invariable recurrence following maximum resection and chemoradiotherapy. As most GSCs that are located in the perivascular and perinecrotic niches should be remo...

    journal_title:Stem cells international

    pub_type: 杂志文章

    doi:10.1155/2018/5387041

    authors: Nishikawa M,Inoue A,Ohnishi T,Kohno S,Ohue S,Matsumoto S,Suehiro S,Yamashita D,Ozaki S,Watanabe H,Yano H,Takahashi H,Kitazawa R,Tanaka J,Kunieda T

    更新日期:2018-08-23 00:00:00