Genome mining and prospects for antibiotic discovery.

abstract：:The discovery of tubulin-like cytoskeletal proteins carried on the genomes of bacteriophages that are actively used for phage propagation during both the lytic and lysogenic cycle have revealed that there at least two ways that viruses can utilize a cytoskeleton; co-opt the host cytoskeleton or bring their own homolog...

journal_title：Current opinion in microbiology

authors： Erb ML,Pogliano J

更新日期：2013-12-01 00:00:00

abstract：:There has been a dramatic increase in the number of completely sequenced bacterial genomes during the past two years as a result of the efforts both of public genome agencies and the pharmaceutical industry. The availability of completely sequenced genomes permits more systematic analyses of genes, evolution and genom...

journal_title：Current opinion in microbiology

authors： Brutlag DL

更新日期：1998-06-01 00:00:00

abstract：:Just as we thought that we know everything about superantigens, new molecular and structural studies indicate that we have only just begun to unravel the secrets of these fascinating molecules. Recent structure-function analysis of superantigens from Gram-positive bacteria, with emphasis on their interaction with majo...

journal_title：Current opinion in microbiology

authors： Kotb M

更新日期：1998-02-01 00:00:00

abstract：:Arginine is an integral part of host defense when invading pathogens are encountered. The arginine metabolite nitric oxide (NO) confers antimicrobial properties, whereas the metabolite ornithine is utilized for polyamine synthesis. Polyamines are crucial to tissue repair and anti-inflammatory responses. iNOS/arginase ...

journal_title：Current opinion in microbiology

authors： Gogoi M,Datey A,Wilson KT,Chakravortty D

更新日期：2016-02-01 00:00:00

abstract：:Successful execution of differentiation programs requires cells to assess multitudes of internal and external cues and respond with appropriate gene expression programs. Here, we review how Bacillus subtilis sporulation network deals with these tasks focusing on the lessons generalizable to other systems. With feedfor...

journal_title：Current opinion in microbiology

authors： Narula J,Fujita M,Igoshin OA

更新日期：2016-12-01 00:00:00

abstract：:The protozoan parasite Trypanosoma brucei is the causative agent of African sleeping sickness and the wasting disease, nagana, in cattle. The parasite is transmitted to the mammalian host by the bite of a tsetse fly. These parasites lack transcriptional regulation, and their gene expression is mainly regulated post-tr...

journal_title：Current opinion in microbiology

authors： Michaeli S

更新日期：2014-08-01 00:00:00

abstract：:Biochemical, serological and microbiological methods have been used to dissect pathogens and identify the components useful for vaccine development. Although successful in many cases, this approach is time-consuming and fails when the pathogens cannot be cultivated in vitro, or when the most abundant antigens are vari...

journal_title：Current opinion in microbiology

authors： Rappuoli R

更新日期：2000-10-01 00:00:00

abstract：:High throughput, deep sequencing assays are powerful tools for gaining insights into virus-host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be characterized, describe important genes in the host ...

journal_title：Current opinion in microbiology

authors： Wylie KM,Weinstock GM,Storch GA

更新日期：2013-08-01 00:00:00

abstract：:Dictyostelium genome sequencing predicts an unexpectedly large number of genes. Many are absent from yeast but present in animals and presumably support cellular abilities not found in yeast. Prominent amongst these abilities is chemotaxis, where great strides are being made in understanding how cells orient in a grad...

journal_title：Current opinion in microbiology

authors： Kay RR

更新日期：2002-12-01 00:00:00

abstract：:Most studies of small regulatory RNAs in bacteria have focussed on conserved transcripts in intergenic regions. However, several recent developments including single-nucleotide resolution transcriptome profiling by RNA-seq and increased knowledge of the cellular targets of the RNA chaperone Hfq suggest that the bacter...

journal_title：Current opinion in microbiology

authors： Miyakoshi M,Chao Y,Vogel J

更新日期：2015-04-01 00:00:00

abstract：:The post-translational attachment of ubiquitin or ubiquitin-like modifiers (ULMs) to proteins regulates many cellular processes including the generation of innate and adaptive immune responses to pathogens. Vice versa, pathogens counteract immune defense by inhibiting or redirecting the ubiquitination machinery of the...

journal_title：Current opinion in microbiology

authors： Viswanathan K,Früh K,DeFilippis V

更新日期：2010-08-01 00:00:00

abstract：:Leishmania parasites are able to delay the onset of cell-mediated immunity by selectively impairing the ability of infected macrophages to produce interleukin (IL)-12. Leishmania infection arrests the JAK/STAT-mediated signal transduction involved in activation of the IL-12 p40 promoter; the phosphorylation defects ma...

journal_title：Current opinion in microbiology

authors： McDowell MA,Sacks DL

更新日期：1999-08-01 00:00:00

abstract：:The Saccharomyces cerevisiae genome sequence, augmented by new data on gene expression and function, continues to yield new findings about eukaryote genome evolution. Analysis of the duplicate gene pairs formed by whole-genome duplication indicates that selection for increased levels of gene expression was a significa...

journal_title：Current opinion in microbiology

authors： Seoighe C,Wolfe KH

更新日期：1999-10-01 00:00:00

abstract：:Antibiotics started to be used almost 90 years ago to eradicate life-threatening infections. The urgency of the problem required rapid, broad-spectrum elimination of infectious agents. Since their initial discovery, these antimicrobials have saved millions of lives. However, they are not exempt from side effects, whic...

journal_title：Current opinion in microbiology

authors： de la Fuente-Nunez C,Torres MD,Mojica FJ,Lu TK

更新日期：2017-06-01 00:00:00

abstract：:Aspergillus fumigatus is an opportunistic fungal pathogen that causes life-threatening infections in immunocompromised individuals. Siderophore-mediated iron acquisition has been shown to be essential for virulence. New studies have revealed that enzymes involved in siderophore biosynthesis and uptake are compartmenta...

journal_title：Current opinion in microbiology

authors： Moore MM

更新日期：2013-12-01 00:00:00

abstract：:A specialized cortical domain is organized by the septins at the necks of budding yeast cells. Recent findings suggest that this domain serves as a diffusion barrier and also as a local cell-shape sensor. We review these findings along with what is known about the organization of the septin cortex and its regulation d...

journal_title：Current opinion in microbiology

authors： Gladfelter AS,Pringle JR,Lew DJ

更新日期：2001-12-01 00:00:00

abstract：:In Gram-negative bacteria such as Escherichia coli the peptidoglycan sacculus resides in the periplasm, a compartment that experiences changes in pH value, osmolality, ion strength and other parameters depending on the cell's environment. Hence, the cell needs robust peptidoglycan growth mechanisms to grow and divide ...

journal_title：Current opinion in microbiology

authors： Pazos M,Peters K,Vollmer W

更新日期：2017-04-01 00:00:00

abstract：:Natural prokaryotic populations are composed of multiple clonal lineages that are different in their core genomes in a range that varies typically between 95 and 100% nucleotide identity. Each clonal lineage also carries a complement of not shared flexible genes that can be very large. The compounded flexible genome p...

journal_title：Current opinion in microbiology

authors： Rodriguez-Valera F,Martin-Cuadrado AB,López-Pérez M

更新日期：2016-06-01 00:00:00

abstract：:Germ line encoded antiviral defenses in vertebrate cells tend to be either broadly acting factors that exploit general features of viral replication or effectors with strong pathogen preference by virtue of specific recognition of viral proteins. The Mx GTPases, however, are atypical since they have broad antiviral ac...

journal_title：Current opinion in microbiology

authors： Mitchell PS,Emerman M,Malik HS

更新日期：2013-08-01 00:00:00

abstract：:The three dimensional ultrastructure of cells and tissues comes to light with tomography. There is an inherent tension between representing molecular detail at the highest possible resolution, on one hand, and visualizing spatial relations between large organelles or even neighboring cells in large volumes, on the oth...

journal_title：Current opinion in microbiology

authors： Elbaum M

更新日期：2018-06-01 00:00:00

abstract：:Extracytoplasmic function σ factors (ECFs) represent a fundamental and widely distributed principle of bacterial signal transduction that connects the perception of a stimulus (input) with the induction of an appropriate set of genes (output). In recent years, comparative genomics analyses have not only allowed a syst...

journal_title：Current opinion in microbiology

authors： Mascher T

更新日期：2013-04-01 00:00:00

abstract：:Sequestered from the action of complement, antibody and lytic peptides, phagosomal pathogens pose a unique problem for the innate immune system both in terms of detection and disposal. An immunologically induced 47-kDa (p47) GTPase family recruited to nascent phagosomes (PGs) has provided new insights into how vertebr...

journal_title：Current opinion in microbiology

authors： MacMicking JD

更新日期：2005-02-01 00:00:00

abstract：:The continued evolution of antimicrobial resistance in the hospital and more recently in the community threatens to seriously compromise our ability to treat serious infections. The major success of the seven-valent Streptococcus pneumoniae vaccine at reducing both infection and resistance has been followed by the eme...

journal_title：Current opinion in microbiology

authors： Rice LB

更新日期：2009-10-01 00:00:00

abstract：:Complete and partial genome sequence information is underway in several parasitic and symbiotic fungi that infect humans, other animals and plants. Comparative analyses of these sequences will provide new insights into the genomic plasticity and evolution of parasitism and mutualism in fungi. ...

journal_title：Current opinion in microbiology

authors： Tunlid A,Talbot NJ

更新日期：2002-10-01 00:00:00

abstract：:Infections caused by the apicomplexan parasites Plasmodium and Toxoplasma are wide-spread, life-threatening and therapeutically challenging. These pathogens are obligate intracellular microorganisms that invade mammalian cells by forming a self-made niche, the parasitophorous vacuole that is impervious to host lysosom...

journal_title：Current opinion in microbiology

authors： Coppens I

更新日期：2017-12-01 00:00:00

abstract：:Bacterial two-component systems (TCSs) and small regulatory RNAs (sRNAs) form densely interconnected networks that integrate and transduce information from the environment into fine-tuned changes of gene expression. Many TCSs control target genes indirectly through regulation of sRNAs, which in turn regulate gene expr...

journal_title：Current opinion in microbiology

authors： Göpel Y,Görke B

更新日期：2012-04-01 00:00:00

abstract：:All organisms must secure essential trace nutrients, including iron, zinc, manganese and copper for survival and proliferation. However, these very nutrients are also highly toxic if present at elevated levels. Mammalian immunity has harnessed both the essentiality and toxicity of micronutrients to defend against micr...

journal_title：Current opinion in microbiology

authors： Ballou ER,Wilson D

更新日期：2016-08-01 00:00:00

abstract：:One defining feature of apicomplexan parasites is their special ability to actively invade host cells. Although rapid, invasion is a complicated process that requires coordinated activities of host cell attachment, protein secretion, and motility by the parasite. Central to this process is the establishment of a struc...

journal_title：Current opinion in microbiology

authors： Shen B,Sibley LD

更新日期：2012-08-01 00:00:00

abstract：:Viruses attach to specific receptors, but identified receptors are often absent from the epithelial surfaces where infections begin. Viruses can bind to alternative receptor molecules present on epithelial surfaces and they can enter hosts in ways that bypass mucosal barriers to infection. To understand how viruses cr...

journal_title：Current opinion in microbiology

authors： Bergelson JM

更新日期：2003-08-01 00:00:00

abstract：:In response to starvation, myxobacteria build multicellular fruiting bodies that contain many thousands of cells and that have particular species-specific shapes. To coordinate fruiting body development, the myxobacterial cells signal to each other. The timing of and cellular responses to these signals help to give fo...

journal_title：Current opinion in microbiology

authors： Kaiser D

更新日期：1998-12-01 00:00:00