Abstract：
:Pulmonary emphysema is a respiratory condition characterized by alveolar destruction that leads to airflow limitation and reduced lung function. Although with extensive research, the pathophysiology of emphysema is poorly understood and effective treatments are still missing. Evidence suggests that mesenchymal stem cells (MSCs) possess the ability to engraft the injured tissues and induce repair via a paracrine effect. Thus, the aim of this study was to test the effects of the intratracheal administration of lung-derived mouse MSCs in a model of elastase-induced emphysema. Pulmonary function (static lung compliance) showed an increased stiffness induced by elastase, while morphometric findings (mean linear intercept and tissue/alveolar area) confirmed the severity of alveolar disruption. Contrarily, MSC administration partially restored lung elasticity and alveolar architecture. In the absence of evidence that MSCs acquired epithelial phenotype, we detected an increased proliferative activity of aquaporin 5- and surfactant protein C-positive lung cells, suggesting MSC-driven paracrine mechanisms. The data indicate the mediation of hepatocyte growth factor in amplifying MSC-driven tissue response after injury. Our study shed light on supportive properties of lung-derived MSCs, although the full identification of mechanisms orchestrated by MSCs and responsible for epithelial repair after injury is a critical aspect yet to be achieved.
journal_name
Stem Cells Intjournal_title
Stem cells internationalauthors
Cappetta D,De Angelis A,Spaziano G,Tartaglione G,Piegari E,Esposito G,Ciuffreda LP,Liparulo A,Sgambato M,Russo TP,Rossi F,Berrino L,Urbanek K,D'Agostino Bdoi
10.1155/2018/9492038subject
Has Abstractpub_date
2018-03-14 00:00:00pages
9492038eissn
1687-966Xissn
1687-9678journal_volume
2018pub_type
杂志文章abstract：:Hematopoietic stem cell transplantation (HSCT) is one of a range of therapeutic options available to patients suffering from various diseases. HSCT procedure involves important ethical and legal aspects that can occur at every phase of the procedure: the clinical choice of whether to perform the procedure, pretranspla...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/1286246
更新日期：2017-01-01 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility in women of reproductive age. Chronic inflammation is considered to be the cause of ovarian dysfunction. Increasing evidence in animal studies and in preliminary clinical trials has demonstrated that MSCs possess immunomodulatory effe...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/9782373
更新日期：2019-09-12 00:00:00
abstract：:Cord blood transplantation (CBT) is an attractive alternative therapy in adult patients with advanced hematological malignancies in whom matched donors are unavailable. However, the risk of complications, especially infections, post-CBT increases the mortality rates in these patients. Although the incidence of acute a...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.4061/2011/607569
更新日期：2011-01-01 00:00:00
abstract：:Human mesenchymal stem/stromal cells (hMSCs) have generated great interest in regenerative medicine mainly due to their multidifferentiation potential and immunomodulatory role. Although hMSC can be obtained from different tissues, the number of available cells is always low for clinical applications, thus requiring i...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/6597815
更新日期：2017-01-01 00:00:00
abstract：:Previously, we demonstrated a high quality of minerals formed by serum-free cultured jaw periosteal cells (JPCs) by Raman spectroscopy but the mineralization extent was not satisfactory. In the present study, we analyzed the proliferation and mineralization potential of human platelet lysate- (hPL-) cultured JPCs in c...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/8303959
更新日期：2017-01-01 00:00:00
abstract：Background:Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/1302672
更新日期：2018-08-29 00:00:00
abstract：:Intestinal stem cells are located at the base of the crypts and are surrounded by a complex structure called niche. This environment is composed mainly of epithelial cells and stroma which provides signals that govern cell maintenance, proliferation, and differentiation. Understanding how the niche regulates stem cell...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/8387297
更新日期：2017-01-01 00:00:00
abstract：:Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/3206807
更新日期：2016-01-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are a reliable source for cell-based regenerative medicine owing to their multipotency and biological functions. However, aging-induced systemic homeostasis disorders in vivo and cell culture passaging in vitro induce a functional decline of MSCs, switching MSCs to a senescent status with...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2020/8836258
更新日期：2020-09-10 00:00:00
abstract：:Oral mesenchymal stem/progenitor cells (MSCs) are renowned in the field of tissue engineering/regeneration for their multilineage differentiation potential and easy acquisition. These cells encompass the periodontal ligament stem/progenitor cells (PDLSCs), the dental pulp stem/progenitor cells (DPSCs), the stem/progen...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2020/1327405
更新日期：2020-02-25 00:00:00
abstract：:Background. The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid. Study Design. Animal experiment. Method. We used 74 New Zealand...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/9010279
更新日期：2016-01-01 00:00:00
abstract：:Bone tissue regeneration is considered to be the optimal solution for bone loss. However, diabetic patients have a greater risk of poor bone healing or bone grafting failure than nondiabetics. The purpose of this study was to investigate the influence of the complexes of an adipose-derived stem cell sheet (ASC sheet) ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/2506463
更新日期：2019-07-31 00:00:00
abstract：:Faced with the end stage of heart disease, the current treatments only slow worsening of heart failure. Stem cells have the potential of self-renewal and differentiation. It is expected to replace and repair damaged myocardium. But many clinical trials have shown that the stem cell therapy of heart failure is modest o...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.4061/2011/310928
更新日期：2011-01-01 00:00:00
abstract：:Branching morphogenesis (BrM), an essential step for salivary gland development, requires epithelial-mesenchymal interactions. BrM is impaired when the surrounding mesenchyme is detached from the salivary epithelium during the pseudoglandular stage. It is believed that the salivary mesenchyme is indispensable for BrM,...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/502136
更新日期：2012-01-01 00:00:00
abstract：:Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and str...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2017/5979741
更新日期：2017-01-01 00:00:00
abstract：:The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts. In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense. These processes are still poorly...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2017/8010961
更新日期：2017-01-01 00:00:00
abstract：:Chicken embryonic stem cells (cESCs) obtained from stage X embryos provide a novel model for the study of avian embryonic development. A new way to maintain cESCs for a long period in vitro still remains unexplored. We found that the cESCs showed stem cell-like properties in vitro for a long term with the support of D...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/2157451
更新日期：2018-05-09 00:00:00
abstract：Objective:To investigate the effects of mesenchymal stem cells (MSCs) coated by the extracellular matrix (ECM) on wound healing in diabetic rats. Methods:Mesenchymal stem cells were cocultured with ECM. Cell viabilities were evaluated using MTT assay. The diabetes model was established using both STZ and high-glucose/...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/9564869
更新日期：2019-01-28 00:00:00
abstract：:Mesenchymal stem cells (MSCs) possess immunosuppressive properties and have been described in the tumor microenvironment of glioblastoma multiforme (GBM). This manuscript has two major topics-first, to describe isolated and cultured MSCs derived from GBM (GB-MSCs) and second, to examine their in vitro immunosuppressiv...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/6904638
更新日期：2019-05-02 00:00:00
abstract：:Aging of population brings related social problems, such as muscle attenuation and regeneration barriers with increased aging. Muscle repair and regeneration depend on muscle stem cells (MuSCs). Obstructive sleep apnea (OSA) rises in the aging population. OSA leads to hypoxia and upper airway muscle injury. However, l...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2020/8412598
更新日期：2020-03-04 00:00:00
abstract：:There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype. Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth. Moreover, cancer cells are able to switch between CSC and non-CSC ...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2018/4516454
更新日期：2018-10-10 00:00:00
abstract：:Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/1741072
更新日期：2016-01-01 00:00:00
abstract：:Podocyte death and regeneration are major topics in kidney research but remain controversial. Data obtained in humans demonstrate the existence of cells sited along Bowman's capsule that behave as podocyte progenitors in vitro and in in vivo mouse models of podocyte injury xenotrasplanted with this human-derived popul...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2015/678347
更新日期：2015-01-01 00:00:00
abstract：:Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling and proliferation and secretion ability, is played by matrix met...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2018/5034679
更新日期：2018-03-11 00:00:00
abstract：:Efficient ex vivo expansion of hematopoietic stem cells with a concomitant preservation of stemness and self-renewal potential is still an unresolved ambition. Increased numbers of methods approaching this issue using three-dimensional (3D) cultures were reported. Here, we describe a simplified 3D hanging drop model f...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/4148093
更新日期：2016-01-01 00:00:00
abstract：:Aged tendon-derived stem/progenitor cells (TSPCs) lead to age-related tendon disorders and impair tendon healing. However, the underlying molecular mechanisms of TSPC aging remain largely unknown. Here, we investigated the role of connective tissue growth factor (CTGF) in TSPC aging. CTGF protein and mRNA levels were ...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2019/6257537
更新日期：2019-11-11 00:00:00
abstract：:Mesenchymal stem cells (MSCs) derived from bone marrow can secrete cytokines and growth factors and can transdifferentiate into liver cells. We transplanted polymeric membrane bioencapsulated MSCs into the spleens of 90% partial hepatectomized rats. This resulted in 91.6% recovery rates. This is compared to a recovery...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2012/697094
更新日期：2012-01-01 00:00:00
abstract：:Stem cells isolated from adipose tissue show great therapeutic potential in veterinary medicine, but some points such as the use of fresh or cultured cells and route of administration need better knowledge. This study aimed to evaluate the effect of autologous stromal vascular fraction (SVF, n = 4) or allogeneic cultu...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2014/391274
更新日期：2014-01-01 00:00:00
abstract：:Cardiovascular diseases (CVDs), including atherosclerosis, stroke, and myocardial infarction, is a major cause of death worldwide. In aspects of cell therapy against CVD, it is generally accepted that endothelial progenitor cells (EPCs) are potent neovascular modulators in ischemic tissues. In response to ischemic inj...
journal_title：Stem cells international
pub_type： 杂志文章,评审
doi：10.1155/2016/8340257
更新日期：2016-01-01 00:00:00
abstract：:The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. The role of noncanonical Wnt signaling in the regulation of properties of lung cancer stem cells and chemoresistance was interrogated, by accessing capacities of cell proliferation, migration, invasion, an...
journal_title：Stem cells international
pub_type： 杂志文章
doi：10.1155/2016/1690896
更新日期：2016-01-01 00:00:00
