Primordial Germ Cells: Current Knowledge and Perspectives.

Abstract:

:Infertility is a condition that occurs very frequently and understanding what defines normal fertility is crucial to helping patients. Causes of infertility are numerous and the treatment often does not lead to desired pregnancy especially when there is a lack of functional gametes. In humans, the primordial germ cell (PGC) is the primary undifferentiated stem cell type that will differentiate towards gametes: spermatozoa or oocytes. With the development of stem cell biology and differentiation protocols, PGC can be obtained from pluripotent stem cells providing a new therapeutic possibility to treat infertile couples. Recent studies demonstrated that viable mouse pups could be obtained from in vitro differentiated stem cells suggesting that translation of these results to human is closer. Therefore, the aim of this review is to summarize current knowledge about PGC indicating the perspective of their use in both research and medical application for the treatment of infertility.

journal_name

Stem Cells Int

journal_title

Stem cells international

authors

Nikolic A,Volarevic V,Armstrong L,Lako M,Stojkovic M

doi

10.1155/2016/1741072

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

1741072

eissn

1687-966X

issn

1687-9678

journal_volume

2016

pub_type

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