Abstract:
:The Saccharomyces cerevisiae genome sequence, augmented by new data on gene expression and function, continues to yield new findings about eukaryote genome evolution. Analysis of the duplicate gene pairs formed by whole-genome duplication indicates that selection for increased levels of gene expression was a significant factor determining which genes were retained as duplicates and which were returned to a single-copy state, possibly in addition to selection for novel gene functions. Proteome comparisons between worm and yeast show that genes for core metabolic processes are shared among eukaryotes and unchanging in function, while comparisons between different yeast species identify 'orphan' genes as the most rapidly evolving fraction of the proteome. Natural hybridisation among yeast species is frequent, but its long-term evolutionary significance is unknown.
journal_name
Curr Opin Microbioljournal_title
Current opinion in microbiologyauthors
Seoighe C,Wolfe KHdoi
10.1016/s1369-5274(99)00015-6subject
Has Abstractpub_date
1999-10-01 00:00:00pages
548-54issue
5eissn
1369-5274issn
1879-0364pii
S1369-5274(99)00015-6journal_volume
2pub_type
杂志文章,评审abstract::Fluency in a common language allows individuals to convey information and carry out complex activities that otherwise would be difficult or even impossible without the benefit of shared communication. Cyclic (di)nucleotides have recently been recognized as such an accessible language understood by both microbe and the...
journal_title:Current opinion in microbiology
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abstract::Bacterial two-component systems (TCSs) and small regulatory RNAs (sRNAs) form densely interconnected networks that integrate and transduce information from the environment into fine-tuned changes of gene expression. Many TCSs control target genes indirectly through regulation of sRNAs, which in turn regulate gene expr...
journal_title:Current opinion in microbiology
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abstract::Proteomic studies are designed to yield either qualitative information on proteins (identification, distribution, posttranslational modifications, interactions, structure and function) or quantitative information (abundance, distribution within different localizations, temporal changes in abundance due to synthesis an...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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abstract::In response to starvation, myxobacteria build multicellular fruiting bodies that contain many thousands of cells and that have particular species-specific shapes. To coordinate fruiting body development, the myxobacterial cells signal to each other. The timing of and cellular responses to these signals help to give fo...
journal_title:Current opinion in microbiology
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abstract::Natural prokaryotic populations are composed of multiple clonal lineages that are different in their core genomes in a range that varies typically between 95 and 100% nucleotide identity. Each clonal lineage also carries a complement of not shared flexible genes that can be very large. The compounded flexible genome p...
journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
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abstract::An understanding of the molecular bases of pathogenicity in Blastomyces dermatitidis and related systemic dimorphic fungi has been limited until recent years. Yeast cells of B. dermatitidis display an adhesion promoting protein termed WI-1. Recent studies entailing homologous gene targeting and mutation of WI-1 have p...
journal_title:Current opinion in microbiology
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2010.04.006
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abstract::Endosymbiotic theory goes back over 100 years. It explains the similarity of chloroplasts and mitochondria to free-living prokaryotes by suggesting that the organelles arose from prokaryotes through (endo)symbiosis. Gene trees provide important evidence in favour of symbiotic theory at a coarse-grained level, but the ...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2014.09.008
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abstract::In Myxococcus xanthus morphogenetic cell movements constitute the basis for the formation of spreading vegetative colonies and fruiting bodies in starving cells. M. xanthus cells move by gliding and gliding motility depends on two polarly localized engines, type IV pili pull cells forward, and slime extruding nozzle-l...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2004.10.004
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abstract::The DNA-binding domains of eucaryotic GATA factors comprise a four-cysteine Zn finger and an adjacent basic region. Fungal GATA factors regulate nitrogen metabolism, light induction, siderophore biosynthesis and mating-type switching. Hydrophobic interactions determine binding-site specificity. Interactions with other...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s1369-5274(00)00063-1
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abstract::Dectin-1 is an innate immune pattern recognition receptor (PRR) that, through its ability to bind β-glucans, is involved in the recognition of several pathogenic fungi. Dectin-1 can stimulate a variety of cellular responses via the Syk/CARD9 signalling pathway, including phagocytosis, cytokine production and the respi...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2011.07.001
更新日期:2011-08-01 00:00:00
abstract::Bacteria furnish tractable models for complex biological processes, and morphogenesis is now taking its turn. We can already explain in general terms how such elementary forms as rods and cocci are produced, and the shapes of several individual organisms are coming into focus. In most bacteria shape is maintained by t...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2007.07.003
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abstract::Virulence associated protein type III secretion systems (T3SSs) are intricately structured organic nanosyringes that achieve the translocation of bacterial proteins from the prokaryotic cytoplasm across three membranes into the host cytosol. The substrates for these systems number in the hundreds, with remarkably dive...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2009.11.001
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abstract::The continued evolution of antimicrobial resistance in the hospital and more recently in the community threatens to seriously compromise our ability to treat serious infections. The major success of the seven-valent Streptococcus pneumoniae vaccine at reducing both infection and resistance has been followed by the eme...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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更新日期:1999-06-01 00:00:00
abstract::Systems biology is a rapidly expanding field fuelled by the 'omics' era coupled to several new technological advances that have increased the precision of data obtainable, meaning that it is now feasible to obtain quantitative measurements from a single cell. The aim of systems biology is to understand the structure, ...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2009.08.007
更新日期:2009-10-01 00:00:00
abstract::Recently developed techniques allow genomic DNA sequencing from single microbial cells [Lasken RS: Single-cell genomic sequencing using multiple displacement amplification. Curr Opin Microbiol 2007, 10:510-516]. Here, we focus on research strategies for putting these methods into practice in the laboratory setting. An...
journal_title:Current opinion in microbiology
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doi:10.1016/j.mib.2008.05.006
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abstract::Secretion systems play a central role in infectious diseases by enabling pathogenic bacteria to deliver virulence factors into target cells. The type VI secretion system (T6SS) mediates bacterial antagonism in various environments including eukaryotic niches, such as the gut. This molecular machine injects lethal toxi...
journal_title:Current opinion in microbiology
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doi:10.1016/j.mib.2015.11.006
更新日期:2016-02-01 00:00:00
abstract::Legionella pneumophila is a water-borne opportunistic pathogen causing a life-threatening pneumonia called 'Legionnaires' disease'. The Legionella quorum sensing (Lqs) system produces and responds to the α-hydroxyketone signaling molecule 3-hydroxypentadecane-4-one (Legionella autoinducer-1, LAI-1). The Lqs system con...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
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abstract::Atomic force microscopy imaging and force spectroscopy have recently opened a range of novel applications in microbiology. During the past two years, rapid advances have been made using atomic force microscopy to visualize the surface structure of two-dimensional bacterial protein crystals, biofilms and individual cel...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/s1369-5274(03)00058-4
更新日期:2003-06-01 00:00:00
abstract::Barring bioavailability and nutritional limitations, virtually all organic anthropogenic chemicals can be naturally biodegraded. It is to this phenomenon we owe thanks to the long established 'tritrophic trinity' of microbe-plant-insect interactions. Over hundreds of millennia these organisms have coevolved, producing...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2004.04.007
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abstract::Molecular techniques are providing unprecedented insights into the organismal and functional make-up of natural microbial consortia. Apart from nucleic acid based approaches, community proteomics has the potential to provide a high-resolution representation of genotypic and phenotypic traits of distinct community memb...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2009.03.004
更新日期:2009-06-01 00:00:00
abstract::Single cell genomics (SCG) uncovers hereditary information at the most basic level of biological organization. It is emerging as a powerful complement to cultivation-based and microbial community-focused research approaches. SCG has been instrumental in identifying metabolic features, evolutionary histories and inter-...
journal_title:Current opinion in microbiology
pub_type: 杂志文章,评审
doi:10.1016/j.mib.2012.09.001
更新日期:2012-10-01 00:00:00